Clinical trials: sponsored by Oregon Health and Science University
Peripheral Arterial Disease
Augmentation of Limb Perfusion With Contrast Ultrasound
Our laboratory has discovered that ultrasound (US) imaging together with clinically approved microbubble ultrasound contrast agents can augment limb tissue perfusion.
- Trial name
- NCT03195556
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Peripheral Artery Disease
Contrast Ultrasound Assessment of Perfusion Changes After Peripheral Artery Revascularization
This study represents an important step to validate the use of contrast-enhanced ultrasound (CEU) as a clinical research tool that can be used as a biologic readout of new therapies for Peripheral Artery Disease (PAD), and as a…
- Trial name
- NCT02877563
- Testing
- Contrast ultrasound perfusion imaging of the limb
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Myocardial Ischemia
Ischemic Memory Imaging With Myocardial Contrast Echocardiography
The overall aim of this study is to determine whether non-invasive imaging with myocardial contrast echocardiography using can provide information on the presence and spatial extent of recent myocardial ischemia by non-invasive…
- Trial name
- NCT03009266
- Testing
- Sonazoid
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Heart Failure
Skeletal Muscle Perfusion With LVAD
Advanced heart failure (when the heart pump fails) is associated with symptoms such as shortness of breath and extreme fatigue. Some of these symptoms are simply due to failure of the pump, however abnormal regulation of blood…
- Trial name
- NCT02105831
- Testing
- Contrast ultrasound skeletal muscle perfusion imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Hypothyroidism
Neurocognitive and Metabolic Effects of Mild Hypothyroidism
Patients with hypothyroidism are routinely treated with thyroid hormone (l-thyroxine) for replacement therapy. Physicians monitor the thyroid hormone dose by measuring a thyroid stimulating hormone (TSH) level in the blood, with…
- Trial name
- NCT00565864
- Testing
- L-thyroxine (L-T4)
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- Oregon Health and Science University
Postoperative Pneumonia
Prospective Clinical Evaluation of the Taperguard Endotracheal Tube
This protocol is designed to determine if a transition from barrel-shaped cuff designs to the Taperguard endotracheal tube (ETT) reduces the incidence of postoperative pneumonia in a prospective evaluation of a large general…
- Trial name
- NCT02450929
- Volunteers
- 102 people
- Sponsor
- Oregon Health and Science University
Hypoxemia, Trauma
Comparison of Pharyngeal Oxygen Delivery by Different Oxygen Masks
The intent of this study is to determine the difference in pharyngeal oxygen concentration in patients who have a natural airway (not intubated) using commonly available oxygen delivery systems.
- Conditions
- Hypoxemia, Trauma, Acute Myocardial Infarction
- Trial name
- NCT02523586
- Testing
- Oxygen administration
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pain, Anxiety
Evaluation of Oral Midazolam in First-trimester Surgical Abortions
The purpose of this study is to determine the level of pain, anxiety and side effects that women experience with a surgical abortion and the effect that the anti-anxiety medication, midazolam, might have when used along with…
- Conditions
- Pain, Anxiety, Nausea
- Trial name
- NCT01830881
- Testing
- Midazolam, Ibuprofen, Lidocaine
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Oregon Health and Science University
Wounds and Injuries, Health Promotion
Evaluation of COMmunity of Practice And Safety Support (COMPASS) for Home Care Workers
The current project is a safety and health intervention for home care workers conducted within the Oregon Healthy Workforce Center (OHWC), a NIOSH Center of Excellence in Total Worker Health.
- Trial name
- NCT02113371
- Testing
- Intervention
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson's Disease
Cholinergic Augmentation in Frequently Falling Subjects With Parkinson's Disease
The purpose of this study is to find out if a medication that increases levels of a brain chemical called acetylcholine will improve balance and reduce falls in patients with parkinson's disease who have the problem of very poor…
- Trial name
- NCT00912808
- Testing
- Donepezil
- Volunteers
- 23 people
- Sponsor
- Oregon Health and Science University
Microvascular Dysfunction
Elucidating the Role of Microvascular Dysfunction in Heart Disease in Women
The purpose of this study is to determine if women with chest pain and "clean" heart blood vessels have impaired blood flow to the heart due to problems with the small blood vessels that provide blood and oxygen to the heart.
- Trial name
- MVD (NCT00663520)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Fuchs' Endothelial Dystrophy
OCT-guided DSAEK Graft Shaping and Smoothing
The primary goal of this study is to determine if excimer laser smoothing of the cornea before Descemet's stripping automated endothelial keratoplasty (DSAEK)improves postoperative Best Spectacle Corrected Visual Acuity (BSCVA).
- Trial name
- DSAEK (NCT01586234)
- Testing
- DSAEK with graft shaping and smoothing, Standard DSAEK
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Oregon Health and Science University
Corneal Opacity
OCT-guided LALAK in Children
The primary goal of the trial is to determine if laser-assisted lamellar anterior keratoplasty (LALAK) will reduce the risks of post-operative complications such as adhesions, glaucoma and cataract that are associated with…
- Trial name
- LALAK (NCT01579643)
- Testing
- OCT guided laser-assisted lamellar anterior keratoplasty (LALAK), Penetrating Keratoplasty (KP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Oregon Health and Science University
Corneal Opacities
Corneal Opacities in Children
A prospective observational study on corneal opacities in infants and children (1 month to 18 years old) will be conducted at CHLA. Most of these cases will be due to congenital corneal opacity (e.g.
- Trial name
- OCT (NCT02117323)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Oregon Health and Science University
Glaucoma, Macular Disease
CEI Van Outreach Screening Study
The primary goal of the trial is to show that optical coherence tomography (OCT) technology can be used to effectively screen for diseases of the eye including glaucoma, macular diseases and keratoconus.
- Conditions
- Glaucoma, Macular Disease, Keratoconus
- Trial name
- NCT01510392
- Testing
- OCT imaging, the FDA Cleared iVue
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Glaucoma
Advanced Imaging for Glaucoma Study
The specific aims of the clinical studies are to: 1. Predict the development of glaucomatous visual field (VF) abnormality in glaucoma suspects and pre-perimetric glaucoma patients based on anatomic abnormalities detected by…
- Trial name
- AIGS (NCT01314326)
- Where
- 5 sites in United States
- Volunteers
- 832 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis
Using Optical Coherence Tomography to Capture Retinal Microvascular Changes Associated With Multiple Sclerosis
Recent studies have shown that people with multiple sclerosis (MS) who also have diseases related to vascular health such as high cholesterol, high blood pressure, diabetes, cardiovascular disease, and others, may end up more…
- Trial name
- OCT in MS (NCT01596881)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Proliferative Diabetic Retinopathy
Diabetes PRP and OCT
The purpose of this study is to evaluate the effectiveness of investigational Doppler Optical Coherence Tomography (OCT) and OCT angiography in the management of proliferative diabetic retinopathy (PDR - a leading cause of…
- Trial name
- PRP (NCT01928550)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis
Evaluation of a Web-Based Fall Prevention Program on People With Multiple Sclerosis
This study evaluates the effectiveness of a web-based fall prevention program called Free From Falls Online (FFFO) on people with multiple sclerosis.
- Trial name
- NCT02885233
- Testing
- Free From Falls Online, Waitlist Control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Keratoconus and Post-keratoplasty
Observational Study of Keratoconus and Post-keratoplasty Eyes
A prospective observational study on keratoconus and post-keratoplasty will be conducted. We will enroll 50 subjects in each of 3 groups: keratoconus, post-PK, and post-DSAEK.
- Trial name
- NCT02109848
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Oregon Health and Science University