Clinical trials: sponsored by Rennes University Hospital
Malnutrition
Nutritional State and Care Pathway of Hospitalized Malnourished Patients, Within 3 Months of Admission
Malnourished patients are at risk of many complications, including infections, pressure ulcers and readmissions. Little is known about their care pathway after hospital discharge.
- Trial name
- Nutriker (NCT04244851)
- Testing
- Malnourished patients
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Rennes University Hospital
Depression
Clinical and Neurobiological Profile Predictive of Pejorative Outcome of Depression
Depression is a frequent disease which can be marked by therapeutic resistance. It is described as one of the most disabling disease with high cost for society.
- Trial name
- DEPREDICT (NCT03690856)
- Testing
- inflammatory, neuropsychological and neuroimaging assessment
- Where
- 8 sites in France
- Volunteers
- 37 people
- Sponsor
- Rennes University Hospital
Intensive Care Unit Syndrome
PREMAPIV : Intravesical Pressure Variation at Different Bladder Instillation Volumes in Newborn Children
Abdominal Compartment Syndrome (ASC) is defined by an Intra Abdominal Hypertension (IAH) associated with a new organ failure. The occurrence of this syndrome is not well known in infants.
- Trial name
- NCT01296724
- Testing
- Measure of intravesical pressure
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Rennes University Hospital
Arthritis Knee
Preoperative Radiographic Evaluation of Medial Tibiofemoral Knee Osteoarthritis
Observational study.
- Trial name
- RX-FTI (NCT03704558)
- Sponsor
- Rennes University Hospital
Fracture Fixation, Internal
Could the Intraoperative Radiation Exposure (Fluoroscopy) of Percutaneous Pedicle Screw Fixation be Reduced Using an Electronic Conductivity Device?
To compare classical pedicle finder versus pedicle finder with impedancemetry on the perioperative radiation exposure of PPTLO. These two devices are already used in common practice.
- Trial name
- PEDI-PDS (NCT03238521)
- Testing
- Spinal osteosynthesis with classical pedicle finder, Spinal osteosynthesis with pedicle finder with impedancemetry
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Rennes University Hospital
Doppler Echocardiography
Validation Study of the Accuracy of E/e' in Estimating Left Ventricular Filling Pressure
The non-invasive estimation of left ventricular end diastolic pressure (LVeDP) is a main goal for performing an echocardiography in the routine clinical practice.
- Trial name
- EUROFILLING (NCT02883504)
- Testing
- Echo-Doppler examination and left heart catheterization
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Rennes University Hospital
Malnutrition, Child
The "Self Evaluation of Food Intake" (SEFI) as a Screening Test for Hospital Malnutrition in Children Over 10 Years
The goal is to find a simple tool that can be used by medical and paramedical staff and that is reliable to identify children at risk for malnutrition.
- Trial name
- SEFI (NCT04536974)
- Testing
- SEFI tool
- Where
- 6 sites in France
- Volunteers
- 368 people
- Sponsor
- Rennes University Hospital
Buccal Microbiota
Clinical Trial to Determine the Effect of a Mouthwash on the Preservation of the Ecology of the Oral Microbiome and Its Compatibility With Health
The microbiota of the human body is essential to life, and plays an essential role in the protection and development of various pathological conditions.
- Trial name
- BUCCOTHERM (NCT04973358)
- Testing
- buccotherm mouthwash
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Premature
Gut Bacteria and Brain of the Baby
The project is a prospective French population based cohort. A hundred moderate preterms born at GA30-326/7 will be enrolled for a longitudinal follow-up up to 2 years of corrected age.
- Trial name
- BaBBa (NCT04432636)
- Testing
- Data collection of environmental factors, Collection of maternal feces, Collection of infant feces
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Rennes University Hospital
COVID-19, Intensive Care Unit Syndrome
COVID-19 Critically Ill Patients' Evolution After Medical Transport by Train From Paris Intensive Care Units to West of France Intensive Care Units
Since early 2020, France knows a sanitary crisis with a massive influx of COVID-19 patients admitted in Intensive Care Units (ICU).
- Trial name
- TOCCIP (NCT04433325)
- Where
- 2 sites in France
- Volunteers
- 37 people
- Sponsor
- Rennes University Hospital
Cirrhosis
Decompensation of Cirrhosis and Iron Metabolism
Iron is a crucial metal whose metabolism is tightly regulated. Iron deficiency or iron overload are both deleterious at the cellular, organic and systemic levels.
