Clinical trials: sponsored by Sheba Medical Center
Metastatic Melanoma
Adoptive Cell Therapy Following Non-myeloablate Chemotherapy in Metastatic Melanoma Patients
Metastatic melanoma is an aggressive and highly malignant cancer. The five-year survival rate of patients with metastatic disease is less than 5% with a median survival of only 6-10 months.
- Trial name
- NCT00287131
- Testing
- Procedure - Adoptive cell transfer
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Sheba Medical Center
Morbid Obesity
Neuromuscular Blockade and Surgical Conditions
The aim of the present study is to prospectively assess whether deep neuromuscular blockade (NMB) (zero response to train of four and a post tetanic count of no more than 10 responses using a nerve stimulator monitoring) until…
- Trial name
- Sugamadex (NCT01564576)
- Testing
- Profound neuromuscular blockade (Rocuronium, Rocuronium bromide, sugammadex, Bridion)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Upper Respiratory Tract Infections
Vitamin D Supplementation and Upper Respiratory Tract Infections in Adolescent Swimmers
Background: The medical and economic burden of upper respiratory tract infections (URTIs) is extremely high, while prevention and treatment options are limited.
- Trial name
- NCT01215682
- Testing
- vitamin D
- Where
- 4 sites in Israel
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Cystic Fibrosis
The Use of Visual Feedback in Airway Clearance
Cystic Fibrosis (CF) patients perform airway clearance incorporating various breathing strategies, to clear secretions from their lungs.
- Trial name
- NCT01546779
- Testing
- Tri-Gym
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Lung Cancer
Exhaled Breath Biomarkers in Lung Cancer
Analysis of volatile organic compounds (VOCs) is a new attractive non-invasive field in medical diagnostics. These VOCs can be detected via the exhaled breath.
- Trial name
- NCT01386203
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Hemophilia C
A Single and Low Dose of Recombinant Factor VIIa in Patients With Severe Factor XI Deficiency Undergoing Surgery
Lately the investigators found that patients with severe factor XI deficiency and inhibitors could undergo major surgery with a single low dose of recombinant factor VIIa and tranexamic agent.
- Trial name
- rFVIIa (NCT01538160)
- Testing
- recombinant factor VIIa
- Where
- 3 sites in Israel
- Volunteers
- 15 people
- Sponsor
- Sheba Medical Center
Pain, Pregnancy
Efficacy Study of Prophylactic Ibuprofen Versus Placebo on Pain Relief and Success Rates of Medical Abortion
In the current study, we want to evaluate the prophylactic use of ibuprofen versus a placebo for medical abortion by mifepristone and misoprostol, at a gestational age of up to 7 weeks, in regard to the effect on pain relief and…
- Trial name
- NCT00997074
- Testing
- ibuprofen
- Where
- Israel
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Hypertrophic Cardiomyopathy
Exercise Training in Patients With Hypertrophic Cardiomyopathy
Exercise training (ET) is highly beneficial in heart failure patients and has been suggested to confer significant symptomatic and functional improvements in patients with diastolic dysfunction.
- Trial name
- NCT01518114
- Testing
- Exercise Training
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Spinal Cord Injury
Detection of Peripheral Blood Biomarkers in Intermediate Phase Spinal Cord Injury: Correlation With Neurological and Functional Outcomes, and Comparison to Other Central and Peripheral Neurological Conditions.
This research looks for markers in the blood of people with spinal cord injury that may be a sign of injury severity, or serve as a clue to the degree of recovery.
- Trial name
- NCT01516385
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Catocholamine Induced Finger Necrosis
Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis
Patients in the intensive care unit (ICU) often require blood pressure support of vasoactive drugs such as amines. Finger necrosis (so called "blue toe syndrome") is a well documented phenomena with incidence reaching as high as…
- Trial name
- NCT01500668
- Testing
- Botox
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Acquired Brain Injury
The Effect of Auditory Stimuli on Heart Rate Variability (HRV) Among Patients With Acquired Brain Injury (ABI)
Heart Rate Variability (HRV) reflects the responsiveness of the autonomic system to an external stimuli. The aim of this system is to maintain homeostasis.The variability implies on the interaction between the sympathetic and the…
- Trial name
- NCT01454557
- Testing
- Auditory Stimuli
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Infiltration, Extravasation
Intravenous Sodium Bicarbonate Verifies Intravenous Position of Catheters in Spontaneously Breathing Adult Volunteers
Vascular access in patients carries a significant risk of accidental extravasation of intravenous (IV) fluids and medications with the potential for tissue injury.
- Trial name
- NCT01458873
- Testing
- sodium bicarbonate 4.2%, diluted sodium bicarbonate 2.1%, normal saline
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Brain Injury
The Evaluation of Balance Control by Quantification of Temporospatial Measures While Forward and Side Reaching
Balance control is the sum action of the sense and reaction systems. In order to perform different activities in different postures one must have the ability to control and to adjust his balance in different conditions.A deficit…
- Trial name
- NCT01451216
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Walking Performance
Evaluating Walking Kinetic of Children Who Suffer Central Nervous System (CNS) Damage
The goal of the present study is to look at the effect of changing walking parameters on the dynamic walking characteristics among children post severe traumatic brain injury, and typically developed controls.
- Trial name
- NCT01158027
- Testing
- gait evaluation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Acquired Brain Injury
The Reliability of Heart Rate Variability Among Patients With Brain Injury as Measured by POLAR RC810XE Compared to HOLTER
Following a brain injury (BI) in addition to all other systems, there can be a failure in the control of the autonomic system activity. Heart rate (HR) has its own normal variability.
- Trial name
- NCT01451242
- Testing
- no intervention is made
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Healthy
The Effects of TMS on Memory-consolidation in Human Primary Visual Cortex
Rapid Transcranial Magnetic Stimulation will be used in order to examine whether the human primary visual cortex is essential to visual memory consolidation.
- Trial name
- NCT00480012
- Testing
- rTMS
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Depression
Hormonal Levels in Men With Major Depressive Disorder
Subjects will be 1000 men meeting the following inclusion criteria: 1) male, age 18-65 years; 2) meeting DSM-IV criteria for major depressive disorder within the past one year, with a HAM-D score >12.
- Trial name
- NCT00429689
- Testing
- Saliva sample
- Volunteers
- 2,000 people
- Sponsor
- Sheba Medical Center
Hemophilia A
The Influence of "Karate" on Bleeding in Hemophilic Patients.
Hemophilia patients tend to lower their physical activity level due to the fear of increasing bleeding episodes. Although recent literature has shown that with routine muscle strengthening and physical activity, the frequency and…
- Trial name
- NCT00281333
- Testing
- "Karate" exercises and strengthening exercises
- Volunteers
- 12 people
- Sponsor
- Sheba Medical Center
Urethral Strictures
Efficiency of Cold vs. Laser Internal Urethrotomy Treatment of Urethral Strictures
The purpose of this study is to determine whether laser internal urethrotomy (IU) is as efficient as cold knife internal urethrotomy for treatment of anterior urethral strictures regarding post operative urination outflow…
- Trial name
- IU (NCT01196572)
- Testing
- Internal Urethrotomy
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Blepharoptosis
Saline Injection - Assisted Anesthesia in Eyelid Surgery
The investigators hypothesize that injection of saline to the upper eyelids prior to lidocaine/adrenaline injection will reduce pain of the local anesthetic in comparison to injection of lidocaine alone.
- Trial name
- NCT01239498
- Testing
- Injection of Saline + Lidocaine/Adrenaline, Lidocaine/Adrenaline only
- Where
- 2 sites in Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center