Clinical trials: sponsored by NYU Langone Health
Sudden Unexplained Death Syndrome, Sudden Unexplained Death in Childhood
Sudden Unexplained Death in Childhood (SUDC) Registry
The purpose is to increase the understanding of the characteristics, circumstances, medical histories and pathologies of children from ages 11 months through 18 years who have died suddenly and unexpectedly, and in some…
- Trial name
- SUDC (NCT03109197)
- Testing
- Biospecimin Collection
- Where
- United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Total Knee Replacement
The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty
The purpose of this study is to explore the acceptability and feasibility of weighted blankets in total knee replacement (TKR) patients.
- Trial name
- NCT07219329
- Testing
- Weighted Blanket
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Monkeypox, Mpox
New York City Observational Study of Mpox Immunity
The goal of this study is to assess the immune response, tolerance, and safety of the low-dose intradermal (forearm) mpox vaccine in people who are HIV+ compared to people who are HIV-, and compared to the standard-dose…
- Conditions
- Monkeypox, Mpox, HIV
- Trial name
- NYC OSMI (NCT05654883)
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Prostate Cancer
PRISM Study: Prostate Recurrence Detection Using Imaging With PSMA PET/MRI Post-high Intensity Focused Ultrasound
The purpose of this study is to compare the sensitivity of PSMA PET/MRI and standard MRI in detecting focal therapy failure in the prostate one year after High-Intensity Focused Ultrasound (HIFU) treatment.
- Trial name
- NCT07184970
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Type 2 Diabetes, Mild Cognitive Impairment
Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring With Mobile Health: Improving Outcomes for Older Adults With Mild Cognitive Impairment
Eligible older adults with Type 2 Diabetes-Mild Cognitive Impairment (T2D-MCI) will be provided a Continuous Glucose Monitoring (CGM) device and asked to share CGM data with their care partners for daily decision-making for…
- Trial name
- CP-CGMH (NCT05601583)
- Testing
- Continuous Glucose Monitor (CGM)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Type 2 Diabetes
Novel Digital Patient-Reported Outcomes Tool for Diabetes Management
Investigators will conduct a hybrid type 1 effectiveness-implementation randomized controlled trial (RCT) to evaluate the effectiveness of iMatter2 versus usual care on reduction in HbA1c at 12-months (primary outcome) among…
- Trial name
- NCT05884775
- Testing
- Mobile Health (mHealth) Patient-Reported Outcome (PRO) tool
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- NYU Langone Health
AVB - Atrioventricular Block, Fetal AVB
Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)
Fetal complete (i.e., third degree, 3°) atrioventricular block (AVB), identified in the 2nd trimester of pregnancy in an otherwise normally developing heart, is almost universally associated with maternal anti-Ro autoantibodies…
- Trial name
- NCT04474223
- Testing
- Dexamethasone, IVIG
- Where
- 24 sites in United States, Canada
- Volunteers
- 1,300 people
- Sponsor
- NYU Langone Health
Overdose, Harm Reduction
Shelter HArm Reduction Evaluation
The proposed study will use mixed methods research to examine overdose and other health-related impacts of harm reduction initiatives in NYC homeless shelters.
- Trial name
- SHARE (NCT07170072)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- NYU Langone Health
Metastatic Melanoma, Advanced Melanoma
ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab
The purpose of this study is to investigate the use of ctDNA measurements to guide first-lien therapy choice for patients with advanced or metastatic melanoma. Primary endpoints include progression-free survival.
- Trial name
- NCT07504796
- Testing
- Nivolumab, Relatlimab, Ipilimumab
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- NYU Langone Health
Primary Renal Cancer
Stereotactic MR-Adaptive Radiation Therapy for Early-stage Renal Cancer
The purpose of this study is to investigate the use of an MR-guided linear accelerator to treat early stage renal cancer patients, considered inoperable or in patients declining surgerys.
- Trial name
- SMARTER (NCT07767500)
- Testing
- MRI-guided linear accelerator, Magnetic resonance imaging (MRI)-guided radiation therapy (MRgRT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Healthy
High Resolution Pharyngeal Manometry (HRPM) Biofeedback
The purpose of this study is to quantify the added benefit of visual biofeedback from High Resolution Pharyngeal Manometry (HRPM) for swallowing rehabilitation.
