Clinical trials: sponsored by Tel-Aviv Sourasky Medical Center
Diabetes Mellitus, Type 2, Sarcopenia
Mediterranean Diet, Circuit Resistance Training, Empagliflozin in Elderly With Type 2 Diabetes: a Study Protocol
Primary objective: To assess the effects of a modified plant-based Mediterranean diet (vegeterranean diet), circuit resistance training (CRT) and empagliflozin alone or in combination on metabolic and physical function in elderly…
- Conditions
- Diabetes Mellitus, Type 2, Sarcopenia, Weight Loss
- Trial name
- NCT03560375
- Testing
- Circuit resistance training (CRT), Vegeterranean diet (V-Med diet), Empagliflozin 10 MG
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Gender Dysphoria, Adult, Blood Coagulation
Comparing the Effects of Sublingual Estradiol Treatment Versus Oral Estradiol With Cyproterone Acetate (CPA) Treatment on The Coagulation System in Transgender Women: A Prospective, Controlled Cohort Study
The goal of this clinical trial is to learn about the effects of different routes of estradiol administration on blood clotting in transgender women starting gender-affirming hormone therapy.
- Conditions
- Gender Dysphoria, Adult, Blood Coagulation, Coagulation Factors, Transgender Persons, M01.777.500
- Trial name
- NCT07145281
- Testing
- Estradiol (E2), Cyproterone Acetate (Androcur, BAY94-8367)
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Myeloma, Lymphoma
Assesment of the Immune Response to RSV Vaccine in Patients With Myeloma, Lymphoma and Hematological Leukemia
A prospective study in which hematological oncology patients who were vaccinated against RSV will undergo a blood test to assess their immune response to the vaccine.
- Conditions
- Myeloma, Lymphoma, CLL, Myelodysplastic Syndrome
- Trial name
- NCT06944119
- Where
- Israel
- Volunteers
- 250 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
Cyclosporine in Combination With Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Refractory to Carfilzomib and High Expression of PPIA Gene in Myeloma Cells
This phase 1, open-label, single-arm, prospective, single center study will evaluate the safety, tolerability and efficacy of cyclosporine in combination with carfilzomib and dexamethasone in patients with relapsed and refractory…
- Trial name
- NCT04813653
- Testing
- cyclosporine in combination with carfilzomib and dexamethasone
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Metabolic and Bariatric Surgery
Tailored One Anastomosis Gastric Bypass
One Anastomosis Gastric Bypass (OAGB) is the most common metabolic and bariatric surgery (MBS) in Israel, recognized for its effectiveness in achieving sustainable weight loss and mitigating obesity-related diseases.
- Trial name
- OAGB-TL (NCT06829381)
- Testing
- Tailored BPL length, Control - BPL 180 cm
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Ovarian Cancer, Ovarian Cancer Metastatic Recurrent
Inhibiting Beta-adrenergic and COX-2 Signaling During the Perioperative Period to Reduce Ovarian Cancer Progression
This study investigates the impact of perioperative inhibition of beta-adrenergic and COX-2 signaling in ovarian cancer patients undergoing debulking surgery.
- Trial name
- OC-POP-PT (NCT06839144)
- Testing
- Propranolol (Beta-Blocker) and Etodolac (COX-2 Inhibitor)
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions
Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older Adults
This study is testing how different types of protein - from red meat, legumes (like lentils and beans), or a mix of both - affect muscle strength, body composition, and metabolic health in older adults with obesity who are also…
- Conditions
- Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions, Obesity (Body Mass Index >30 kg/m2), Sarcopenia
- Trial name
- NCT07030738
- Testing
- Legume-Based High-Protein Diet + Resistance Training, Meat-Based High-Protein Diet + Resistance Training, Mixed Legume and Meat High-Protein Diet + Resistance Training
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
ST Segment Elevation Myocardial Infarction (STEMI), Cardiogenic Shock Post Myocardial Infarction
Early Beta Blocker Administration in STEMI Patients With SCAI B Status
This study is looking at how a medication called beta-blockers (metoprolol) affects patients with a heart attack (STEMI) who are in the cardiac intensive care unit.
- Trial name
- NCT06967194
- Testing
- Metoprolol (MET), Plcacebo
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pain Management, Critical Illness
Evaluation of Fentanyl Transdermal Patch Absorption in Hemodynamically Unstable ICU Patients.
This study investigates how well fentanyl is absorbed through the skin when delivered via a transdermal patch in critically ill surgical ICU patients.
- Trial name
- NCT06966869
- Testing
- Transdermal fentanyl patch
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Temporomandibular Disorders (TMD), Temporomandibular Dysfunction (TMD)
Emotional Release After Trigger Point Needling to Treat Myofascial Pain of the Head and Neck - Prospective Study
Temporomandibular Dysfunction (TMD) as classified by the DC-TMD has a significant psychosocial component referred to as "Axis II".
