Clinical trials: sponsored by Tanta University
Cardiotoxicity
Cardioprotection Effect of Linagliptin
1. Background and Rationale Breast cancer is one of the most common malignancies affecting women worldwide and represents a major health burden in Egypt.
- Trial name
- Linagliptin (NCT07852546)
- Testing
- Doxorubicin, Empaglifloz 5 mg orally once daily
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Tanta University
Breast Cancer
Comparative Study Between (SGLT-2i) and (DPP-4i) in the Prevention of DIC
Background: Breast cancer is the most frequently diagnosed malignancy among women worldwide and a major cause of morbidity and mortality.
- Trial name
- SGLT2i/DPPi (NCT07436663)
- Testing
- Dapagliflozin (5-10 mg daily) - SGLT2 Inhibitor Therapy, Sitagliptin (DPP4 inhibitor), Standard Care (in control arm)
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tanta University
Hysterectomy, Ovarian Cyst
Oral Contraceptive Pills on Woman With Post Hysterectomy Ovarian Cyst
To evaluate the therapeutic effect of combined oral contraceptive pills in women with benign post-hysterectomy ovarian cysts.
- Conditions
- Hysterectomy, Ovarian Cyst, Contraceptive
- Trial name
- NCT07876037
- Testing
- Group 1 (Control group), Group 2 (Study group)
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Nail Psoriasis
Comparative Study of Intralesional Methotrexate Versus Intralesional Triamcinolone Acetonide in Treatment of Nail Psoriasis
The goal of this clinical trial is to compare methotrexate injections with triamcinolone acetonide injections for treating nail psoriasis.
- Trial name
- NCT07875608
- Testing
- Methotrexate, Triamcinalone Acetonide
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Tanta University
Evaluate the Anatomical Variations of the Palatal Canal in Maxillary Permanent Molars Using CBCT
Hidden Complexities of the Palatal Canal in Maxillary Permanent Molars
the current study will be directed to evaluate the anatomical variations of the palatal canal in maxillary permanent molars using CBCT
- Trial name
- NCT07870863
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Tanta University
Inflammatory Bowel Diseases
Repurposing Fenofibrate in Modulating AMPK/NLRP3 Inflammasome in Patients With Ulcerative Colitis
Fibrates, specific pharmacological agonists of PPARα, have been widely used to treat hypercholesterolemia and hypertriglyceridemia.
- Trial name
- NCT05781698
- Testing
- Mesalamine, Fenofibrate
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Fibrinogen, Albumin
Fibrinogen-to-Albumin Ratio as a Predictor of Acute Respiratory Distress Syndrome in Traumatic Brain Injury
this study aims to assess the ability of fibrinogen-to-albumin ratio to predict the development of Acute respiratory distress syndrome in traumatic brain injury patients.
- Conditions
- Fibrinogen, Albumin, ARDS, TBI (Traumatic Brain Injury)
- Trial name
- FARDS (NCT07664358)
- Testing
- Fibrinogen-to-albumin ratio
- Where
- Egypt
- Volunteers
- 350 people
- Sponsor
- Tanta University
CAD/CAM, 3D-printed
Clinical Evaluation of 3D-Printed Resin Versus CAD/CAM-Milled Lithium Disilicate Overlay Restorations
The aim of this study is to clinically evaluate the performance of 3D-printed resin and CAD/CAM lithium disilicate overlay restorations.
- Conditions
- CAD/CAM, 3D-printed, Lithium Disilicate, Overlay Restorations
- Trial name
- NCT07853118
- Testing
- 3D-printed ODYX-CR ceramic-filled resin, CAD/CAM-milled lithium disilicate ceramic
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tanta University
Postoperative Pain
Assessment of Postoperative Pain Following Root Canal Obturation of Permanent Mature Teeth Using Three Different Obturation Techniques: A Randomized Clinical Trial
purpose: to evaluate the postoperative pain incidence and intensity after three different obturation techniques (Cold lateral condensation technique (CLC), Vibration thermo-dynamic technique (Vibra-Tho) and Injection of…
- Trial name
- NCT07863622
- Testing
- Cold Lateral condensation technique, Vibration thermo-dynamic technique, Injection of thermo-plasticized gutta-percha
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Cross Bite, Malocclusion
Impact of Anterior Cross Bite Treatment on Children's Speech Performance
The goal of this prospective, single-arm clinical trial is to evaluate the speech performance of children with anterior dental crossbite before and after correction.
