Clinical trials: sponsored by Semmelweis University
Cardiac Surgery
Psychosocial Development of Children Undergoing Open Cardiac Surgery
In recent years, improvement of medical treatments leads to the effect, that 90% of children originally born with congenital heart disease (CHD) are reaching adulthood.
- Trial name
- NCT03646565
- Where
- Hungary
- Volunteers
- 80 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Cardiac Surgery, Hepatic Impairment
The Role and Dynamics of Liver Dysfunction in Patients Undergoing Cardiac Surgery
The aim of the present study is the evaluation of the occurrence and effect of hepatic dysfunction on outcome following cardiac surgery, as well as the monitoring of changes in liver haemodynamics in the early postoperative…
- Conditions
- Cardiac Surgery, Hepatic Impairment, Heart Failure
- Trial name
- NCT02893657
- Where
- Hungary
- Volunteers
- 150 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Mild Cognitive Impairment
Computer Games to Prevent Mild Cognitive Impairment and Dementia
The aim of the study is to show that regular playing with the logic games developed in the framework of the M3W (Mental Wellness Toolset) project (https://m3w-project.eu/) can prevent mild cognitive impairment (MCI) and dementia.
- Trial name
- NCT02310620
- Testing
- Cognitive training
- Where
- Hungary
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Retinal Artery Occlusion
Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion
Purpose of the study is to examine the retinal blood flow in chronic cases of retinal artery occlusion with non-invasive, non-contact optical coherence tomography angiography.
- Trial name
- RAO-OCTA (NCT03357146)
- Testing
- Optical coherence tomography angiography
- Where
- Hungary
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Coronavirus Infection
COvid iMaging With POSitron Emission Tomography
We aim to study if metabolic intensity and extent according to pathologic pulmonary 18F-2-fluoro-2-deoxy-D-glucose (FDG)-uptake may correlate with the course of COVID-19 pneumonia and potentially yield prognostic value.
- Trial name
- COMPOSIT (NCT05009563)
- Testing
- FDG-PET/CT
- Where
- Hungary
- Volunteers
- 50 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Alveolar Bone Resorption, Alveolar Ridge Enlargement
Modified Ridge Splitting Technique Using Autogenous Bone Blocks (MRS)
In this clinical study ridge splitting procedures are preformed using autogenous bone blocks. After a 3-month healing, at the time of dental implant placement bone core biopsy samples are harvested.
- Trial name
- MRS (NCT05005858)
- Testing
- Alveolar ridge splitting, Creating osteotomies with piezoelectric device
- Where
- Hungary
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Vasodilatation, Oral Soft Tissue Conditions
Endothelium Dependent and Non-dependent Vasodilatation in Human Gingiva
The aim of this study is to compare the endothelim-dependent and non-dependent vasodilatation between genders in the human gingiva.
- Trial name
- NCT04918563
- Testing
- Nitroglycerin, Acetylcholine
- Where
- Hungary
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Hypoxic-Ischaemic Encephalopathy, Perinatal Asphyxia
Hypoxic-Ischemic Encephalopathy Therapy Optimization in Neonates for Better Neuroprotection With Inhalative CO2
This is a Phase I, open-label, single center trial to evaluate the feasibility and safety of low concentration CO2 gas mixture (5% CO2 + 95% air) inhalation in asphyxiated, cooled, mechanically ventilated newborns at risk of…
- Conditions
- Hypoxic-Ischaemic Encephalopathy, Perinatal Asphyxia, Hypocapnia
- Trial name
- HENRIC (NCT02700854)
- Testing
- 5% carbon-dioxide inhalation
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Semmelweis University
Disorder Related to Cardiac Transplantation
Heart Transplant Registry of Városmajor
The purpose of this registry is to determine the long term outcomes of heart transplantations performed at the Semmelweis University Heart and Vascular Center.
- Trial name
- NCT02347371
- Where
- Hungary
- Volunteers
- 11 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Autoimmune Diseases, Coronary Artery Disease
Coronary Artery and Systemic Autoimmune Disease: Diagnostics and Treatment
This study evaluates in vivo intracoronary imaging using intravascular ultrasound and optical coherence tomography and safety and efficacy of new generation fully bioresorbable vascular scaffolds in four well defined systemic…
- Trial name
- NCT02510092
- Testing
- Percutaneous coronary intervention with new generation fully resorbable scaffold
- Where
- Hungary
- Volunteers
- 11 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Partial-edentulism
Accuracy of Half-guided Implant Placement
The aim of the present prospective randomized controlled study is to compare the accuracy of implant placement performed either with a surgical motor or a torque wrench as part of a half-guided surgical protocol after maxillary…
- Trial name
- NCT04854239
- Testing
- Half-guided implant placement
- Where
- Hungary
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Endometriosis, Endometriosis Ovary
The Role of Galectins in the Non-invasive Diagnosis of Endometriosis
Endometriosis is one of the most common infertility-related gynecologic disorder that affect approximately 10-15% of women in reproductive age. The main symptoms are chronic pelvic pain, infertility, dysmenorrhea and dyspareunia.
