Clinical trials: sponsored by McMaster University
IBD (Inflammatory Bowel Disease), Ulcerative Colitis (UC)
Assessing Interventions of Diet in IBD
In this study, we are trying to learn how certain diets affect people with inflammatory bowel disease (IBD). We want to understand what makes it hard or easy for them to stick to different eating plans, like intermittent fasting…
- Conditions
- IBD (Inflammatory Bowel Disease), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- AID-IBD (NCT06773182)
- Testing
- Intermittent Fasting Intervention, Mediterranean Diet Intervention, Low FODMAP Diet Intervention
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- McMaster University
Atrial Fibrillation, Atrial Flutter
Anteroposterior Versus Anterolateral Electrode Position for Electrical Cardioversion of Atrial Fibrillation
Atrial fibrillation is the most common heart rhythm disorder (arrhythmia) worldwide. Nearly 40 million people are affected by atrial fibrillation worldwide, and this number is expected to increase by over 50% by 2050.
- Trial name
- SHOCK-VECTOR (NCT05511389)
- Testing
- Anterolateral electrode position, Anteroposterior electrode position, Manual pressure
- Where
- 4 sites in Canada
- Volunteers
- 1,750 people
- Sponsor
- McMaster University
Postpartum Depression
CBT for Postpartum Depression and Infant Emotion Regulation
The primary objective of this study is to determine if online group cognitive behavioral therapy (CBT) for maternal postpartum depression (PPD) added to treatment as usual (TAU) leads to greater improvements in infant emotion…
- Trial name
- NCT05269732
- Testing
- Group Cognitive Behavioural Therapy (CBT)
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- McMaster University
Creativity
The Creative Team Member: A Study of the Influence of AI Integration Timing on Brainstorming and Ideation
This study aims to examine how the timing of artificial intelligence (AI) integration during group brainstorming activities affects the creativity and ideation of participants.
- Trial name
- NCT07693803
- Testing
- Artificial Intelligence First (Early Integration), Artificial Intelligence Last (Late Integration)
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Squamous Cell Carcinoma, Oropharyngeal Cancers
Oral Mucositis Management in Patients Receiving Radiation for Head and Neck Cancer: An Evaluation of a Barrier Based Treatment
Patients who are undergoing radiation therapy on their head and/or neck, are highly likely to experience oral mucositis, which is inflammation and irritation of the mucus membranes in your mouth.
- Conditions
- Squamous Cell Carcinoma, Oropharyngeal Cancers, Nasopharyngeal Cancer, Hypopharyngeal Cancer
- Trial name
- TOPHAT (NCT07697287)
- Testing
- Gelclair Oral Mouth Rinse
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- McMaster University
Fracture, Fractures, Hip
The PREVENT Trial: a Pragmatic Cluster Randomized Controlled Trial of a Multifaceted Fracture Prevention Model for Long-term Care
Hip fractures occur nearly twice as often for older adults residing in long-term care as they do in older adults of a similar age still living in other settings.
- Conditions
- Fracture, Fractures, Hip, Osteoporosis
- Trial name
- PREVENT (NCT04947722)
- Testing
- PREVENT Program
- Where
- Canada
- Volunteers
- 3,060 people, healthy volunteers welcome
- Sponsor
- McMaster University
Long COVID
Fatigue in Long COVID
Long COVID affects about 6 in 100 people after a COVID-19 infection. It can cause ongoing problems like ongoing tiredness, muscle pain, and "brain fog." We know very little about which treatments might be helpful for long COVID.
- Trial name
- FALCON (NCT07697261)
- Testing
- Lightning Process, Activity Pacing
- Volunteers
- 100 people
- Sponsor
- McMaster University
Pulmonary Atelectasis
Ventilation During Cardiopulmonary Bypass (CPB) for Cardiac Surgery
During most types of heart surgery cardiopulmonary bypass (CPB) is used. CPB enables blood to be directed away from the heart and the lungs and pumped through the body while the heart is not beating.
- Trial name
- NCT02070445
- Where
- Canada
- Sponsor
- McMaster University
Diabetes Mellitus Type 2
Continuation of Metformin to Improve And Keep Peri-operative Glycemic Control
Type II Diabetes Mellitus patients having surgery who adhere to their regular scheduled metformin dosing and take this medication on the morning of surgery will have better glycemic control peri-operatively and potentially suffer…
- Trial name
- CANTAKE (NCT02571608)
- Testing
- Metformin
- Sponsor
- McMaster University
Postdural Puncture Headache
Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches
Postdural puncture headache (PDPH) is a severe, debilitating complication of dural puncture that can arise from insertion of an epidural or spinal needle for labour analgesia.
