Clinical trials: sponsored by Samsung Medical Center
Chronic Coronary Syndrome, Coronary Artery Bypass Graft CABG
Antiplatelet Strategy for CCS Patients Undergoing CABG
To evaluate the long-term outcomes of different antiplatelet strategies, including DAPT, aspirin monotherapy, and clopidogrel monotherapy, in CCS patients undergoing CABG.
- Trial name
- CABG_DAPT_SAPT (NCT06881901)
- Volunteers
- 29,898 people
- Sponsor
- Samsung Medical Center
Chronic Obstructive Pulmonary Disease
Pulmonary Rehabilitation Program in COPD Patient
This study was designed in order to evaluate the compliance of a pulmonary rehabilitation program using a wearable device and the application effect of the program according to the characteristics of each patient, in COPD…
- Trial name
- NCT05906264
- Testing
- Tele-intervention
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Samsung Medical Center
Acute Myocardial Infarction, Cancer
Acute Myocardial Infarction in Cancer Patients
Using national health insurance service database, current study aim to evaluate the risk and prognosis of acute myocardial infarction in cancer patients and to find the optimal treatment strategy for acute myocardial infarction…
- Trial name
- NCT06281054
- Testing
- Revascularization
- Where
- South Korea
- Volunteers
- 4,500,000 people
- Sponsor
- Samsung Medical Center
Heart Failure With Reduced Ejection Fraction, Ischemic Cardiomyopathy
Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction
Randomized trial to compare clinical outcomes between revascularization versus medical treatment alone in patients with ischemic cardiomyopathy and left ventricular dysfunction.
- Trial name
- RESTORE-PCI (NCT05828719)
- Testing
- Percutaneous coronary intervention
- Where
- South Korea
- Volunteers
- 900 people
- Sponsor
- Samsung Medical Center
Ischemic Heart Disease, Microvascular Coronary Artery Disease
Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function
The DIAST-CMD registry (Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function) is prospective registry which enrolled patients who underwent echocardiography, cnically-indicated invasive coronary…
- Conditions
- Ischemic Heart Disease, Microvascular Coronary Artery Disease, Diastolic Dysfunction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DIAST-CMD (NCT05058833)
- Testing
- Echocardiography, Coronary flow reserve and index of microcirculatory dysfunction
- Where
- 4 sites in United States, South Korea
- Volunteers
- 800 people
- Sponsor
- Samsung Medical Center
Abdominal Aortic Aneurysms (AAA), Endovascular Aneurysm Repair (EVAR)
Efficacy and Safety of Antiplatelet Therapy After Endovascular Aortic Repair
This study was a target trial emulation using the National Health Claims database established by the Korean National Health Insurance Service (K-NHIS). 8,325 patients were included.
- Trial name
- EVAR_DAPT_SAPT (NCT06876727)
- Volunteers
- 8,325 people
- Sponsor
- Samsung Medical Center
ST-segment Elevation Myocardial Infarction (STEMI)
Angio-IMR and Cardiac MR-derived MVO in STEMI Patients
Coronary microcirculatory dysfunction has been known to be prevalent even after successful revascularization of ST-segment elevation myocardial infarction (STEMI) patients.
- Trial name
- NCT04828681
- Testing
- Cardiac magnetic resonance imaging
- Where
- 2 sites in United States, China
- Volunteers
- 324 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Coronary Artery Stenosis
Nationwide Cohort Study of Antiplatelet Agents as Primary Prevention
There is no specific recommendation regarding pharmacologic treatment as primary prevention for patients with intermediate coronary artery stenosis whose revascularization was deferred based on negative fractional flow reserve…
- Trial name
- NHIS (NCT06281041)
- Testing
- Antiplatelet Agents
- Where
- South Korea
- Volunteers
- 4,657 people
- Sponsor
- Samsung Medical Center
Stable Angina, Non ST Segment Elevation Myocardial Infarction
INsTantenous wavE-Free Ratio-guided PCI Versus Fractional Flow REserve-Guided PCI in rouTine Clinical Practice, Prospective, Multicenter Registry
The current study sought to evaluate the clinical relevance of iFR-guided strategy in real world clinical practice using unrestricted study population from stable angina to acute coronary syndrome including acute ST-segment…
- Conditions
- Stable Angina, Non ST Segment Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction, Silent Myocardial Ischemia
- Trial name
- INTERPRET (NCT03338309)
- Testing
- Instantaneous wave-free ratio measurement
- Where
- 4 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Acute Coronary Syndrome, Ischemic Heart Disease
PreDiction and Validation of Clinical CoursE of Coronary Artery DiSease With CT-Derived Non-Invasive HemodYnamic Phenotyping and Plaque Characterization (DESTINY Study)
Acute coronary syndrome (ACS) and sudden cardiac death can be the first manifestation of coronary artery disease and are the leading cause of death in the majority of the world's population.
