Clinical trials: sponsored by Peking University
Gastrointestinal Tumors
Phase 1 Trial of AZD6422 in CLDN18.2+ GI Tumors
This is a FTiH, Phase 1 IIT to evaluate the safety, feasibility, cellular kinetics (CK), pharmacodynamics (PD), immunogenicity, and preliminary antitumor activity of AZD6422 in adult participants with advanced or metastatic…
- Trial name
- NCT05981235
- Testing
- AZD6422 CLDN18.2 CAR-T product
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Peking University
Aged, Intensive Care Units
Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients
Patients with mechanical ventilation in the intensive care unit (ICU) often develop anxiety and agitation, sleep distuebances, and delirium. Delirium occurrence is associated with worse early and long-term outcomes.
- Conditions
- Aged, Intensive Care Units, Ventilators, Mechanical, Dexmedetomidine
- Trial name
- NCT06468436
- Testing
- Dexmedetomidine-Esketamine Combination, Dexmedetomidine
- Where
- 3 sites in China
- Volunteers
- 1,508 people
- Sponsor
- Peking University First Hospital
Pancreatic Cancer, Surgery
Perioperative Epidural Block and Dexamethasone in Pancreatic Cancer Surgery
Pancreatic cancer remains a devastating disease with an average 5-year survival rate of about 3-5%. Previous retrospective studies showed that perioperative epidural block and/or dexamethasone are associated with improved outcome…
- Conditions
- Pancreatic Cancer, Surgery, Epidural Block, Dexamethasone
- Trial name
- NCT04025840
- Testing
- Epidural block, Dexamethasone
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Peking University First Hospital
Sexual Function Abnormal, Spinal Cord Injuries (SCI)
A Prospective Cohort Study on the Effect of Spinal Spinal Cord Injury on Sexual Function in Male Patients
1. Background and Rationale Spinal cord injury (SCI) represents a devastating neurological condition with multidimensional consequences.
- Trial name
- NCT07093827
- Testing
- Posterior decompression surgery, unilateral open-door laminoplasty, Posterior lumbar discectomy with fusion
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Peking University Third Hospital
Benzodiazepines, Bladder Cancer
Impact of Remimazolam on Prognosis After Bladder Cancer Surgery
Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer.
- Conditions
- Benzodiazepines, Bladder Cancer, Delirium, Surgery
- Trial name
- NCT04532606
- Testing
- Remimazolam, Propofol
- Where
- 6 sites in China
- Volunteers
- 1,128 people
- Sponsor
- Peking University First Hospital
Scoliosis Correction, Postoperative Analgesia
Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes
Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe acute postoperative pain is one of the major risk factors of CPSP.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, Esketamine, Dexmedetomidine
- Trial name
- NCT06087510
- Testing
- Esketamine
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University First Hospital
Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension
Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery
Acute renal injury (AKI) is a common complication after cardiac surgery and is associated with worse outcomes. It is now realized that intraoperative hypotension is an important risk factor for the development of AKI.
- Conditions
- Coronary Artery Bypass, Off-Pump, Intraoperative Hypotension, Acute Kidney Injury, Preventive Medicine
- Trial name
- NCT03629418
- Testing
- Targeted blood-pressure management, Routine blood-pressure management
- Where
- China
- Volunteers
- 612 people
- Sponsor
- Peking University First Hospital
Local Anesthetics, Analgesia
Liposomal vs. Conventional Bupivacaine for Pain Control
The goal of this pilot study is to test the hypothesis that liposomal bupivacaine extends the duration of paravertebral block in patients undergoing radical nephrectomy, achieving improved analgesia compared to conventional…
- Conditions
- Local Anesthetics, Analgesia, Regional Block, Paravertebral Block
- Trial name
- NCT06231355
- Testing
- Performing paravertebral nerve block with lipo-bupivacaine, Performing paravertebral nerve block with bupivacaine
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Peking University First Hospital
Scoliosis Correction, Postoperative Analgesia
Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes
Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe postoperative acute pain is one of the major risk factors of CPSP.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, Esketamine, Dexmedetomidine
- Trial name
- NCT05718544
- Testing
- Esketamine, Dexmedetomidine, Sufentanil
- Where
- China
- Volunteers
- 199 people
- Sponsor
- Peking University First Hospital
Alzheimer's Disease，Mild Cognitive Impairment
Cohort Study on Cognitive Decline in Elderly
Alzheimer's Disease (AD) prevention and control currently face severe challenges, with limited treatment options and effectiveness available. Once the disease progresses to the AD stage, it is essentially irreversible.
- Trial name
- NCT07093892
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
S-ketamine, Postoperative Analgesia
Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery
Despite opioid-based multimodal analgesia, moderate-to-severe pain remains a big problem in patients following multi-segment spinal fusion.
