Clinical trials: sponsored by McMaster University
Crohn's Disease of Both Small and Large Intestine
Crohn's Disease - Inflammation and Microbial Proteolytic Activity
This study postulates that altered microbiota associated with areas of mucosal inflammation in CD, can be characterized by an increased proteolytic profile.
- Trial name
- CIMPA (NCT06503081)
- Testing
- Colonoscopy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Menstrual Cycle, Resistance Exercise
Menstrual Cycle Phase Based Training
The primary purpose of this study is to employ state-of-the-art methods to fill current knowledge gaps on the effects of the menstrual cycle on resistance exercise training adaptations.
- Trial name
- MCPBT (NCT05936424)
- Testing
- Unilateral Resistance Exercise Leg, Non-Exercise Control Leg
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Dermatitis, Atopic, Dermatitis
Effect of Benralizumab in Atopic Dermatitis
Atopic Dermatitis (AD), also known as eczema, is a common skin disease characterized by itchy lesions. The prevalence of AD has increased over the past few decades, with 15-30% of children and 2-10%of adults being affected.
- Conditions
- Dermatitis, Atopic, Dermatitis, Eczema, Skin Diseases
- Trial name
- NCT03563066
- Testing
- Benralizumab
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Hemophilia, Chronic Disease
Patient Reported Outcomes Burdens and Experiences - Phase 3
The PROBE Phase-3 study will collect data on patient reported outcomes, burdens, and experiences in patients living with hemophilia.
- Trial name
- PROBE-3 (NCT03549858)
- Testing
- Quality of life measure (survey)
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- McMaster University
Head and Neck Cancer, Nerve Injury
Assessing Spinal Accessory Nerve Recovery After Post-operative Electrical Stimulation
Shoulder weakness and pain are common after neck dissection surgery for head and neck cancer. This is often caused by injury to the spinal accessory nerve, which controls important shoulder muscles.
- Conditions
- Head and Neck Cancer, Nerve Injury, Neck Dissection
- Trial name
- SpARES (NCT07074392)
- Testing
- Electrical Stimulation
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McMaster University
Glucose Tolerance Impaired
Dose Response Relationship Between Fat Ingestion and Metabolism
The goal of this clinical trial is to compare features of metabolism in healthy, young adults after they consume four meals of differing fat quantity.
- Trial name
- AFDR (NCT05906342)
- Testing
- 20% fat meal, 40% fat meal, 60% fat meal
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Covid-19, Asthma
COVID-19 Related Lung Ventilation and Perfusion Injury
Little is currently known about the immediate and long-term effect of COVID-19 on lung ventilation (delivery of air to the lungs) and lung perfusion (delivery of blood to the lungs).
- Conditions
- Covid-19, Asthma, Healthy
- Trial name
- NCT04549636
- Testing
- V/Q SPECT-CT, St. George's Respiratory Questionnaire (SGRQ), mMRC (Modified Medical Research Council) Dyspnea Scale
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
Depression, Anxiety
Evaluate the Usefulness of Mental Health e-Learning
In this proposal, the investigators plan to study the impact of In this proposal, we plan to study the impact of e-learning on mental health literacy and stigma related to anxiety and depression.
- Trial name
- NCT06393322
- Testing
- Depression e-Learning A, Depression e-Learning B, Anxiety e-Learning A
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- McMaster University
ADHD
Evaluating a Digital Cognitive Training Intervention in Adults With ADHD
The goal of this clinical trial is to evaluate whether a digital cognitive training program can reduce symptoms of ADHD, improve executive functioning, and decrease problematic internet use in adults aged 18-65 with a diagnosis…
- Trial name
- NCT07050225
- Testing
- Digital Cognitive Training, Digital Non-cognitive Training Intervention
- Volunteers
- 52 people
- Sponsor
- McMaster University
Hand; Fracture, Phalanx
IM Screw vs. K-wire Fixation of Proximal/Middle Phalanx Fractures
When people break their fingers, sometimes surgery is needed to align the bones to heal them properly. There are different ways to fix broken bones in hands, such as plates, pins, or screws.
