Clinical trials: sponsored by The Cleveland Clinic
Multiple Sclerosis
The Therapeutic Effects of Forced Aerobic Exercise in Multiple Sclerosis
This project will investigate the feasibility and initial efficacy of two aerobic exercise training approaches, forced and voluntary, to improve motor function in persons with multiple sclerosis (MS).
- Trial name
- NCT04906057
- Testing
- Forced Aerobic Exercise (FE), Voluntary Aerobic Exercise (VE)
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- The Cleveland Clinic
Surgery
The COSMOS Trial. A Pilot Study A Pilot Study
The investigators plan a pilot study to evaluate patient tolerance of the GE Portrait Mobile Monitoring Solution, along with appropriate alert thresholds, and clinical utility.
- Trial name
- NCT05280574
- Testing
- Blinded GE Portrait Monitoring, Unblinded GE Portrait Monitoring
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The Cleveland Clinic
Type 2 Diabetes
Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2D
This study is designed to determine whether therapy with once-weekly sc semaglutide in combination with once-daily insulin degludec will be capable of maintaining (or improving) glycemic control, when substituted for multiple…
- Trial name
- TRANSITION-T2D (NCT04538352)
- Testing
- Semaglutide, Insulin Degludec, Insulin aspart
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Neuromuscular Blockade
Postoperative Urinary Retention in Patients After Noncardiac Surgery and Reversal of Neuromuscular Block
The investigators propose a randomized trial comparing sugammadex and neostigmine for the reversal of neuromuscular blocks induced by rocuronium or vecuronium in adults having general anesthesia with muscular block for noncardiac…
- Trial name
- NCT05545280
- Testing
- Neostigmine with glycopyrrolate, Sugammadex
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The Cleveland Clinic
Surgery
McGrath Videolaryngoscopy and Direct Laryngoscopy Rapid Sequence Intubation
The study seeks to compare the efficacy of conventional direct laryngoscopy using a Macintosh blade with the McGrath videolaryngoscope for rapid sequence endotracheal intubation.
- Trial name
- NCT05850052
- Testing
- McGrath videolaryngoscope for rapid sequence endotracheal intubation, Conventional direct laryngoscopy using a Macintosh blade
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- The Cleveland Clinic
Postoperative Pain, Opioid Use
STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial
Overprescribing opioids is considered a major contributor to the opioid crisis. Hill et al. demonstrated that within a general surgery practice, over 70% of the prescribed opioid pills were never taken.
- Conditions
- Postoperative Pain, Opioid Use, Prolapse; Female, Incontinence
- Trial name
- STOP-PAIN (NCT04491617)
- Testing
- Standard opioid prescribing, Restrictive opioid prescribing
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- The Cleveland Clinic
Telangiectasia, Hereditary Hemorrhagic
Pomalidomide for the Treatment of Bleeding in HHT
This is a Phase II placebo-controlled double-blind study of pomalidomide in patients with hereditary hemorrhagic telangiectasia (HHT) with moderate to severe epistaxis who have anemia and/or require parenteral iron infusions or…
- Trial name
- PATH-HHT (NCT03910244)
- Testing
- Pomalidomide Oral Product
- Where
- 14 sites in United States
- Volunteers
- 145 people
- Sponsor
- The Cleveland Clinic
Satisfaction, Patient
Virtual Visits for Postoperative Care Following Urogynecologic Surgery
The proposed VIDEO randomized trial will help inform clinical practice regarding the utility and perceived value of videoconferencing for postoperative care of urogynecologic patients by comparing patient satisfaction with…
- Trial name
- VIDEO (NCT05641077)
- Testing
- Virtual Visit, Office Visit
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Cleveland Clinic
Osteoporosis, Fractures, Bone
A Comparison of Serum and Urine N-telopeptide Marker
This is a prospective specimen collection cohort study to evaluate the correlation between serum and urine values of the bone marker of interest, and their association with baseline DEXA scan measures and fracture risk within 6…
- Trial name
- NCT05326815
- Testing
- N-Telopeptide, Bone Marker
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- The Cleveland Clinic
Type 2 Diabetes, Obesity
EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial
This is a pragmatic, 24 month, single-center, randomized, open-label, parallel-group trial comparing an obesity-centric approach with a medically-supervised and comprehensive weight loss program (Cleveland Clinic's Endocrinology…
- Trial name
- EMPOWER-T2D (NCT04531176)
- Testing
- Weight Management Program (WMP), Traditional care, Phentermine / Topiramate Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- The Cleveland Clinic
Autism Spectrum Disorder, Sleep Disturbance
Telehealth Delivery of Treatment for Sleep Disturbances in Young Children With Autism Spectrum Disorder
Study Design: Ninety children with Autism Spectrum Disorder (ASD), between the ages of 2 to less than 7 years, and their parents will be recruited for this 10 week randomized clinical trial.
