Clinical trials: sponsored by Radboud University Medical Center
Esophageal Cancer
Perioperative SDD to Prevent Infectious Complications After Esophagectomy
The primary aim of the PERSuaDER-trial is to evaluate the effect of SDD on infectious complications after esophagectomy, focussed on the prevention of pneumonia
- Trial name
- PERSuaDER (NCT05865743)
- Testing
- SDD
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 854 people
- Sponsor
- Radboud University Medical Center
Cochlear Implants, Hearing Loss, Sensorineural
Clinical Trial to Compare Two Surgical Approaches to the Cochlea
This is a prospective multicenter multinational randomized control trial. The duration of the study for the individual patient will be approximately 1 year (pre-operative assessments, 1 week, 3 months and 12 months follow-up…
- Trial name
- BULLS-I (NCT06453343)
- Testing
- Surgical approach: cochleostomy or extended round window
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease, Parkinson
Super-resolution of Brain Magnetic Resonance Images in Deep Brain Stimulation for Parkinson's Disease
The goal of this study is to increase magnetic resonance image quality in patients suffering from Parkinson's disease. The main question it aims to answer is: can super-resolution improve clinical magnetic resonance image quality…
- Trial name
- SuperResDBS (NCT05596201)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Cerebral Contributions to Symptom Progression in PD
Motor symptom progression in early-stage Parkinson's disease varies substantially between individual patients. This progression correlates poorly with striatal dopamine depletion, which is largely complete four years…
- Trial name
- NCT05169827
- Where
- Netherlands
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Early-stage Lung Cancer
Injection of 99mTc-nanocolloid and ICG to Identify, Retrieve and Qualify TDLN in Early-stage NSCLC
The patient wil receive intra- or peritumoral injections of 99mTc-nanocolloid if malignancy is found during a navigation bronchoscopy. A SPECT/CT-scan will be made to image injections sites and sentinel lymph nodes (SLN).
- Trial name
- INITIATE (NCT05555199)
- Testing
- 99mTc-nanocolloid, ICG
- Where
- Netherlands
- Volunteers
- 72 people
- Sponsor
- Radboud University Medical Center
Fertility Preservation, Ovarian Tissue Cryopreservation
Preservation of Ovarian Cortex Tissue in Girls With Turner Syndrome
Rationale: Infertility due is a major concern for girls with Turner syndrome (TS) and their parents. Physicians are often asked about possible options to preserve their fertility.
- Conditions
- Fertility Preservation, Ovarian Tissue Cryopreservation, Turner Syndrome, Live Birth
- Trial name
- NCT03381300
- Testing
- Ovarian tissue cryopreservation
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Pancreas Cancer
Percutaneous Holmium Injection in Pancreatic Cancer
This investigator initiated study with a medical device aims to assess the safety and feasibility of percutaneous injected holmium-166 microsphere brachytherapy in patients with irresectable pancreatic cancer.
- Trial name
- SLOTH-2a (NCT05880472)
- Testing
- Intratumoral
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Endotoxemia, Sepsis
Determining the Fingerprint of Endotoxin Tolerance
An explorative, prospective study in 100 healthy volunteers who will be challenged with endotoxin twice to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance
- Conditions
- Endotoxemia, Sepsis, Systemic Inflammation, Immunosuppresion
- Trial name
- 100LPS (NCT06801873)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Quality of Life, Postoperative Complications
Low Pressure Pneumoperitoneum and Deep Neuromuscular Block vs. Standard During RARP to Improve Quality of Recovery; a Randomized Controlled Study.
Intra-abdominal pressure (IAP) needed to create sufficient workspace during laparoscopic surgery affects the surrounding organs with ischemia-reperfusion injury and a systemic immune response.
- Conditions
- Quality of Life, Postoperative Complications, Acute Pain, Immune System Tolerance
- Trial name
- RECOVER-2 (NCT04250883)
- Testing
- Low intra-abdominal pressure, Deep neuromuscular blockade (NMB), Standard intra-abdominal pressure
- Where
- Netherlands
- Volunteers
- 97 people
- Sponsor
- Radboud University Medical Center
Stage III Non-small Cell Lung Cancer
The Beneficial Value of PET/CT in the Follow-up of Stage III Non-small Cell Lung Cancer Patients
The primary objective of this study is to compare the 3-year overall survival of stage III NSCLC patients during follow-up surveillance with 18F-Fluorodeoxyglucose Positron Emission Tomography/ Computerized Tomography (18F FDG…
- Trial name
- NVALT31-PET (NCT06082492)
- Testing
- 18F FDG PET/CT, CT scan
- Where
- 27 sites in Netherlands
- Volunteers
- 690 people
- Sponsor
- Radboud University Medical Center
Melanoma (Skin)
Melanoma Patients Immunized with Natural DenDritic Cells
The aim of this study is to determine whether adjuvant treatment with nDC vaccination, after complete radical lymph node dissection or sentinel node procedure in stage IIIB and IIIC melanoma patients, improves recurrence-free…
- Trial name
- MIND-DC (NCT02993315)
- Testing
- nDC vaccination
- Where
- 5 sites in Netherlands
- Volunteers
- 148 people
- Sponsor
- Radboud University Medical Center
Preeclampsia, Stress, Psychological
Stress Reduction in Formerly Preeclamptic Women; Sofa or Sports
The goal of this clinical trial is to evaluate stress and cardiovascular risk factors in women with preeclampsia in the medical history.
