Clinical trials: sponsored by Samsung Medical Center
Non-small Cell Lung Cancer
Pemetrexed (ALIMTA) and Gefitinib (IRESSA®) in Never-Smoker and Adenocarcinoma Patients With Non-Small Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy
Pemetrexed was known to be effective to pulmonary adenocarcinoma and gefitinib was known to be more effective to non-small cell lung cancer (NSCLC) patients with clinical characteristics such as adenocarcinoma, never smoker and…
- Trial name
- NCT01066195
- Testing
- iressa, alimta
- Where
- South Korea
- Volunteers
- 129 people
- Sponsor
- Samsung Medical Center
Advanced Gastric Cancer
Phase II Study of Epirubicin, Cisplatin and Capecitabine (ECX) Versus Cisplatin and Capecitabine (CX) for Advanced Gastric Cancer (AGC)
Recently, 3-drug (ECX) and 2-drug (CX) combination chemotherapy involving capecitabine showed promising results in randomized clinical trials for advanced gastric cancer (AGC).
- Trial name
- NCT00743964
- Testing
- Epirubicin, Cisplatin, capecitabine
- Where
- South Korea
- Volunteers
- 91 people
- Sponsor
- Samsung Medical Center
Acute Myeloid Leukemia
Vorinostat Combined With Gemtuzumab Ozogamicin, Idarubicin and Cytarabine in Acute Myeloid Leukemia
The prognosis of elderly patients with relapsed or refractory acute myeloid leukemia (AML) is grave. Because of their chronological age and/or the presence of multiple co-morbidities, treatment-related mortality in elderly…
- Trial name
- NCT01039363
- Testing
- Salvage reinduction chemotherapy including Gemtuzumab ozogamicin, Idarubicin and Cytarabine and Vorinostat
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Samsung Medical Center
Gynecologic Laparoscopic Surgery for Benign Adnexa Disease
The Effect of Local Anesthesia and Simple Maneuver on Shoulder Pain After Gynecologic Laparoscopy
This prospective, randomized controlled trial was designed to compare the efficacy of a simple maneuver using lower airway pressure (30 cm H2O) and intraperitoneal instillation of bupivacaine, alone or in combination, to reduce…
- Trial name
- NCT01039441
- Testing
- Intraperitoneal instillation of bupivacaine, CO2 removal by means of a pulmonary recruitment maneuver, Intraperitoneal instillation of bupivacaine +CO2 removal by means of a pulmonary recruitment maneuver
- Where
- South Korea
- Volunteers
- 291 people
- Sponsor
- Samsung Medical Center
Cervical Ripening
Cervical Priming With Misoprostol Prior to Operative Hysteroscopy
The primary outcome measure in this study was the preoperative cervical width after misoprostol administration. The secondary outcomes were duration of cervical dilatation, up to Hegar number 10, complications during cervical…
- Trial name
- NCT01024270
- Testing
- Misoprostol
- Where
- South Korea
- Volunteers
- 141 people
- Sponsor
- Samsung Medical Center
Primary Congenital Glaucoma
The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma
Primary congenital glaucoma, which presents at birth or in infancy, if left untreated, may threaten vision. The incidence of congenital glaucoma varies among different geographic locations and ethnic groups.
- Trial name
- NCT01020721
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Lymphoma, T-Cell
Clinical Study of Chemoradiation Followed by VIPD in Nasal Natural Killer (NK)/T-cell Lymphoma
Nasal NK/T-cell lymphoma is a peculiar clinico-pathologic subtype of non-Hodgkin's lymphoma (NHL). Although most patients present with stage I/II, only 30-60% of the patients remain disease-free.
- Trial name
- NCT00418535
- Testing
- Concurrent Radiotherapy (RT)/cisplatin, VIPD
- Where
- South Korea
- Sponsor
- Samsung Medical Center
Peripheral T-Cell Lymphomas, Non-Hodgkin Lymphoma
Bortezomib and CHOP in Patients With Advanced Stage Aggressive T Cell or Natural Killer (NK)/T Cell Lymphomas
Peripheral T-cell lymphomas (PTCLs) are neoplasias from post-thymic T-cells at different stages of differentiation and are a heterogeneous group of malignancies which present with different morphological patterns, phenotypes, and…
- Trial name
- NCT00374699
- Testing
- Velcade
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Samsung Medical Center
Angioplasty, Transluminal, Percutaneous Coronary
Efficacy Study of Cilostazol Loading in Elective Percutaneous Coronary Intervention
The purpose of this study is to investigate the effect of cilostazol loading before planned PCI on major adverse cardiac and cerebrovascular events in patients with coronary artery disease.
