Clinical trials: sponsored by The Methodist Hospital Research Institute
Estrogen Receptor Positive Breast Cancer
TAK-228 Plus Tamoxifen in Patients With ER-Positive, HER2-negative Breast Cancer
This is an open label phase II clinical trial to determine the efficacy, toxicity, and safety of TAK-228 plus tamoxifen in patients with newly diagnosed ER-positive, HER2-negative breast cancer.
- Trial name
- ANETT (NCT02988986)
- Testing
- TAK-228, Tamoxifen
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- The Methodist Hospital Research Institute
Breast Cancer
Neoadjuvant TDM1 With Lapatinib and Abraxane Compared With Trastuzumab Plus Pertuzumab With Paclitaxel
This is a randomized, open label Phase II neoadjuvant study comparing the efficacy and safety of trastuzumab emtansine (T-DM1) plus lapatinib (L)followed by abraxane (A) versus trastuzumab plus pertuzumab followed by paclitaxel…
- Trial name
- TEAL (NCT02073487)
- Testing
- T-DM1, Trastuzumab, Lapatinib
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- The Methodist Hospital Research Institute
Lung Neoplasms, Thoracic Neoplasms
A Multimodality Image-guided System for Peripheral Lung Cancer Diagnosis and Therapy
The goal of this clinical research study is to test the use of a minimally invasive multimodality image-guided (MIMIG) intervention system used for performing a lung biopsy.
- Conditions
- Lung Neoplasms, Thoracic Neoplasms, Neoplasms by Site, Neoplasms
- Trial name
- MIMIG (NCT02111824)
- Testing
- MIMIG System, Indocyanine Green (ICG)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The Methodist Hospital Research Institute
Bladder Dysfunction, Neurogenic Bladder
Deep Brain Stimulation in Patients With LUTS
Deep brain stimulation (DBS) is a neurosurgical procedure using a device that improves motor symptoms of specific neurological and movement disorders such as Parkinson's disease or Essential Tremor.
- Trial name
- NCT03202251
- Testing
- It's is a cohort
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The Methodist Hospital Research Institute
Rabies, Rabies Human
Improving Adherence to Rabies PEP Guideline Recommendations
This quasi-experimental, quality improvement study will be conducted across the Houston Methodist system, including all hospital-based and freestanding emergency departments (ED).
- Conditions
- Rabies, Rabies Human, Rabies Virus Infection
- Trial name
- NCT04213950
- Testing
- Rabies PEP quality improvement bundle
- Where
- 15 sites in United States
- Volunteers
- 70 people
- Sponsor
- The Methodist Hospital Research Institute
Spinocerebellar Ataxia Type 10
Genetic Mechanism of Conserved Ancestral Haplotype in SCA10
Spinocerebellar ataxia type 10 (SCA10) is a hereditary ataxia whose ancestral mutation occurred in East Asia. The mutation is likely to have migrated during peopling of American continents from East Asia.
- Trial name
- CAHSCA10 (NCT04495426)
- Testing
- Non-interventional study
- Where
- 3 sites in United States, Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
High-risk Prostate Cancer, Prostate Cancer
Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & Surgery
This is a prospective phase II study to assess the efficacy and toxicity of HSV-tk+ valacyclovir gene therapy in combination with androgen deprivation therapy, brachytherapy, external beam radiotherapy, and prostatectomy in…
- Trial name
- NCT03541928
- Testing
- HSV-Tk, Valacyclovir, Bicalutamide
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Methodist Hospital Research Institute
Acute (Cellular) Renal Allograft Rejection
Single Dose rATG for Renal Allograft Rejection
Rabbit antithymocyte globulin (rATG) is approved for the treatment of acute rejection following kidney transplantation and is routinely administered as a series of 5-7 consecutive daily doses via central intravenous…
- Trial name
- NCT02102854
- Testing
- rATG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Methodist Hospital Research Institute
COVID-19 Infection
Clazakizumab vs. Placebo - COVID-19 Infection
The purpose of this study is to investigate the effectiveness and safety of treatment with clazakizumab compared to a placebo (inactive substance).
