Clinical trials: sponsored by Rennes University Hospital
Parkinson Disease, Deep Brain Stimulation
Evaluation of the Benefit Provided by Sessions of Sophrology on the Per Operative Management of Parkinsonian Patients Planned for a Deep Brain Stimulation Surgery.
Deep brain stimulation surgery, which consists of intracerebral implantation of electrodes, is considered one of the most effective techniques for controlling the motor fluctuations of Parkinson's disease.
- Trial name
- SOPHROSTIM (NCT03273816)
- Testing
- sessions of sophrology
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Rennes University Hospital
Depressive Disorder
Study of Morphological and Perfusion Imaging Predictors of Pejorative Outcome in Major Depressive Disorder
Depression is a debilitating illness with a risk of developing a treatment resistant form. Currently, diagnosis is purely clinical with little features available to identify potentially adverse developments.
- Trial name
- LONGIDEP (NCT02286024)
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Rennes University Hospital
Multiple Myeloma
Immunomonitoring and Multiple Myeloma: Impact of Lenalidomide on Immune Checkpoint Expression
The myeloma microenvironment is the target of many drugs in development, and it is unclear how they can be combined with reference treatments such as lenalidomide.
- Trial name
- IMMUNO-MYELO (NCT04872023)
- Testing
- Blood and bone marrow sampling
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Rennes University Hospital
COVID
Functional and Respiratory Rehabilitation and Nutritional Care of COVID-19 Patients (RECOVER-19)
Following the acute phase of COVID, some patients may have sequelae, such as breathing difficulties or malnutrition. We hypothesize that a functional and respiratory rehabilitation program associated with personalized nutritional…
- Trial name
- RECOVER-19 (NCT04466800)
- Testing
- Intervention group_rehabilitation program
- Where
- 5 sites in France
- Volunteers
- 160 people
- Sponsor
- Rennes University Hospital
Depressive Disorder, Major
Does Nurse Semi Structured Interview Added to a rTMS Improve Patients With Major Depressive Disorder?
Repeated Transcranial Magnetic Stimulation - R.TMS - is currently part of the treatment for depressive illness. This non-invasive technique is designed to stimulate certain areas of the cerebral cortex involved in this pathology.
- Trial name
- DESTIMCARE (NCT03436823)
- Testing
- nurse semi-structured interview, Music & Relaxation with eyes closed
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
Rare Iron Overlaods
Cohort of Patients With Rare Iron Overloads Excluding C282Y Homozygosity
The study explores the hepcidin deficiency causes of rare iron overload (excluding C282Y homozygosity), and aim to characterize this iron overload in term of clinical, biological, genetic and functional spacificities.
- Trial name
- HEPCICOR (NCT02619955)
- Testing
- samples with DNA
- Where
- 9 sites in France
- Volunteers
- 60 people
- Sponsor
- Rennes University Hospital
Cardiac Surgery
Patient Reported Outcome (PRO) in CARDiac Surgery.
The use of Patient Reported Outcomes (PROs) in anaesthesia provides a measure of the patient's quality of postoperative recovery based on his/her own experience.
- Trial name
- PRO-CARDS (NCT05684354)
- Testing
- Patient Reported Outcomes (PROs)
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Rennes University Hospital
Rheumatoid Arthritis
Investigation of Immunological and Pharmacological Factors for Response to Adalimumab in Rheumatoid Arthritis
Interventional study with minimal risks and constraints, prospective, mono-centric.
- Trial name
- PROMETHEE (NCT03110094)
- Testing
- Adalimumab, Healthy volunteers
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Liver Transplantation
De Novo Everolimus Versus Tacrolimus in Combination With Mofetil Mycophenolate and Low Dose Corticosteroids to Reduce Tacrolimus Induced Nephrotoxicity in Liver Transplantation: a Prospective, Multicentric, Randomised Study
Tacrolimus is a calcineurin inhibitor. This is the immunosuppression of reference for patients undergoing a first liver transplant.
- Trial name
- FOREVER (NCT02909335)
- Testing
- Tacrolimus, Everolimus, Mycophenolate mofetil
- Sponsor
- Rennes University Hospital
Surgery, Cardiac, Infection
Mediastinitis and Staphylococcus Aureus
Cardiac surgery with extracorporeal circulation (ECC) yields a deep immune system dysfunction that exposes patients to postoperative infectious complications.
- Trial name
- MEDIASTAPH (NCT03262558)
- Testing
- No intervention
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Rennes University Hospital
Healthy Volunteers
Magnetic Resonance Imaging (MRI) Sequences Optimization in Healthy Subjects
Magnetic resonance imaging (MRI) is a noninvasive and non-ionizing (no use of X-rays) imaging modality. Today it is considered an anatomical and functional exploration reference technique.