- Conditions
- Preeclampsia, Stress, Psychological, Stress, Physiological, Sports Physical Therapy
- Trial name
- SOS (NCT06402604)
- Testing
- Aerobic exercise training, Mindfulness Based Stress Reduction training
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Prostate Cancer
18F-PSMA-1007 PET Imaging to Detect Primary Prostate Cancer
To study the added value of 18F-PSMA-1007 PET to mpMRI in the detection of local prostate cancer lesions.
- Trial name
- PICture (NCT04487847)
- Testing
- 18F-PSMA-1007 PET/CT
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Radboud University Medical Center
Tissue Adhesions
Cine-magnetic Resonance Imaging (MRI) Detecting Intra Abdominal Adhesions
Official title: Sensitivity and predictive value of functional cine magnetic resonance imaging (MRI) detecting intra-abdominal adhesions Background: Adhesions are a frequent problem in abdominal surgery.
- Trial name
- NCT00882167
- Testing
- CineMRI
- Where
- 5 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Adhesive Small Bowel Obstruction
Elective Adhesiolysis vs. a Wait-and-see Policy to Prevent Recurrences After Conservative Treatment of Adhesive Small Bowel Obstruction
Rationale: Adhesive small bowel obstruction (aSBO) is a frequent surgical emergency, associated with 3-8% hospital mortality and a high risk of recurrence (20% at two years of follow-up).
- Trial name
- AWARE (NCT06777446)
- Testing
- Elective Adhesionlysis, Adhesion barrier
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 380 people
- Sponsor
- Radboud University Medical Center
HIV Infections
Pharmacokinetics of Antiretroviral Agents in HIV-infected Pregnant Women.
Due to the potential for pregnancy-induced changes in the pharmacokinetics of medication, one cannot assume that the currently licensed doses of the medication to be tested under this protocol lead to adequate exposure in an…
- Trial name
- PANNA (NCT00825929)
- Where
- 21 sites in Belgium, Germany and 5 more
- Volunteers
- 176 people
- Sponsor
- Radboud University Medical Center
Mitochondrial Diseases, Diabetes-Deafness Syndrome Maternally Transmitted
MItochondrial Diabetes LOw Carb- Diet Study
In daily practice, doctors and dietitians in the clinic receive many questions in general from patients with a Mitochondrial Disease (MD), and more specific whether nutritional changes can alleviate their symptoms.
- Trial name
- MIDLOC (NCT06185790)
- Testing
- LCHF diet
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Radboud University Medical Center
Muscular Dystrophy, Facioscapulohumeral
Magnetic Resonance Imaging and Ultrasound Comparison With Load Evaluation
Facioscapulohumeral dystrophy (FSHD) is one of the most common hereditary neuromuscular disorders (NMD), with an estimated prevalence of 2000 patients in the Netherlands.
- Trial name
- MUSCLE+ (NCT06227182)
- Testing
- Muscle ultrasound with surface electromyography and dynamometry, MRI scan
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Diagnosis and Treatment of Complications After Esophagectomy
ImpRovEd Care After eSophageCtomy Using an Algorithm for postoperativE Complications - RESCUE Trial
The objective of the RESCUE-trial is to investigate whether implementation of a consensus-based clinical care algorithm to standardize diagnosis and management of postoperative complications reduces 90-day mortality, ICU…
- Trial name
- RESCUE (NCT06762652)
- Testing
- Wash-in period, Algorithm-based care
- Volunteers
- 1,050 people
- Sponsor
- Radboud University Medical Center
Tissue Adhesion, Chronic Pain
Histological and Molecular Mechanisms of Pain in Patient With Chronic Pain From Adhesions
11-20% of patients undergoing abdominal surgery develop chronic abdominal pain. Adhesions are a common cause of chronic pain following surgery. Adhesions develop after up to 90% of laparotomies and 70% of laparoscopic surgeries.
- Conditions
- Tissue Adhesion, Chronic Pain, Surgery
- Trial name
- PAIN PAD (NCT03938168)
- Testing
- Biopsy, fecal sample
- Where
- 3 sites in Netherlands
- Volunteers
- 61 people
- Sponsor
- Radboud University Medical Center