Clinical trials: sponsored by Northwell Health
Discharge Readiness
Using NICU Discharge Education Tools to Enhance Discharge Preparation for Parents of Moderate to Late Preterm Infants
The goal of this clinical trial is to improve the transition to home for preterm infants born between 33-36 weeks gestational age and discharged from the neonatal intensive care unit (NICU) through the use of two interventions, a…
- Trial name
- NCT06177951
- Testing
- NICU Discharge Passport, NICU Infant Care Class
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Parkinson Disease
Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson's Disease
The objective of this study is to further the understanding and application of 60Hz subthalamic deep brain stimulation (STN-DBS) in Parkinson's patients with gait disorder.
- Trial name
- NCT04184791
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Northwell Health
Alcohol Withdrawal, Alcohol Use Disorder
Using Transcutaneous Auricular Vagus Nerve Stimulation to Treat Acute Alcohol Withdrawal
The purpose of this study is to see if stimulation of the vagus nerve via a non-invasive device placed behind external ear can reduce physical and psychological discomfort during acute alcohol withdrawal in patients with alcohol…
- Trial name
- NCT04159909
- Testing
- Transcutaneous Nerve Stimulation
- Where
- United States
- Sponsor
- Northwell Health
Cancer of the Oropharynx
Image-Guided Stereotactic Radiosurgery (SRS) Boost for HPV-Oropharyngeal Cancer
This is a Phase I study looking to evaluate the safety of dose escalated stereotactic radiotherapy (SRS) without exceeding the maximum tolerated dose in patients with high-risk human papilloma virus (HPV)- unassociated…
- Trial name
- NCT02703493
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Northwell Health
Sepsis, Acute Kidney Injury Due to Sepsis
Renin Angiotensin Aldosterone System In Septic Kids
Prospective observational cohort study; pediatric sepsis vs. healthy pediatric subjects and pediatric sepsis with acute kidney injury (AKI) vs without AKI.
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Acute Kidney Injury (Nontraumatic)
- Trial name
- RISK (NCT06295393)
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Cesarean Section Complications, Cesarean Wound; Dehiscence
PICO Negative Pressure Wound Therapy in Obese Women Undergoing Elective Cesarean Delivery.
A randomized controlled, parallel group, superiority, open-label, single-institution, Phase 3 interventional clinical trial to evaluate clinical outcomes in obese gravidas undergoing elective cesarean delivery whose wounds were…
- Conditions
- Cesarean Section Complications, Cesarean Wound; Dehiscence, Cesarean Wound Disruption
- Trial name
- NCT03414762
- Testing
- PICO Negative Pressure Wound Therapy, Standard Dressing
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Outpatient Breast Surgery, Mastopexy
Serratus Plane Block for Postoperative Pain Control
This is a randomized, double-blinded, placebo-controlled trial of serratus plane blocks in subjects undergoing outpatient unilateral or bilateral breast surgery.
- Conditions
- Outpatient Breast Surgery, Mastopexy, Augmentation, Revision
- Trial name
- NCT02865928
- Testing
- Bupivicaine HCl, Normal Saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Northwell Health
Healthy Volunteers
Using a Transcutaneous Electrical Auricular Stimulator to Harness the Cholinergic Anti-Inflammatory Pathway
Persistent chronic inflammation is an important underlying event in multiple diseases including rheumatoid arthritis, inflammatory bowel diseases and type 2 diabetes.
- Trial name
- TEACAP (NCT02910973)
- Testing
- Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Psychotic Disorders
Striatal Connectivity and Clinical Outcome in Psychosis
This is an observational neuroimaging treatment study. This study involves examining the neural circuitry of controlled treatment of patients presenting with a first-episode of psychosis with risperidone or aripiprazole.
- Trial name
- NCT02822092
- Testing
- Risperidone or Aripiprazole (patients only)
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Lack of Diversity in Scientific Leadership
The MAVEN Senior Scientist Initiative
MAVEN is an education training program designed to expand the national pool of qualified women and minority candidates for senior scientist positions across all NIGMS areas of science.
- Trial name
- NCT05171101
- Testing
- MAVEN
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Myositis
Belimumab in Idiopathic Inflammatory Myositis
The goal of the trial is to evaluate the efficacy and safety of belimumab as a maintenance therapy in adults with refractory Idiopathic inflammatory myositis (IIM) as compared with standard of care.
