Clinical trials: sponsored by Region Skane
Transplant; Failure, Heart
A Randomized Controlled Trial Comparing Non-ischemic to Ischemic Preservation in Adult Cardiac Transplantation
The overall aim of this proposal is to compare a new state-of-the-art ex-vivo organ preservation method with standard ischemic cold static storage of donor hearts in adult cardiac transplantation.
- Trial name
- NIHP (NCT03150147)
- Testing
- Non-ischemic preservation, Ischemic cold static storage
- Where
- Sweden
- Volunteers
- 47 people
- Sponsor
- Region Skane
Head and Neck Cancer, Pain, Musculoskeletal
Continous Popliteal Block for Microvascular Free Flap Reconstruction in Ear, Nose and Throat Surgery
The aim of the study is to assess the effects of a continuous popliteal block on postoperative pain and recovery after major ear, nose and throat surgery with microvascular free flap reconstruction using a fibula graft.
- Trial name
- NCT03607227
- Testing
- Levobupivacaine, Saline Solution
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Region Skane
Adrenal Incidentaloma, Cortisol Overproduction
Morbidity and Mortality in Autonomous Cortisol Secretion
Benign enlargements of the adrenal glands (adrenal adenomas) are frequent in adults. In the general population these adenomas are rare in subjects below 40 years of age but at the age of 60 and 80 years the prevalence is 6 and…
- Trial name
- NCT03919734
- Where
- Sweden
- Volunteers
- 4,596 people
- Sponsor
- Region Skane
Coagulation Factor Deficiency, Coagulopathy, Consumption
Effect of Vitamin K in Critically Ill Patients
Critically ill patients with spontaneously prolonged pro-thrombin time, where administration of intravenous administration of phytomenadione (vitamin K) has been ordered by the treating physician will be identified.
- Conditions
- Coagulation Factor Deficiency, Coagulopathy, Consumption, Vitamin K Deficiency
- Trial name
- VITAKOAG (NCT03782025)
- Testing
- Phytomenadione
- Where
- 2 sites in Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Substance Use Disorders
3M Study - Maria Malmö Mobile Telephone Study
The present study, in an out-patient setting for substance use treatment in adolescents, examines the effect on treatment retention of a mobile telephone follow-up technique (interactive voice response), with or without personal…
- Trial name
- NCT01706380
- Testing
- Interactive voice response with personal feedback, Interactive voice response without personal feedback
- Where
- Sweden
- Volunteers
- 73 people
- Sponsor
- Region Skane
Panic Disorder (With or Without Agoraphobia)
Psychotherapy Outcome and Self-selection Effects in Panic Disorder
The efficacy of two forms of psychotherapy with panic disordered patients, a cognitive-behavioral and a psychodynamic one, are compared under two different, randomized conditions: randomization or self-selection.
- Trial name
- NCT01606592
- Testing
- Panic Control Treatment (PCT), Panic-Focused Psychodynamic Psychotherapy (PFPP), Waiting-list
- Where
- Sweden
- Volunteers
- 216 people
- Sponsor
- Region Skane
Same-day Surgery
Is Partial Knee Replacement as Same-day Surgery Generalizable?
Fast-track/rapid recovery/Enhanced Recovery After Surgery (ERAS) programs have proven both safe and effective in joint replacement surgery, to the degree where same-day surgery have been tested in selected cases.
- Trial name
- NCT04790591
- Testing
- Same-day surgery
- Where
- 2 sites in Sweden
- Volunteers
- 33 people
- Sponsor
- Region Skane
Oropharyngeal Microbiology
Probiotics Against Pathogenic Bacteria in Connection With Anaesthesia
Longer surgical procedures require intubation and there is a potential risk of contaminating the lower airways with pathogenic bacteria from the mouth and oropharynx.
- Trial name
- NCT01521650
- Testing
- Probiotics
- Where
- Sweden
- Volunteers
- 42 people
- Sponsor
- Region Skane
Low Anterior Resection Syndrome, Rectal Cancer
Bowel Dysfunction 3 Years After Anterior Resection a in a Swedish National Cohort
The primary objectives are to evaluate the prevalence of LARS and Quality of Life in rectal cancer patients 3 years after anterior resection, to investigate if anastomotic technique is a risk factor for major LARS and to study…
- Trial name
- NCT04591821
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane
Gastrointestinal Motility Disorders
Safety and Efficacy Study of the FTRD System for Obtaining Full-thickness Intestinal Biopsies
The aim of this study is to evaluate FTRD (full-thickness resection device) in terms of obtaining full-thickness biopsies form the gastrointestinal tract endoscopically in the work-up of patients with gastrointestinal motility…
- Trial name
- NCT02673983
- Testing
- Endoscopic full-thickness biopsy
- Sponsor
- Region Skane
Colorectal Polyp
The Impact of Traction Assisted ESD on Procedural Time and Outcome
The aim of this study is to evaluate the role of traction assisted ESD in comparison to traditional ESD on procedural time and outcome in patients with large, non pedunculated colorectal polyps.
