Clinical trials: sponsored by McMaster University
Traumatic Brain Injury
Measurement of Optic Nerve Sheath in Traumatic Raised Intracranial Pressure
Trauma patients are at risk for serious head trauma. The consequences of serious head trauma are often life altering. Currently, the only method available to rapidly assess the severity of head injury and need for neurosurgical…
- Trial name
- MOONSTRIP (NCT00783809)
- Where
- Canada
- Volunteers
- 560 people
- Sponsor
- McMaster University
Diabetes
Detecting Diabetes Sooner With a Risk Survey for the Family Doctor:Comparing Internet and Traditional Methods of Communication for Patients and Doctors
This pilot RCT study aims to develop and evaluate the uptake, feasibility, and potential value of a strategy for web-diabetes risk assessment versus paper-based methods in an undiagnosed diabetes population over 40 years of age…
- Trial name
- NCT01529918
- Testing
- CANRISK (Canadian Diabetes Association Assessment)
- Volunteers
- 2,000 people
- Sponsor
- McMaster University
Major Depression, Bipolar Disorder
Longitudinal Study of People Presenting for First Treatment of a Mood Disorder
The goal of this project is to study the course and outcome of illness in individuals who present with a first episode of depression or mania, or who have a recurrent disorder but have never received treatment.
- Trial name
- NCT01529905
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- McMaster University
Low Back Pain
The Effect Of A Neurodynamic Treatment On Nerve Conduction In Clients With Low Back Pain
The purpose of this study is to determine if a certain treatment for low back pain can change the way nerves in the leg send messages.
- Trial name
- NCT01402895
- Testing
- Exercise, Mobilizations
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- McMaster University
Major Depressive Disorder, Insomnia
Quetiapine Extended Release (XR) for the Treatment of Menopausal Depression
The study was designed to examine the efficacy and tolerability of quetiapine XR for the treatment of women who suffer from depression in the context of the menopausal transition and postmenopausal years.
- Conditions
- Major Depressive Disorder, Insomnia, Hot Flashes
- Trial name
- NCT00723970
- Testing
- Quetiapine Extended Release
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Pain
A Pilot Study Evaluating a Multidisciplinary Chronic Pain Group Therapy in a Primary Care Setting
The investigators will evaluate the effectiveness of "Living Everyday Above-and-beyond Pain" (LEAP) program in the primary care setting.
- Trial name
- LEAP (NCT01517256)
- Testing
- Living Everyday Above-and-beyond Pain (LEAP), Wait-listed
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Congestive Heart Failure
Hospital Versus Home Based Exercise in Patients With Chronic Stable Heart Failure
The objective of this study is to compare the effect of monitored, home-based exercise versus hospital-based exercise on the quality of life of patients with congestive heart failure.
- Trial name
- PEAK-HF (NCT01480921)
- Testing
- Home-based exercise training, Supervised hospital-based exercise training
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- McMaster University
Deep Vein Thrombosis
Selective D-Dimer Testing Compared With Uniform D-Dimer Testing in the Diagnosis of Deep Vein Thrombosis (SELECT)
The purpose of this study is to compare two diagnostic interventions to improve the way D-dimer blood testing (MDA D-dimer) is used to diagnose first time symptomatic deep vein thrombosis.
- Trial name
- SELECT (NCT00157677)
- Testing
- D-dimer testing
- Where
- 5 sites in Canada
- Volunteers
- 1,727 people
- Sponsor
- McMaster University
Inflammatory Arthritis
The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis
Inflammatory arthritis is a major cause of permanent joint damage. Joint damage causes functional disability and physical deformity.
- Trial name
- MRx (NCT00808496)
- Testing
- MRI, Radiography, Standard of Care
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- McMaster University
Influenza
Hutterite Influenza Prevention Study
The goal of this randomized clinical trial is to determine whether immunizing children in Hutterite colonies with inactivated influenza vaccine can prevent influenza and its complications in other colony members.
- Trial name
- NCT00877396
- Testing
- Influenza vaccination, Hepatitis A Vaccine
- Volunteers
- 4,771 people, healthy volunteers welcome
- Sponsor
- McMaster University
Stroke
A Comparison of Two Intensive Walking Training Interventions in Community Dwelling Individuals With History of Stroke
Stroke is a major cause of disability in Canadian adults. Following a stroke, many people have difficulty walking in their home and in the community.