- Trial name
- NCT07508059
- Testing
- Swallowing Maneuvers, High Resolution Pharyngeal Manometry (HRPM)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Systemic Lupus Erythematosus
Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease
Hydroxychloroquine (HCQ) is a systemic lupus erythematosus (SLE) medication that has been very effective in reducing lupus disease activity and keeping patients stable with reduced symptoms.
- Trial name
- SHIELD (NCT05799378)
- Testing
- Hydroxychloroquine
- Where
- 12 sites in United States
- Volunteers
- 330 people
- Sponsor
- NYU Langone Health
Drug Use, Substance Abuse
Harm Reduction Services
The purpose of this study is to assess whether an integrated harm reduction intervention (IHRI), compared to harm reduction (HR) services as usual, will improve harm reduction service utilization among Black and Latinx people who…
- Conditions
- Drug Use, Substance Abuse, Mental Illness
- Trial name
- HRS (NCT05776316)
- Testing
- Integrated Harm Reduction Intervention (IHRI)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Colonoscopy
Novel Irrigation Solution for Colonoscopy Visualization Pilot
The purpose of this study is to assess the provider experience with a novel colonoscopy irrigation solution and determine the feasibility of introducing this solution into the endoscopy unit and assess efficacy on a small scale…
- Trial name
- NCT07769905
- Testing
- Olympus colonoscope, Irrigation solution
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- NYU Langone Health
Glioblastoma (GBM)
Hypoxia-targeted Radiotherapy Boost for GBM
The purpose of this study is to evaluate the use of dynamic contrast-enhanced MRI (DSC-MRI) to identify and target hypoxic tumor regions in glioblastoma (GBM).
- Trial name
- NCT07769918
- Testing
- Dynamic susceptibility contrast MRI (DSC-MRI), Cercare Medical Neurosuite (CMN) DSC-MRI-derived hypoxia maps, Varian TrueBeam
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- NYU Langone Health
Anterior Cruciate Ligament Reconstruction
Prospective Evaluation of Silk Fibroin Incision Dressings in ACL Reconstruction
The purpose of this study is to compare the incidence of early postoperative skin complications including allergic contact dermatitis, blistering, and erythema between silk fibroin incision dressings and cyanoacrylate closure in…
- Trial name
- NCT07217613
- Testing
- silk fibroin-based incision dressing, cyanoacrylate-based closure system
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Heart Failure
Multi-Center Project: Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure
This study will test an automated, electronic health record (EHR-)embedded alert to improve prescribing of guideline-directed medical therapy for patients with heart failure and reduced ejection fraction (HFrEF).
- Trial name
- BETTER CARE-HF (NCT06457152)
- Testing
- EHR-Emedded Alert
- Where
- 4 sites in United States
- Volunteers
- 1,136 people
- Sponsor
- NYU Langone Health
Severe Congenital Diaphragmatic Hernia
Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Fetuses With Severe CDH
The purpose of this pilot study is to evaluate the feasibility of using Fetoscopic Endoluminal Tracheal Occlusion (FETO) in 10 pregnant individuals carrying fetuses with severe congenital diaphragmatic hernia (CDH).
- Trial name
- NCT07767825
- Testing
- Goldballoon Detachable Balloon (GOLDBAL2)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Graft Failure, Poor Graft Function
CD34+ Selected Stem Cell for Poor Graft Function or Graft Failure
The proposed trial is a single arm, non-randomized, single center pilot study utilizing CliniMACS CD34 Reagent System for patients following allogeneic hematopoietic stem cell transplant (HSCT) requiring treatment of graft…
- Trial name
- NCT06569082
- Testing
- CD34+ Selected Donor Cell Boost, Blood Stem Cell Infusion
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- NYU Langone Health
Cardiovascular Diseases
Identifying Strategies to Reduce Cardiovascular Risk Among Mothers of Young Children
This single-site research study will pilot-test a context-specific cardiovascular disease (CVD) risk prevention program, Mom♥Health, using two childhood centers at Family Health Centers (FHC) at NYU Langone as platforms for…
- Trial name
- NCT06796075
- Testing
- Mom♥Health
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
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