Clinical trials: completed, sponsored by UNC Lineberger Comprehensive Cancer Center
Tobacco Products, Cigarettes
Pilot Study of Communication for Dual Users of Cigarettes and E-cigarettes
The study is a pilot test of effectiveness of communication campaign ads on interest in quitting combustible cigarettes and e-cigarettes.
- Conditions
- Tobacco Products, Cigarettes, Electronic Cigarettes
- Trial name
- NCT07599462
- Testing
- communication
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Larynx, Lip
Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN
The purpose of this study is to investigate other drugs that may be combined with radiation to treat cancer. The study focuses on determining whether a combination of durvalumab with radiation can both improve cure rate and at…
- Conditions
- Larynx, Lip, Oral Cancer, Digestive Organs--Diseases
- Trial name
- NCT03529422
- Testing
- Durvalumab, Intensity Modulated Radiotherapy Treatments
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Health Behavior
Consumer Perceptions of Alcoholic Beverages
This study aims to examine the effects of marketing claims on alcoholic beverage packaging on alcohol consumers' perceptions and intentions.
- Trial name
- NCT07226271
- Testing
- Natural Claim, Sugar Claim, Fruit Claim
- Where
- United States
- Volunteers
- 1,534 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Neoplasms, Carcinoma
Addressing Cancer-Related Financial Toxicity in North Carolina Oncology Care Settings
The financial burden, or financial toxicity (FT), of cancer is a consequential and growing problem, particularly for rural patients.
- Trial name
- NCT04931251
- Testing
- Financial Navigation
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Vaping Behavior
Impact of E-Cigarette Prevention Messages on Adolescents
The purpose of this trial is to determine whether a vaping prevention text message program reduces susceptibility to vaping among adolescents and young adults.
- Trial name
- NCT05985538
- Testing
- Vaping prevention text messages, Wellness behaviors text messages
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Human Papilloma Virus
Impact of Financial Incentives
This trial will look at the impact of clinic-level financial incentives to improve provider communication and increase HPV vaccine uptake. Some clinics will receive communication training.
- Trial name
- NCT05744960
- Testing
- Communication training, financial Incentive
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer, Breast Neoplasms
Dissemination of BREASTChoice AIM1-B
This registration covers only Aim 1b, which focuses on testing usability. The study will include 20 participants who are breast cancer patients.
- Trial name
- BREASTChoice (NCT07396766)
- Testing
- Baseline Questionnaire, Semi structured Interview, Post Survey
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Overweight and Obesity, Overweight
Piloting a Reinforcement Learning Tool for Individually Tailoring Just-in-time Adaptive Interventions
The purpose of this pilot study is to conduct a 12-week pilot feasibility study testing usability of a reinforcement learning model (AdaptRL) in a weight loss intervention (ADAPT study).
- Conditions
- Overweight and Obesity, Overweight, Obesity
- Trial name
- NCT05751993
- Testing
- ADAPT
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervical Cancer, CIN2
Acceptability and Feasibility of Combination Treatment for Cervical Precancer Among South African Women Living With HIV
The purpose of this study is to explore whether an anti-cancer medication (5-fluorouracil cream) placed in the vagina after a surgical excision procedure is an acceptable and useful form of treatment for cervical precancer among…
- Conditions
- Cervical Cancer, CIN2, CIN3, Human Immunodeficiency Virus
- Trial name
- ACT 2 (NCT05413811)
- Testing
- 5 Fluorouracil (5 FU) Cream
- Where
- South Africa
- Volunteers
- 180 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Multicentric Castleman Disease
Safety and Efficacy of Rituximab for Treatment of Multicentric Castleman Disease in Malawi
The purpose of this study is to determine the safety and efficacy of first-line, risk-stratified Rituximab-based Multicentric Castleman Disease (MCD) treatment in Malawi in a single-arm, phase II clinical trial.
