Clinical trials: completed, sponsored by UNC Lineberger Comprehensive Cancer Center
Hematologic Neoplasms
Understanding What Matters Most to Patients: Establishing the Validity of a Best-Worst Scaling Survey
This study will evaluate the validity of using a survey to quantify patient preferences at the point-of-care and the potential effectiveness of the survey to improve goal-concordant care.
- Trial name
- NCT05061095
- Testing
- Assessment Surveys, Qualitative Interviews
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Complex Atypical Hyperplasia, Endometrial Cancer
Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients
Purpose: This is an open label, single-arm, single-center study of the addition of metformin to standard levonorgestrel-releasing intrauterine device (LR-IUD) treatment of 30 evaluable non-surgical patients with either complex…
- Trial name
- NCT02035787
- Testing
- Metformin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervix Lesion, Cervical Cancer
Application of Plasma Circulating HPV DNA Testing to Management of Cervical Intraepithelial Neoplasia
The purpose of this study is to see if circulating HPV DNA (cHPVDNA) can be used as a noninvasive biomarker for cervical intraepithelial neoplasia (CIN) 2-3 in hopes of reducing procedures and costs for patients, as well as…
- Trial name
- NCT04274465
- Testing
- digital PCR (dPCR) assay
- Where
- United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Carcinoma, Squamous Cell, Head and Neck Neoplasms
De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca
The purpose of this research study is to learn about the effectiveness of using lower-intensity radiation and chemotherapy to treat human papillomavirus (HPV) associated low-risk oropharyngeal and/or unknown primary squamous cell…
- Conditions
- Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms
- Trial name
- NCT01530997
- Testing
- Intensity Modulated Radiotherapy (IMRT), Cisplatin, Limited surgical evaluation
- Where
- 5 sites in United States
- Volunteers
- 45 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Head and Neck Cancer
Pembrolizumab + Radiation for Locally Adv SCC of the Head and Neck (SCCHN) Not Eligible Cisplatin
This study is being done to evaluate the efficacy of Pembrolizumab, concomitant with and following standard of care definitive radiation, for locally advanced squamous cell carcinoma of the head and neck patients who are not good…
- Trial name
- NCT02609503
- Testing
- Pembrolizumab, Intensity Modulated Radiation Therapy
- Where
- 3 sites in United States
- Volunteers
- 29 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Nausea and Vomiting
Effect of Aprepitant on Cyclophosphamide Pharmacokinetics in Patients With Breast Cancer
RATIONALE: Antiemetic drugs, such as aprepitant, may help lessen or prevent nausea and vomiting in patients undergoing chemotherapy.
- Trial name
- NRR (NCT00719173)
- Testing
- aprepitant, cyclophosphamide
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prostate Cancer
Efficacy of a Couple-Focused mHealth Symptom Self-management Program
In this study, the investigators propose to test the efficacy of a couple-focused, web-based tailored prostate cancer symptom management program, Prostate Cancer Education and Resources for Couples (PERC) in a randomized clinical…
- Trial name
- NCT03489057
- Testing
- Prostate Cancer Education and Resources for Couples (PERC), usual care plus NCI website
- Where
- United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Radiation Therapy During Surgery in Treating Older Women With Invasive Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation during surgery may be an effective treatment for breast cancer.
- Trial name
- NRR (NCT00182728)
- Testing
- surgery, therapy, radiation therapy
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Myeloid Leukemia, in Relapse
High Dose Cytarabine Followed by Pembrolizumab in Relapsed/Refractory AML
Rationale:The purpose of this research study is to test the effectiveness of the standard high dose cytarabine (HiDAC) on days 1 through 5 followed by a single dose of pembrolizumab on day 14 as induction therapy in patients with…
- Trial name
- NCT02768792
- Testing
- pembrolizumab,
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Acute Myeloid Leukemia
RN-Led Palliative and Supportive Care Intervention
This single institution feasibility and acceptability study includes patients with acute leukemia which is designed to examine a novel palliative and supportive care intervention (Palliative and supportive Care inTervention…
- Trial name
- NCT04570709
- Testing
- Palliative And supportive Care inTervention (PACT)
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Study of the P16 Gene as a Predictor of Myelosuppression in Breast Cancer Patients
The primary purpose of this study is to measure the association between baseline expression of the senescence effector protein p16INK4a and myelosuppression due to chemotherapy in patients with breast cancer.