- Trial name
- SPGB (NCT04515901)
- Testing
- 2% lidocaine
- Where
- Canada
- Sponsor
- McMaster University
Dementia, Alzheimer s Disease
Brain Wave Informed Non-invasive Brain Stimulation: Improving Neural Networks of Working Memory in Dementia: a Proof-of-concept Study
Working memory helps us hold information for a short time so one can think and make decisions. It keeps thoughts on track. As one gets older, working memory gets weaker.
- Trial name
- BWIBS-WM (NCT07673770)
- Testing
- EEG-triggered TMS
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Syphilis
The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barriers to Care
The goal of this clinical trial is to learn if a finger-prick blood test for rapid diagnosis of syphilis infection can be implemented in a low-barrier prenatal clinic for people at risk of syphilis in pregnancy.
- Trial name
- PRESSING (NCT06829602)
- Testing
- Rapid Syphilis/HIV point-of-care test
- Where
- Canada
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- McMaster University
Prostate Cancer, Cardiovascular Disease
A Study for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients
RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a…
- Trial name
- RADICALPC (NCT03127631)
- Testing
- Nutrition, Exercise, Smoking cessation
- Where
- 61 sites in United States, Australia and 7 more
- Volunteers
- 5,000 people
- Sponsor
- McMaster University
Cannabis Use Disorder, Moderate, Cannabis Use Disorder, Severe
Tirzepatide in the Treatment of Cannabis Use Disorder
Cannabis is the most commonly used psychoactive substance in Canada. A sub-group of cannabis users develop Cannabis Use Disorder (CUD).
- Trial name
- NCT07671248
- Testing
- Tirzepatide
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Type 2 Diabetes (T2DM)
Remission Evaluation of Metabolic Interventions in Type 2 Diabetes in Primary Care (REMIT-Prime)
The Remission Evaluation of Metabolic Interventions in Type 2 diabetes (REMIT) program incorporates a non-surgical-remission-inducing therapeutic approach, pairing health coaching with physician-led pharmacotherapy.
- Trial name
- REMIT-Prime (NCT07665567)
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- McMaster University
Pain, Post Operative Nausea and Vomiting
Satisfactory Analgesia Minimal Emesis in Day Surgeries
Currently nearly 70% or more surgeries are being done as ambulatory (day care) procedures as they offer significant benefit to the patients as well as to the hospitals.
- Trial name
- SAME-Day (NCT02223377)
- Testing
- Morphine, Hydromorphone
- Where
- 2 sites in Canada
- Volunteers
- 402 people
- Sponsor
- McMaster University
Healthy Volunteers, Female
Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS)
The goal of this clinical trial is to learn if micronized progesterone (PROMETRIUM®) influences the muscle-building response to resistance exercise in healthy premenopausal women aged 18-30 years.
- Conditions
- Healthy Volunteers, Female, Progesterone, Premenopausal
- Trial name
- MP4 MPS (NCT07173361)
- Testing
- Micronized progesterone (oral capsules)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mobility Limitation
Stepping-Up: Partnering With the Community to Prevent Early Mobility Decline
Preclinical mobility limitations (PCML) manifest early in the process of declining mobility, and are not typically identified or acted upon by clinicians.
- Trial name
- Stepping-Up (NCT04368949)
- Testing
- Stepping-Up, Telephone-Based Coaching Walking Program, Chair-Based Yoga Program
- Where
- Canada
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- McMaster University
Parkinson Disease(PD)
Rhythm Psychophysics With Parkinson's Patients
The goal of this interventional study is to understand how the rhythmic abilities of individuals in the early stages of Parkinson's Disease (PD) are impacted by their levels of dopamine.
- Trial name
- RPPD (NCT07647913)
- Testing
- Withholding Levodopa
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- McMaster University
Back Pain
Ultrasound Guided Diagnostic Lumbar Medial Branch Blocks
Can an ultrasound machine be used to perform a diagnostic lumbar medial branch block?
- Trial name
- NCT00909272
- Testing
- Lumbar medial branch block, Ultrasound landmarks
- Where
- Canada
- Sponsor
- McMaster University