Clinical trials: sponsored by Sheba Medical Center
Myocardial Infarction, Death
Association of Endothelial Function and Clinical Outcomes in Subjects Admitted to Chest Pain Unit
It is recognized that endothelial dysfunction is a major factor contributing to the atherogenic process. Abnormal function of the endothelium is detectable prior to obvious intimal lesions in patients with risk factors for…
- Conditions
- Myocardial Infarction, Death, Cerebrovascular Accident, Congestive Heart Failure
- Trial name
- NCT01618123
- Where
- 2 sites in United States, Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Myocardial Infarction, Death
Serum Magnesium Levels in Desalination Tap Water and Outcomes in Acute Myocardial Infarction Patients
Association between serum magnesium and clinical outcome in patients with acute MI (AMI) with 1 year follow-up in 300 patients in regions supplied by desalinated drinking water (DSW) (Sheba MC) and 150 patients in regions with…
- Conditions
- Myocardial Infarction, Death, Congestive Heart Failure, Acute-MI
- Trial name
- NCT02356393
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Crohn Disease of Intestine
MILESTONE-CD -A Prospective Multiomic Inception Real -Life Study To Evaluate Predictors of Disease Outcomes & respoNse to Biologic Treatment in Crohn's Disease
Crohn's' disease (CD) is a lifelong-chronic inflammatory condition of the digestive tract. CD frequently manifests during the 2nd or 3rd decade; prolonged disease duration frequently results in major structural complications such…
- Trial name
- MILESTONE-CD (NCT04612621)
- Testing
- combination of diagnostic tests
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Crohn Disease
Pillcam Crohn's Capsule for Monitoring of Panenteric Mucosal Healing in Crohn's Disease Patients With Vedolizumab
The main aim of the study is to evaluate the lielihood of panenteric mucosal healing in Crohn's disease patients treated with vedolizumab The study will include patients with active Crohn's disease who are starting treatment with…
- Trial name
- NCT03889613
- Testing
- prospective follow-up with videocapsule
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Injury; Blood Vessel, Wrist, Radial Artery
Correlation Between Endothelial Function and Trans Radial-procedural Events
The aim of this study is to investigate the relation between the previous presence of endothelial dysfunction and the development of radial artery vasospasm during the trans-radial coronary evaluation.
- Trial name
- NCT02017028
- Where
- Israel
- Sponsor
- Sheba Medical Center
Post-Acute COVID-19 Syndrome
Enhanced External Counterpulsation to Treat Long COVID-19 Fatigue
The goal of this double blind, outcome-assessor blind, randomized controlled trial, is to compare the effectiveness of external encounter counterpulsation (EECP) versus sham procedure in participants with long COVID-19 fatigue.
- Trial name
- EXPECT (NCT05668039)
- Testing
- Enhanced external counterpulsation
- Where
- Israel
- Volunteers
- 32 people
- Sponsor
- Sheba Medical Center
Aortic Stenosis
Clinical Outcome of Patients With Low-gradient Severe Aortic Stenosis
To assess the ability of baseline clinical parameters and imaging modalities to predict short and long term left ventricular function and clinical outcome of subjects with low-gradient, severe aortic stenosis.
- Trial name
- NCT02010177
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Trans Catheter Aortic Valve, Aortic Stenosis
Functional and Quality of Life Improvement Following Transcatheter Heart Valve Implantation
The objective is to observe trends in patient characteristics and outcomes after aortic or mitral transcatheter heart valve replacement over time.
- Trial name
- NCT02023060
- Where
- 5 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Acute Myeloid Leukemia
CAR-T CD19 for Acute Myelogenous Leukemia With t 8:21 and CD19 Expression
Chimeric antigen receptor (CAR-T) engineered T cells against the CD19 protein have been shown to be effective against acute lymphoma and lymphocytic leukemia and are approved by the US (FDA), European (EMA) and Health Basel.