- Trial name
- NCT01305954
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer, Bladder Cancer
Connecting Audio and Radio Sensing Systems to Improve Care at Home
This study aims to assess the usability of the innovative Audio + Radio (AURA) system in enhancing personalized supportive care for cancer patients and caregivers during the post-ostomy care transition by collecting information…
- Conditions
- Colorectal Cancer, Bladder Cancer, Ovarian Cancer, Cervical Cancer
- Trial name
- AURA (NCT05344950)
- Testing
- Audio + Radio (AURA)
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
CIN 2/3, HIV Infections
5-fluorouracil Following Cervical Intraepithelial Neoplasia Treatment Among HIV-positive Women in East Africa
This is a single arm study on the safety, feasibility, and acceptability of adjuvant, self-administered, intravaginal 5-Fluorouracil (5-FU) following treatment for high-grade cervical precancer (CIN2/3) among women living with…
- Trial name
- NCT05362955
- Testing
- Intravaginal 5-Fluorouracil (5-FU)
- Where
- Kenya
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Neoplasms, Cancer
An Evaluation of the Families Addressing Cancer Together (FACT) Intervention
This is a pilot feasibility and acceptability study to inform the development and testing of a novel communication intervention to support parents in their communication with children about cancer.
- Conditions
- Neoplasms, Cancer, Parenting, Communication
- Trial name
- FACT (NCT04342871)
- Testing
- FACT
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Small Renal Mass, Kidney Tumor
GRADE-SRM: Genomic Risk Assessment and Decisional Evaluation for Small Renal Masses
Purpose: The purpose of this study is to evaluate the role of renal mass biopsy on decision-making for patients presenting with clinical T1 kidney tumors.
- Trial name
- GRADE-SRM (NCT03819569)
- Testing
- Small Renal Mass Biopsy, No Small Renal Mass Biopsy
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Neoplasms, Cancer
The Families Addressing Cancer Together Intervention for Parents With Cancer
The proposed pilot randomized controlled trial will test the FACT (Families Addressing Cancer Together) intervention designed to improve parents' confidence and ability to talk about their cancer with their minor children.
- Conditions
- Neoplasms, Cancer, Parenting, Communication
- Trial name
- FACT (NCT05377749)
- Testing
- FACT
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Von-Hippel Lindau, Kidney Disease, Chronic
Contrast-enhanced Ultrasound as a Screening Tool for Kidney Cancer in Patients With Von-Hippel Lindau
The purpose of this study is to determine if contrast-enhanced ultrasound can detect abnormal features of kidney lesions in patients with Von-Hippel Lindau with the same accuracy as conventional ultrasound and contrast-enhanced…
- Trial name
- CEUS-VHL (NCT03907657)
- Testing
- Perflutren lipid microsphere, Sulfur hexafluoride lipid microspheres
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Carcinoma, Squamous Cell, Head and Neck Neoplasms
P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC
The primary objective of this study is to evaluate whether genomic based risk-stratification can be used in deciding whether to de-intensify in patients with Human Papillomavirus (HPV)-associated Oropharyngeal Squamous Cell…
- Conditions
- Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms
- Trial name
- NCT03077243
- Testing
- Intensity Modulated Radiotherapy (IMRT), Cisplatin (or alternative), Assessment for surgical evaluation
- Where
- 4 sites in United States
- Volunteers
- 195 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Vaping
Impact of Vaping Prevention Advertisements
The purpose of this randomized controlled trial is to determine whether exposure to vaping prevention advertisements (ads) reduce susceptibility to vaping among adolescents.
- Trial name
- NCT04836455
- Testing
- The FDA's The REal Cost vaping prevention ads - Health harms theme, The FDA's The Real Cost vaping prevention ads - Addiction theme, Neutral vaping ads
- Where
- United States
- Volunteers
- 1,565 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervical Cancer
Finding Barriers and Designing Solutions to Promote Women s Cancer Screening in South Africa
The primary aim of the study explore drivers of cervical cancer screening and barriers contributing to low screening coverage among women in South Africa.
- Trial name
- FIND (NCT05414097)
- Testing
- Semi-structured focus group discussions - Women, semi-structured focus groups discussions - Men, In-depth key stakeholders interviews
- Where
- South Africa
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center