Clinical trials: sponsored by Rennes University Hospital
Medication Reconciliation at Discharge
Guaranteeing the Continuity of the Care Pathway for the Elderly Patient: Evaluation of a Territorial Approach of Clinical Pharmacy
In the context of the ageing of the French population, drug iatrogeny in the elderly is a major public health issue, responsible for approximately 7,500 deaths per year and 3.4% of hospitalizations among patients aged 65 and…
- Trial name
- CONPARMED (NCT04018781)
- Testing
- medication reconciliation
- Where
- 6 sites in France
- Volunteers
- 443 people
- Sponsor
- Rennes University Hospital
Diabetes
Impact of the COVID-19 Epidemic on Glycemic Balance and the Level of Stress in Diabetic Patients
Prospective, non-interventional, multicentric study
- Trial name
- COVIGLYSTRESS (NCT04924673)
- Where
- 11 sites in France
- Volunteers
- 202 people
- Sponsor
- Rennes University Hospital
Hemochromatosis Type 1
Impact of Bloodletting on Iron Metabolism in Type 1 Hemochromatosis
Hemochromatosis type 1 is one of the most frequent genetic disease since the genetic predisposition (homozygosity for the C282Y mutation of the HFE gene) is encountered in about 3/1000 white subjects (5/1000 in Brittany, France).
- Trial name
- SAIFER (NCT01810965)
- Testing
- First evaluation phase : no intervention / Second evaluation phase: bloodletting of 7 ml/kg (with a maximum of 500ml)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Rennes University Hospital
Stroke
Evaluation of the Improvement of Independence by the Resumption of a Significant Activity Such as a Cooking Workshop in Adult Patients With Stroke Benefiting From Traditional Rehabilitation
A non-randomized, monocentric, pilot study comparing the level of independence for each individual with significant resumption of activity in adult patients with stroke
- Trial name
- EVIC-AVC (NCT03274843)
- Testing
- Activity of everyday life
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Rennes University Hospital
Severe Cardiac Insufficiency
Evaluation of Antithrombin Deficiency in Patients of Intensive Care Unit Placed on Extracorporeal Membrane Oxygenation
Prospective, monocentric, non-interventional study in patients placed on extracorporeal membrane oxygenation (ECMO)
- Trial name
- ATECMO (NCT04133844)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Rennes University Hospital
ARDS Secondary to COVID-19 Pneumonia
CACOLAC : Citrulline Administration in the Hospital Patient in Intensive Care for COVID-19 Acute Respiratory Distress Syndrome
Respiratory involvement of SARS-CoV2 leads to acute respiratory distress syndrome (ARDS) and significant immunosuppression (lymphopenia) exposing patients to long ventilation duration and late mortality linked to the acquisition…
- Trial name
- CACOLAC (NCT04404426)
- Testing
- L-citrulline
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Rennes University Hospital
Monoclonal Gammopathy of Undetermined Significance, Smoldering Myeloma
Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM.
The purpose of this study is to describe DNA copy number variations and gene expression profiles of bone marrow plasma cells of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).
- Trial name
- GENOMGUS (NCT01079429)
- Testing
- Genetic study of DNA copies
- Where
- 27 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Rennes University Hospital
Liver Transplantation
Interest of an Early Rehabilitation Program in Liver Transplant Surgery
Monocentric, prospective study to evaluate 10 liver transplanted patients
- Trial name
- RAC-TH (NCT03976765)
- Testing
- Rehabilitation program
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Rennes University Hospital
Kidney Failure, Acute
Modalities of Renal Replacement Therapy in Pediatric Acute Kidney Injury
Limited prospective data is available to compare morbidity and mortality between renal replacement modalities in pediatric acute renal failure.
