Clinical trials: sponsored by Northwell Health
Medication Adherence
A BCT Intervention for Medication Adherence Among Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of medication adherence among participants on primary prevention statin…
- Trial name
- NCT05273736
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pulmonary Embolism, Pulmonary Hypertension
Peripheral Systemic Thrombolysis Versus Catheter Directed Thrombolysis for Submassive PE
To determine whether peripheral low dose systemic thrombolysis (PLST) is non-inferior to catheter directed acoustic pulse thrombolysis (ACDT) in improving RV function and reducing pulmonary artery pressures in submassive…
- Conditions
- Pulmonary Embolism, Pulmonary Hypertension, Thromboembolism, Right Ventricular Dysfunction
- Trial name
- NCT03581877
- Testing
- Alteplase, EKOS
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Electroconvulsive Therapy Treated Patients
Neural Biomarkers of Electroconvulsive Therapy Response
In the proposed study, the investigators will utilize resting-state functional MRI (fMRI) and structural MRI-based electrical field modeling to study the effect of electroconvulsive therapy on human neural circuitry.
- Trial name
- NCT04763655
- Testing
- clinical and neuropsychological testing
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Northwell Health
Knee Osteoarthritis, Pain, Postoperative
Influence of Patient Sex on Pain Control and Multimodal Analgesia in Total Knee Arthroplasty
The purpose of this study is to examine the influence of sex on postoperative pain, following total knee arthroplasty (TKA). Patients will first be stratified by sex and then be randomized into one of two multimodal analgesic…
- Trial name
- NCT04471233
- Testing
- Multimodal analgesia including pregabalin, Multimodal analgesia not including pregabalin
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Northwell Health
Crohn Disease, Ulcerative Colitis
Transcutaneous VNS to Treat Pediatric IBD
The current available therapies for inflammatory bowel disease (IBD), including immunomodulator and biologic medications may have toxicities limiting use or inadequate effect.
- Trial name
- STIMIBD (NCT03863704)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Tricuspid Regurgitation, Mechanical Ventilation Pressure High
Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV)…
- Conditions
- Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
- Trial name
- NCT06229886
- Testing
- Application of positive-end-expiratory pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
First Episode Psychosis
Disengagement in CSC: Identifying Those at Risk and Addressing Their Needs
Maintaining treatment engagement is critical for first episode psychosis patients to experience gains possible with coordinated specialty care (CSC).
- Trial name
- NCT04005378
- Testing
- CSC Step-down intervention, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Scoliosis; Juvenile, Scoliosis; Adolescence
Virtual Reality's Effect on Decreasing Pain and Subsequent Opioid Use in Pediatric Patients in the Post-Operative Period Following Scoliosis Repair
The goal of this study is to determine whether introducing VR in the immediate post-operative period following scoliosis repair can reduce perceived pain and stress in pediatric patients and in turn ultimately decrease opioid…
- Conditions
- Scoliosis; Juvenile, Scoliosis; Adolescence, Scoliosis
- Trial name
- NCT05888038
- Testing
- virtual reality
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Postoperative Quality of Recovery
Opioid Free Anesthesia and Bariatric Surgery
The morbidly obese bariatric surgery population is susceptible to opioid-induced complications such as respiratory depression and postoperative nausea and vomiting.
- Trial name
- NCT04144153
- Testing
- Opioid Free Total Intravenous Anesthesia, Total Intravenous anesthesia with opioid
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Northwell Health
First Episode Psychosis
Early-Phase Schizophrenia: Practice-based Research to Improve Outcomes
The goal if the project is to develop a learning health network devoted to the treatment of first episode psychosis.
- Trial name
- ESPRITO (NCT04004364)
- Testing
- Coordinated Specialty Care (CSC)
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Northwell Health
Sleep Disturbance
Feasibility Study of Personalized Trials to Improve Sleep Quality
The purpose of this pilot study is to assess the feasibility of using N-of-1 methods in a virtual research study of melatonin intervention for poor sleep quality.
- Trial name
- NCT05349188
- Testing
- Melatonin 3 mg, Melatonin 0.5 mg
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Lung Cancer
Virtual Personalized Exercise Program for Lung Cancer Patients
This is a prospective study providing lung cancer subjects at R.J. Zuckerberg Cancer Center with a customized exercise program provided by Salaso, with the goal of improving functional status and outcomes.
- Trial name
- NCT06540495
- Testing
- Salaso Virtual Exercise Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Medication Adherence
Reducing African-American CVD Disparities Intervention Optimization (RADIO) Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of medication adherence among Black and African American individuals on…
- Trial name
- RADIO (NCT05954000)
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Depression
rTMS for Depression
This is a longitudinal observational study, where we will track outcomes in patients undergoing 5 weeks of FDA approved right DLPFC rTMS treatment.
- Trial name
- NCT06484413
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Systemic Lupus Erythematosus
Electroencephalogram Recording in Patients With Systemic Lupus Erythematosus
Patients with systemic lupus erythematosus (SLE) often experience a frustrating decline of their cognitive skills that includes considerable problems in attention, learning, and memory.
- Trial name
- NCT06378736
- Testing
- Electroencephalography (EEG) signals, which will be detected noninvasively from dry scalp surface electrodes while the subjects are in a state of wakeful rest.
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Stress Disorders, Post-Traumatic
taVNS to Reduce PTSD Symptoms in WTC Responders
This study seeks to conduct a randomized, double-blind pilot study, to determine whether the Transcutaneous Auricular Vagus Nerve Stimulation and study procedure are feasible and acceptable for use with World Trade Center…
- Trial name
- taVNS (NCT05212714)
- Testing
- taVNS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Chronic Lymphocytic Leukemia
B Cell Repertoires in Chronic Lymphocytic Leukemia and Aging
B-CLL is the most prevalent leukemia in the Western hemisphere, accounting for ~25% of all leukemia's (1). This disease occurs virtually exclusively in the aging population, with the median age of diagnosis ranging between the…
- Trial name
- NCT01028430
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Human Blood Cell Disorders, Lymphoid, Myeloid and Erythroid Proliferative Disease
Human Blood Cell Disorders Tissue Bank
The Human Blood Cell Disorder Tissue Bank will provide a convenient, comprehensive source of tissue containing populations of human blood cells from patients with various types of lymphoid, myeloid, and erythroid proliferative…
- Trial name
- NCT00902447
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Chronic Lymphocytic Leukemia
B-type Chronic Lymphocytic Leukemia (B-CLL) Subgroups: Maturation Stage and Gene Expression
B type chronic lymphocytic leukemia (B-CLL) is the most prevalent leukemia in the western world. It is a disease that occurs primarily in aging individuals and occurs more frequently in males than females.
- Trial name
- NCT01030913
- Where
- United States
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Intervertebral Disc Degeneration, Back Pain
Tissue Collection for Understanding Intervertebral Disc Degeneration and Back Pain
The purpose of the research is to collect and examine spinal disc and ligament tissues to see if there are any biological markers that can be correlated with MRI images to help us learn more about causes of back pain.
- Trial name
- NCT01633034
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northwell Health