- Trial name
- ESD (NCT03180788)
- Testing
- Traction assisted ESD, Traditional ESD
- Where
- Sweden
- Sponsor
- Region Skane
Prostate Cancer (Diagnosis)
New Biopsy Needle - Evaluation of Prostate Biopsy Quality
Patient blinded randomized prospective trial evaluating prostate biopsy quality of a novel biopsy needle.
- Trial name
- NCT04091230
- Testing
- TRUSbx
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Region Skane
Elderly, Frail
Are Geriatric Out-patient Care Better Than Usual Care?
Frailty and multimorbidity is one of the biggest challenges of todays health care due to the demographic development with more and more elderly surviving many diseases that was mortal just a few decades ago.
- Trial name
- NCT02923843
- Testing
- Comprehensive Geriatric Assessment
- Where
- Sweden
- Volunteers
- 450 people
- Sponsor
- Region Skane
Sports-related Concussions, Selective Head-neck Cooling, Return to Play
Medical Cooling of Ice Hockey Players
The incidence of Sports-related concussions (SRCs) has risen in recent years, not least in ice hockey, and available treatment options are limited.
- Trial name
- NCT04701125
- Testing
- selective head-neck cooling using PolarCap system
- Where
- Sweden
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Region Skane
Advanced ENT Surgery, Microbiological Flora in the Oropharynx and Lower Airways
Probiotics Against Pathogenic Bacteria in Advanced ENT-Surgery
Surgery in the mouth and oropharynx is performed in an area colonised by bacteria non-pathogenic and pathogenic. Antibiotics are used regularly resulting in disturbances in the intestinal microbiological flora and consequently…
- Trial name
- NCT01730066
- Testing
- L. plantarum 299 and L. plantarum 299v (+maltodextrin)
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Region Skane
Pharyngeal Bacterial Colonization, Pneumonia
Changes of Oropharyngeal Flora
Hospitalised patients have in contrast to healthy people enteric pathogenic bacteria in their oropharynx Increased risk of pneumonia due to the pathogens in the oropharynx Probiotics can reduce such bacteria in intubated…
- Trial name
- NCT02303301
- Testing
- Probiotics
- Where
- Sweden
- Volunteers
- 145 people
- Sponsor
- Region Skane
Microdialysis, Ischemia
Local Metabolism of the Gastric Tube Reconstruction After Esophagectomy
Postoperative surveillance of local metabolism of the surgical reconstruction after esophagectomy by means of Microdialysis. Dialysate is collected continuously for seven postoperative Days.
- Conditions
- Microdialysis, Ischemia, Anastomotic Leakage
- Trial name
- NCT04319835
- Testing
- OnZurf Probe
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Region Skane
Self Harm, Suicide, Attempted
DBT-SS for Cognitively Challenged Individuals With Deliberate Self-harm
The study evaluates the effect of Dialectic Behavior Therapy Skills System (DBT-SS) in individuals with Intelligence Quotient 65-85 and recurrent self-harm.
- Conditions
- Self Harm, Suicide, Attempted, Borderline Personality Disorder
- Trial name
- NCT03627663
- Testing
- Dialectic Behavior Therapy - Skills System
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Region Skane
Respiratory Insufficiency, Ventilator-associated Pneumonia
Biofilm Formation on Different Endotracheal Tube Materials
Three endotracheal tubes (ETTs) with different surfaces properties will be studied regarding formation and structure of the biofilm formed on those ETTs.
- Trial name
- NCT02284438
- Testing
- Endotracheal tube
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Region Skane
Chronic Kidney Diseases, Uremia
12 Weeks of Hemodialysis With Medium Cut-Off Filter Compared to Hemodiafiltration With Standard High-flux Filter.
The medium cut-off dialysis (MCO) membrane has been developed to improve middle molecule removal compared to standard high-flux dialysis filters.
- Trial name
- NCT03416192
- Testing
- MCO-HD, high-flux HDF
- Sponsor
- Region Skane