Clinical trials: sponsored by Oregon Health and Science University
Gestational Diabetes
Exercise in Pregnant Women With Gestational Diabetes
Gestational diabetes (GDM) impacts 1 in 10 pregnancies; hyperglycemia and hypertriglyceridemia are common features of the condition.
- Trial name
- NCT04145479
- Testing
- physical activity
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Diabetes Mellitus (DM)
Post ACA Reform: Evaluation of Community Health Center Care of Diabetes
This innovative and timely study will measure the impact of Affordable Care Act (ACA) Medicaid expansions on diabetes mellitus (DM) prevention, treatment, expenditures and health outcomes.
- Trial name
- PREVENTD (NCT02685384)
- Testing
- Medicaid Expansion
- Volunteers
- 1,938,375 people
- Sponsor
- Oregon Health and Science University
Opioid-use Disorder, Hiv
Comparing Treatments for HIV-Infected Opioid Users in an Integrated Care Effectiveness Study (CHOICES) Scale-Up
The Primary Objective of this study is to compare the effectiveness of HIV clinic-based extended-release Naltrexone (XR-NTX) in decreasing substance use and increasing HIV viral suppression in HIV-infected participants with…
- Trial name
- NCT03275350
- Testing
- Naltrexone Injectable Suspension, Treatment as usual
- Where
- 5 sites in United States
- Volunteers
- 114 people
- Sponsor
- Oregon Health and Science University
Retinopathy of Prematurity
Clinical and Genetic Analysis of ROP
Retinopathy of Prematurity (ROP) is a vascular disease affecting the retinas (back of the eye) of low birth weight infants. Although it can be treated effectively if diagnosed early, it continues to be a leading cause of…
- Trial name
- (ROP) (NCT04420156)
- Testing
- No intervention administered.
- Where
- 5 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson Disease, Movement Disorders
Characterizing Biomarkers of Early Parkinson's Disease Progression (TREG)
The purpose of this study is to look at a blood marker of inflammation in early untreated Parkinson's disease.
- Trial name
- TREG (NCT03716258)
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Oregon Health and Science University
Hyperlipidemias
Food Pharmacy at Oregon Health & Science University (OHSU) Knight Cardiovascular Institute (KCVI)
Participants in the intervention group of this study will receive weekly home deliveries of fruit \& vegetables for 3 months. The primary objective of this study is to determine if increased access to fruits and vegetables leads…
- Trial name
- NCT04036773
- Testing
- Fruit and vegetable deliveries
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Subarachnoid Neurocysticercosis
SANCC: Clinical Trial Early Intervention
Subarachnoid neurocysticercosis (SANCC) is a severe infection of the brain by the tapeworm Taenia solium. People who have this infection are usually diagnosed late in the disease process leading to very poor prognosis.
- Trial name
- NCT03950037
- Testing
- Albendazole
- Sponsor
- Oregon Health and Science University
Human Papilloma Virus
Increasing HPV Immunization Rates: The Rural Adolescent Vaccine Enterprise
The goal of this study is to engage rural primary care clinics and community organizations to test interventions designed to increase HPV vaccinations in both male and female patients aged 9-26 years.
- Trial name
- RAVE (NCT03604393)
- Testing
- Practice facilitation
- Where
- United States
- Volunteers
- 22,000 people
- Sponsor
- Oregon Health and Science University
Language Impairment
Delivering EMT Via Telehealth to Children and Families
In the U.S., approximately 12% of children under 36 months have language impairments, yet less than 2% receive early language intervention.
- Trial name
- NCT04604821
- Testing
- Enhanced Milieu Teaching, Parent Education
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Down Syndrome
Delivering Early Intervention to Children With Down Syndrome
Children with Down syndrome (DS) are at risk for significant language and communication impairments. Enhancing the service delivery of early intervention for children with DS is a key research and policy issue given the…
- Trial name
- NCT03935620
- Testing
- Enhanced Milieu teaching
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Oregon Health and Science University
Sarcoidosis, Pulmonary, Sarcoidosis Lung
Tofacitinib Hypothesis-generating, Pilot Study for Corticosteroid-Dependent Sarcoidosis
This is a pilot study to determine whether further research is warranted to assess whether tofacitinib is an effective steroid sparing treatment for pulmonary sarcoidosis.
