Clinical trials: sponsored by Sheba Medical Center
Ischemic Cardiomyopathy
Radial Strain ECHO-Guided Implantation of Cardiac Resynchronization Therapy
The purpose of this study is to evaluate the use of radial strain imaging using speckle tracking analysis to predict the response to CRT in patients with ischemic cardiomyopathy (ICMP) with NYHA functional class 2-4 heart failure…
- Trial name
- RAISE-CRT (NCT01603706)
- Testing
- Echo guided implantation group
- Where
- 9 sites in United States, Israel
- Volunteers
- 172 people
- Sponsor
- Sheba Medical Center
Defibrillation Capacity of Defibrilators After Replacement
Cardioverter Defibrillator Replacement With Induction of Ventricular Fibrillation and Defibrillation Testing
The SIMPLE study was a large one, and lasted quite a few years due to its design as a randomized controlled trial and the follow up needed to reach an endpoint.
- Trial name
- SIMPLER (NCT02513030)
- Testing
- Defibrillation testing during ICD replacement
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Atrial Fibrillation
Subclinical Postoperative Atrial Fibrillation
Postoperative atrial fibrillation and atrial flutter (POAF) is the most common complication after cardiac surgery requiring intervention or prolonged hospital stay.
- Trial name
- POAF-ILR (NCT02522364)
- Testing
- BioMonitor device, Standard
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Diabetes, Cancer
Diabetes, Glucose Control, Glucose Lowering Medications, and Cancer Risk: A 10-year Population-based Historical Cohort
This is a large nationwide population study, with 10 year follow-up, of the effect of diabetes, metabolic control and a large number of glucose-lowering medications, on total and site-specific cancer incidence and survival.
- Trial name
- DBCA (NCT02072902)
- Where
- Israel
- Volunteers
- 2,188,669 people
- Sponsor
- Sheba Medical Center
Lymphoma, Multiple Myeloma
Lonquek for Autologous Stem Cell Mobilization
The aim of this study is to evaluate the efficacy and tolerability of Lonquek which is a pegylated (long-acting) version of Filgrastim recombinant human G-CSF (G-CSF) in mobilizing sufficient number of stem cells for autologous…
- Trial name
- NCT02488382
- Testing
- Lonquek
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Sheba Medical Center
Amputation, Traumatic
Changes in Trans Tibial Amputee Running Asymmetry During Prolonged Effort
The purpose of this study is to determine the effect of prolonged effort in long distance running on the biomechanical bilateral asymmetry in the lower limbs of trans tibial amputee running with running specific prosthesis.
- Trial name
- NCT02601456
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Comparing Use of Hand Hygiene Products
Magen Haim Project - Assessing Hand Hygiene Formulas
Background: Procedures of hand hygiene are an important component in prevention of cross-transmission of infections in hospitals.
- Trial name
- NCT03188549
- Testing
- AniosGel 85 NPC, Softa-Man (Braun), Septol
- Where
- Israel
- Volunteers
- 1,505 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Familial Mediterranean Fever
Inflammatory Proteins in Familial Mediterranean Fever During Attack and Remission
Familial Mediterranean fever (FMF) is a genetic disease, caused by mutations in the FMF gene, entitled MEFV. The disease is characterized by painful attacks of inflammation in sites lined by serous membranes (e.g.
- Trial name
- NCT00323440
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Ovarian Stimulation
Mechanical Stimulation of the Ovary for Infertility Treatment in Patients With Very Low Ovarian Reserve
Examine the possibility that mechanical stimulation and ovarian fragmentation in women with premature ovarian failure or low ovarian reserve intended for egg donation may cause early follicular recruitment and increase chances of…
- Trial name
- NCT03298750
- Testing
- Resection of ovarian tissue and mechanical stimulation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Traumatic and/or Non-traumatic Brain Injury
Assessing Special Features of Impaired Gait After Acquired Brain Injury With an Instrumented Treadmill
Hemiparetic gait following acquired brain injury (ABI) is grossly characterized by decreased speed of walking, increased stance time on the unaffected side, and decreased stance time on the affected side.These abnormalities are…
- Trial name
- NCT01413321
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Intestinal Diseases
Microbiome Changes in Travelers to Tropical Destinations
The human gut contain a wide range of microorganisms creating the gut microbiome. The microbiome has great impact on metabolic and immunologic processes and responses.
