Clinical trials: sponsored by McMaster University
Postpartum Depression
Public Health Nurse-Peer Co-Led Group Cognitive Behavioral Therapy for Postpartum Depression
The purpose of this study is to determine the effectiveness of an online 9-week group Cognitive Behavioural Therapy (CBT; a type of talking therapy) intervention that is co-led by public health nurses (PHNs) and individuals who…
- Trial name
- NCT06597448
- Testing
- Cognitive Behavioral Therapy for Postpartum Depression (PPD)
- Where
- Canada
- Volunteers
- 170 people
- Sponsor
- McMaster University
Antiphospholipid Syndrome, Arterial Thrombosis
Registry on Augmented Antithrombotic Treatment Regimens for Patients With Arterial Thrombotic APS
The goal of this registry is to gather more information on the efficacy and safety of various antithrombotic regimens. The registry collects data on patients with antiphospholipid syndrome and an arterial event within the past 12…
- Trial name
- NCT05646394
- Testing
- Dual antiplatelet therapy, Combined antithrombotic therapy, Vitamin K antagonist standard intensity
- Where
- 3 sites in Argentina, Canada
- Volunteers
- 150 people
- Sponsor
- McMaster University
Shoulder Dislocation
Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode
Each year within Canada and the US, more than 30,000 children and adolescents will have an injury to their shoulder resulting in a shoulder dislocation.
- Trial name
- PROMPT (NCT04887337)
- Testing
- Arthroscopic stabilization, Rehabilitation including a period of immobilization followed by physical therapy
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- McMaster University
Hip Fracture Surgery, Cardiovascular Prevention
Hip Fracture Surgery Arterial and Venous Thrombotic Events Prevention
A third of patients undergoing surgery for a hip fracture develop a myocardial injury (i.e., an elevated troponin measurement), and these patients are at substantial risk of death and morbidity.
- Conditions
- Hip Fracture Surgery, Cardiovascular Prevention, Venous Thromboembolism (VTE)
- Trial name
- HIPSTER-Pilot (NCT07228663)
- Testing
- rivaroxaban and ASA, Low-molecular weight heparin, Fondaparinux
- Where
- 3 sites in Canada, Italy
- Volunteers
- 100 people
- Sponsor
- McMaster University
Firefighters
PeerOnCall: Implementing and Evaluating App-Based Peer Support in Canadian Fire Services
The goal of this clinical trial is to test how best to implement a mobile peer support app called PeerOnCall in Canadian fire services. The main questions it aims to answer are: 1.
- Trial name
- NCT07199387
- Testing
- App Users (Structured Implementation), App Users (Standard Implementation)
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- McMaster University
Shoulder Dislocation, Sport Injury
RCT Evaluating First Time Shoulder Dislocation
The primary objective of the pilot study is to assess the feasibility of a definitive trial to determine the effect of arthroscopic soft tissue stabilization vs.
- Conditions
- Shoulder Dislocation, Sport Injury, Anterior Dislocation
- Trial name
- REDUCE (NCT05715021)
- Testing
- Bankart + Remplissage Procedure
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Shoulder Dislocation, Sport Injuries
Shoulder Instability Trial Comparing Arthroscopic Stabilization Benefits Compared With Latarjet Procedure Evaluation - STABLE Definitive Trial
The primary objective of the study is to evaluate the functional shoulder recovery of patients with recurrent shoulder dislocations at 24 months when treated with either arthroscopic capsuloligamentous repair (Bankart Procedure…
- Conditions
- Shoulder Dislocation, Sport Injuries, Anterior Dislocation
- Trial name
- STABLE-2 (NCT05705479)
- Testing
- Bankart + Remplissage Procedure, Latarjet Procedure
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- McMaster University
Stroke
Optimizing Recruitment to Drive Equitable Research Opportunity in Stroke Rehabilitation Trials in Canada
Stroke is a major health issue in Canada. Stroke affects over 400,000 Canadians, and this number is expected to nearly double by 2038.
- Trial name
- ORDER-P (NCT06576089)
- Testing
- Supported, women-centred and aphasia-friendly recruitment and enrollment process (ORDER), Traditional recruitment and enrollment processes (TRAD)
- Where
- 5 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McMaster University
Diabetes Mellitus, Congestive Heart Failure
Relative Impacts on Preventative Primary Care--a Longitudinal Evaluation of COVID-19:Phase 1
The goal of this observational study is to describe the impacts of COVID-19 on primary care chronic condition management in Canada within various patient populations.