- Trial name
- DESTINY (NCT04794868)
- Testing
- CCTA-derived high risk plaque characteristics, CFD-derived hemodynamic parameters
- Where
- 2 sites in China, South Korea
- Volunteers
- 356 people
- Sponsor
- Samsung Medical Center
Cardiac Amyloidosis
Physiologic Assessment of Microvascular Function in Patients With Cardiac Amyloidosis
The aim of the study is to evaluate coronary flow reserve (CFR), index of microcirculatory resistance (IMR), and proportion of overt microvascular disease, defined as depressed CFR as well as elevated IMR in patients with cardiac…
- Trial name
- NCT02798705
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Samsung Medical Center
Cardiac Allograft Vasculopathy
Physiologic Assessment of Microvascular Function in Heart Transplant Patients
The aim of the study is to evaluate the impact of early microvascular disease assessed by coronary physiologic indices such as fractional flow reserve (FFR), coronary flow reserve (CFR), index of microvascular resistance (IMR) on…
- Trial name
- NCT02798731
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Congenital Heart Disease
Impact of a Cardiac and Mental Health Rehab Program on Well-Being and Fitness in Young Adults With Fontan Circulation: A Randomized Trial
Helping Young Adults With Fontan Circulation Feel Better and Stay Active What is the study about? This study looked at how a special program could help young adults with Fontan circulation feel better mentally and physically.
- Trial name
- (NCTXXXXXXXX) (NCT06844149)
- Testing
- CPR; (Cardiac and Psychosocial Rehabilitation) with Cardiac Rehabilitation, CR; Home-Based Cardiac Rehabilitation, Usual Care
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Samsung Medical Center
Chronic Stroke, Subacute Stroke
Effect of Lower Limb Constraint Induced Movement Therapy Using a Torque-Assisted Exoskeletal Wearable Device
The aim of this study was to investigate the effects of lower limb constraint induced motor therapy using the robotic rehabilitation device on ambulatory function in chronic stroke patients.
- Trial name
- CIMT (NCT06830707)
- Testing
- experimental group
- Where
- South Korea
- Volunteers
- 16 people
- Sponsor
- Samsung Medical Center
Coronary Artery Calcification, Metabolic Syndrome
High-intensity Statin and Ezetimibe Therapy for Asymptomatic Patients With Positive Coronary Calcium
The aim of this study is to compare safety and efficacy between the aggressive treatment with combination of high-intensity statin and ezetimibe and the current standard lipid lowering treatment in asymptomatic patients with…
- Conditions
- Coronary Artery Calcification, Metabolic Syndrome, Dyslipidemias
- Trial name
- DECISION-CAL (NCT05845424)
- Testing
- Guideline directed statin therapy, High intensity statin plus ezetimibe therapy
- Where
- South Korea
- Volunteers
- 6,000 people
- Sponsor
- Samsung Medical Center
Coronary Atherosclerosis Due to Calcified Coronary Lesion
Routine Versus As-Needed Stress Testing in Asymptomatic Patients With High-Risk Coronary Calcium
The purpose of the SMART-EXAM (SMart Angioplasty Research Team-Pragmatic Randomized Trial for Comparing Routine versus As-Needed EXercise or Pharmacologic Stress Testing in Asymptomatic Patients with High-Risk Coronary CalciuM)…
- Trial name
- SMART-EXAM (NCT05796739)
- Testing
- Non-invasive stress test, Medical treatment without further testing
- Where
- South Korea
- Volunteers
- 3,000 people
- Sponsor
- Samsung Medical Center
Pediatric Cancer, Psychology, Child
Usability and Utility of Mindfulness-based Life Management Social Robots for Children and Adolescents in the Long-term Treatment
The purpose of this study is to apply social robot-based mindfulness-based life management content to pediatric and adolescent patients in the long-term disease treatment process and to assess usability and effectiveness of the…
- Trial name
- NCT06763042
- Testing
- Mindfulness-based Life Management Social Robots
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Samsung Medical Center
Premenopausal HR+/HER2- Metastatic Breast Cancer
PALbociclib Endocrine Therapy Followed by Talazo Vs. Talazoz-Atezo Study
This study is a prospective, two-arm, randomized phase II study of talazoparib versus talazoparib plus atezolizumab in ER+ premeonopausal women with metastatic breast cancer harboring HRD scar 1st line treatment: GnRH agonist +…
- Trial name
- Young-PALETTA (NCT04819243)
- Testing
- Pabociclib, Endocrine(or ET + CDK4/6 inhibitors), Talazoparib, Atezolizumab, Pabociclib, Endocrine(or ET + CDK4/6 inhibitors), Talazoparib,
- Where
- South Korea
- Volunteers
- 178 people
- Sponsor
- Samsung Medical Center
Telemedicine, Ultrasonography
Tele-education in Ultrasound Training
The study aims to assess the impact of remote guidance in ultrasound training for medical professionals new to abdominal ultrasound.
- Conditions
- Telemedicine, Ultrasonography, Education, Medical, Continuing
- Trial name
- NCT06171828
- Testing
- Head-Mounted Display (HMD) to communicate with a supervisor remotely
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Nursing, Education
Utilizing of Augmented Reality Technology Education Program for Nurse
It is important to provide practice-oriented education for nurses in a safe environment. As it became difficult to maintain face-to-face education and practice environment due to COVID-19, a new paradigm for nurse education was…
- Trial name
- NCT05629663
- Testing
- AR guidance with Hololens 2
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center