Clinical trials: sponsored by Radboud University Medical Center
Interstitial Cystitis, Chronic, Overactive Bladder Syndrome
Real-life Clinical Experience With Ialuadapter Study
A retrospective study from a single center was performed. Quantitative and qualitative data was obtained on the use of the syringe adapter (IALUADAPTER®) in 61 patients with IC/BPS (n=48), rUTI (n=6) and mixed /other diagnoses…
- Conditions
- Interstitial Cystitis, Chronic, Overactive Bladder Syndrome, Recurrent Urinary Tract Infection
- Trial name
- Ialuadapter (NCT06540248)
- Testing
- Ialuadapter
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- Radboud University Medical Center
Treatment, Anastomotic Leakage
TreatmENT of AnastomotiC LeakagE After COLON Cancer Resection
This international multicentre retrospective cohort study aims to research anastomotic leakage after colon cancer resection and has two main objectives: 1.
- Conditions
- Treatment, Anastomotic Leakage, Resection, Colon Cancer
- Trial name
- TENTACLE-Colon (NCT06528054)
- Testing
- Development of a model for predicting 90-day mortality and to compare various treatment strategies for anastomotic leakage
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease, Acute Coronary Syndrome
South East (Zuid Oost) Netherlands Heart Registry
Rationale: Patients undergoing percutaneous coronary intervention (PCI) for chronic coronary syndrome (CCS) or acute coronary syndrome (ACS) have a residual risk of ischemic events after PCI due to the progression of…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome
- Trial name
- ZON-HR (NCT06512493)
- Where
- 4 sites in Netherlands
- Volunteers
- 99,999 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease, Atherosclerosis of Coronary Artery
Functional Improvement of Coronary Artery Narrowing by Cholesterol Reduction With a PCSK9 Antibody
In a large number of patients who experienced an acute coronary syndrome, multiple narrowings of the coronary arteries are identified.
- Trial name
- FITTER (NCT04141579)
- Testing
- Evolocumab 140 MG/ML [Repatha]
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Mild Cognitive Impairment, Cognitive Decline
BreinZorg: Feasibility Study Into an Online Lifestyle Platform for MCI and SCD
Dementia is the most common disease in older individuals and this century's biggest healthcare challenge. Many patients who visit the memory clinic with memory complaints do not have dementia but instead are diagnosed with mild…
- Trial name
- NCT06309758
- Testing
- Breinzorg
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Palliative Sedation
The Clinical Practice of Palliative Sedation
Palliative Sedation (PS) is defined as the intentional lowering of consciousness of a patient in the last phase of life, to relieve patients suffering from refractory symptoms.
- Trial name
- PALLSED (NCT04719702)
- Where
- 8 sites in Belgium, Germany and 3 more
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Esophageal Stricture, Anastomotic Stenosis
NKI Therapy Compared to Usual Care of Recurrent Esophagogastric Anastomotic Strictures
Rationale: The study hypothesizes that NKI followed by endoscopic bougie dilation therapy will result in an increased dysphagia-free period, a reduction of endoscopic procedures and dysphagia-related quality of life, and lower…
- Conditions
- Esophageal Stricture, Anastomotic Stenosis, Dilation of Esophagus Due to Disease
- Trial name
- SAMURAI (NCT04406428)
- Testing
- NKI followed by EBD
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Prostatic Neoplasms, Castration-Resistant
Effect of a Reduced Dose Enzalutamide in Frail (m)CRPC Patients on Cognitive Side Effects
Prostate cancer is the most commonly diagnosed cancer among men in Western countries. When the disease recurs as castration-resistant prostate cancer (CRPC) it is associated with a median overall survival of approximately 2 years…
- Trial name
- REDOSE (NCT03927391)
- Testing
- Enzalutamide
- Where
- 3 sites in Netherlands
- Volunteers
- 57 people
- Sponsor
- Radboud University Medical Center
Cancer
Pharmacokinetic Boosting of Olaparib to Improve Exposure, Tolerance and Cost-effectiveness
Olaparib is a poly-adenosine diphosphate ribose polymerase (PARP) inhibitor, originally used for the maintenance treatment of women with platinum-sensitive relapsed breast cancer gene (BRCA)-mutated high grade serious epithelial…
- Trial name
- PROACTIVE (NCT05078671)
- Testing
- Olaparib, Cobicistat
- Where
- 10 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Radboud University Medical Center
Primary Hypertension
Multi-Omics to Predict the Blood Pressure Response to Antihypertensives
The goal of this clinical trial is to develop biomarkers composed of multiple OMICs (MOMICs) for prediction of blood pressure response to antihypertensive drugs in the treatment of primary hypertension.