- Conditions
- Temporomandibular Disorders (TMD), Temporomandibular Dysfunction (TMD), Temporomandibular Joint and Muscle Disorder
- Trial name
- NCT06912438
- Testing
- Fill out questionnaire
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Multiple Myeloma (MM)
Multiple Myeloma is a Hematologic Malignancy Characterized by the Accumulation of Malignant Plasma Cells in the Bone Marrow. Despite Advances in Treatment, Many Patients Experience Disease Relapse. Bispecific Antibodies Offer an Innovative Therapeutic Approach, But Approximately 30%-40% of Patients
This prospective, non-interventional study aims to characterize the molecular and cellular mechanisms underlying the response and resistance of multiple myeloma (MM) patients to bispecific antibodies (BisAb) and CAR-T therapies.
- Trial name
- MMOMICS (NCT06888856)
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Multiple Sclerosis
The Effect of a Mediterranean Diet on Quality of Life in Multiple Sclerosis Patients
The role of dietary interventions in improving symptoms of multiple sclerosis (MS) is of high interest amongst patients and researchers, but data supporting this evidence are limited.
- Trial name
- Mediet4MS (NCT06764563)
- Testing
- Mediterranean Medical Nutrition Therapy (counselling)
- Where
- Israel
- Volunteers
- 140 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Crohn Disease, Ulcerative Colitis
Special Physical Exercises as a Therapeutic Intervention for Inflammatory Bowel Disease
The investigator is hypothesize that physical activity can have positive effects on health, general well-being , sleep quality and stress in Inflammatory Bowel Disease patients.
- Trial name
- NCT04303260
- Testing
- Physical exercises
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Temperature Change, Body, Cesarean Delivery
Maternal Postop Temperature After Cesarean Delivery
It is unclear whether routine addition of intra-operative forced-air warming in addition to warmed intravenous fluids during cesarean delivery under spinal anesthesia is beneficial.
- Conditions
- Temperature Change, Body, Cesarean Delivery, Spinal Anesthesia
- Trial name
- NCT05661136
- Testing
- Warm air blower, Control: Lower body blanket not attached to warm air blower
- Where
- Israel
- Volunteers
- 66 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
PD - Parkinson's Disease
Freezing of Gait - Clinical Outcomes Assessment
To develop a reliable and accurate clinician-reported outcome (ClinRO) measure (against a new and precise definition) and patient reported outcome (PRO) for use by clinicians and researchers to quantify the severity of Freezing…
- Trial name
- FOG-COA (NCT06519279)
- Testing
- Opals, Axivity
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pain, Injection
Does Pre-injection Local Anesthesia Affect Experienced Pain During Intra-articular Hip Injections.
Intra-articular hip injections are commonly used for diagnostic and therapeutic purposes but are often associated with patient anxiety and fear.
- Conditions
- Pain, Injection, Prevention, Assessment
- Trial name
- NCT06760559
- Testing
- Intra-articular corticosteroid injection
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Transgender, Transgender Persons, M01.777.500
Changes in Energy Expenditure (EE) in Transsexuals Undergoing Hormonal Therapy
Examining Metabolic Rate in Transgender individuals before starting hormonal treatment and 6-12 months after initiation
- Trial name
- NCT06733415
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Junctional Hemorrhage, Extremity Hemorrhage
Blind Vs US Guided Manual Pressure Points
the goal of this clinical trial is to compare the effectiveness of manual pressure points (femoral and supra-clavicular) for hemorrhage control by military medics using either the traditional blind manual technique or an…
- Trial name
- NCT06007209
- Testing
- Manual Pressure Point
- Where
- Israel
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Pain, Postoperative, Anesthesia
Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain.
We propose a double-blind randomized controlled trial to evaluate the effect of intravenously administered morphine at surgery conclusion on acute postoperative pain in patients recovering from craniotomy surgery.
- Conditions
- Pain, Postoperative, Anesthesia, Analgesia
- Trial name
- NCT05117034
- Testing
- Morphine, Nacl 0.9%
- Where
- Israel
- Volunteers
- 115 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Oral Lichen Planus
Hypnotherapy for Oral Lichen Planus. Patients with Clinically and Histologically Confirmed Oral Lichen Planus Would Be Randomized for Hypnotherapy Vs Psychoeducation About the Pyschoneuroimmune System. Follow Up Would Be Done At 2, 6, 12 Weeks After.
60 patients with clinically and histologically confirmed Oral Lichen Planus, which are are typically followed up at our oral mucosal disease clinic with a standing diagnosis for at least 1 year would be randomized.
- Trial name
- HypnOLP (NCT06697574)
- Testing
- Hypnosis aimed at stress reduction and health of the oral mucosa, Psychoeducation
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center