Clinical trials: sponsored by Oregon Health and Science University
Methamphetamine Abuse
Peer Engagement in Methamphetamine Harm-Reduction With Contingency Management (PEER-CM)
The main goal of this study is to tests the effect of incentivizing achievement of self-identified, personal harm reduction goals (Contingency management or CM) compared with standard of care (peer harm reduction service with…
- Trial name
- NCT05700994
- Testing
- Peer Contingency Management, Standard of Care Contingency Management
- Where
- 2 sites in United States
- Volunteers
- 1,283 people
- Sponsor
- Oregon Health and Science University
Cervical Mucus
Insights in Endocervical Mucus Secretion
Single arm interventional study looking at biological outcomes at 4 time points throughout the cycle before and after taking an oral gonadotropin-releasing hormone antagonist (gnRH).
- Trial name
- NCT07111247
- Testing
- Gonadotropin Releasing Hormone Antagonists Relugolix
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Opioid Use Disorder
Reentry Incentives and Support for Engagement With Contingency Management
People leaving jail face a very high risk of overdose, especially in the first few weeks after release. Staying on medication for opioid use disorder (MOUD) can greatly reduce this risk, but many people stop treatment during this…
- Trial name
- RISE-CM (NCT07322588)
- Testing
- Reentry Incentives and Support for Engagement with Contingency Management (RISE-CM) Intervention
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Oregon Health and Science University
Methamphetamine Abuse
Maternal Outcomes With Methamphetamine Use and Cardiac Assessment for Rural Dissemination (MOM CARD)
The purpose of this study is to develop a pilot screening protocol, comparing cardiac point-of-care ultrasound (POCUS), electrocardiogram (EKG), serum biomarkers (N-terminal pro b-type natriuretic peptide (NT-proBNP), high…
- Trial name
- NCT07309757
- Volunteers
- 35 people
- Sponsor
- Oregon Health and Science University
Pancreatitis, Pancreas Divisum
SpHincterotomy for Acute Recurrent Pancreatitis
The purpose of this study is to determine if a procedure called Endoscopic Retrograde CholangioPancreatography (ERCP) with sphincterotomy reduces the risk of pancreatitis or the number of recurrent pancreatitis episodes in…
- Conditions
- Pancreatitis, Pancreas Divisum, Pancreatitis, Acute, Pancreatitis Idiopathic
- Trial name
- SHARP (NCT03609944)
- Testing
- ERCP with miES, EUS
- Where
- 21 sites in United States, Canada
- Volunteers
- 181 people
- Sponsor
- Oregon Health and Science University
Perinatal Depression
Center M Randomized Trial
This is a randomized controlled trial with an intervention of Center M compared to treatment as usual. Center M consists of weekly digital one-hour group sessions led by a trained therapist aligned with mindfulness based…
- Trial name
- NCT07304895
- Testing
- Center M
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Glaucoma
Rocklatan Retinal Perfusion OCT Study
The main purpose of this study is to learn more about how Rocklatan eye drops affects blood flow in the eye. The secondary purpose is to see if our study devices can detect changes in blood flow before and after instillation of…
- Trial name
- NCT07174401
- Testing
- Rocklatan eye drops will be instilled nightly in one eye diagnosed with glaucoma for up to 12 months., Two optical coherence tomography (OCT) devices will be used to assess blood flow changes.
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Cardiac Arrest
Early Amiodarone in Shockable Cardiac Arrest
The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute…
- Trial name
- Early-Amio (NCT06680869)
- Testing
- Amiodarone Hydrochloride Injection, Usual Care Protocol
- Where
- United States
- Volunteers
- 585 people
- Sponsor
- Oregon Health and Science University
Hypertension, Preeclampsia
A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia
This is an open-label, randomized feasibility trial in which patients admitted to Oregon Health \& Science University (OHSU) after a pregnancy complicated by preeclampsia who are considering a progestin-only pill contraception…
- Trial name
- NCT07293728
- Testing
- Norethindrone 0.35 MG, Drospirenone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Healthy, Aging
Safety, Tolerability, and Pharmacokinetics of an Oral Withania Somnifera Product in Older Adults
This study will measure the oral bioavailability and pharmacokinetics of known compounds from a standardized Withania somnifera botanical dietary supplement in healthy older adults.