- Trial name
- OSS-IRM (NCT02900339)
- Testing
- Magnetic Resonance Imaging
- Where
- France
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Stroke
Neurofeedback for Upper-limb Recovery After Stroke
Interventional study with minimal risks and constraints, prospective, monocentric.
- Trial name
- NeuroFB-AVC (NCT03766113)
- Testing
- Neurofeedback coupling electroencephalogram and functional MRI in time actual, Electroencephalogram-neurofeedback program or Neurofeedback-free mental imaging program with electroencephalogram recording, Neurofeedback coupling electroencephalogram and functional MRI in time actual or a neurofeedback-free mental imaging program with electroencephalogram recording
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Arteriopathy
Effect of a Neuromuscular Electrical Stimulation Program on Walking Capacity in Peripheral Artery Disease Patients
Lower extremity peripheral arterial disease (LEPAD) is a highly prevalent chronic disease. Cardiovascular mortality of LEPAD patients at five years ranges between 18 to 30%.
- Trial name
- ELECTROPAD (NCT03795103)
- Testing
- neuromuscular electrical stimulator, Walking sessions, Advices
- Where
- 5 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Optic Neuritis
Can Diffusion Tensor Imaging (DTI) of the Optic Ways Contributes to Predict the 6 Months Prognosis of Optic Neuritis (ON)?
Can diffusion tensor imaging (DTI) of the optic ways contributes to predict the 6 months prognosis of Optic Neuritis (ON)?
- Trial name
- DTI et NOI (NCT03570385)
- Testing
- MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Rennes University Hospital
Invasive Procedure
HYPIC Hypnosis for Procedural Pain in the Intensive Care Unit
Procedural pain in resuscitation is common in the conscious patient. However, analgesia and sedation may be impossible because of the acute pathology leading to resuscitation, comorbidities or the urgency of the invasive…
- Trial name
- HYPIC (NCT04129333)
- Testing
- Hypnosis, No hypnosis
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Glioblastoma, Adult
Interest of Fluorescein in Fluorescence-guided Resection of Gliomas (FLEGME)
Fluorescence guidance is a safe and efficient tool for glioblastomas resection. The most widely used technique is based on 5-aminolevulinic acid (5ala), which stains glioblastoma cells through a metabolic abnormality and thus…
- Trial name
- FLEGME (NCT03291977)
- Testing
- Fluorescéine Sodique Faure, White-light surgery
- Where
- France
- Volunteers
- 51 people
- Sponsor
- Rennes University Hospital
Type 1 Diabetes
Study to Assess the Metabolic Impact of IRTA© and Patients Satisfaction in Type 1 Diabetic Patients, Treated by Either Insulin Pump or Multiple Daily Insulin Injections, and Using Freestyle Libre®, a Real-time Continuous Glucose Monitoring
A prospective monocentric " before and after " study, ruled in 2 periods of 3 months : during the first period, the patient will adjust insulin treatment as usual, during the second period, the patient will adjust insulin…
- Trial name
- IRTA (NCT04211220)
- Testing
- A decision support software
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Rennes University Hospital
Renal Insufficiency, Chronic, Organ Graft
Therapeutic Education of Chronic Renal or Renal Transplant Patient in the Management of EPO Injections
In chronic kidney disease, ESAs (Erythropoiesis-stimulating agents) are used to treat anemia. This anemia is due to decreased renal production of erythropoietin (EPO), a hormone that stimulates the production of red blood cells…
- Trial name
- SELFEPO (NCT03481686)
- Testing
- Patients with injections of ESA
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Rennes University Hospital
IUD
Evaluation of the Influence of the Virtual Reality Helmet on Pain During IUD Insertion
Given the current lack of satisfactory options for the management of IUD insertion pain, could the virtual reality headset be an innovative and effective tool? The objective is to compare the pain experienced during IUD insertion…
- Trial name
- REAVIST (NCT04539899)
- Testing
- VR+
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Cardiopulmonary Bypass
Maintaining Mechanical Ventilation During Cardiopulmonary Bypass for Cardiac Surgery
The main objective of this study is to measure the incidence of postoperative infections in 2 groups of patients: one group of patients ventilated and one group of patients without mechanical ventilation during cardiopulmonary…
- Trial name
- VECAR (NCT03372174)
- Testing
- Maintaining mechanical ventilation during surgery, Absence of mechanical ventilation during surgery
- Where
- 6 sites in France
- Volunteers
- 1,401 people
- Sponsor
- Rennes University Hospital