Clinical trials: sponsored by Sheba Medical Center
Parkinson Disease, Essential Tremor
Brain Network Activation in Patients With Movement Disorders
The diagnosis and management of movement disorders, such as Parkinson's disease (PD), parkinson-plus syndromes (PPS), dystonia, essential tremor (ET), normal pressure hydrocephalus (NPH) and others is challenging given the lack…
- Conditions
- Parkinson Disease, Essential Tremor, Dystonia, Normal Pressure Hydrocephalus
- Trial name
- BNA-MDi (NCT03269201)
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Parkinson Disease
Self-motion Perception in Parkinson's Disease
Parkinson's Disease as well as being a disorder of motor function also causes a wide range of non-motor disturbances many of which are involved in the prodromal stage prior to the onset of motor symptoms.
- Trial name
- SMP_PD (NCT03137238)
- Testing
- Investigation of self-perception in Parkinson's disease
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Fragile X Associated Tremor-ataxia Syndrome, FXTAS
Brain Network Activation and Gait and Posture in FXTAS
In this study the investigators aim to identify and characterize a potential neurophysiological biomarker by mapping functional networks of brain activity (Brain Network Activation, BNA) based on analysis of evoked response…
- Trial name
- FXTAS-BNA (NCT02936531)
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Sheba Medical Center
Covid19, Fertility Issues
Semen Analysis Parameters Following Pfizer's COVID-19 Vaccine
In this study the investigators will explore the effect of the BNT162b2 COVID-19 Vaccine on semen analysis parameters among 75 fertile men.
- Trial name
- NCT04778033
- Testing
- Sperm collection
- Where
- Israel
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Metastatic Urothelial Carcinoma
A Phase 2, Single-Center, Open Label Study of Autologous, Adoptive Cell Therapy Following a Reduced Intensity, Non-myeloablative, Lymphodepleting Induction Regimen in Metastatic Urothelial Carcinoma Patients
An autologous, Adoptive Cell Therapy Following a Reduced Intensity, Non-myeloablative, Lymphodepleting Induction Regimen in Metastatic Urothelial Carcinoma Patients.
- Trial name
- NCT04383067
- Testing
- Tumor Infiltrating Lymphocytes (TIL), Proleukin
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Stroke
Intensive Upper Extremity Training Program During the Early Subacute Phase After Stroke: A Feasibility Study
The study assesses the feasibility of a 4-week upper extremity training program emphasizing quality of movement practiced at high intensity and dosage applied during the early subacute phase after stroke.
- Trial name
- NCT04737395
- Testing
- upper extremity training program ("Meditouch","MSQUARE")
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Cerebral Palsy
Treatment of Children With Cerebral Palsy With Autologous Umbilical Cord Blood, a Pilot Study
This study is a phase II, prospective, double blind, placebo-controlled study of the efficacy of autologous umbilical cord blood infusion.
- Trial name
- NCT04243408
- Testing
- Autologous umbilical cord blood transfusion
- Where
- Israel
- Volunteers
- 72 people
- Sponsor
- Sheba Medical Center
Congenital Heart Disease, Brain Injuries
Autologous Umbilical Cord Blood Treatment of Neonate With CHD
The aim of the study is to evaluate the feasibility and safety and efficacy of collecting and infusing autologous umbilical cord blood (UCB) in newborn infants with hypoplastic left heart syndrome (HLHS) and transposition of…
- Conditions
- Congenital Heart Disease, Brain Injuries, Low Cardiac Output Syndrome, Neonatal Disorder
- Trial name
- NCT03558269
- Testing
- Autlogous UCB infusion
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Autistic Spectrum Disorder
Treatment of Children With Autistic Spectrum Disorder With Autologous Umbilical Cord Blood, a Pilot Study
This study is a phase II, prospective, double blind, placebo-controlled study of the efficacy of autologous umbilical cord blood infusion. The study population will consist of 60 children ages 18 months to 12 years with ASD.
- Trial name
- NCT04243382
- Testing
- Autologous umbilical cord blood
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Wound Heal, Duplex Volume Flow
Correlation Between the Volume Flow of the CFA After Angioplasty of Critical Ischemic Limb and Wound Healing
in our study we are examining the volume flow of the common femoral artery before and after angigraphy of a critical ischemic limb, as a predictor for wound healing after the treatment
- Trial name
- NCT04672668
- Testing
- duplex ultrasound for the common femoral artery
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Radiation Dermatitis
Use of Gelronate Gel vs. Aloevera in Preventing/Minimizing Radiation-induced Dermatitis in Breast Cancer Patients
The aim of the study is to evaluate the effect of Gelronate gel, NaHA based product (medical device for topical application) vs.
