Clinical trials: sponsored by Seattle Children's Hospital
Cleft Palate, Cleft Lip and Palate
Book Sharing for Toddlers With Clefts
Children with clefts exhibit difficulty with language and literacy compared to children without clefts. However, little is known about interventions to address these difficulties in the cleft population.
- Trial name
- BOOST (NCT06338319)
- Testing
- Book-Sharing for Toddlers with Clefts (BOOST)
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Seattle Children's Hospital
Concussion, Brain, Concussion, Mild
Mobile Subthreshold Exercise Program for Concussion--R01
Approximately 1.9 million youth sustain a concussion each year, and up to 30% experience persistent post-concussive symptoms (PPCS) such as headache, dizziness, and difficulty focusing that continue for weeks or months.
- Conditions
- Concussion, Brain, Concussion, Mild, Brain Injuries, Traumatic, Persistent Post Traumatic Headache
- Trial name
- MSTEP-R01 (NCT04688255)
- Testing
- MSTEP, Stretching
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Seattle Children's Hospital
Chronic Pain
Using Ecological Momentary Assessment to Develop an Adaptive Psychological Intervention for Young Adults With Chronic Pain
The goal of this observational study is to determine real-time contextual vulnerabilities associated with pain in young adults to inform ideal treatment targets for a just-in-time adaptive intervention (JITAI).
- Trial name
- NCT06932432
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Seattle Children's Hospital
Child Disruptive Behavior Disorders, Parent Child Relationship
Examining the Feasibility, Acceptability, and Fidelity of Utilizing Parent Training Graduates as Peer Supports
Disruptive behavioral disorders are common in early childhood, affecting up to 15% of preschool-aged children. Behavioral parent training programs are a first-line evidence-based treatment for child disruptive behaviors.
- Conditions
- Child Disruptive Behavior Disorders, Parent Child Relationship, Parent Management Training, Peer Support
- Trial name
- NCT06366620
- Testing
- FAST-B PEERS, FAST-B (First Approach Skills Training - Behavior)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Obesity, Childhood, Physical Activity
Fit 5 Kids Screen Time Reduction Curriculum for Latino Preschoolers
Childhood obesity and metabolic risk are at record high levels in the US, and Latino children are at very high risk. This project will test an intervention called Fit 5 Kids, designed for Latino preschoolers to decrease their…
- Conditions
- Obesity, Childhood, Physical Activity, Nutrition
- Trial name
- Fit5Kids (NCT03575884)
- Testing
- Screen Time Reduction Curriculum
- Where
- 3 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Concussion, Brain, Brain Injury Traumatic Mild
Concussion Health Improvement Program
More than 1 million U.S. youth sustain a concussion each year, and up to 30% report persistent post-concussive symptoms (PPCS) lasting 1 month or more.
- Trial name
- CHIP (NCT06036147)
- Testing
- Concussion-focused cognitive behavioral therapy, Parent skills training, Care management
- Where
- United States
- Volunteers
- 304 people
- Sponsor
- Seattle Children's Hospital
Asthma
Text2Breathe: Enhance Parent Communication to Reduce Pediatric Asthma Disparities
Text2Breathe (T2B) is a randomized controlled trial aimed at improving communication between parents and their children's' primary care providers about asthma.
- Trial name
- T2B (NCT03032159)
- Testing
- Text2Breathe Study Group
- Where
- 2 sites in United States
- Volunteers
- 221 people
- Sponsor
- Seattle Children's Hospital
Cancer, Bone Marrow Neoplasms
The PRISM Intervention for Adolescents and Young Adults Receiving Hematopoietic Cell Transplantation
Multisite Randomized Controlled Trial (RCT) testing the efficacy of the Promoting Resilience in Stress Management (PRISM) intervention among Adolescents and Young Adults receiving hematopoietic cell transplantation for hematology…
- Conditions
- Cancer, Bone Marrow Neoplasms, Anxiety, Depression
- Trial name
- NCT03640325
- Testing
- PRISM (Promoting Resilience in Stress Management)
- Where
- 5 sites in United States
- Volunteers
- 143 people
- Sponsor
- Seattle Children's Hospital
Autism Spectrum Disorder, Behavior
Pilot Trial of the RUBI Program for Autistic Adults
The goal of this clinical trial is to evaluate if a redesigned version of the RUBI parenting intervention can reduce challenging behaviors and improve adaptive skills in autistic adults with co-occurring challenging behaviors.