- Conditions
- Endometriosis, Endometriosis Ovary, Endometriosis Rectovaginal Septum
- Trial name
- NCT04401592
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Chronic Heart Failure, Vitamin D Adverse Reaction
Vitamine D Treatment in Chronic Heart Failure
The investigators hypothesized that in vitamin D deficiency the 25-OH-D3 vitamin substitution improve the heart function in chronic heart failure.
- Trial name
- NCT01535196
- Testing
- Vigantol oil and MCT oil
- Where
- 2 sites in Hungary
- Volunteers
- 8 people
- Sponsor
- Semmelweis University
Maxillary Sinus Augmentation
Lateral Bony Wall Repositioning in Maxillary Sinus Floor Augmentation
The aim of the present prospective randomized controlled study is to clinically and histologically investigate the safety and efficacy of bony wall repositioning compared to rotary window preparation with membrane coverage in…
- Trial name
- NCT04811768
- Testing
- Maxillary sinus augmentation
- Where
- Hungary
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Periodontal Diseases
Treatment of Periodontal Intrabony Defects With A-PRF+ or EMD
The aim of this randomized clinical trial was to clinically evaluate and compare the healing of intrabony defects after treatment with advanced platelet-rich fibrin (A-PRF+) to enamel matrix derivatives (EMD) in periodontitis…
- Trial name
- NCT04404374
- Testing
- A-PRF/EMD
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University
Blood Loss, Postoperative, Liver Transplant
Individualized Multimodal Hemostasis Evaluation Pyramid (IMHOTEP)
This study evaluates the hemostatic changes defined as hemostasis reserve capacity (HRC) in the first perioperative 48 hours of bloodless liver transplanted patients.
- Conditions
- Blood Loss, Postoperative, Liver Transplant, Hemostatic Disorder
- Trial name
- NCT03555383
- Testing
- Coagulation factor levels
- Where
- Hungary
- Volunteers
- 59 people
- Sponsor
- Semmelweis University
Chronic Lymphoid Leukemia
The Effect of 25-OH-Vitamin-D3 Substitution in Patients With Malignant and Immune-hematologic Diseases
Recent data have shown that the inadequate vitamin D status plays a role in the manifestation of the haematologic tumors and serum vitamin D level has a prognostic role also as it determines the tumor mortality.
- Trial name
- D-HEM (NCT01518959)
- Testing
- Cholecalciferol, oleum neutralicum
- Where
- Hungary
- Volunteers
- 31 people
- Sponsor
- Semmelweis University
Vasoconstriction, Oral Soft Tissue Conditions
Evidence of Spreading Vasoconstriction in Human Gingiva
The aim of this study is to observe the mechanism of spreading vasoconstriction in human healthy gingiva. Epinephrine solution is applied on the attached gingiva in group "A" and on the surface of the tooth next to the ginvial…
- Conditions
- Vasoconstriction, Oral Soft Tissue Conditions, Dental and Gingival Conditions
- Trial name
- NCT04131283
- Testing
- Epinephrine
- Where
- Hungary
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Coronavirus Infection
HUNgarian COronaVirus Disease-19 Epidemiological Research
Hungarian CoronaVirus disease-19 Epidemiological Research
- Trial name
- NCT04370067
- Where
- 4 sites in Hungary
- Volunteers
- 11,200 people, healthy volunteers welcome
- Sponsor
- Semmelweis University Heart and Vascular Center
Ventilator Associated Pneumonia, Corona Virus Infection
Epidemiology and Outcome of Ventilator-associated Pneumonia Among Critically Ill COVID-19 Patients
The aim of this study is to determine the risk factors for development of ventilator-associated pneumonia (VAP) and to identify the prognostic factors of VAP among Coronavirus Disease 2019 (CoViD-19) patients.
- Trial name
- NCT04372576
- Testing
- Assessment of ventilator-associated pneumonia criteria
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Semmelweis University