- Conditions
- Sarcoidosis, Pulmonary, Sarcoidosis Lung, Sarcoidosis
- Trial name
- NCT03793439
- Testing
- Tofacitinib 5mg Oral Tablet [Xeljanz] 16 week trial, Spirometry, RNA Sequencing
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oregon Health and Science University
Maternal Psychological Distress, Postpartum Depression
Mindfulness Based Cognitive Therapy (MBCT) During Pregnancy
The study is a pilot randomized control trial of a validated intervention, Mindfulness Based Cognitive Therapy (MBCT) adapted for pregnancy, developed to reduce risk for postpartum depression.
- Conditions
- Maternal Psychological Distress, Postpartum Depression, Prenatal Stress
- Trial name
- NCT03809572
- Testing
- Mindfulness Based Cognitive Therapy
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson Disease, Hypertension
Clinical Characteristics of Parkinson's Disease Subjects With Severe Hypertension During Motor OFFs.
Current management of hypertension in PD motor fluctuators is flawed. The current practice often is to treat transient hypertensive spikes reported by patients or measured in clinics with anti-hypertensive medications.
- Conditions
- Parkinson Disease, Hypertension, Antiparkinsonism Drugs Causing Adverse Effects in Therapeutic Use
- Trial name
- CLIN-HTN-PD (NCT03433950)
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Surgery, Pain, Postoperative
Virtual Reality for Postoperative Pain Management
This trial studies an active virtual reality (VR) experience as a means for non-pharmacologic postoperative pain management among patients after head and neck surgery.
- Conditions
- Surgery, Pain, Postoperative, Incision, Otolaryngological Disease
- Trial name
- NCT04464304
- Testing
- Smartphone, Virtual Reality (Oculus Quest)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson's Disease
The Effect of Donepezil on Gait and Balance in Parkinson's Disease
This study involves Parkinson's disease (PD). Symptoms include slow movement, tremor, and muscle rigidity. Current medications for the treatment of PD do not improve gait and balance difficulties in individuals with PD.
- Trial name
- NCT01521117
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Alcohol Withdrawal, Nutrition Disorders
Riboflavin for Glutamate Reduction in Alcohol Withdrawal
This RCT intends to investigate the use of oral Riboflavin (Vitamin B2) for reduction of blood glutamate levels in the setting of acute alcohol withdrawal.
- Conditions
- Alcohol Withdrawal, Nutrition Disorders, Alcohol Use Disorder
- Trial name
- RGRAW (NCT04232800)
- Testing
- Riboflavin
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Dietary Exposure
Change in Leptin as a Predictor of Satiety With High Protein Feeding
Body weight can be affected by the content of fat and carbohydrate in the diet. On average, people will lose a modest (< 5 kg) amount of weight when switched from a high fat diet to a low fat, high carbohydrate diet.
- Trial name
- HiProLep (NCT05002491)
- Testing
- High protein diet
- Volunteers
- 19 people
- Sponsor
- Oregon Health and Science University
Pregnancy Related
Clatsop Astoria Maternal Partnership Study (CAMPS) - Healthy Eating in Pregnancy Intervention
Purpose of this study is to learn more about how nutritional advice given during pregnancy affects a mother's food choices and her baby's growth.
- Trial name
- CAMPS (NCT03210870)
- Testing
- nutritional education classes
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Aging
Ambient Independence Measures for Guiding Care Transitions
The purpose of this study is to learn more about how to maintain health and independence for seniors by developing tools that collect data constantly from their home.
- Trial name
- AIMs (NCT02566239)
- Testing
- Share activity data with care team
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Amyloidosis Transthyretin, Athlete Heart
Exercise Effect on Transthyretin Stability
The goal of this study to investigate if exercise predisposes to transthyretin instability. The investigators will evaluate the effect of exercise on transthyretin biochemistry.
- Trial name
- NCT04986826
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University