- Trial name
- HANDFIX (NCT06372067)
- Testing
- Intramedullary screw, Kirschner wire
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- McMaster University
COVID-19, SARS-CoV2 Infection
Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol
This is a phase 1 study in healthy volunteers who have received at least three doses of an mRNA COVID-19 vaccine, to evaluate the safety and immune responses that develop in the blood and lungs following the administration by…
- Trial name
- NCT05094609
- Testing
- Ad5-triCoV/Mac, ChAd-triCoV/Mac
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hip Fracture
A Randomised, Controlled Comparison of Vitamin D Strategies is Acute Hip Fracture Patients
The purpose of the study is to determine the best dose of Vitamin D to give to hip fracture patients to achieve the optimal therapeutic level.
- Trial name
- NCT00424619
- Testing
- Vitamin D2
- Volunteers
- 64 people
- Sponsor
- McMaster University
High Altitude Hypoxia, Exercise
Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral…
- Trial name
- NCT07063732
- Testing
- Ketone Monoester (KME)
- Where
- 2 sites in United States, Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McMaster University
Frailty
Frailty Rehabilitation
Frailty is an important clinical state that contributes to falls, hospitalization, institutionalization and death. When an individual simultaneously has many health problems, a frailty "tipping point" may be triggered by even a…
- Trial name
- NCT03824106
- Testing
- Control, Group Exercise, Nutrition and Medication review
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- McMaster University
Osteoporosis
Gaining Optimal Osteoporosis Assessments in Long-Term Care (GOAL)
The aim of this study is to disseminate the 2010 Osteoporosis Canada clinical practice guidelines, using a multi-faceted Knowledge Translation (KT) model, as KT aims to close the gap between knowledge generated from research and…
- Trial name
- GOAL (NCT01887392)
- Testing
- Knowledge Translation Education Sessions
- Where
- Canada
- Volunteers
- 6,800 people
- Sponsor
- McMaster University
Hip Osteoarthritis, Knee Osteoarthritis
FitJoints: Getting Fit for Hip and Knee Replacement
Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis.
- Trial name
- NCT05100966
- Testing
- FitJoints Multi-modal Intervention
- Where
- 4 sites in Canada
- Volunteers
- 192 people
- Sponsor
- McMaster University
Osteoporosis
Vitamin D Osteoporosis Long-Term Care Study
The research question is, does a multifaceted, multidisciplinary intervention including small groups, chart audits and point of care tools, increase the number of people receiving optimal vitamin D therapy in the long term care…
- Trial name
- ViDOS (NCT01398527)
- Testing
- Educ sessions & LTC Osteoporosis toolkit
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Osteoporosis, Frailty
The iCARE Study: Education Modules for Fracture Prevention
A large proportion of older adults living in long term care homes are frail and have osteoporosis. With age, there is a gradual and progressive decline in bone quality and quantity and an increase in frailty, which is associated…
- Conditions
- Osteoporosis, Frailty, Chronic Conditions, Multiple, Fracture
- Trial name
- iCARE (NCT05445336)
- Testing
- PREVENT Program
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Frailty, Frail Older Adults
Cognitive Groove (Brought to You by GERAS DANCE)
The goal of this clinical trial is to determine the effect of a community-based rehabilitation intervention (Cognitive Groove, Brought to you by GERAS DANCE), compared to usual care, on clinical outcomes in community-dwelling…
- Conditions
- Frailty, Frail Older Adults, Frailty in Aging, Frailty Syndrome
- Trial name
- GERAS DANCE (NCT06870149)
- Testing
- Dance Rehabilitation Intervention
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
Colitis, Ulcerative
Comparison of Medical RESCUE Strategies for Patients With Steroid-refractory Acute Severe Ulcerative Colitis
This study aims to examine patients with acute severe UC who are refractory to intravenous corticosteroids and determine whether a strategy of using upadacitinib first followed by infliximab in upadacitinib non-responders is…
- Trial name
- RESCUE UC (NCT06660693)
- Testing
- Upadacitinib Oral Product
- Where
- Canada
- Volunteers
- 134 people
- Sponsor
- McMaster University