Clinical trials: sponsored by Oregon Health and Science University
Hypertrophic Cardiomyopathy (HCM)
Mavacamten to Aficamten Transition in Patients With Obstructive Hypertrophic Cardiomyopathy
This is an investigator-initiated two-center study. The goal of this study is to investigate the feasibility, safety and efficacy outcomes of a seamless transition from mavacamten to aficamten in patients with obstructive…
- Trial name
- CMI-SWITCH (NCT07600177)
- Testing
- Aficamten
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Cardiovascular Risk Factor, Circadian Dysregulation
Body Weight, Sleep, and Heart Health
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity.
- Conditions
- Cardiovascular Risk Factor, Circadian Dysregulation, Obesity
- Trial name
- NCT03388788
- Testing
- Positron Emission Tomography (PET) scanning of cardiac function at 3 time points across the 24 hour circadian cycle
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Glut1 Deficiency, GLUT1DS1
A Phase II Study With Exploratory Outcomes of Fucose Supplementation in GLUT1 Deficiency Syndrome
This is a single-center, randomized, double-blind, placebo-controlled, cross-over study to evaluate the efficacy and safety of L-fucose supplementation in subjects with GLUT1 deficiency syndrome (GLUT1DS).
- Trial name
- NCT07432490
- Testing
- L-fucose
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Oregon Health and Science University
Pregnancy
Providing Birth Control Through Home Health Visits
This study will evaluate a program that provides birth control to low income and minority women through home visits by a community health nurse. The goal of the program is to reduce unwanted pregnancies.
- Trial name
- NCT00065078
- Testing
- Home dispensing of contraception, Family Planning Counseling
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Mycobacterium Avium Complex
Clofazimine in the Treatment of Pulmonary Mycobacterium Avium Complex (MAC)
The purpose of this study is to evaluate the clinical effectiveness and safety of clofazimine when used to treat Mycobacteria avium complex (MAC) lung disease. Funding Source - FDA OOPD
- Trial name
- NCT02968212
- Testing
- Clofazimine, sugar pill
- Where
- 6 sites in United States
- Volunteers
- 102 people
- Sponsor
- Oregon Health and Science University
IUD
IUD Self-Removal Study
This is a pilot study designed to test the effectiveness of several techniques for intrauterine device (IUD) self-removal and to understand patient preferences regarding IUD self-removal and indicators of success as well as…
- Trial name
- NCT05339555
- Testing
- Instructions for IUD Self-Removal Provided to Participant
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Asthma in Children
Treating Respiratory Emergencies in Children Study
Over 200,000 children have a 911 Emergency Medical Services (EMS) activation for respiratory distress each year, most of whom have acute wheezing.
- Trial name
- T-RECS (NCT06074185)
- Testing
- Ipratropium Bromide
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Oregon Health and Science University
Amyloidosis, Transthyretin Amyloidosis
Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis
This is a single center prospective study evaluating 124I-evuzumitide in patients with systemic amyloidosis. The purpose of this study is to 1) Establish the diagnostic accuracy of 124I-evuzumitide in cardiac amyloidosis 2)…
- Trial name
- NCT05758493
- Testing
- 124I-Evuzamitide
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Oregon Health and Science University
Hypertension, Multiple Chronic Conditions
Collaboration Oriented Approach to Controlling High Blood Pressure
Hypertension is a significant contributor to poor cardiovascular outcomes. Self-management support tools can increase patient behaviors to improve blood pressure.
- Trial name
- COACH (NCT06124716)
- Testing
- Enhanced COACH CDS Tool, Usual Care COACH CDS Tool
- Where
- 3 sites in United States
- Volunteers
- 550 people
- Sponsor
- Oregon Health and Science University
Healthy, Aging
Ashwagandha Pharmacokinetics Study in Older Adults
This study will measure the oral bioavailability and pharmacokinetics of known compounds from a standardized Withania somnifera botanical dietary supplement in healthy older adults.
- Trial name
- NCT06171724
- Testing
- Shoden
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Child Sleep
Brief Sleep Intervention for Bedtime Resistance
This is non-controlled feasibility study testing the delivery of a brief sleep intervention for children aged 3-7 who struggle to fall asleep independently.