- Conditions
- Autism Spectrum Disorder, Behavior, Parenting
- Trial name
- RUBI-A (NCT06593613)
- Testing
- RUBI-A, R-ISLEA
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Seattle Children's Hospital
Chronic Nonbacterial Osteomyelitis, Chronic Recurrent Multifocal Osteomyelitis
CHronic Nonbacterial Osteomyelitis International Registry
The objective of the study is to establish a prospective disease registry for chronic recurrent multifocal osteomyelitis (CRMO)/chronic nonbacterial osteomyelitis (CNO) in order to investigate the natural history of the disease…
- Trial name
- CHOIR (NCT04725422)
- Testing
- Methotrexate, Sulfasalazine, Leflunomide
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Seattle Children's Hospital
Chronic Recurrent Multifocal Osteomyelitis
Medication Adherence Intervention in Chronic Recurrent Multifocal Osteomyelitis (CRMO)
This project aims to quantify and evaluate rates of non-adherence and barriers to medication adherence in pediatric patients with CRMO followed at Seattle Children's Hospital's robust CRMO program, which is the only clinical…
- Trial name
- NCT06232603
- Testing
- Education of medication management
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Seattle Children's Hospital
Type 1 Diabetes Mellitus
PRISM for Adolescents With Type 1 Diabetes
It is well-known that adolescents with type 1 diabetes are at high risk for elevated diabetes-specific distress and poor glycemic control.
- Trial name
- NCT03847194
- Testing
- Promoting Resilience in Stress Management (PRISM)
- Where
- 2 sites in United States
- Volunteers
- 172 people
- Sponsor
- Seattle Children's Hospital
Postpartum Depression, Anxiety
Yoga in the NICU for Parents Study
The purpose of this proposal is to test the efficacy of yoga as a mind and body intervention to decrease stress, anxiety, and depression in parents of critically ill neonates hospitalized in the Seattle Children's and University…
- Conditions
- Postpartum Depression, Anxiety, Depression, Stress Disorder
- Trial name
- YiN (NCT05322161)
- Testing
- yoga classes
- Where
- 2 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Concussion, Brain
Developing an Implementation Strategy for Post-concussion Communication With Low Health Literacy Parents in the Emergency Department
Investigators will conduct a hybrid implementation-effectiveness evaluation of an educational intervention that supports communication with families post-concussion in the emergency department.
- Trial name
- NCT04112914
- Testing
- Post-concussion education for families
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Activity, Motor
Preschoolers Learning and Active in PLAY (PLAY Extension)
The PLAY 2 Study is the continuation of an R21 pilot PLAY study. In the R21, we tested the acceptability, feasibility and initial efficacy of three early childhood education setting- based, multi-level interventions to promote…
- Trial name
- PLAY (NCT04772638)
- Testing
- PLAY, Wait list control
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Microtia, Microtia-Anotia
Craniofacial Microsomia: Accelerating Understanding of the Significance and Etiology
The CAUSE study is a multicenter study, with domestic (n=4) and international (n=6) study sites. Children and young adults (ages 0-18) who have microtia and/or craniofacial microsomia and their parents are invited to participate.
- Conditions
- Microtia, Microtia-Anotia, Craniofacial Microsomia, Goldenhar Syndrome
- Trial name
- CAUSE (NCT04351893)
- Where
- 10 sites in United States, Colombia and 2 more
- Volunteers
- 935 people
- Sponsor
- Seattle Children's Hospital
Craniofacial Microsomia, Hemifacial Microsomia
Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)
This study is a multi-center, longitudinal cohort study of 125 infants with craniofacial microsomia (CFM) and 100 infants without craniofacial anomalies.
- Conditions
- Craniofacial Microsomia, Hemifacial Microsomia, Oculo-Auriculo-Vertebral-Syndrome, Goldenhar Syndrome
- Trial name
- CLOCK (NCT02224677)
- Where
- 5 sites in United States
- Volunteers
- 417 people
- Sponsor
- Seattle Children's Hospital
Twin to Twin Transfusion as Antepartum Condition, Monochorionic Diamniotic Placenta
Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome
The purpose of this study is to evaluate the use of diode laser photocoagulation of the communicating vessels in twin-to- twin transfusion syndrome (TTTS) with respect to maternal, fetal and neonatal outcomes.
- Trial name
- NCT05008744
- Testing
- Fetoscopic laser ablation
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Seattle Children's Hospital
Inflammatory Bowel Diseases, Functional Gastrointestinal Disorders
The Healthy Endoscopy Study
Researchers at Seattle Children's Research Institute want to find ways to understand gastrointestinal disease such as Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS) and Graft-Versus-Host-Disease (GVHD).
- Trial name
- NCT04369963
- Testing
- Esophagogastroduodenoscopy and Colonoscopy with Biopsies
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Congenital Heart Defects
Phase 3 Triiodothyronine Supplementation for Infants After Cardiopulmonary Bypass
This is a study to determine the safety and efficacy of liothyronine sodium/triiodothyronine (Triostat), a synthetic thyroid hormone, when given to infants with congenital heart disease during cardiopulmonary bypass surgery.
- Trial name
- TRICC-2 (NCT02320669)
- Testing
- Triostat
- Where
- 3 sites in United States
- Volunteers
- 220 people
- Sponsor
- Seattle Children's Hospital