Clinical trials: sponsored by Radboud University Medical Center
Quality of Life, Sarcoma
QUEST: QUality of Life and Experiences of Sarcoma Trajectories
Background: The prognosis of patients with rare cancers in general and sarcomas in particular suffers from delay in diagnosis. Routes to diagnosis for sarcoma need to be quicker and more streamlined, but have neither been studied…
- Conditions
- Quality of Life, Sarcoma, Diagnostic Interval, Diagnostic Pathway
- Trial name
- QUEST (NCT03441906)
- Where
- 8 sites in Netherlands, United Kingdom
- Volunteers
- 350 people
- Sponsor
- Radboud University Medical Center
Critical Illness, Infectious Disease
Population Pharmacokinetics of Antibiotics in Critically Ill Children (POPSICLE)
Infections are common on the Intensive Care for both adult and pediatric patients. Adequately dosing antibiotic treatment is of vital importance but both under- and overdosing is frequent due to pathophysiological changes during…
- Conditions
- Critical Illness, Infectious Disease, Children
- Trial name
- POPSICLE (NCT03248349)
- Testing
- Pharmacokinetics
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Radboud University Medical Center
Frailty at Older Adults
Social Robot Support for Healthcare Professionals
This study evaluates the effectiveness of integrated care pathway steps supported by social robots. Half of the participants will receive regular care, while for the other half a social robot dialogue will be included as part of…
- Trial name
- NCT03857789
- Testing
- Questionnaire
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Radboud University Medical Center
Renal Cell Carcinoma
MRI in Renal Tumors
Diagnostic imaging for renal masses of unknown nature using conventional imaging modalities such as 3 phase contrast-enhanced computed tomography (CT) is not always conclusive.
- Trial name
- NCT02325921
- Testing
- Magnetic Resonance Imaging
- Where
- Netherlands
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Surgery
The Impact of Preoperative FoodforCare at Home
Preoperative nutritional state is closely related to perioperative morbidity and complications. This study aims to determine the effect of a protein-rich meal service in the preoperative setting compared to usual care.
- Trial name
- NCT03488511
- Testing
- FoodforCare at home
- Where
- 2 sites in Netherlands
- Volunteers
- 126 people
- Sponsor
- Radboud University Medical Center
Chronic Hepatitis c
'Fibrosis in the Lost Hepatitis C Population - Track, Trace and Treat'
Objective: To coordinate active tracing of chronic hepatitis C patients lost to follow-up to inform them about there disease severity and treatment options.
- Trial name
- Track&Trace (NCT03088917)
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Head-and-neck Cancer
Long Term Complications in Head and Neck Cancer Patients
Problem: With increasing numbers of cancer survivors, strategies to prevent long-term complications in cancer patients become more important.
- Trial name
- NCT04257968
- Testing
- Ultrasonography, MRI, Neuro Psychological Assessment Battery
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Antidepressants
Discontinuation of Antidepressant Medication in Primary Care.
To investigate the effectiveness of the combination of Supported Protocolized Discontinuation (SPD) and Mindfulness-Based Cognitive Therapy (MBCT) in comparison with SPD alone in successful discontinuation of long-term use of…
- Trial name
- NCT03361514
- Testing
- Supported Protocolized Discontinuation (SPD), Mindfulness Based Cognitive Therapy (MBCT)
- Where
- Netherlands
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Prostate Cancer Recurrent
F18-PSMA-1007 PET for Early Biochemical Recurrence of Prostate Cancer
18F-PSMA-1007 is a new radiopharmaceutical for the detection of prostate cancer with potential benefits over the registered 18F-Fluciclovine (Axumin).
- Trial name
- PROPER-ABX (NCT04239742)
- Testing
- F18-fluciclovine PET/CT, F18-PSMA-1007 PET/CT
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Oropharyngeal Squamous Cell Carcinoma
Imaging of Tumour Microenvironment in Patients With Oropharyngeal Head and Neck Squamous Cell Carcinoma Using RGD PET/CT Imaging
Known risk factors inducing squamous cell carcinomas of the head and neck are tabacco and alcohol intake. However, the incidence of human papillomavirus (HPV) related oropharyngeal carcinomas is increasing.