- Conditions
- Cross Bite, Malocclusion, Speech, Quality of Life
- Trial name
- NCT06168695
- Testing
- removable anterior expansion screw, Speech and language evaluation, Oral Health Related Quality of Life (OHRQoL) Assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Edentulism in Lower Jaw
Evaluation of PEEK Versus Titanium Bar Attachments With Implant Assisted Mandibular Complete Overdenture Fabricated by CAD/CAM Technology
Evaluation of PEEK versus Titanium Bar Attachments with Implant Assisted Mandibular Complete Overdenture fabricated by CAD/CAM Technology measuring retention of the overdenture and implant evaluation for 6 months and one year
- Trial name
- Evaluation (NCT07262307)
- Testing
- implant overdenture
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Tanta University
Sepsis
Effect of Adjunctive Ursodeoxycholic Acid on Oxidative Stress, Inflammation, and Organ Dysfunction in Adults With Sepsis
epsis is a life-threatening syndrome characterized by acute organ dysfunction resulting from a dysregulated host response to infection.
- Trial name
- NCT07852780
- Testing
- Standard medical treatment, Ursodeoxycholic Acid
- Volunteers
- 80 people
- Sponsor
- Tanta University
3-Needle, 5-Needle
3-Needle vs 5-Needle of Genicular Nerve Block on Pain and Quality of Life in Knee Osteoarthritis
This study aims to compare the 3-needle and 5-needle of genicular nerve block on pain and quality of life in Knee osteoarthritis (KOA).
- Conditions
- 3-Needle, 5-Needle, Genicular Nerve Block, Pain
- Trial name
- NCT07853170
- Testing
- 3-nerve-targeted group, 5-nerve-targeted group
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Space Maintenance, Gingival Health
Clinical Evaluation of 3-D Printed Partial Denture Space Maintainer
Primary dentition is the most suitable space maintainer for permanent teeth. However, as infants often lose their primary teeth too soon, using a space maintainer is the most efficient, long-lasting, and economical way to prevent…
- Trial name
- NCT06825273
- Testing
- space maintainer
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
3D-Printed, Direct Composite
Clinical Evaluation of 3D-Printed Versus Direct Composite Restorations in Class II Cavities
The aim of this study is to clinically evaluate the performance of 3D-printed composites compared to direct conventional composite restorations in Class II cavities
- Conditions
- 3D-Printed, Direct Composite, Resin Restorations
- Trial name
- NCT07861659
- Testing
- PG4 Dentsprint 3D-printed composite resin, Filtek P60 (3M) Packable composite
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Emergence Agitation
Preemptive Intravenous Micro-dose Dexmedetomidine to Prevent Emergence Agitation in Adult Patients Undergoing Septoplasty Surgeries
This prospective randomized controlled study will be conducted to evaluate the effect of preoperative single, micro-dose of dexmedetomidine (0.3μg/kg) on the incidence and severity of EA in adults undergoing Septoplasty surgeries
- Trial name
- NCT07302815
- Testing
- Dexmedetomidine, Saline
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
Removal of Intracanal Medication
Removal of Intracanal Medicaments by Different Techniques Using Cone Beam Computed Tomography Analysis
the goal of this study is to evaluate the efficency of different activation techniques in removal of intracanal medication using cone beam computed tomography analysis
- Trial name
- Ca(OH)2- CBCT (NCT07719985)
- Testing
- Manual Dynamic Agitation, Sonic Activation, XP-Endo Finisher Activation
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Pulpitis Reversible, Pulp Exposure, Dental
Pomegranate Peel Extract for Primary Molar Pulpotomy
Pomegranate peel extract has demonstrated a range of potential uses in the biomedical industry in recent years because of its numerous benefits, which include anti-inflammatory, antibacterial, anti-apoptotic, antioxidant, and…
- Trial name
- NCT07108738
- Testing
- Pulpotomy, Radiation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Tanta University
Thyroidectomy, Bupivacaine
Ketamine Versus Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound Guided Bilateral Superficial Cervical Plexus Block in Thyroidectomy
The aim of this study is to compare the analgesic efficacy of Dexmedetomidine and Ketamine as adjuvants to Bupivacaine in ultrasound-guided Bilateral SCPB in patients undergoing thyroidectomy
- Conditions
- Thyroidectomy, Bupivacaine, Dexmedetomidine
- Trial name
- NCT07838831
- Testing
- Group C (Control group), Group D (Dexmedetomidine group), Group K (Ketamine group)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Spinal Induced Hypotension, Old Age; Debility
Efficacy of Subclavian Vein/Artery Diameter Index in Predicting the Incidence of the Spinal-Induced Hypotension in Geriatric Patients
The hypothesis of the study will be that the subclavian vein/subclavian artery diameter (SCVD/SCAD) index will be a good predictor of spinal-induced hypotension in geriatric patients.
- Trial name
- NCT07286422
- Testing
- Assessment of the SCV & SCA, Assessment of the IVC and aorta
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Tanta University