- Trial name
- HT-PREDICT (NCT05917275)
- Testing
- Amlodipine, Olmesartan, Hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 96 people
- Sponsor
- Radboud University Medical Center
eHealth, Telemedicine
Luchtbrug Junior: the Next Step
Rationale: The introduction of e-health in the monitoring and management of patients with chronic conditions can be beneficial and efficient.
- Conditions
- eHealth, Telemedicine, Wheezing
- Trial name
- NCT05682664
- Testing
- Luchtbrug Junior (online monitoring), Usual care
- Volunteers
- 270 people
- Sponsor
- Radboud University Medical Center
Hypertension, Frailty
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Rationale: Systolic hypertension represents the leading risk for burden of disease among older adults (age >70 years), with an increasing prevalence due to the increase in lifespan.
- Conditions
- Hypertension, Frailty, Old Age; Dementia, Orthostatic Intolerance
- Trial name
- BLUEBERRY (NCT05529147)
- Testing
- Antihypertensive Agents
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Diabetes Mellitus, Type 2
Imaging Pituitary ActiVation by Exendin
The main goal is the comparison of pituitary uptake of Ga-68-NODAGA-exendin-4 in patients with and without adequate response (based on HbA1c or weight loss) to GLP-1R agonist treatment.
- Trial name
- iPAVE (NCT03923114)
- Testing
- Ga-68-NODAGA-exendin-4 PET/CT
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Head and Neck Cancer
Individualized Follow-Up for Head and Neck Cancer
This pilot study evaluates offering Head and Neck Cancer (HNC) patients a choice between standardized and individualized follow-up after HNC treatment.
- Trial name
- INFLUENCE (NCT05386225)
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Radboud University Medical Center
Bladder Pain Syndrome
GAG-therapy Efficacy Trial Solution for Bladder Pain Syndrome/ Interstitial Cystitis (GETSBI Study)
Rationale: Efficacy study (RCT) for glycosaminoglycan(GAG)-therapy for the indication bladder pain syndrome / interstitial cystitis with Hunner lesion subtype (BPS-IC H+).
- Trial name
- GETSBI (NCT05518864)
- Testing
- IALURIL Prefill
- Where
- 8 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Coronary Vasospasm, Coronary Microvascular Dysfunction
The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)
The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational.
- Conditions
- Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis
- Trial name
- NL-CFT (NCT06083155)
- Testing
- Coronary Function Test, Patient questionnaires
- Where
- 15 sites in Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Radboud University Medical Center
Predictive Cancer Model
Prognostic Evaluation Prediction Model Survival Spinal Epidural Metastases
Patients with symptomatic spinal metatstasis will be prosepectively included in a database after theu signes informed consent. Minimally six months after inclusion the survival status is analyzed.
- Trial name
- NCT06411015
- Where
- Netherlands
- Volunteers
- 428 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease, Parkinsonism
Head-up Tilt Sleeping to Alleviate Orthostatic Hypotension, Supine Hypertension and Nocturia in Parkinson's Disease
Autonomic dysfunction is common and often underrecognized in Parkinson's disease (PD). Orthostatic hypotension (OH) affects up to a third of PD patients and often coincides with supine hypertension.
- Trial name
- NCT05551377
- Testing
- Head-up tilt sleeping
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Infection Prosthesis Hip and Knee, Infection, Prosthesis Related
Results of Extended Versus Single Dose Antibiotic Prophylaxis In Orthopedic Revision Arthroplasty in Nijmegen.
The goal of this randomized control trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
- Conditions
- Infection Prosthesis Hip and Knee, Infection, Prosthesis Related, Joint Infection, Infection, Surgical Site
- Trial name
- REViSION (NCT06402591)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 751 people
- Sponsor
- Radboud University Medical Center
Rectal Cancer, Pancreatic Cancer
Multimodal Imaging in Rectal Cancer & Pancreatic Cancer
Most digestive cancers show (over)expression of the tumour marker carcinoembryonic antigen (CEA). Therefore, interest in CEA-targeting tracers has increased over the past years.
- Trial name
- MIRCA & MIPAC (NCT06395337)
- Testing
- [111In]In-DOTA-ANTI-CEA antibody injection, SPECT/CT scan, Resection surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center