- Trial name
- EPURE (NCT01569698)
- Testing
- acute extra renal replacement therapy
- Where
- 19 sites in Canada, France and 1 more
- Volunteers
- 310 people
- Sponsor
- Rennes University Hospital
Spina Bifida Aperta, Acquired Traumatic Spinal Cord Injury
Self-esteem and Neuro-urological Follow-up in Patients With Spina Bifida or Spinal Cord Injury
With improved life expectancy over the last fifty years, spina bifida has become a disease of the adult. One of the major stakes for these patients is the preservation of a regular follow-up of uro-nephrologicals risk factors and…
- Trial name
- ESTIME (NCT01606618)
- Where
- 16 sites in France
- Volunteers
- 111 people
- Sponsor
- Rennes University Hospital
Vascular Diseases
Study of the Reproducibility of Laser Measurement in the Detection of Digital Obstructive Arterial Disease (DOAD)
At the digital level, the diagnosis of obstructive arteriopathy is very difficult in the absence of ulcer or of true ischemic signs, and the arteriography, which is an examination to inject an intra-arterial contrast agent, is…
- Trial name
- REPROLASER (NCT03264820)
- Testing
- Laser Doppler, Laser speckle, pain evaluation
- Where
- France
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Covid-19
Characterization of Fungal Infections in COVID-19 Infected and Mechanically Ventilated Patients in ICU
Characterization of fungal infections in COVID-19 infected and mechanically ventilated patients in ICU
- Trial name
- MY-CO-VID (NCT04368221)
- Where
- 22 sites in France
- Volunteers
- 576 people
- Sponsor
- Rennes University Hospital
Iron and Fat Hepatic Overload
Evaluation of MRI Sequences in Hepatic Overload
MRI, without any contrast injection, allows a non-invasive evaluation and quantification of hepatic overloads, especially iron (liver iron content LIC) and fat (steatosis) overloads, but in certain clinical circumstances, cases…
- Trial name
- HEPAT_MR (NCT01865461)
- Where
- France
- Volunteers
- 706 people
- Sponsor
- Rennes University Hospital
Arthritis
External Validation of a Septic Arthritis Prognosis Score
Observational study
- Trial name
- SYNOLACTATES + (NCT03819855)
- Where
- France
- Volunteers
- 244 people
- Sponsor
- Rennes University Hospital
Unfractionated Heparin Treatment
Evaluation of the Effect of Dextran Sulphate on Anti-Xa Activities Measured
The measurement of anti-Xa activity is classically used for the dose adjustement of unfractionated heparin (UFH) treatment and to monitor reversal of UFH by protamine during cardiac surgery with cardiopulmonary bypass (CPB).
- Trial name
- DEXHEP (NCT04700670)
- Testing
- measurement of anti-Xa activities
- Where
- 8 sites in France
- Volunteers
- 164 people
- Sponsor
- Rennes University Hospital
Liver Transplantation, Kidney Transplantation
Impact of P-gp, MRP2, ENT-1 and CNT3 on the Blood Concentration / Intra-PBMC Concentration of Tacrolimus
Prospective and monocentric pharmacokinetic study
- Trial name
- TRANS-TAC (NCT03910868)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Rennes University Hospital
Weakness of the Lower Limbs
VERARE : Effectiveness of Virtual Motor Actions for Improving Walking in Patients With Post-resuscitation Muscle Weakness
After a hospitalization in Intensive Care Unit (ICU), approximately 50% of patients usually have a ICU-Weakness, i.e. nerves and muscles injury secondary to immobilization and to treatments which had to be used.
- Trial name
- VERARE (NCT04441164)
- Testing
- Observation of Virtual Actions, Relaxation, Acceptability questionnaire
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Dysmetabolic Iron Overload Syndrome
A Prospective, Mono-center, Interventional Study Evaluating the Effect of One Year Initial Care by Hygieno-dietary Advices With or Without Phlebotomy on Glycemia After at Least 5 Years in Patients With Dysmetabolic Iron Overload Syndrome
A prospective, mono-center, interventional study evaluating the effect of one year initial care by hygieno-dietary advices with or without Phlebotomy on glycemia after at least 5 years in Patients with dysmetabolic iron overload…
- Trial name
- EvoHSD (NCT03942432)
- Testing
- Oral Glucose Tolerance Test (OGTT), Clinical exam, Blood sample
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Preventive Use of COrticosteroids During the Post-Partum in Relapsing MS Patients (COPP-MS)
Multiple Sclerosis (MS) is most prevalent among women of childbearing age. The post-partum (PP) period is a critical phase in MS patients, during which a recrudescence of disease activity is expected.
- Trial name
- COPP-MS (NCT03917589)
- Where
- 5 sites in France
- Volunteers
- 350 people
- Sponsor
- Rennes University Hospital
Covid19
Managerial and Environmental Risk for COVID 19 in French Long Term Care Institutions
REMPAR EHPAD study addresses environmental and managerial factors associated with an outbreak of COVID 19 in French Long Term Care Institutions in the spring of 2020.
- Trial name
- REMPAR-EHPAD (NCT04579289)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Rennes University Hospital