- Conditions
- Diabetes Mellitus, Congestive Heart Failure, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease
- Trial name
- RIPPLE-C (NCT05813652)
- Testing
- Pre-pandemic time period (Jun 22, 2018 to March 12, 2020), Peri-pandemic time period (March 13, 2020 to December 3, 2021)
- Where
- Canada
- Volunteers
- 919,928 people
- Sponsor
- McMaster University
Covid19, Corona Virus Infection
Functional Recovery of Hospitalised Patients With COVID-19: The COREG Extension Study
Older adults and those with chronic underlying health conditions are the most susceptible to COVID-19 and its complications. Although there has been a rapid response to studying the effects of COVID-19 in the acute stages, little…
- Conditions
- Covid19, Corona Virus Infection, Mobility Limitation, Frailty
- Trial name
- NCT04602260
- Where
- Canada
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation
Mepolizumab in Chronic Obstructive Pulmonary Diseases (COPD) With Eosinophilic Bronchitis
Some patients with chronic obstructive pulmonary diseases (COPD) have large number of specific white blood cells called eosinophils in their airways.
- Conditions
- Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation, Bronchitis
- Trial name
- NCT01463644
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
Chronic Cough, Eosinophilic Bronchitis
Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
Cough is the most common presenting symptom to family physician. Chronic Cough affects approximately 10-12% of the general population and is one of the commonest reasons for referral to secondary care.
- Conditions
- Chronic Cough, Eosinophilic Bronchitis, Asthma
- Trial name
- MUCOSA (NCT04765722)
- Testing
- Mepolizumab, Normal Saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McMaster University
Psychological Stress
Intermittent Fasting Interventions on Brain Health in Women
Adults experience high psychological stress due to many factors such as school, workplace, or personal life. Adult women are known to experience higher stress levels than men.
- Trial name
- NCT05628727
- Testing
- Time Restricted Feeding, 5:2 Fasting
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- McMaster University
Post-operative Delirium, Major Non-cardiac Surgery
MIND After Surgery
Delirium is the most common neurological adverse outcome in elderly surgical patients. It is associated with an increased mortality and morbidity, including need for prolonged hospital stay and institutional care.
- Trial name
- MIND (NCT03785158)
- Testing
- Liquid Melatonin
- Where
- 2 sites in Canada
- Volunteers
- 88 people
- Sponsor
- McMaster University
Asthma
Therapeutic Relevance of Abnormal Airway Morphology in Asthma
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of…
- Trial name
- AirPATH (NCT06970080)
- Testing
- Inhaled corticosteroid (ICS), Oral Corticosteroid (OCS)
- Where
- 2 sites in Canada
- Volunteers
- 242 people
- Sponsor
- McMaster University
Alcohol Use Disorder, Alcohol Drinking
Using Neuroeconomics to Characterize State-Based Increases and Decreases in Alcohol Value
This study uses techniques from an area of research known as neuroeconomics, which integrates concepts and methods from psychology, neuroscience, and economics to better understand how people make decisions and how these…
- Trial name
- NCT04067765
- Testing
- Cue Exposure
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- McMaster University
Pain, Postoperative, Pain, Acute
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed
- Trial name
- COPE (NCT04274530)
- Testing
- Cognitive Behavioural Therapy
- Where
- 10 sites in United States, Canada
- Volunteers
- 1,024 people
- Sponsor
- McMaster University
Chronic Cough (CC), Asthma
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough.
- Trial name
- NCT07085975
- Testing
- Adenosine 5'-triphosphate
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aging
Virtual GERAS DANCE Feasibility RCT
GERAS DANcing for Cognition and Exercise (DANCE) is a therapeutic mind-body program for older adults (aged 60+) developed with rehabilitation and geriatric medicine expertise at the GERAS Centre for Aging Research at Hamilton…
- Trial name
- NCT05202522
- Testing
- Virtual GERAS DANCE
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- McMaster University
Crohn's Disease of Both Small and Large Intestine
Crohn's Disease - Inflammation and Microbial Proteolytic Activity
This study postulates that altered microbiota associated with areas of mucosal inflammation in CD, can be characterized by an increased proteolytic profile.
- Trial name
- CIMPA (NCT06503081)
- Testing
- Colonoscopy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University