Clinical trials: sponsored by McMaster University
Pediatric Obesity
Family-centred E-health in Pediatric Weight Management: A Pilot Study
This is a pilot study to examine the feasibility of implementing an objective physical activity and sleep monitoring tool into a pediatric weight management program in conjunction with a personal health record (PHR) for children…
- Trial name
- NCT01912183
- Testing
- Communication through PHR outside clinic, Monitoring device in PHR, Physical activity and sleep monitor
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Older Adults, Muscle Protein Synthetic Response to Protein
Influence of Reduced Daily Step Count and Anabolic Interventions on Muscle Protein Metabolism in Older Persons
As the loss of muscle mass with aging is associated with a dysregulation of muscle protein synthesis (MPS) that is generally characterized by an 'anabolic resistance' to nutrients, the primary outcome of the trial is to…
- Conditions
- Older Adults, Muscle Protein Synthetic Response to Protein, Reduced Physical Activity
- Trial name
- NCT02347137
- Testing
- step-reduction, step-reduction plus resistance exercise
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Venous Thrombosis, Pulmonary Embolism
Extended Out-of-hospital Low-molecular-weight Heparin Prophylaxis Against DVT and PE in Patients Undergoing Major Lung Resection
Postoperative venous thromboembolism (VTE) is a significant health-care problem, resulting in significant morbidity, mortality and resource utilization. The true incidence is unknown, and may range from 1% to 15%.
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Lung Neoplasms
- Trial name
- NCT02258958
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- McMaster University
Respiratory Insufficiency of Prematurity
Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD).
- Trial name
- NIPPV (NCT00433212)
- Testing
- nCPAP, NIPPV
- Where
- 35 sites in United States, Austria and 8 more
- Volunteers
- 1,011 people
- Sponsor
- McMaster University
Apnea of Prematurity
Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study
Apnea of prematurity is a common condition that is usually treated with methylxanthines. Methylxanthines are adenosine receptor blockers that have powerful influences on the central nervous system.
- Trial name
- CAP-S (NCT01020357)
- Testing
- Caffeine citrate injection
- Where
- 4 sites in Australia, Canada
- Volunteers
- 201 people
- Sponsor
- McMaster University
Osteoarthritis, Hip
Outcomes Following Anterior Approach to Total Hip Arthroplasty
Osteoarthritis disables approximately 10% of people who are 60 years or older and compromises the quality of life of more than 20 million Americans every year.
- Trial name
- AAP (NCT01353885)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Lung Neoplasms, Pleural Effusion
Comparison of Pleural Drainage Systems on Reducing Pleural Effusion Formation Following Lung Resection
The chest cavity contains a small amount of fluid (pleural effusion). In normal circumstances this fluid is kept in balance. When surgery is performed on the lung, there can be accumulation of more fluid due to many causes.
- Trial name
- NCT01776372
- Testing
- Medela Thopaz Thoracic Drainage System, Atrium Express Dry Seal Chest Drain
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- McMaster University
Spinal Cord Injury
Physical Activity Guidelines for People With Spinal Cord Injury (SCI)
The first evidence-based physical activity guidelines for people with spinal cord injury were released in March, 2011. This project will evaluate the implementation of the new physical activity guidelines in a community exercise…
- Trial name
- NCT01368172
- Testing
- Physical Activity Guidelines
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Atrial Fibrillation, Valvular Heart Disease
Prolongation of the Interval Between Prothrombin Time Tests in Stable Patients II
More than 2 million patients in North America are treated with warfarin - a "blood thinner" - to prevent blood clots in arteries or veins.
