Clinical trials: sponsored by Region Skane
Coronary Arterial Disease (CAD), Valve Replacement
Prolonged Chest Tube Treatment to Reduce Rates of Atrial Fibrillation Following Cardiac Surgery
Evacuation of pericardial blood by posterior pericardiotomy or use of a posterior pericardial chest tube lowers postoperative atrial fibrillation (POAF) rates after cardiac surgery by 45-68%.
- Conditions
- Coronary Arterial Disease (CAD), Valve Replacement, Aortic Surgery
- Trial name
- PROPER (NCT06800781)
- Testing
- Prolonged treatment with posterior pericardial chest tube plus standard care
- Where
- Sweden
- Volunteers
- 624 people
- Sponsor
- Region Skane
Self-harm
Intractable Self-harm-What Support is Effective?
The aim of this project is to evaluate a novel treatment program for individuals with intractable and lethal self-harm. The main questions are: 1: Is there, in individuals with intractable self-harm, a relevant improvement in…
- Trial name
- NCT06099561
- Testing
- National specialized medical care unit for severe self-harm behaviour-Consultation model
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Skane
Retinopathy of Prematurity
Pharmacokinetics and Safety of Dexamethasone Eye Drops in Preterm Infants
Background and study aims When an infant is born premature, the blood vessels in the eyes have not developed fully on the retina, and can start to grow incorrectly and result in blindness.
- Trial name
- NCT05387941
- Testing
- Dexamethasone Ophthalmic
- Where
- 2 sites in Sweden
- Volunteers
- 11 people
- Sponsor
- Region Skane
Osteoarthritis of the Knee or Hip
Comparison Between Blocks or Not in Joint Arthroplasty
The purpose of this study is to evaluate the effect on postoperative pain, opioid consumption and function by adding a combination of regional blocks with local anaesthetic before total hip- and knee arthroplasty compared to…
- Trial name
- BLAST (NCT06230081)
- Testing
- Ropivacain 5 mg/ml + Clonidine
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Skane
Anhedonia, Depression
Long-term Efficacy of Pramipexole in Anhedonic Depression
The purpose of the study is to assess the long-term efficacy and safety of add-on pramipexole for treatment of patients with anhedonic depression.
- Trial name
- LONG-PRAXOL (NCT05825235)
- Testing
- Pramipexole
- Where
- Sweden
- Volunteers
- 55 people
- Sponsor
- Region Skane
Cardiac Arrest (CA), Proteomics
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy
Cardiac arrest remains a large contributor to morbidity and mortality. Animal studies suggest an improvement in mortality and neurological function with hypothermia after cardiac arrest, a finding that could not be verified in…
- Trial name
- NCT07017374
- Testing
- Proteomic analysis, targeted temperature management
- Where
- Sweden
- Volunteers
- 682 people
- Sponsor
- Region Skane
Psychiatric Disorders Mood, Anhedonia
Pramipexole for Anhedonic Depression
The heterogeneity of depression suggests that several different neurocircuits and pathophysiological mechanisms are involved. Anhedonia - the inability to experience pleasure from, or the lack of motivation to carry out, usually…
- Conditions
- Psychiatric Disorders Mood, Anhedonia, Depression
- Trial name
- PRIME-PRAXOL (NCT05355337)
- Testing
- Pramipexole
- Where
- Sweden
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Region Skane
Wrist Injuries, Wrist Fracture
Splinted Wrist Study
Randomized clinical trial comparing SAM aluminium splint vs pain relief as usual in patients seeking emergency department care for suspected wrist fractures.
- Conditions
- Wrist Injuries, Wrist Fracture, Pain, Acute
- Trial name
- NCT07553000
- Testing
- SAM splint
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Skane
Interstitial Lung Disease (ILD)
Efficacy of L-menthol on Breathlessness in Interstitial Lung Disease
The purpose of this study is to assess the effect of L-menthol on breathlessness and exercise capacity in patients with Interstitial lung disease (ILD).
- Trial name
- Ment-ILD (NCT07398287)
- Testing
- L-menthol
- Where
- 2 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Region Skane
Primary Hyperparathyroidism
Surgery for Primary Hyperparathyroidism (pHPT) in Patients Older Than 65 Years Compared With Follow-up
General consensus and contemporary guidelines, recommend surgery for primary hyperparathyroidism (pHPT)for all patients below the age of 50, for patients with pronounced hypercalcemia and for patients with organ complications to…
- Trial name
- NCT01087619
- Testing
- Parathyroid surgery
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Region Skane
Febrile Illness Acute, Meningitis, Bacterial
Febrile Infants Swedish Study
Approximately one million febrile infants aged ≤60 days present annually to pediatric emergency departments (PEDs) in Europe and the United States.
