Clinical trials: sponsored by Northwell Health
Alzheimer Disease, Alzheimer Disease With Delusions
Tau Networks in Psychotic Alzheimer's Disease
This research project aims to understand the brain mechanisms behind the manifestation of psychotic symptoms in Alzheimer´s disease (AD), and nature of the unique relationship with tau pathology.
- Conditions
- Alzheimer Disease, Alzheimer Disease With Delusions, Alzheimer Disease With Psychosis
- Trial name
- NCT05847192
- Testing
- [18F]-PI2620 PET scan
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Premature Ventricular Contraction
Non-invasive Vagal Stimulation for Frequent Premature Ventricular Complexes
A prospective sham-controlled randomized clinical trial to assess the effect of low-level tragus stimulation (LLTS) in patients with frequent premature ventricular complexes (PVCs)
- Trial name
- (NoVa-PVC) (NCT05341544)
- Testing
- Parasym device
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Stroke, Ischemic
Intra-Arterial Neuroprotective Agents and Cold Saline in Ischemic Stroke Intervention
Ischemic stroke is the leading cause of long-term disability in the United States. Endovascular intervention with mechanical thrombectomy has become the standard of care for acute large vessel occlusion (LVO) stroke since…
- Trial name
- NCT05032781
- Testing
- Intra-arterial cold saline, minocycline, and magnesium
- Where
- United States
- Sponsor
- Northwell Health
Loneliness
Reduce Loneliness in Care Partners of Persons With AD/ADRD
More than 60% of care partners of persons with AD/ADRD report feeling lonely. Building on the existing evidence that increasing meaning and purpose in life is a strong predictor of decreased loneliness, interventions to reduce…
- Trial name
- NCT05460494
- Testing
- RELOAD-C
- Where
- 4 sites in United States
- Volunteers
- 96 people
- Sponsor
- Northwell Health
Spinal Cord Injuries, Traumatic Spinal Cord Injury
SCIVAX: Biomarkers of Immune Dysfunction and Vaccine Responsiveness in Chronic SCI
The purpose of this observational research study is to better understand immune responses to vaccines against viruses (influenza or SARS-CoV2).
- Conditions
- Spinal Cord Injuries, Traumatic Spinal Cord Injury, Healthy Controls, Flu Vaccine
- Trial name
- SCIVAX (NCT05869968)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Stress
Personalized Trials for Stress Management Against Standard of Care
The purpose of this study is to determine if an N-of-1 study design, or within-subject trials that the investigators are calling "Personalized Trials" can improve health outcomes over standard practice for common stress…
- Trial name
- NCT05408832
- Testing
- Personalized Trial ABCCBA, Personalized Trial CBAABC, Stress Management Techniques with No Randomization Sequence (or order)
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Bladder Cancer, Patient Engagement
Recovery Support for Bladder Cancer Patients and Caregivers
For patients with certain types of bladder cancer, the removal of the bladder and the construction of an artificial bladder or reservoir are the only treatment options.
- Conditions
- Bladder Cancer, Patient Engagement, Patient Empowerment, Ileal Conduit
- Trial name
- NCT04055311
- Testing
- Cancer Resource Information Support (CRIS), Usual Care Enhanced
- Where
- 2 sites in United States
- Volunteers
- 174 people
- Sponsor
- Northwell Health
Colorectal Cancer Metastatic
INFINITIVE: ImmuNotherapy For PatIeNts wIth colorecTal LIVer MEtastases
Nelitolimod is a classC toll-like receptor 9 (TLR9) agonist that binds to TLR9 receptors on myeloid-derived suppressor cells(MDSCs) and helps reshape the tumor microenvironment (TME) and promote antitumor immunity.
- Trial name
- NCT07172282
- Testing
- Nelitolimod
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Northwell Health
Healthy Volunteers, Spinal Cord Injury
Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis
This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves…
- Conditions
- Healthy Volunteers, Spinal Cord Injury, Stroke, Paralysis
- Trial name
- NCT04755699
- Testing
- Transcutaneous Electrical Stimulation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cardiac Disease, Surgery
Factor VIII Inhibitor Bypass Activity (FEIBA) Versus Fresh Frozen Plasma As First Line Therapy For Bleeding After Cardiac Surgery
Coagulopathic-induced bleeding after cardiopulmonary bypass in cardiac surgery patients is common and is associated with adverse outcomes in cardiac surgery.