- Trial name
- PIVOT (NCT04222543)
- Testing
- RGD PET/CT
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Pulmonary Nodule, Solitary
The Benefit of UHR-CT: Precision of Repeated Volume Measurements of Pulmonary Nodules
To assess the variability of semi-automated volume measurements of pulmonary nodules on same-day repeated scans of equal radiation dose from two different CT scanners: One high-end CT scanner with standard spatial resolution…
- Trial name
- Coffee Break (NCT04209972)
- Testing
- Precision Ultra-High-Resolution CT scanner, Genesis high-end CT scanner
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Radboud University Medical Center
Chronic Hepatitis c
Hepatitis C Elimination in the Netherlands
The aim of CELINE is to retrieve and re-evaluate lost to follow-up chronic hepatitis C patients in the Netherlands.
- Trial name
- CELINE (NCT04208035)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Lung Cancer
CT-Controlled Advanced Navigation Techniques for Transbronchial Pulmonary Lesion Access; Evaluation of Electromagnetic Navigation Based Diagnostic Yield
In this clinical trial we will investigate the diagnostic yield of a combination of commercially available imaging and navigation techniques for reaching peripheral lung lesions.
- Trial name
- CONTROL-E (NCT03355586)
- Testing
- Electromagnetic navigation
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Lung Cancer
CT-controlled Advanced Navigation Techniques for Transbronchial Pulmonary Lesion Access; Evaluation of Augmented Fluoroscopy Bronchoscopic Navigation Based Diagnostic Yield
In this exploratory adaptive clinical trial the investigators will examine the diagnostic yield of a combination of commercially available imaging and navigation techniques for reaching peripheral lung lesions.
- Trial name
- CONTROL-A (NCT03274609)
- Testing
- Augmented fluoroscopy
- Where
- Netherlands
- Volunteers
- 47 people
- Sponsor
- Radboud University Medical Center
Allogeneic Stem Cell Transplant, Acute Graft Versus Host Disease
Pharmacokinetics of Posaconazole (Noxafil®) as Prophylaxis for Invasive Fungal Infections
This study evaluates the the pharmacokinetics of posaconazole (new solid oral and IV) given as prophylaxis to patients who are at risk for developing fungal infections after receiving conditioning therapy (except strictly…
- Conditions
- Allogeneic Stem Cell Transplant, Acute Graft Versus Host Disease, Acute Myeloid Leucaemia, Myelo Dysplastic Syndrome
- Trial name
- PIRAÑA (NCT02805946)
- Testing
- posaconazole
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 21 people
- Sponsor
- Radboud University Medical Center
Lung Cancer
E- Predict: EBUS ELASTOGRAPHY STRAIN in Lung Cancer
EBUS elastography is a method to determine stiffness of lymph nodes, based on the minute deformation of the node by the beating heart.
- Trial name
- E-PREDICT (NCT02488928)
- Where
- 7 sites in Denmark, Italy and 1 more
- Volunteers
- 327 people
- Sponsor
- Radboud University Medical Center
Gastrointestinal Cancer, Colorectal Cancer
Microbiome Analysis in esoPhageal, PancreatIc and Colorectal CaNcer Patients Undergoing Gastrointestinal Surgery
The MA-PPING is a multicenter prospective observational study that includes patients undergoing surgery for gastrointestinal cancer.
- Conditions
- Gastrointestinal Cancer, Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer
- Trial name
- MA-PPING (NCT04189393)
- Volunteers
- 60 people
- Sponsor
- Radboud University Medical Center
Systemic Sclerosis, Raynaud Phenomena
The Effect of High Dose Methylprednisolone on Nailfold in Early Systemic Sclerosis ( SSc )
This is a 12 week double-blind randomized placebo controlled trial in which 30 patients with very early SSc, fulfilling the Very Early Diagnosis Of Systemic Sclerosis (VEDOSS) criteria (9) will be randomized in a 2:1 fashion to…
- Trial name
- NCT03059979
- Testing
- Methylprednisolone, sodium chloride
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Bacterial Infections
Pharmacokinetics of Piperacillin and Tazobactam in Critically Ill Patients
Optimal understanding of piperacillin-tazobactam pharmacokinetics in critically ill patients is lacking resulting in large variation of achieved exposure and possible inadequate therapy.
- Trial name
- PICTAR (NCT03738683)
- Testing
- Piperacillin/tazobactam
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Radboud University Medical Center
Prostatic Neoplasms, Immunotherapy
Natural Dendritic Cells for Immunotherapy of Chemo-naive Metastatic Castration-resistant Prostate Cancer Patients
Prostate cancer is the only type of cancer in which conventional dendritic cells (DC) treatment has a beneficial effect on the overall survival.
- Conditions
- Prostatic Neoplasms, Immunotherapy, Dendritic Cells, Vaccines
- Trial name
- NCT02692976
- Testing
- mDC vaccination, pDC vaccination, mDC and pDC vaccination
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Radboud University Medical Center