- Trial name
- DeCiFer (NCT04807023)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Rennes University Hospital
Infection
EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION
The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Extracorporeal Membrane Oxygenation.
- Trial name
- EC-MOTION (NCT02917486)
- Testing
- blood sample
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Rennes University Hospital
Haematological Malignancy
Hématologie Adulte Prevalence of Adrenal Insufficiency Post-chemotherapy Adrenocorticotropia in Adult Hematology
A recent meta-analysis involving 3753 patients treated with corticosteroids notes that the population with the highest prevalence of biological IS (68%) is onco-hematology.
- Trial name
- HemaSur (NCT03688789)
- Testing
- Hydrocortisone supplementation
- Sponsor
- Rennes University Hospital
Interventional Cardiology
The Intra-Aortic Balloon Pumps Insertion Registry on Behalf of the Groupe Des Angioplasticiens de la Région Ouest
Intra-aortic Balloon Pumps (IABP) have been used for roughly 50 years in Critical Care Units, Intensive Care Units, Cath labs as a way to improve systemic and coronary circulation in patients in cardiogenic shock (CS) or at high…
- Trial name
- CP-GARO (NCT02900456)
- Where
- 25 sites in France
- Volunteers
- 177 people
- Sponsor
- Rennes University Hospital
Multiple Sclerosis
Impact of Multiple Sclerosis From the Viewpoint of the Patients and Their Caregivers
Patients with chronic illness and their relatives have exhaustive and specific experience of healthcare and the health service.These unique experiences must be taken into account for quality of care management assessment.
- Trial name
- AQUASEP (NCT02388334)
- Testing
- to develop standardized questionnaires
- Where
- France
- Volunteers
- 1,080 people
- Sponsor
- Rennes University Hospital
ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2, Acute Refractory Heart Failure Related to SARS-CoV 2
Extracorporeal Membrane Oxygenation (ECMO) and Coronavirus Disease (COVID) 19
The role of ECMO in the treatment of patients with severe COVID-19 (Acute Respiratory Distress Syndrome (ARDS) and/or acute refractory heart failure) is not yet known.
- Trial name
- ECMO-SARS (NCT04397588)
- Where
- 44 sites in France
- Volunteers
- 761 people
- Sponsor
- Rennes University Hospital
Blood Concentrations of Nine Anti-cancer Drugs : Axitinib, Olaparib, regorafénib, Cabozantinib, Niraparib, Talazoparib, Palbociclib, Abemaciclib, Tucatinib
Microsampling Approach for Monitoring of Kinase Inhibitor Targeted Therapies
The MISTIK project aims at clinically validating the technique of oral anticancer drugs determination by volumetric absorptive micro-sampling and at comparing the results to measurements performed on venous samples.
- Trial name
- MISTIK (NCT05598788)
- Testing
- Measurement of drug concentrations
- Where
- 3 sites in France
- Volunteers
- 160 people
- Sponsor
- Rennes University Hospital
Hemochromatosis
Haemochromatosis and Periodontitis
Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth. It is strongly associated with the major pathogenic "red complex", including Porphyromonas gingivalis, Tannerella forsythia and Treponema…
- Trial name
- HEMOPARO (NCT04006249)
- Testing
- dental probes
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Rennes University Hospital
Traumatic Brain Injury, Magnetic Resonance Imaging (MRI)
PASTRAMI : Patient-specific Statistics for Microstructure-augmented Connectomics
Traumatic brain injury (TBI) represent a major public health issue, accounting for approximately 1.5 million hospital admissions annually across the European Union and 160,000 cases in France.
- Trial name
- PASTRAMI (NCT07527949)
- Testing
- Measures of brain microstructure
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
To Compare 2 Models of Midwifery Care in Maternity Care
Support and Personalized Care in Alternative Midwifery Birth Units Versus Traditional Units in France: Effects on the Psychological Health of Couples and on the Health of the Mother and Child at the Age of 2 Years.
Majority of pregnancies and childbirths in France occur without complication. While the impact of care failure on maternal and neonatal morbi-mortality is now well- established, the literature reveals that an overmedicalization…
- Trial name
- PhysioCareTwo (NCT06630741)
- Testing
- alternative midwifery units (AMU)
- Where
- 3 sites in France
- Volunteers
- 793 people
- Sponsor
- Rennes University Hospital