- Conditions
- Cardiac Disease, Surgery, Bleeding
- Trial name
- NCT07032792
- Testing
- FEIBA, FFP
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Northwell Health
Cardiovascular Diseases, Physical Inactivity
MoST-Influenced Behavioral Intervention for Walking
This study is a randomized, factorial experiment using the basic Science of Behavior Change (SOBC) approach to efficiently test the effects of four distinct behavior change techniques (BCTs), goal setting, action planning, self…
- Trial name
- NCT05425641
- Testing
- Goal Setting, Action Planning, Self-Monitoring of Behavior
- Where
- United States
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Heart Failure NYHA Class III
Optimizing HFrEF Patients Using BaroStim and CardioMems
The goal of this study is to utilize CardioMems (measurement of pulmonary artery diastolic pressure) to assess BaroStim. At the time of CardioMems insertion, patients will be screened for candidacy to receive a BaroStim device.
- Trial name
- NCT07399587
- Testing
- BaroStim
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Northwell Health
Paroxysmal Atrial Fibrillation
Determinates of Atrial Tracking and Prevalence of Atrial Fibrillation in the Micra AV2 (DANCE AFIB)
This is a prospective, descriptive study. Safety endpoints will not be assessed. All eligible patients that have a history of paroxysmal atrial fibrillation and an indication to undergo Micra AV2 device placement as per standard…
- Trial name
- DANCE AFIB (NCT07344961)
- Testing
- Micra AV2- Observational
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Sleep Insufficiency
A Personalized Mind-Body Intervention (MBI) for Improving Sleep Among Women Working in Healthcare
The goal of this pilot study is to determine if a personalized trial testing a Mind-Body Intervention (MBI) can produce a meaningful increase in the average daily sleep duration among women 40-60 years of age working in…
- Trial name
- NCT05789212
- Testing
- Personalized Trial ABCCBA, Personalized Trial CBAABC
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Delirium
Implementation Outcome Assessments of the Emergency Department Delirium Screening and Detection Program
Delirium occurs in up to 20% of older adults presenting to the Emergency Department (ED) and is associated with poor outcomes. Failure to identify patients with ED delirium not only prevents initiation of mitigation strategies…
- Trial name
- ED-DDP (NCT05606328)
- Testing
- Emergency Department Delirium Screening and Detection Program (ED-DDP)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Stress Urinary Incontinence
Feasibility of BOTOX Injection on Improving Female Stress Urinary Incontinence
The purpose of this study is to assess the effect of onabotulinumtoxin A (BOTOX) injection into the detrusor muscle on increasing bladder compliance to reduce urinary leakage in women suffering from stress urinary incontinence…
- Trial name
- NCT04984317
- Testing
- onabotulinumtoxin A
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Colorectal (Colon or Rectal) Cancer
Evaluation of Circulating Immune Response After Histosonics in Colorectal Cancer (ECHO-CRC)
This is a single-center, non-randomized, open-label, single-arm pilot study investigating the systemic immune response to histotripsy in patients with colorectal cancer with liver metastasis.
- Trial name
- ECHO CRC (NCT07361107)
- Testing
- Histotripsy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwell Health
Feasibility and Acceptability, Prevention Childhood Obesity
Starting Early to Prevent Obesity Using Telehealth (StEP OUT): Pilot RCT
The goal of this clinical trial is to test an online program that teaches healthy habits during pregnancy and infant to prevent early child obesity in Latino families.
- Trial name
- NCT07254065
- Testing
- StEP OUT, Infant Safety Education
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Northwell Health
Psychosis, Prodromal Schizophrenia
Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk
This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability…
- Conditions
- Psychosis, Prodromal Schizophrenia, Prodromal Symptoms
- Trial name
- SCORES (NCT05131035)
- Testing
- SCORES (Specific COgnitive Remediation with Support)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Prostate Cancer, Magnetic Resonance Imaging
Utility of Biparametric MRI (Magnetic Resonance Imaging) as a Screening Tool for Prostate Cancer in a High-Risk Cohort
To determine whether using bpMRI in subjects who are at high risk of developing prostate cancer in conjunction with PSA will improve prostate cancer screening protocols.
- Conditions
- Prostate Cancer, Magnetic Resonance Imaging, Population at Risk
- Trial name
- NCT05384535
- Testing
- Bi-parametric MRI
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Northwell Health