- Trial name
- NCT03941665
- Testing
- Gelronate, Aloevera
- Where
- Israel
- Volunteers
- 136 people
- Sponsor
- Sheba Medical Center
Acute Lymphoblastic Leukemia, B-precursor, Non-Hodgkin Lymphoma, B-cell
T-cells Expressing Anti-CD19 CAR in Pediatric and Young Adults With B-cell Malignancies
This phase 1 / 2 study will evaluate the response of B-cell malignancies expressing CD19 to autologous T cells transduced with a second generation anti-CD19 chimeric antigen receptor in children and young adults.
- Trial name
- NCT02772198
- Testing
- CD19 CAR T cells
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Urine Output Decreased
Automatic Urine Output Measuring Device Performance Validation and Efficacy.
To evaluate the efficacy of Serenno Medical Automatic Urine Output measuring device in patients with indwelling urinary catheter hospitalized in the cardiac surgery intensive care unit.
- Trial name
- NCT03952689
- Testing
- Serenno Medical Automatic Urine Output measuring device
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Pulmonary Disease, Chronic Obstructive, Rehabilitation
Remote Prescribed and Monitored Exercise Program After Pulmonary Rehabilitation in Individuals With Chronic Lung Disease
Remote Prescribed and Monitored Exercise Program After Pulmonary Rehabilitation in Individuals with Chronic Lung Disease
- Trial name
- NCT04599387
- Testing
- Remote Exercise Prescription, Usual Care
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
Osteoporosis Fracture, Spinal Cord Injuries
Evaluation of Romosozumab vs. Zoledronic Acid Effect in Patients With Spinal Cord Injury and Low Bone Mineral Density
This is a randomized study to determine the effects of monthly romosozumab for one year or one-time zoledronic acid on bone mineral density (BMD) and biochemical markers of bone formation and resorption, in patients with spinal…
- Trial name
- NCT04597931
- Testing
- Romosozumab, Zoledronic Acid
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Inferior Vena Cava Thrombosis
Study on Inferior Vena Cava Thrombosis
This study will focus on patients having inferior vena cava (IVC) thrombosis, either with or without thrombosis in other veins. The purpose of this study is to assess risk factors, safety and effectiveness of treatment options…
- Trial name
- SIVECT (NCT04470986)
- Volunteers
- 200 people
- Sponsor
- Sheba Medical Center
The Relationship Between Oral Vitamin A Administration and the Incidence of BPD in Preterm Infants Born Before Week 29 of Pregnancy
Vitamin A for BPD Prevention
Chronic bronchopulmonary dysplasia (BPD) is a very common complication in preterm infants born at a young gestational age, and is a serious disease that impairs respiratory long-term outcome and is associated with…
- Trial name
- NCT04563429
- Testing
- Oral Vitamin A
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Non-Hodgkin's Lymphoma
Zevalin-beam for Aggressive Lymphoma
The study hypothesis is that the addition of zevalin radioimmunotherapy to the conditioning regimen given prior to BEAM high-dose chemotherapy and autologous stem cell transplantation in patients with aggressive lymphoma will…
- Trial name
- NCT00491491
- Testing
- ibritumomab tiuxetan, BEAM chemotherapy and autologous stem-cell transplantation
- Where
- 9 sites in United States, Germany and 2 more
- Volunteers
- 60 people
- Sponsor
- Sheba Medical Center
Acute Myelogenous Leukemia, Allogeneic Stem Cell Transplantation
Bisantrene for Relapsed /Refractory AML
Induction of response in patients with AML that are either primary resistant (failed induction and or salvage therapy) or relapsed including post allogeneic stem cell transplantation and failed salvage therapy or cannot receive…
- Trial name
- NCT03820908
- Testing
- Bisantrene
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Sheba Medical Center
Newly Diagnosed Glioblastoma Who Underwent at Least Partial Resection of the Tumor Surgically
Potentiation of Chemotherapy in Brain Tumors by Zinc
Glioblastoma (GB) is the most common and aggressive type of primary malignant brain tumor in adults. Despite advances in surgical resection, radiotherapy and chemotherapy, prognosis remains very poor.
- Trial name
- NCT04488783
- Testing
- zinc and ascorbate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center