- Trial name
- PRECEDE (NCT00938522)
- Testing
- Cilostazol
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Samsung Medical Center
Overactive Bladder
Microorganism in Overactive Bladder Patients
The objective of this prospective study is to determine the incidence of mycoplasma in women with overactive bladder (OAB) symptoms and whether antibiotic therapy targeting these organisms is effective.
- Trial name
- NCT00883818
- Testing
- azithromycin, doxycycline
- Where
- 3 sites in South Korea
- Volunteers
- 84 people
- Sponsor
- Samsung Medical Center
Colorectal Neoplasms
A Phase I/II Trial of TS-1 and Oxaliplatin in Patients With Advanced Colorectal Cancer
Capecitabine and oxaliplatin(XELOX) is active first-line therapy for patients with metastatic colorectal cancer. Phase II study of TS-1, a novel oral fluoropyrimidine derivative, showed activity in patients with metastatic…
- Trial name
- NCT00531245
- Testing
- TS-1, oxaliplatin
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Samsung Medical Center
Demographic Findings, Presenting Symptoms on First Hospital Visit
Clinical Characteristics of Patients Under the Age 21 Years Who Underwent Gynecological Surgery
Young patients with adnexal lesions may have variable presenting symptoms. In this study, we reviewed the clinical characteristics of young Korean patients who took the operation in university hospital with adnexal lesions over…
- Conditions
- Demographic Findings, Presenting Symptoms on First Hospital Visit, Preoperative Radiologic Findings, Operation Method
- Trial name
- NCT00928369
- Volunteers
- 494 people
- Sponsor
- Samsung Medical Center
Gynecologic Operations, Anti-Mullerian Hormone
The Impact of Gynecological Surgery on Ovarian Function in Women of Reproductive Age: Postoperative Changes of Serum Anti-Müllerian Hormone (AMH)
Besides the removal of lesions, the purpose of surgeries has been extended to the improvement of quality of life after procedures. Minimally invasive surgeries enabled women to experience less pain, less hospital days.
- Conditions
- Gynecologic Operations, Anti-Mullerian Hormone, Ovarian Reserve
- Trial name
- NCT00928044
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Vesicoureteral Reflux
Efficacy of Endoscopic Subureteral Injection for Vesicoureteral Reflux in Adults With Decreased Bladder Compliance
Endoscopic subureteral injection for vesicoureteral reflux has become an established alternative to ureter reimplantation in children. Some recent studies suggest that ESI can be also a primary treatment option for VUR in adults.
- Trial name
- NCT00815334
- Testing
- Endoscopic subureteric injection
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Samsung Medical Center
Benign Prostatic Hyperplasia
Effect of Dutasteride on Bladder Wall Hypertrophy in Patients With Benign Prostatic Obstruction
Increased bladder mass occurs as a consequence of bladder outlet obstruction in animals and patients, and relief of bladder outlet obstruction reverses an increased bladder mass.
- Trial name
- NCT00827814
- Testing
- Dutasteride
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Samsung Medical Center
Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia
Impact of 80 W KTP Laser Vaporization Prostatectomy on Severity of Obstruction in Benign Prostatic Hyperplasia
The purpose of this study is to compared the efficacy of 80W KTP photoselective laser vaporization prostatectomy (PVP) and transurethral resection of the prostate (TURP) in reducing the volume of prostate and relieving the…
- Trial name
- NCT00908427
- Testing
- photoselective vaporization prostatectomy (PVP), Transurethral resection of the prostate
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Samsung Medical Center
Nocturia
Desmopressin in the Treatment of Mixed Nocturia With Nocturnal Polyuria and Low Nocturnal Bladder Capacity
Nocturia is defined as waking one or more times to void during the period between going to bed with the intention of sleeping and waking with the intention of arising.The pathophysiology of nocturia is multifactorial and can be…
- Trial name
- NCT00902655
- Testing
- Desmopressin
- Where
- 6 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Samsung Medical Center
Overactive Bladder
Urinary Urgency Outcomes Following Propiverine Treatment for an Overactive Bladder
Overactive bladder (OAB) is defined as "urgency, with or without urge incontinence, usually with frequency and nocturia" in the absence of local pathological or endocrine factors.
- Trial name
- NCT00903045
- Testing
- Propiverine hydrochloride
- Where
- South Korea
- Volunteers
- 264 people
- Sponsor
- Samsung Medical Center
Angina Pectoris, Variant
Efficacy Study of Atorvastatin to Treat Variant Angina
The objective of this study is to evaluate effect of statin treatment for vasospastic angina.
- Trial name
- ESAVA (NCT00620204)
- Testing
- atorvastatin
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Samsung Medical Center
Central Serous Chorioretinopathy
Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy
This study is a comparison of multifocal electroretinogram assessment between the laser treatment group and the photodynamic therapy group in chronic central serous chorioretinopathy.
- Trial name
- NCT00803517
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Samsung Medical Center