- Trial name
- NCT06970392
- Testing
- Bedtime Pass
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Early Childhood Emotional and Behavioral Concerns
Using the Adaptive Behavioral Counseling Decision Framework to Guide Single-Session Intervention for Preschool Behavioral Concerns in Pediatric Primary Care: A Feasibility Trial
The goal of this clinical trial is to evaluate the feasibility, acceptability, and initial effectiveness of using the Adaptive Behavioral Counseling Decision Framework to provide behavioral counseling for common preschool…
- Trial name
- ABD-DeF (NCT07520331)
- Testing
- Adaptive Behavioral Counseling Decision Framework
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Lower Extremity Musculoskeletal Injury
Evaluation of Lower Extremity Athletic Injuries and Response to Treatment Using SWE and MFI
Primary Objective: To explore changes in shear wave elastography (SWE) and microvascular flow imaging (MFI) measurements from time of injury through the recovery phase of lower extremity musculoskeletal injuries to determine if a…
- Trial name
- NCT05608824
- Testing
- Shear wave elastography and microvascular flow imaging.
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Oregon Health and Science University
Dementia, Alzheimer Disease
Using Technology to Support Care Partners for Persons With Alzheimer's Disease: Tele-STELLA
The purpose of this study is to test a revised psychoeducational intervention to help Care Partners for family members with dementia understand and reduce the distressing behaviors that come with progressive dementia.
- Conditions
- Dementia, Alzheimer Disease, Caregiver Burnout, Family Members
- Trial name
- Tele-STELLA (NCT04627662)
- Testing
- Tele-STELLA
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Oregon Health and Science University
Gender Affirmation Surgery, Perioperative Care
Support for Transgender and Non-Binary Individuals Seeking Vaginoplasty Study
The STRIVE study is the first national randomized trial to focus on improving well-being, access to surgical care and other health outcomes for transgender and nonbinary (referred to as trans) people seeking genital…
- Conditions
- Gender Affirmation Surgery, Perioperative Care, Transgender Health
- Trial name
- STRIVE (NCT06436560)
- Testing
- STRIVE Peer Support Intervention
- Where
- 9 sites in United States
- Volunteers
- 290 people
- Sponsor
- Oregon Health and Science University
Sleep
Assessing Construction Execution Under Sleep Impairment
The goal of this study is to learn whether virtual reality (VR) construction tasks can detect performance changes associated with prior sleep, and to determine the extent to which these changes can be distinguished from…
- Trial name
- ACES (NCT07431970)
- Testing
- Construction Virtual Reality Stress Challenges, No Construction Virtual Reality Stress Challenges
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hypertension, Cardiovascular Diseases
Sleep and Circadian Mechanisms in Hypertension
This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure (BP) in people with hypertension (HTN).
- Conditions
- Hypertension, Cardiovascular Diseases, Cardiovascular Risk Factors, Circadian Rhythms
- Trial name
- NCT05184933
- Testing
- At-home Polysomnography, Circadian Protocol, Rested Wakefulness Trial
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Oregon Health and Science University
Sleep, THC
Tetrahydrocannabinol (THC) and Sleep
The investigators will test the effects of 10-60mg dronabinol (oral THC) on sleep in non-frequent and frequent cannabis users.
- Conditions
- Sleep, THC, Marijuana, Cannabis
- Trial name
- NCT03560934
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Spinal Cord Injury
Randomized Trial of Early Hemodynamic Management of Patients Following Acute Spinal Cord Injury
The purpose of this study is to learn more about how participants heal from acute spinal cord injury.
- Trial name
- TEMPLE (NCT02878850)
- Testing
- Augmented Blood Pressure
- Where
- 11 sites in United States
- Volunteers
- 94 people
- Sponsor
- Oregon Health and Science University
Gestational Diabetes, Postpartum
Stelo Real-time Continuous Glucose Monitor Use Postpartum for Lifelong Optimal Wellness
The purpose of this prospective observational study is to gather exploratory and practical use data of the Dexcom Stelo Glucose Biosensing System (Stelo), an over-the-counter (OTC) real-time Continuous Glucose Monitoring (CGM)…
- Trial name
- STELO-GLOW (NCT07356986)
- Testing
- Dexcom Stelo real-time Continuous Glucose Monitor
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University