- Trial name
- NCT02295254
- Testing
- feces sample
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
No-Reflow Phenomenon, STEMI - ST Elevation Myocardial Infarction
NGAL and Its Association With the No-reflow Phenomenon in ST-elevation Myocardial Infarction
The aim of this study is to investigate the association between NGAL plasma levels in ST-elevation myocardial infarction and the no-reflow phenomenon, adverse events during hospitalization and at 30-day follow-up.
- Trial name
- NCT03264859
- Testing
- NGAL levels early and post STEMI
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Fasting Hyperglycemia
The Effect of Late Night Meals on Fasting Glucose in Type 2 Diabetes Patients
High fasting glucose is a very common problem in type 2 diabetic patients. The cause is probably glucose production by the liver, known as the "dawn phenomenon".
- Trial name
- NCT00986700
- Testing
- late night meal
- Volunteers
- 19 people
- Sponsor
- Sheba Medical Center
MODY-2 Diabetes
The Effect of ß-cell Specific Glucokinase Mutation on Glucose Homeostasis and Insulin Secretion in a MODY-2 Family
Type 2 diabetes mellitus patients exhibit many glucose homeostasis abnormalities in different tissues and organs. Among the more important defects are disturbed hepatic glucose metabolism and defective pancreatic β-cell function.
- Trial name
- NCT01960231
- Testing
- OGTT
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
BRAIN MALIGNANCIES AFTER RADIATION THERAPY
Hyperbaric Oxygen Stimulation for Patients With Brain Malignancies After Radiation Therapy.
Radiotherapy is the mainstay of treatment for brain malignancies and is associated with significant neurotoxicity. Due to continuous increase in patient's survival, the long term risk for radiation-induced brain inflammation and…
- Trial name
- NCT01808625
- Testing
- HYPERBARIC OXYGEN STIMULATION
- Where
- Israel
- Volunteers
- 2 people
- Sponsor
- Sheba Medical Center
Meconium
Detection of Meconium in Amniotic Fluid in Post Term Pregnancies
Meconium constitutes the bowel contents of the fetus and is normally expelled only after birth. However, it may be secreted into the amniotic fluid of 20% of all fetuses.
- Trial name
- NCT01429974
- Testing
- amniometer model po1
- Where
- Israel
- Volunteers
- 27 people
- Sponsor
- Sheba Medical Center
Injury of Radial Artery
Feasibility and Outcomes of Repetitive Radial Approach
The purpose of this study is to assess the feasibility of performing repetitive coronary angiograms via the radial approach
- Trial name
- NCT02017054
- Testing
- Cath
- Where
- Israel
- Sponsor
- Sheba Medical Center
Pulmonary Disease
The Role of Endothelial Function Test in Risk Stratification for Early and Late Complications After Pulmonary Embolism
The aim of this study is to investigate the association between endothelial dysfunction, measured by RHI as assessed by the peripheral arterial tonometry method, and PE complications defined as re-event of PE or DVT, systemic…
- Trial name
- NCT03149471
- Testing
- Endothelial dysfunction test
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Inflammatory Bowel Diseases, Primary Immune Deficiency Disorder
Immunological Characteristics of Patients With PID and IBD
The investigators wish to characterize alterations in the architecture and function of immune cells in patients with a primary immunodeficiency that also develop inflammatory bowel disease.
- Trial name
- NCT03148028
- Where
- 2 sites in Israel
- Volunteers
- 45 people
- Sponsor
- Sheba Medical Center
Diabetic Nephropathies
Colchicine for Diabetic Nephropathy Trial
Forty patients with diabetic nephropathy will be treated with colchicine up to 2 mg, or placebo, for 18 months. A follow up will be performed after 12 additional months.
- Trial name
- CDNT (NCT02442921)
- Testing
- Colchicine
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center