Clinical trials: sponsored by Oregon Health and Science University
School Readiness, Preschool Enrollment
A Kinder Coaching Program With Community Health Workers "READY"
In this study, the investigators compare two novel primary care interventions (School Readiness Checklist vs. Kinder Coaching) for low-income parents, which were co-developed by parent, clinical, and educational stakeholders.
- Conditions
- School Readiness, Preschool Enrollment, Parent School Readiness Confidence
- Trial name
- READY (NCT07677618)
- Testing
- Kinder Coaching
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Diet, High-Fat, Circadian Rhythm
Food and Circadian Timing
The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to…
- Trial name
- FACT (NCT04743271)
- Testing
- High-Fat Diet, Low-Fat Diet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
E Coli Infection, ESBL Producing E.Coli
Cefotetan Therapy for Escherichia Coli Infections
This pilot study will compare clinical outcomes among patients treated with cefotetan versus standard of care antibiotics for bacteremia caused by E. coli.
- Trial name
- NCT07318584
- Testing
- Cefotetan, Carbapenems, Beta Lactam Antibiotics
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Infertility of Tubal Origin
Clinical Evaluation of a Tubal Selective Delivery System
A single center study to evaluate the performance and optimize the design of a novel intrauterine catheter system intended as a nonsignificant risk medical device to aid in evaluating tubal patency as part of the initial…
- Trial name
- NCT05775913
- Testing
- Tubal Selective Delivery System (TSDS)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Bleeding, Contraceptive Device; Complications
Tranexamic Acid to Reduce Contraceptive-related Bleeding Side Effects
This randomized double blinded trial seeks to determine whether tranexamic acid (TXA) is an efficacious treatment for contraceptive induced menstrual changes (CIMC) including irregular, bothersome bleeding caused by the…
- Trial name
- NCT06000423
- Testing
- Tranexamic acid
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Oregon Health and Science University
Contraception
Endometrial Biopsy in Progestin Contraceptive Users
The purpose of the study is to learn more about menstrual changes in progestin contraception users. The investigators are hoping to find out what changes in the endometrium lead to different bleeding patterns during the first…
- Trial name
- NCT05760144
- Testing
- DMPA, Etonogestrel implant
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Chronic Rhinosinusitis, Olfactory Dysfunction
Determinants of Olfactory Dysfunction in Chronic Rhinosinusitis
Olfactory dysfunction is a cardinal symptom of chronic rhinosinusitis, a disease which affects 12.5% of the adult population across all racial and ethnic groups.
- Trial name
- NCT02720653
- Testing
- Endoscopic sinus surgery
- Volunteers
- 418 people
- Sponsor
- Oregon Health and Science University
Pyoderma Gangrenosum
Topical Ruxolitinib in the Treatment of Adults With Pyoderma Gangrenosum
This is a single-center, open-label, single-arm pilot study evaluating topical ruxolitinib (OPZELURA) as a treatment for adults with Pyoderma Gangrenosum (PG), a chronic inflammatory skin condition that causes painful ulcers.
- Trial name
- TRIUMPH (NCT07783412)
- Testing
- topical ruxolitinib 1.5% cream
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Pyoderma Gangrenosum, Skin Diseases
Guselkumab in the Treatment of Adults With Pyoderma Gangrenosum (PG)
A single-arm open-label study assessing short-term (week 6, 16) and long-term (week 32) efficacy of guselkumab in adult participants with pyoderma gangrenosum (PG)
- Conditions
- Pyoderma Gangrenosum, Skin Diseases, Wound Heal, Pyoderma
- Trial name
- GEORGE (NCT06563323)
- Testing
- Guselkumab
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Oregon Health and Science University
Rheumatic Diseases
The COVID-19 VaccinE Response and Co-Administration in Rheumatology Patients (COVER-CoAd)
Based on the experience with influenza, pneumococcal, and shingles vaccinations in rheumatic disease populations, it is clear that some disease modifying anti-rheumatic drugs and the immunomodulatory therapies used to treat…
- Trial name
- NCT05543642
- Testing
- Hepatitis A vaccine, Diphtheria, pertussis, and tetanus booster vaccine
- Where
- 7 sites in United States
- Volunteers
- 129 people
- Sponsor
- Oregon Health and Science University
Mild Traumatic Brain Injury (mTBI), Concussion, Mild Traumatic Brain Injury
Postural Motor Activation Deficits After mTBI; Translating Laboratory Findings to Clinical Care
This work will address an important gap in physical therapy rehabilitation after concussion. Physical therapy usually focuses on how the brain processes sensory information such as inner ear and vision for balance rehabilitation…
- Trial name
- NCT07549529
- Testing
- Motor Activation Physical Therapy for mTBI, Standard of Care Physical Therapy for mTBI
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Hypertrophic Cardiomyopathy (HCM)
Individualized Exercise Training in Hypertrophic Cardiomyopathy
Exercise intervention trials in patients with hypertrophic cardiomyopathy (HCM) have demonstrated an association with improvement in resting and exercise hemodynamics, ventricular remodeling, and anxiety/depression.