- Trial name
- NCT03668873
- Testing
- Sleep Parent Training, Sleep Parent Education
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- The Cleveland Clinic
Intubation, Laryngoscopy
Endotracheal Intubation Using Videolaryngoscopy Versus Conventional Direct Laryngoscopy
The investigators will evaluate the endotracheal intubation using video laryngoscopy versus conventional direct laryngoscopy on intubation success, quantified by the number of intubation attempts.
- Trial name
- NCT04701762
- Testing
- GlideScope videolaryngoscope (Verathon, Bothell, Washington 98011), Direct laryngoscopy
- Where
- United States
- Volunteers
- 7,736 people
- Sponsor
- The Cleveland Clinic
Vaginal Hysterectomy, Laparoscopic Supracervical Hysterectomy
Vaginal Hysterectomy vs Supracervical Hysterectomy at the Time of Sacrocolpopexy
The primary objective of the proposed study is to determine the difference in surgical time between minimally invasive (laparoscopic) sacrocolpopexy performed with concurrent vaginal hysterectomy versus laparoscopic supracervical…
- Trial name
- ColoplastLSC (NCT04797585)
- Testing
- Laparoscopic supracervical hysterectomy, Vaginal hysterectomy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The Cleveland Clinic
Parkinson Disease
Dual-task Augmented Reality Treatment for Parkinson's Disease
Activities of daily living (ADL) frequently involve the simultaneous performance of two or more tasks, such as crossing the street while holding a conversation, commonly referred to as dual tasking.
- Trial name
- DART (NCT04634331)
- Testing
- Augmented Reality Multi-Modal Training, Traditional Multi-Modal Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The Cleveland Clinic
Osteo Arthritis Knee
Euflexxa for the Treatment of Osteoarthritis
The effect of Euflexxa therapy for knee osteoarthritis on levels of inflammatory and degenerative synovial fluid bio-markers in patients with knee osteoarthritis
- Trial name
- NCT03459365
- Testing
- Euflexxa
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Pelvic Organ Prolapse, Urinary Incontinence,Stress
Timing of Repeat Voiding Trials After Outpatient Pelvic Floor Surgery
This study is a randomized controlled trial designed to assess the rate of failure of voiding trials in the early and late post-operative period within patients who underwent outpatient pelvic floor surgery that failed initial…
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence,Stress, Surgery
- Trial name
- NCT03048682
- Testing
- Foley catheter - Early Voiding Trial, Foley catheter - Late Voiding Trial
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- The Cleveland Clinic
Overactive Bladder, Urinary Tract Infection
Urinary Cytokines in Patients With Overactive Bladder (OAB)
Overactive bladder (OAB) is a widespread condition characterized by urgency, urge incontinence, nocturia and excessive urinary frequency, affecting millions of people worldwide.
- Trial name
- NCT00868621
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Postoperative Pain
Preoperative Education
The investigators will evaluate the effect of preoperative education on postoperative opioid.
- Trial name
- NCT04970069
- Testing
- Video on analgesic education, Video on general perioperative education
- Where
- United States
- Volunteers
- 1,057 people
- Sponsor
- The Cleveland Clinic
Postoperative Pain
Feasibility Study for Intrathoracic Nerve Stimulation
The purpose of this study is to conduct an early clinical evaluation of safety and feasibility of peripheral nerve stimulation (PNS) of the intercostal nerves using an electrical lead placed in the thoracic cavity as a safe and…
- Trial name
- NCT04066374
- Testing
- Peripheral Nerve Stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cleveland Clinic
Anesthesia; Adverse Effect
Postoperative Consequences of Intraoperative NOL Titration
To demonstrate that intraoperative NOL-guided titration of fentanyl improves initial recovery characteristics.
- Trial name
- NCT04679818
- Testing
- Routine opioid management, PMD-200 Nol-guided opioid administration
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- The Cleveland Clinic