- Trial name
- NCT07008300
- Testing
- Shoden
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Stillbirth, Placental Insufficiency
Placental Risk Assessment to CusTomize Individualized Pregnancy Care and Evaluation
This is a prospective observational study with the goal of developing and assessing a predictive model of placental insufficiency.
- Trial name
- PRACTICE (NCT07144839)
- Testing
- Data Collection Throughout Pregnancy and Delivery
- Where
- United States
- Volunteers
- 640 people
- Sponsor
- Oregon Health and Science University
Parkinson Disease
Cortical Correlates of Gait in Parkinson's Disease: Impact of Medication and Cueing
The purpose of the study is to determine the effects of a novel, personalized, tactile cueing system on gait automaticity. The researchers hypothesized that step-synchronized tactile cueing will reduce prefrontal cortex activity…
- Trial name
- cueing (NCT05818189)
- Testing
- Personalized tactile cueing, Fixed tactile cueing
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon Health and Science University
Hyperglycemia
Metformin Use in Patients Undergoing Total Joint Replacement Surgery
The goal of this pilot, randomized, single-blind, placebo-controlled trial is to evaluate the feasibility of and provide preliminary information for a multi-center randomized controlled trial that will assess the effects of…
- Trial name
- NCT06280274
- Testing
- Metformin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Obesity
Success & Health Impacts For Transit Drivers During Onboarding
The project is a cluster randomized controlled trial of an occupational health intervention for newly hired bus operators. Transit authorities will be randomized to intervention and usual practice conditions and new bus operators…
- Trial name
- SHIFT Onboard (NCT03730792)
- Testing
- SHIFT Onboard Intervention
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Pain Management, Ergonomics
COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP)
Home care workers (HCWs) are at-risk for chronic pain and associated problems, including emotional distress, opioid use and misuse, and work-related disability.
- Conditions
- Pain Management, Ergonomics, Wounds and Injuries
- Trial name
- COMPASS-NP (NCT05492903)
- Testing
- COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Caregivers Burnout, Frontotemporal Dementia
Support Via Technology: Living and Learning With Advancing FTD
Much effort over the last several decades has been devoted to developing and implementing psychoeducational interventions for family caregiving partners for those with Alzheimer's and relatedm dementias (ADRD).
- Trial name
- STELLA-FTD (NCT05338710)
- Testing
- STELLA-FTD
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson Disease
Mobility in Daily Life and Falls in Parkinson's Disease: Potential for Rehabilitation
The goal of this intervention is to explore the effectiveness of a Turning Intervention (TURN-IT) to improve quality of turning in participants with Parkinson's Disease (PD).
- Trial name
- NCT04897256
- Testing
- TURN-IT exercise program
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Oregon Health and Science University
Circadian Rhythm, Cardiometabolic Health
The Influence of Sleep on Cardiovascular Outcomes
The goal of this study is to identify the effects of sleep regularity on cardiovascular regulatory mechanisms. The investigators are hoping to discover if improving the regularity of sleep timing will improve metabolic and…
- Conditions
- Circadian Rhythm, Cardiometabolic Health, Vascular Health, Pain
- Trial name
- DISCO (NCT06535178)
- Testing
- Sleep Regularity Group
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Essential Tremor
Directional Versus Nondirectional DBS for ET
This will be a single center (OHSU) proof of concept trial to demonstrate that directional deep brain stimulation (DBS) creates a larger therapeutic window for the treatment of essential tremor (ET), effectively treats ET, and…
- Trial name
- NCT04828798
- Testing
- Deep brain stimulation of the VIM Thalamic nuclei
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Oregon Health and Science University
Pantothenate Kinase-Associated Neurodegeneration
CoA-Z in Pantothenate Kinase-associated Neurodegeneration (PKAN)
The purpose of this study is to learn more about how people with the condition pantothenate kinase-associated neurodegeneration (PKAN) respond to a specialized study product.
- Trial name
- NCT04182763
- Testing
- CoA-Z
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Oregon Health and Science University