- Trial name
- GET-FIT HCM (NCT07835854)
- Testing
- Exercise Intervention, Physical Activity Handout
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Methamphetamine Abuse, Substance Use Disorders
rTMS for Craving in Methamphetamine Use Disorder
The primary aim of this project is to use a randomized single-blind sham-controlled study to investigate if high frequency repetitive transmagnetic stimulation (HF-rTMS) can modulate cue-induced craving in adult methamphetamine…
- Conditions
- Methamphetamine Abuse, Substance Use Disorders, Stimulant Dependence, Methamphetamine-dependence
- Trial name
- NCT03470480
- Testing
- Real Repetitive transcranial magnetic stimulation, Methamphetamine visual cues, Neutral visual cues
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Cardiac Amyloidosis
Individualized Exercise Training in Cardiac Amyloidosis
Numerous clinical trials have demonstrated that transthyretin (TTR)-directed medical therapies can reduce the rate of functional decline in patients with transthyretin cardiac amyloidosis (ATTR-CM).
- Trial name
- GET-FIT ATTR (NCT07835867)
- Testing
- Exercise Intervention, Physical Activity Handout
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Chronic Pelvic Pain
Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study
The primary aim is to determine the feasibility of enrolling and 15 women with chronic pelvic pain (CPP) that have failed one conventional for CPP to obtain preliminary safety data on a single administration of a moderate dose of…
- Trial name
- NCT06988319
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis, Sclerosis
Aerobic Exercise for Remyelination in Multiple Sclerosis
This is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).
- Conditions
- Multiple Sclerosis, Sclerosis, Demyelinating Diseases, Autoimmune Diseases of the Nervous System
- Trial name
- NCT04539002
- Testing
- Aerobic exercise, Education Group Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Type 1 Diabetes (T1D)
App-Based Certified Diabetes Education Therapy (AB-CDE)
The purpose of this study is to learn more about a smartphone application (app) called DailyDose, an investigational decision support tool that may help in managing your diabetes.
- Trial name
- AB-CDE (NCT07282639)
- Testing
- DailyDose
- Where
- 6 sites in United States
- Volunteers
- 99 people
- Sponsor
- Oregon Health and Science University
Cardiac Arrest (CA)
The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable in Cardiac Arrest Trial
The purpose of this study is to compare the effectiveness of two defibrillator pad placements, one where pads are placed on the front of the chest and back (anterior-posterior [AP]) and one where the pads are placed on the front…
- Trial name
- VECTORS (NCT07818785)
- Testing
- defibrillator electrode pads
- Volunteers
- 1,500 people
- Sponsor
- Oregon Health and Science University
Obstructive Sleep Apnea, Down Syndrome
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
The overall objective of this randomized clinical trial is to test the effectiveness of a personalized approach to the surgical treatment of OSA in children with Down syndrome (DS).The estimated prevalence of obstructive sleep…
- Trial name
- TOPS-DS (NCT05508971)
- Testing
- DISE-Directed Surgery, Adenotonsillectomy
- Where
- 7 sites in United States
- Volunteers
- 304 people
- Sponsor
- Oregon Health and Science University
Glaucoma
Functional and Structural Imaging for Glaucoma
The specific aims of the clinical studies are to: Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion.
- Trial name
- FSOCT (NCT01957267)
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University