- Trial name
- NCT04257175
- Testing
- CAR-T CD19
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Myelogenous Leukemia, Acute
Bisantrene Combination for Resistant AML
An Open-label, Phase II, Two-stage, Study of Xantrene® (Bisantrene) in combination with Fludarabine and Clofarabine as Salvage Therapy for Adult Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML) Lead-in stage: up…
- Trial name
- NCT04989335
- Testing
- Bisantrene, Fludarabine, Clofarabine
- Where
- Israel
- Volunteers
- 29 people
- Sponsor
- Sheba Medical Center
Stage IV Pancreatic Cancer
Maintenance Ipilimumab + Nivolumab Post Induction Chemotherapy + SBRT for First Line Treatment Stage IV Pancreatic Cancer
In this study we aim to test the efficacy of a combined and novel approach including induction chemotherapy (per standard of care) followed by SBRT and maintenance ipililumab + nivolumab in the first line setting of stage IV…
- Trial name
- NCT05088889
- Testing
- Nivolumab, ipilimumab, Stereotactic body radiation therapy
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Graft Versus Host Disease
Anti T-lymphocyte Immunoglobulin With Post Transplant Cyclophosphamide to Prevent GVHD Post Allogeneic Transplantation
Investigators hypothesize that combination of ATLG with PTCy in matched or mismatched unrelated hematopoietic stem cell transplantation will reduce acute and chronic GVHD incidence.
- Trial name
- NCT03357159
- Testing
- Cyclophosphamide, anti-human T-lymphocyte immunoglobulin (ATLG)
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Prevention
Phase 3 Multicenter Randomized Double Blind Placebo Controlled Study With Antibacterial Prophylaxis in Azacitidine Treated MDS Patients
Infections are a major and prevalent life-threatening complication among patients with myelodysplastic syndrome (MDS). Currently, the role of prophylactic antibacterial agents after chemotherapy in MDS patients remains…
- Trial name
- NCT02981615
- Testing
- Levofloxacin
- Where
- Israel
- Volunteers
- 67 people
- Sponsor
- Sheba Medical Center
TBI (Traumatic Brain Injury)
MR Imaging Study of TBI in Children
This project will combine the data collected from structural and functional MRI scans and neuropsychology performance post-TBI in children.
- Trial name
- MISTIC (NCT03034031)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Parkinson Disease
Assessment of Pupil Light Responses in Patients With Parkinson Disease
Parkinson diseases (PD) is the second most common degenerative disease of the central nervous system. The development of early diagnostic biomarkers may help identify at-risk individuals and allow precocious interventions at the…
- Trial name
- NCT04117555
- Testing
- Pupil response to light stimuli
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Carcinoma, Non-Small-Cell Lung, Genes, erbB-1
Osimertinib for NSCLC With Uncommon EGFR Mutations
This is a multi-center, retrospective study of ucEGFRmut (exon 20 insertions excluded) metastatic NSCLC osimertinib-treated as first EGFR inhibitor.
- Trial name
- UNICORN (NCT05421936)
- Testing
- Osimertinib
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Embryo Transfer, Fertilization in Vitro
Does Sexual Intercourse Affect the Outcomes of Frozen-thawed Embryo Transfer?
The goal of this clinical trial is to test whether sexual intercourse the night after embryo transfer affects thawed embryo implantation rates.
- Conditions
- Embryo Transfer, Fertilization in Vitro, Coitus
- Trial name
- NCT06134609
- Testing
- Sexual intercourse
- Where
- Israel
- Volunteers
- 656 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Morbid Obesity
"Hachi Barie" Project - A Multidisciplinary Program to Accompany Severely Obese Teenagers in the Weight Loss Process for the Benefit of Their Recruitment Into the Israel Defense Forces
Teenagers with body mass values (BMI) above 35 kg/m2 and co-morbidity are designated for medical disqualification from service in the IDF.
- Trial name
- NCT06102538
- Testing
- # The importance of service in the IDF # Physical activity # Healthy nutrition # Psychological support
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Sheba Medical Center
Cesarean Wound Disruption
The Influence of Endometrial Suturing on the Risk of Uterine Scar Defect
Caesarean section (CS) is the commonest major operation performed on women worldwide with progressively rising incidence. Consequently, long-term adverse sequelae due to uterine scar defect have been increasing.
- Trial name
- NCT03851003
- Testing
- Endometrial suturing, Non- endometrial suturing, Vaginal ultrasonography
- Where
- Israel
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Colon Cancer, Liver Metastasis Colon Cancer
Hepatopulmonary Radio-sterilization With Immunotherapy
In this protocol the investigators aim to overcome hepatic-pulmonary metastases-induced resistance to immunotherapy through high dose radiation therapy (SBRT) targeted to the metastases themselves, aiming, when possible, to…
- Conditions
- Colon Cancer, Liver Metastasis Colon Cancer, Rectal Cancer
- Trial name
- TROS-8 (NCT06053996)
- Testing
- Hepatopulmonary radio-sterilization
- Where
- Israel
- Volunteers
- 44 people
- Sponsor
- Sheba Medical Center