- Trial name
- NCT04494724
- Testing
- Clazakizumab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Methodist Hospital Research Institute
Degenerative Disc Disease, Spondylolisthesis, Lumbar Region
Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions
Spinal operations including lumbar fusions for degenerative disorders are becoming more prevalent as the population ages. Inadequate or excessive postoperative analgesia can result in medical comorbidities and prolonged hospital…
- Trial name
- NCT04112550
- Testing
- Methadone Hydrochloride, Oxycodone-Acetaminophen
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Vaginal Vault Prolapse, Post-Hysterectomy Vaginal Vault Prolapse
Intraperitoneal and Extraperitoneal Uterosacral Ligament Suspensions for Post-Hysterectomy Vaginal Vault Prolapse
Post-hysterectomy vaginal vault prolapse is a common pelvic floor disorder described as descent of the vaginal apex after hysterectomy.
- Conditions
- Vaginal Vault Prolapse, Post-Hysterectomy Vaginal Vault Prolapse, Prolapse, Vaginal
- Trial name
- NCT04172896
- Testing
- Intraperitoneal Uterosacral Ligament Suspension, Extraperitoneal Uterosacral Ligament Suspension
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The Methodist Hospital Research Institute
BK Virus Infection
Ciprofloxacin for Prevention of BK Infection
BK infection is an important cause of graft dysfunction and graft loss after renal transplantation. It has been widely accepted that emergence of BK virus correlates with the more potent immunosuppressive agents used to lower…
- Trial name
- NCT01789203
- Testing
- Ciprofloxacin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- The Methodist Hospital Research Institute
Accidents Sports, Injury Prevention
An Injury Prevention Program for Professional Ballet
The aim of this study is to evaluate the efficacy of an injury prevention program for professional ballet dancers.
- Trial name
- NCT04110002
- Testing
- Injury Prevention Program
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Acute Heart Failure
Heart Failure Hospital Readmissions and Physical Therapy
This is a dissertation study which is divided into three different studies in order to answer the main research question (Study 3).
- Trial name
- NCT03517514
- Testing
- Physical Therapy service
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- The Methodist Hospital Research Institute
Breast Cancer
Multi-scale Modeling of Breast Conserving Therapy
The proposed study is a single-center, prospective, pilot, observation study to tabulate and measure the changes that occur during treatment and healing for breast conserving therapy (BCT) in women with non-metastatic breast…
- Trial name
- BCT (NCT02310711)
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Heart Failure, Ventricular Dysfunction
The Use of CoSeal (Sealant Agent) in Patients During Left Ventricular Assist Device Surgery
The purpose of this study is to evaluate the use of a device called CoSeal™. CoSeal™ is an FDA approved synthetic (man-made) surgical sealant which is currently used to help stop leaks in blood vessels during surgery.
- Trial name
- NCT01605019
- Testing
- CoSeal, BioGlue® Surgical Adhesive
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- The Methodist Hospital Research Institute
Glioma, Glioblastoma
Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma
It was previously shown that [18F]Fluorodopa (FDOPA) PET imaging results in intended management changes in 41% of brain tumor patients.
- Conditions
- Glioma, Glioblastoma, Glioblastoma Multiforme
- Trial name
- NCT02176720
- Testing
- FDOPA PET
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- The Methodist Hospital Research Institute
Ischemic Stroke
Stroke Recovery and Music or No Music
The primary outcome of this study is to determine the quantitative increase in connectivity, as measured by fMRI brain and calculated as a percent increase from baseline in patients with ischemic stroke.
- Trial name
- NCT03608904
- Testing
- Music listening, Spoken word (language) listening
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The Methodist Hospital Research Institute
Brain Tumor
MRI-Guided LITT for Treatment Metastatic Brain Tumors
The Methodist Hospital Neurological Institute is conducting a clinical trial for patients suffering from Metastatic brain tumors.
- Trial name
- NCT01736722
- Testing
- Visualase®
- Where
- United States
- Sponsor
- The Methodist Hospital Research Institute
Central Nervous System Tumors, Lymphoma
Temozolomide and Topotecan in Treating Patients With Primary CNS Lymphoma
RATIONALE: Drugs used in chemotherapy, such as temozolomide and topotecan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00109798
- Testing
- temozolomide, topotecan hydrochloride
- Sponsor
- The Methodist Hospital Research Institute