- Trial name
- NCT04585893
- Testing
- Rituximab, Etoposide
- Where
- Malawi
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Lymphoma, Adult T-Cell Leukemia/Lymphoma
BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma
Adult T-cell leukemia/lymphoma (ATLL) is a rare form of cancer found mostly among people from the Caribbean islands, Western Africa, Brazil, Iran, and Japan.
- Conditions
- Lymphoma, Adult T-Cell Leukemia/Lymphoma, Lymphatic Diseases
- Trial name
- NCT03264131
- Testing
- Brentuximab Vedotin, CHEP
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Malignancy, Immune System Diseases
Immuno-Oncology Database and Bioregistry
Immunotherapy, especially immune checkpoint inhibitors (ICIs), are effective in treating many different types of cancers. ICIs fight cancer by driving the immune system into an "activated state" that makes it harder for tumor…
- Conditions
- Malignancy, Immune System Diseases, Autoimmune Diseases
- Trial name
- IOG (NCT04656873)
- Testing
- Biospecimen Collection, Medical Chart Review, Questionnaires/Surveys
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Neoplasms
Physical Activity Centers Empowerment
This research study tests the feasibility of the Physical Activity Centers Empowerment (PACE) physical activity intervention for African American individuals diagnosed with colorectal cancer.
- Trial name
- PACE (NCT06411756)
- Testing
- Narrative videos, A Fitbit activity tracker, Daily text message
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Germ Cell Tumor, Nonseminomatous Germ Cell Tumor
CD30 CAR for CD30+ NSGCT
This is a phase 2 research study that enrolls adult subjects with Nonseminomatous Germ Cell Tumors (NSGCT). The purpose of this study is to create a repository and explore the presence of modified T cells in the subject's plasma…
- Trial name
- NCT05634785
- Testing
- ATLCAR.CD30 Cells, Cyclophosphamid, Fludarabine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Tobacco Use
Little Cigar and Cigarillo Warnings to Reduce Tobacco-Related Cancers and Disease - Eye Tracking
The goal of this research is to determine how removal of little cigar and cigarillo (LCC) flavor descriptors on packaging impacts attention and affective responses to LCC warnings.
- Trial name
- NCT06546618
- Testing
- LCC pack stimuli images
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Vaping
Perceived Effectiveness of Vaping Prevention Ads Among Adolescents and Young Adults
The purpose of the Aim 2 study is to assess the perceived effectiveness of vaping prevention ads among adolescents and young adults and identify which features of video ads predict perceived message effectiveness.
- Trial name
- NCT07116837
- Testing
- Vaping prevention video ads
- Where
- United States
- Volunteers
- 3,113 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer, Breast Cancer
The Care Tracker Study: Using Patient-Reported Data to Address Racial Disparity in Cancer Treatment
This study assesses the feasibility and acceptability of a brief electronic patient-reported outcome (ePRO) tool that allows patients to self-identify impending delays.
- Conditions
- Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT06096623
- Testing
- Weekly Survey
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer, Metastatic Breast Cancer
Adaptation of a Values Assessment Tool
The primary purpose of this study is to evaluate the effect of values assessment tool on patient and caregiver perception of decisional conflict, and communication with their oncology clinician.
- Trial name
- NCT07068477
- Testing
- Values Assessment Tool
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer
Social Media Posts About Cancer: Five Timepoints
The main purpose of this trial was to evaluate the impact of user interface designs on intervening with cancer misinformation on social media.
- Trial name
- NCT07588607
- Testing
- Social cue prompt and policy, Standard prompts
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Cancer
Scaling CRC Screening Through Outreach, Referral, and Engagement (SCORE)
This study will test the effectiveness of mailing fecal immunochemical tests (FITs) in increasing colorectal cancer (CRC) screening rates in U.S. adults ages 45-75.
- Trial name
- SCORE (NCT04406714)
- Testing
- Trial Mailed FIT Intervention - Age Group 50-75, Sub-Study Mailed FIT Intervention Enhanced Envelope - Age Group 45-49, Sub-Study Mailed FIT Active Comparator Plain Envelope - Age Group 45-49
- Where
- 2 sites in United States
- Volunteers
- 4,318 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center