- Conditions
- Febrile Illness Acute, Meningitis, Bacterial, Urinary Tract Infection (Diagnosis), Invasive Bacterial Infection
- Trial name
- FISS (NCT07134751)
- Where
- 11 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Breast Cancer
Mammography Screening With Artificial Intelligence (MASAI)
The purpose of this randomized controlled trial is to assess whether AI can improve the efficacy of mammography screening, by adapting single and double reading based on AI derived cancer-risk scores and to use AI as a decision…
- Trial name
- MASAI (NCT04838756)
- Testing
- AI screening modality, Conventional screening modality
- Where
- Sweden
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Region Skane
Breast Cancer
A Trial on the Use of Point-of-care Ultrasound in the Assessment of Breast Symptoms
The high cost of diagnostic equipment, limited expertise, and inadequate infrastructure are major barriers to early breast cancer diagnosis in low- and middle-income countries.
- Trial name
- Breast-POCET (NCT06932133)
- Testing
- Point-of-care ultrasound
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Skane
Observation, Postoperative
Proteomics and Physiological Parameters Predicting Complications After Colorectal Cancer Surgery
Study combines physiological data from wearables, continuous glucose montiors and proteomics to better assess risk of complications after colorectal surgery
- Trial name
- ProComp (NCT07494669)
- Testing
- Risk stratification with proteomics and data from wearables and CGMs
- Volunteers
- 210 people
- Sponsor
- Region Skane
Gambling Disorder
Seeking Treatment for Gambling - a 10-year Retrospective Clinical and Register Study of Gambling Patterns and Physical and Psychiatric Comorbidity in Patients With Gambling Disorder
Retrospective chart review and register study of all patients who sought treatment at Region Skåne gambling disorder treatment unit, from December, 2015, through November, 2025.
- Trial name
- NCT07488871
- Testing
- Treatment uptake
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Region Skane
Suicide Attempt
Safety Planning Intervention in Swedish Healthcare: A Multisite Study for Suicide Prevention
Suicide is one of the leading causes of premature death and a prioritized public health concern. Safety Planning Intervention (SPI) is a method with strong international research support for reducing suicidal behaviour by…
- Trial name
- NCT07469917
- Testing
- Safety Planning Intervention (SPI)
- Where
- 4 sites in Sweden
- Volunteers
- 8,000 people
- Sponsor
- Region Skane
Huntington Disease
Evaluation of Three Tests to Assess Social Cognition in Huntington Disease
The goal of this observational study is to learn about the usefulness of a test of social functioning in persons with Huntington disease.
- Trial name
- NCT07253038
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Stroke Acute
Fusion Imaging in Endovascular Thrombectomy for Acute Ischemic Stroke
Endovascular thrombectomy (EVT) is the standard of care for acute ischemic stroke (AIS) caused by a large vessel occlusion. Successful recanalization is one of the most important factors for a good patient outcome, especially…
- Trial name
- FUSE-IT (NCT06975696)
- Testing
- Standard endovascular thrombectomy with Fusion, Standard EVT without Fusion
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 300 people
- Sponsor
- Region Skane
Social Anxiety Disorder, Separation Anxiety Disorder
Stepped Versus Stratified Care for Anxiety Disorders in Youth
The goal of this clinical trial is to compare stepped care to stratified care as overall healthcare models for children and adolescents aged 8-17 with anxiety disorders.
- Conditions
- Social Anxiety Disorder, Separation Anxiety Disorder, Specific Phobia, Panic Disorder
- Trial name
- NCT06942429
- Testing
- Internet-delivered cognitive-behavioral therapy, Personalized in-person cognitive-behavioral therapy
- Where
- Sweden
- Volunteers
- 556 people
- Sponsor
- Region Skane
Kidney Stone
Short Interval Versus Long Interval Repeated Extracorporeal Shockwave Lithotripsy (ESWL) for 8-15 mm Renal Stones.
Extracorporeal shockwave lithotripsy (ESWL) is one way to treat renal stones. In this clinical trial our goal is to evaluate if two ESWL the same week is equal good and safe to two ESWL 3 weeks regarding renal stones 8-15 mm.
- Trial name
- NCT07421843
- Testing
- Extracorporeal shockwave lithotripsy (ESWL)
- Where
- 2 sites in Sweden
- Volunteers
- 600 people
- Sponsor
- Region Skane