- Trial name
- NCT00561405
- Testing
- Motor Learning Walking Program, Body Weight Supported Treadmill Training
- Where
- Canada
- Volunteers
- 71 people
- Sponsor
- McMaster University
Breast Hypertrophy
Vertical Scar Versus Inferior Pedicle Reduction Mammoplasty
Main research question: Is vertical scar reduction mammoplasty superior when compared to inferior pedicle reduction mammoplasty in terms of patient quality of life and cost-effectiveness? Why is this research important?: There is…
- Trial name
- NCT00149344
- Testing
- Vertical scar versus inferior pedicle reduction mammoplasty
- Where
- Canada
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- McMaster University
Deep Vein Thrombosis
MDA D-Dimer / Recurrent DVT Study
To determine whether treatment and further investigation can be safely withheld in patients who present with suspected recurrent deep vein thrombosis (DVT) and have either a (i) negative D-Dimer or (ii) a positive D-Dimer with…
- Trial name
- NCT00157599
- Testing
- various diagnostic measures for DVT (e.g., CUS)
- Where
- 6 sites in Canada, Netherlands
- Volunteers
- 500 people
- Sponsor
- McMaster University
Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia
Randomized Trial of Vaginal Self Sampling for Human Papillomavirus (HPV)
Up to 30% of Canadian women do not participate in Pap smear screening for cervical cancer prevention despite many being members of family practices and having access to family physicians.
- Trial name
- NCT01095198
- Testing
- offer of vaginal self collection, 2nd reminder letter for Pap testing
- Where
- Canada
- Volunteers
- 1,440 people
- Sponsor
- McMaster University
Cardiovascular Diseases, Inflammation
Evaluation of Volume Status in Peritoneal Dialysis Patients
Patients with kidney failure on dialysis have a much higher risk of developing cardiovascular disease as compared to the general population.
- Conditions
- Cardiovascular Diseases, Inflammation, Peritoneal Dialysis
- Trial name
- NCT00182338
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McMaster University
Sarcopenia
Dose Response of Whey and Soy Protein Ingestion With and Without Resistance Exercise in Elderly Men
When we age, we lose muscle. It is not exactly clear why this happens, but we do know that this muscle loss can increase health risks and lead to health problems. Lifting weights (i.e.
- Trial name
- NDC (NCT01062711)
- Testing
- Whey or soy protein
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- McMaster University
Overweight, Obesity
"Improving Diet, Exercise And Lifestyle (IDEAL) for Women" Study
Diets all share the same principle: eat less energy than you need. This results in weight loss. However, the weight loss is usually a combination of a loss of body fat and muscle mass.
- Trial name
- NCT00710398
- Testing
- Exercise - Aerobic and Resistance, Dietary - Caloric Restriction
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- McMaster University
Fetal Membranes, Premature Rupture, Induced Labor
Intracervical Catheters for Induction of Labour in Women With Prelabour Rupture of Membranes at Term
The purpose of this study is to examine the feasibility of using intracervical balloon catheters for cervical ripening as part of labour induction in healthy, GBS-negative women with prelabour rupture of membranes at term.
- Trial name
- IC-PROM (NCT00890630)
- Testing
- Intracervical Balloon Catheter, Oxytocin
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- McMaster University
Knowledge Transfer, Clinical Decision-making
The Effect and Mediators of Two Knowledge Translation Strategies
Purpose: This study will compare the effectiveness and mediators of two different knowledge transfer (KT) interventions in terms of their impact on changing knowledge and behavior (utilization and clinical reasoning) related to…
- Trial name
- NCT00298727
- Testing
- SHIPS, ePBL
- Where
- Canada
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- McMaster University
Optimal Anabolic Nutrition Interventions
Post-exercise Dietary Protein Strategies
Protein ingestion increases the rate at which the body builds new proteins in skeletal muscle (muscle protein synthesis. This study is designed to examine how the pattern of feeding affects muscle protein synthesis following…
- Trial name
- NCT01319513
- Testing
- whey protein bolus, whey protein pulses
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University