- Conditions
- Atrial Fibrillation, Valvular Heart Disease, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- PRINT-II (NCT01654042)
- Testing
- Prolonged interval between PT testing
- Where
- Canada
- Sponsor
- McMaster University
Critical Illness
Early Rehabilitation in Critically Ill Children Pilot Study
Critically ill patients are often confined to bedrest, because of the nature of their illness. However, it has now been shown that prolonged bedrest and immobility, particularly in critically ill adults and children, can lead to…
- Trial name
- WeeHab in PCCU (NCT01531816)
- Testing
- Early Rehabilitation intervention
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Heparin-Induced Thrombocytopenia
Heparin-Induced Thrombocytopenia Score Card Study
Main Research Question: Can two new types of test, one called the 4T's score and the other called a rapid assay, help doctors correctly identify which patients are unlikely to have heparin-induced thrombocytopenia (HIT)? HIT is a…
- Trial name
- NCT00489437
- Testing
- ID-PaGIA Heparin/PF4 antibody test, Clinical Prediction Score-HIT Score Card
- Where
- Canada
- Volunteers
- 536 people
- Sponsor
- McMaster University
Perioperative Stroke
Neurological Impact of Vascular Events In Noncardiac Surgery patIents cOhort evaluatioN Pilot Study
Two hundred million adults worldwide have major surgery every year. A million of these patients will have an obvious stroke after their surgery. Another 10 million patients may have "silent" strokes.
- Trial name
- NCT01369537
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Muscle Protein Synthesis
Effect of Supplementing a Mixed Macronutrient Beverage With Graded Doses of Leucine on Myofibrillar Protein Synthesis
Muscle mass is normally maintained through the regulated balance between the processes of protein synthesis (i.e. making new muscle proteins) and protein breakdown (breaking down old muscle proteins).
- Trial name
- NCT01885429
- Testing
- Positive Control, Negative Control, Low Protein Low Leucine Spike
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cardiovascular Disease
The Effects of Tai Chi in Older Patients With Cardiovascular Disease
Cardiac exercise rehabilitation consists of walking and bicycling activities. As the population requiring rehabilitation is aging, other forms of exercise may be useful and better tolerated.
- Trial name
- NCT01592357
- Testing
- Tai Chi exercise
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McMaster University
Gastroesophageal Reflux
A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD
LNF is an effective intervention in the management of patients with chronic GERD requiring maintenance therapy. LNF is cost-effective compared with long-term medical therapy.
- Trial name
- NCT00182260
- Testing
- Proton Pump Inhibitors, Laparoscopic Nissen Fundoplication
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- McMaster University
Allergic Rhinitis
Repeat Dose Nasal Allergen Challenge
What happens in the nose during an allergic reaction? Are there changes that a new drug could treat? What is the best way to test new drugs?The response of the nose to being exposed to cat allergen in someone who is allergic to…
- Trial name
- NCT01110837
- Testing
- Allergen
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Asthma
Effect of Allergen Challenge on Inflammation Induced by Toll-like Receptor Stimulation in a Nasal Model
Asthma is one of the most common diseases affecting about 2.5 million Canadians, and can result in reduced quality of life and difficulties with work and school.
- Trial name
- NCT01204060
- Testing
- Nasal allergen challenge
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Rotator Cuff Tear
Arthroscopic Surgery and Platelet Rich Plasma In Rotator Cuff Tear Evaluation
Rotator cuff tears are a common injury that lead to pain and loss of function for those who suffer from it. Treatment includes the use of arthroscopic surgery to return function to the patient and reduce their pain.
- Trial name
- ASPIRE (NCT01170312)
- Testing
- Autologous conditioned plasma (ACP), Normal saline
- Where
- 3 sites in Canada
- Volunteers
- 25 people
- Sponsor
- McMaster University
Head and Neck Cancer, Dysphagia
A Pilot Study of ALTENS in Improving Dysphagia Induced by IMRT for Head and Neck Cancers
Study hypothesis: ALTENS techniques, administered within the first 3 months after radiation completion, can improve radiation-induced dysphagia and associated symptoms in head and neck cancer patients.
- Trial name
- NCT01697891
- Testing
- Codetron ALTENS
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- McMaster University
Coronary Artery Disease
Comparison of Heparin Types; Efficacy and Safety
Heparin, a blood thinner, is used routinely in Open-heart surgery. Do different brands of this drug have differing clinical effects despite both having exactly the same regulation and marketing specifications?
- Trial name
- NCT01343381
- Testing
- Hepalean Heparin, PPC Heparin
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McMaster University