Clinical trials: sponsored by Tongji Hospital
Cardiopulmonary Bypass
Amobarbital and Cardiopulmonary Bypass
Explore the effects of amobarbital on myocardial protection and prognosis in patients undergoing cardiac surgery with cardiopulmonary bypass, investigate the new usage of old drugs, and provide reliable clinical scientific basis…
- Trial name
- NCT06757868
- Testing
- Amobarbital, Midazolam
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tongji Hospital
Locally Advanced Proximal Gastric or Gastroesophageal Junction Adenocarcinoma
Neoadjuvant PD-1 Inhibitor Plus SOX Chemotherapy With or Without Short-Course Radiotherapy for Locally Advanced Upper Gastric or GEJ Adenocarcinoma
This study is a prospective, open-label, multicenter, randomized controlled clinical trial designed to enroll patients with previously untreated, resectable locally advanced adenocarcinoma of the upper stomach or gastroesophageal…
- Trial name
- POSIT (NCT07674342)
- Testing
- Short-course Radiotherapy, Neoadjuvant Serplulimab and SOX Chemotherapy
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Tongji Hospital
Postoperative Pain, Chronic Postsurgical Pain
Perioperative Quantitative Sensory Testing and Incision Pain Mapping in Thoracic Surgery
Postoperative pain remains a common and clinically important burden after thoracic surgery and may progress to chronic postsurgical pain.
- Conditions
- Postoperative Pain, Chronic Postsurgical Pain, Thoracic Surgery, Lung Resection
- Trial name
- NCT07653932
- Testing
- Perioperative QST and incision pain mapping assessment
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Tongji Hospital
Prehabilitation, Non Small Cell Lung Cancer
Exercise Prehabilitation for Patients With NSCLC Before Surgery
To explore the safety and compliance of a wearable telemedicine device that can receive basic vital signs in real time, and its active supervision mode with real-time adjustment of exercise prescription for preoperative…
- Conditions
- Prehabilitation, Non Small Cell Lung Cancer, Cardiorespiratory Fitness, Surgery
- Trial name
- NCT05608759
- Testing
- Multimodal prehabilitation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tongji Hospital
Postoperative Complications, Thoracic Surgery
Wearable Device-Based Early Warning of Postoperative Complications in Thoracic Surgery
After thoracic surgery, some patients may develop complications such as lung infection, abnormal heart rhythm, fluid around the lung, prolonged air leak, wound infection, emergency department visits, or hospital readmission.
- Conditions
- Postoperative Complications, Thoracic Surgery, Perioperative Monitoring
- Trial name
- wearable (NCT07646730)
- Testing
- Wearable device-based perioperative monitoring
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Tongji Hospital
Huge Hepatocellular Carcinoma (HCC) (>10cm)
The Application of Locoregional Therapy Combined With Systemic Therapy in the Perioperative Period of Huge Hepatocellular Carcinoma: A Retrospective Cohort Study
This retrospective cohort study collected data of patients with huge hepatocellular carcinoma (HCC) treated between June 1, 2018, and December 31, 2023, through the hospital information system.
- Trial name
- NCT07639294
- Testing
- hepatectomy without immune checkpoint inhibitors-based adjuvant therapy, hepatectomy with immune checkpoint inhibitors-based adjuvant therapy, neoadjuvant conversion therapy followed by surgery
- Where
- China
- Volunteers
- 715 people
- Sponsor
- Tongji Hospital
Hepatitis B, Chronic
A Real-world Study: Analysis of the Efficacy of Antiviral Therapy in CHB Patients Over 30 Years Old, HBV DNA Positive and ALT Normal
This is a prospective observational study of CHB patients who have not received antiviral treatment but HBV DNA are positive.Investigators aim to explore the antiviral effect and influencing factors of patients over 30 years old…
- Conditions
- Hepatitis B, Chronic, Treatment
- Trial name
- NCT07637214
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Liver Cancer (Primary and Metastatic)
Prospective Clinical Database Construction for Liver Cancer Diagnosis and Treatment
This study is a prospective, observational, real-world cohort study. We aim to establish a prospective database in the Department of Hepatobiliary and Pancreatic Surgery, systematically collecting and integrating patients'…
- Trial name
- NCT07587216
- Testing
- liver resection, Systemic therapy combined with locoregional interventions
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Tongji Hospital
HCC - Hepatocellular Carcinoma, Machine Learning
Prospective Evaluation of a Locked Risk-Stratified Surveillance Strategy for Extrahepatic Metastasis in Hepatocellular Carcinoma
This is a multicenter prospective observational cohort study in adults with hepatocellular carcinoma (HCC) without baseline extrahepatic metastasis who are receiving routine clinical management and follow-up at participating…
- Conditions
- HCC - Hepatocellular Carcinoma, Machine Learning, Evaluation
- Trial name
- NCT07444905
- Testing
- Machine Learning-Based Risk Assessment
- Where
- China
- Volunteers
- 1,523 people
- Sponsor
- Tongji Hospital
PCNSL, Primary Central Nervous System Lymphoma
A Multicenter, Prospective Clinical Trial With a Concurrent Control Evaluating Methotrexate Combined With Rituximab,Sintilimab and Pirtobrutinib vs. Investigator-Selected Standard of Care in Treatment-Naive PCNSL
The goal of this clinical trial is to evaluate the efficacy and safety of a four-drug combination regimen as first-line treatment for adults aged 18 years and older with newly diagnosed primary central nervous system lymphoma…
- Trial name
- PRIME-PCNSL (NCT07350850)
- Testing
- Pirtobrutinib, Sintilimab, Rituximab, Methotrexate, Standard of Care (Investigator Selected)
- Where
- 4 sites in China
- Volunteers
- 77 people
- Sponsor
- Tongji Hospital
Patients With Large B-cell Lymphoma Receiving CAR-T Cell Therapy
Study on the Effect of Oral Diammonium Glycyrrhizinate in Attenuating Toxicity and Enhancing Efficacy of CAR-T Cell Therapy
The purpose of this study is to evaluate the effect of oral diammonium glycyrrhizinate in reducing toxicity and enhancing efficacy of CAR-T cell therapy in patients with large B-cell lymphoma.