- Conditions
- S-ketamine, Postoperative Analgesia, Spine Fusion
- Trial name
- NCT04964219
- Testing
- S-ketamine
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Peking University First Hospital
NRDS
Impact of Delayed Cord Clamping and Minimally Invasive Surfactant Administration on Outcomes in Premature Infants Less Than 30 Weeks Gestation
Background: Preventing early exposure to invasive mechanical ventilation in premature infants is crucial for reducing the incidence of bronchopulmonary dysplasia (BPD) and improving overall outcomes.
- Trial name
- NCT07092319
- Testing
- deferred cord clamping
- Where
- China
- Volunteers
- 518 people
- Sponsor
- Peking University Third Hospital
Non Small Cell Lung Cancer NSCLC
Phase Ib/II Study of Vebreltinib With Furmonertinib in NSCLC Patients With c-Met Amplification After EGFR-TKI Failure
The goal of phase Ib study was to evaluate efficacy and tolerability of the combination of vebreltinib and furmonertinib in patients with locally advanced or metastatic non-small cell lung cancer with c-met amplification after…
- Trial name
- NCT07087223
- Testing
- Vebreltinib combined with Furmonertinib
- Where
- 12 sites in China
- Volunteers
- 42 people
- Sponsor
- Peking University Cancer Hospital & Institute
Myelodysplastic Syndrome, Acute Leukemia
Reduced ATG Plus Mini PTCy for GVHD Prophylaxis in Haplo-SCT
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is regarded as a curative therapy for a variety of hematological malignancies and nonmalignant diseases.
- Trial name
- NCT06984536
- Testing
- Reduced ATG plus mini PTCy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
Anterior Cruciate Ligament Injuries, Cartilage Degeneration
Effect of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction
A randomized controlled clinical study was conducted to elucidate the relationship between the lower extremity biomechanics of patients undergoing early gait training after ACLR surgery.The relationship between the biochemical…
- Trial name
- NCT06368544
- Testing
- lower-body positive-pressure
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Stage IIIB(N2) Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer
Pembrolizumab and Chemotherapy Neoadjuvant/Adjuvant of NSCLC
This study is to evaluate the efficacy and safety of neoadjuvant pembrolizumab plus chemotherapy following by pembrolizumab adjuvant in stage IIA-IIIB (N2) NSCLC participants without sensitizing EGFR/ALK mutation.
- Conditions
- Stage IIIB(N2) Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer, Stage IIIA Non-small Cell Lung Cancer
- Trial name
- NCT05894889
- Testing
- Pembrolizumab 200 mg IV infusion
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- Peking University
Platinum-resistant Ovarian Cancer (PROC)
Safety and Efficacy of RIF Combined With Anlotinib in the Treatment of Patients With Advanced Recurrent Platinum-Resistant Ovarian Cancer: A Prospective, Multicenter Clinical Study
This project plans to conduct a prospective, multicenter clinical study. The intended participants are patients with histologically confirmed advanced (FIGO III/IV stage) ovarian serous carcinoma, ovarian endometrioid carcinoma…
- Trial name
- RIFOC003 (NCT07075250)
- Testing
- Realgar-Indigo Naturalis Formulation Combined with Anlotinib
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Blood Pressure, Dexmedetomidine
Intraoperative Goal-directed Blood Pressure and Dexmedetomidine on Outcomes
Perioperative organ injuriy remain an important threat to patients undergoing major surgeries. Intraoperative hypotension is associated with an increase in postoperative morbidity and mortality.
- Conditions
- Blood Pressure, Dexmedetomidine, High-risk Patients, Abdominal Surgery
- Trial name
- NCT03933306
- Testing
- Dexmedetomidine, Goal-directed blood pressure management, Routine blood pressure management
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Peking University First Hospital
Immune Thrombocytopenia (ITP), Acute Ischemic Stroke
Longitudinal Cohort Study on Immune Thrombocytopenia Complicated With Acute Ischemic Stroke
Immune thrombocytopenia (ITP) is an acquired bleeding disorder mediated by immune-related platelet destruction and impaired platelet production.
- Trial name
- NCT07070193
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Y-balance, Patellofemoral Pain Syndrome
Assessing Lower Extremity Dynamic Stability in Middle-Aged and Elderly Patients With Patellofemoral Pain Using the Y-Balance Test
Background: Patellofemoral pain syndrome (PFPS) is a common functional disorder of knee joint. Its etiology involves biomechanical abnormalities and dynamic stability defects.
- Trial name
- NCT07068984
- Testing
- Differences between lower limb balances were assessed by the Y-Balance test
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.