- Trial name
- BIM (NCT02347891)
- Testing
- Belimumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwell Health
Schizophrenia, Negative Symptoms
Adjunctive Vortioxetine in Schizophrenia
This is a 16-week, randomized, double-blind, parallel group, placebo-controlled study comparing adjunctive vortioxetine with identically appearing adjunctive placebo pills in 88 stable patients with a research diagnosis of…
- Trial name
- AVIS (NCT02357797)
- Testing
- Vortioxetine
- Where
- 3 sites in United States
- Volunteers
- 88 people
- Sponsor
- Northwell Health
Prostate Cancer, Prostate Disease
Focal US-guided Cryo-ablation Using DynaCAD / UroNAV Preplanning / Guidance of Intermediate Risk Prostate Cancer
The purpose of this research study is to determine the safety and feasibility of using the UroNav software and DynaCAD software for planning and treating prostate cancer as an add on to the already approved workflow of using…
- Trial name
- NCT04656678
- Testing
- Cryo-ablation Using DynaCAD / UroNAV preplanning / guidance
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwell Health
Glioblastoma Multiforme, Brain Tumor
Repeated Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Newly Diagnosed GBM
The high-grade malignant brain tumors, glioblastoma multiforme (GBM), comprise the majority of all primary brain tumors in adults.
- Trial name
- NCT01811498
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Cancer-related Problem/Condition, Depressive Symptoms
Ketamine-Assisted PsychoTherapy ViAbility in Treating Cancer-related Emotional Distress
The present study will investigate if ketamine-assisted psychotherapy during palliative radiation therapy is safe, feasible, and effective at reducing psychological distress.
- Conditions
- Cancer-related Problem/Condition, Depressive Symptoms, Anxiety Disorders
- Trial name
- KAPTIVATED (NCT05344625)
- Testing
- Ketamine 100 MG/ML
- Sponsor
- Northwell Health
Cancer of Head and Neck, Mucositis Oral
Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial
Patients with head and neck cancer generally receive a standard of care of 7 weeks of daily radiation therapy given alongside an aggressive chemotherapy drug called cisplatin.
- Conditions
- Cancer of Head and Neck, Mucositis Oral, Pharyngeal Mucositis
- Trial name
- NCT05331131
- Testing
- Ketamine Topical
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Stridor
POCUS of the Pediatric Critical Airway
The goal of this observational study is to assess the laryngeal air column width difference measurement on point of care ultrasound as a predictive indicator of post-extubation stridor in the pediatric critical care population.
- Trial name
- NCT06212037
- Testing
- Point of Care Ultrasound
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Northwell Health
Tracheostomy, Endotracheal Tube
Airway Microbiome Changes After Artificial Airway Exchange in Critically-ill Pediatric Patients.
Artificial airways, such as endotracheal tubes and tracheostomies, in the pediatric and neonatal intensive care units (PICU, NICU respectively) are lifesaving for patients in respiratory failure, among other conditions.
- Conditions
- Tracheostomy, Endotracheal Tube, Ventilator Associated Pneumonia, Tracheitis
- Trial name
- NCT06201130
- Testing
- Suctioning of artificial airway
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Northwell Health
Subarachnoid Hemorrhage, Aneurysmal
Safety and Efficacy of Non-invasive Vagus Nerve Stimulation in the Treatment of Headache in Subarachnoid Hemorrhage
This is a single site, randomized, sham-controlled, double blinded pilot study assessing the feasibility, safety, tolerability, and efficacy of non-invasive VNS (nVNS), gammaCore, in the treatment of headache in subarachnoid…
- Trial name
- VANQUISH (NCT04126408)
- Testing
- gammaCore
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health
Diabetes Mellitus
Post-operative Complications and Graft Survival With Conventional Versus Continuous Glucose Monitoring in Patients With Diabetes Mellitus Undergoing Renal Transplantation
This will be a prospective, randomized, single-blinded controlled trial in which the investigators evaluate post-operative serum glucose control using conventional point-of-care glucose monitoring in the morning and before meals…
- Trial name
- NCT04742023
- Testing
- Continuous Glucose Monitor Application, Finger Stick Glucose Measurement, Insulin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwell Health