- Trial name
- NCT07616271
- Testing
- Diammonium glycyrrhizinate Capsules
- Volunteers
- 21 people
- Sponsor
- Tongji Hospital
Perimenopausal Syndrome
Clinical Efficacy Study of Jinfeng Pill in the Treatment of Perimenopausal Syndrome
Perimenopausal syndrome (PMS) is a common condition affecting women during the transition to menopause, often causing hot flashes, sweating, insomnia, anxiety, depression, fatigue, and reduced quality of life.
- Trial name
- NCT07606755
- Testing
- Jinfeng Pill
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Rectal Cancer, Anastomotic Leakage
Somatostatin Plus Clear Liquid Diet Versus Diverting Stoma in Patients With Rectal Cancer Undergoing Ultra-Low Anterior Resection
The goal of this clinical trial is to learn if somatostatin plus a clear liquid diet can help prevent severe leakage after rectal cancer surgery in adults with low or mid rectal cancer who are scheduled to have ultra-low anterior…
- Trial name
- SC-Stoma (NCT07605611)
- Testing
- Somatostatin, Clear Liquid Diet, Prophylactic Diverting Stoma
- Where
- 3 sites in China
- Volunteers
- 72 people
- Sponsor
- Tongji Hospital
Ovarian Neoplasms, Ovarian Cancer
Prospective Sample Collection Study for a Blood-Based cfDNA Methylation Assay for Ovarian Cancer Detection
The goal of this observational study is to learn whether a blood-based cell-free DNA (cfDNA) methylation assay can help detect ovarian cancer, especially early-stage ovarian cancer, in women undergoing clinical evaluation for…
- Conditions
- Ovarian Neoplasms, Ovarian Cancer, Early Detection of Cancer
- Trial name
- NCT07593833
- Testing
- Blood-Based cfDNA Methylation Assay for Ovarian Cancer Detection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tongji Hospital
Periampullary Adenocarcinoma
Comparing Laparoscopic and Open Pancreaticoduodenectomy for Nonpancreatic Periampullary Adenocarcinomas
The aim of this study was to evaluate the outcomes of LPD versus OPD in non-pancreatic periampullary adenocarcinoma
- Trial name
- NPPC (NCT05788029)
- Testing
- laparoscopic pancreaticoduodenectomy, open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Tongji Hospital
Liver Diseases
A Study About Remote and Local Liver Surgery
The goal of this clinical trial is to learn if the robotic surgical system producted by Shenzhen Edge Medical Company has a non-inferior textbook outcome in liver surgery in the field of remote surgery compared to local robotic…
- Trial name
- NCT07524699
- Testing
- Remote Liver Surgery, Local Liver Surgery
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Tongji Hospital
Ovarian Clear Cell Carcinoma
INVIGORATE: A Study of QL1706 and Bevacizumab in Advanced First-Line Ovarian Clear Cell Carcinoma
The goal of this phase 3 clinical trial is to evaluate whether QL1706 plus bevacizumab can effectively treat adult female patients (18 to <75 years old) with newly diagnosed FIGO stage IC-IV ovarian clear cell carcinoma.
- Trial name
- INVIGORATE (NCT07002346)
- Testing
- QL1706 (bispecific antibody targeting PD-1 and CTLA-4), Bevacizumab, carboplatin
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Tongji Hospital
Functional Constipation (FC)
Dose-Effect Response in Acupuncture for Functional Constipation
This is a single-center, randomized, parallel-group trial evaluating the dose-response relationship of two experimental interventions: manual acupuncture and electroacupuncture for functional constipation.
- Trial name
- NCT07506122
- Testing
- Manual Acupuncture, Electroacupuncture
- Where
- 2 sites in China
- Volunteers
- 72 people
- Sponsor
- Tongji Hospital
Relapsing or Refractory Multiple Sclerosis (MS), Myasthenia Gravis (MG)
CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases
This single-arm, open-label investigator-initiated trial (IIT) evaluates the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of RD06-05 in patients with autoimmune neurological diseases, including Multiple…
- Conditions
- Relapsing or Refractory Multiple Sclerosis (MS), Myasthenia Gravis (MG), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Autoimmune Encephalitis (AE)
- Trial name
- NCT07337785
- Testing
- CD19/BCMA-targeted CAR-T cells, Lymphodepleting Conditioning
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Tongji Hospital
Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorder (NMOSD)
Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.
This study is an open-label, exploratory, prospective clinical trial with dose escalation(according to "3+3" design), to evaluate the safety and tolerability of QH103(Universal CD19 CAR-γδT Cell Injection)in the treatment of…
- Conditions
- Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorder (NMOSD), Autoimmune Encephalitis (AE), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
- Trial name
- NCT07526493
- Testing
- Universal CD19 CAR-γδT Cell Injection, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Tongji Hospital