Clinical trials: sponsored by Unity Health Toronto
Diabetic Foot Ulcer
A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers
Foot ulcers represent a significant common complication in patients with diabetes. Wound healing is a challenge. Some wounds do not respond to the best practices in wound care.
- Trial name
- NCT00338702
- Testing
- Autologous Platelet Gel
- Where
- Canada
- Sponsor
- Unity Health Toronto
Youth, Homelessness
The Identity Project
Understanding how to create successful pathways out of homelessness is crucial. Thirty young people (aged 18 - 26 years) who have transitioned out of homelessness within the past three years will be offered scholarships to…
- Trial name
- TIP (NCT03772522)
- Testing
- dk Leadership
- Where
- Canada
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Atrial Fibrillation, End Stage Renal Failure on Dialysis
Strategies for the Management of Atrial Fibrillation in patiEnts Receiving Dialysis
The prevention of atrial fibrillation related thromboembolism in the dialysis population is unclear. While the practice of anticoagulation appears favorable in patients with mild-to-moderate chronic kidney disease, no patients…
- Trial name
- SAFE-D (NCT03987711)
- Testing
- Warfarin, Apixaban, No oral anticoagulation
- Where
- 28 sites in Australia, Canada
- Volunteers
- 151 people
- Sponsor
- Unity Health Toronto
Hemorrhagic Shock
Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock
The purpose of the study is to evaluate whether remote ischemic conditioning is a safe and effective intervention to prevent the development of inflammation and coagulopathy in trauma patients with hemorrhagic shock.
- Trial name
- NCT02071290
- Testing
- Pneumatic tourniquet
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Education
RCT of Intensive, Brief, and Control Indigenous Cultural Safety Training Interventions for Health Care Providers
Despite Canada's relative global affluence, striking Indigenous/non-Indigenous health disparities persist. Following the release of the Truth and Reconciliation Commission of Canada's Final Report, and the publication of the…
- Trial name
- NCT05890144
- Testing
- Big Canoe, Little Canoe, Control
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hyperglycemia in Critically Ill Patients
Comparison of 2 Methods to Achieve Tight Glucose Control in Cardiovascular ICU Patients
There is current evidence that maintaining ICU patient's blood sugar between 4.4-6.1 saves lives. However, this is difficult to do in the ICU and carries risks of lowering the blood sugar too much.
- Trial name
- NCT00636714
- Testing
- Nursing judgement, Nomogram
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Obscure Gastrointestinal Bleeding, Gastrointestinal Diseases
Assessing Depth of Small Bowel Insertion at Push Enteroscopy by Using Capsule Endoscopy
Bleeding from the gastrointestinal tract can originate from the small bowel. Typically, upper and lower endoscopies are unable to identify the site of bleeding and patients need to undergo special endoscopies with longer cameras…
- Conditions
- Obscure Gastrointestinal Bleeding, Gastrointestinal Diseases, Gastrointestinal Bleed, Angiodysplasia Intestine
- Trial name
- NCT05731388
- Testing
- Push enteroscopy
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- Unity Health Toronto
10-20mm Colorectal Polyp
Optimal Resection Technique for Medium-sized (10-20mm) Colorectal Polyps
This study will investigate which resection technique (Endoscopic Mucosal Resection (EMR), cold EMR, or underwater EMR) leads to lower recurrence rates and less adverse events in patients with colorectal polyps (10-20mm).
- Trial name
- NCT05849623
- Testing
- Endoscopic Mucosal Resection (EMR), Cold Endoscopic Mucosal Resection (C-EMR), Underwater Endoscopic Mucosal Resection (U-EMR)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Knee Pain Chronic, Osteoarthritis
Cryoneurolysis for TKA - a Pilot Study
Total Knee Arthroplasty (TKA) is also known as a knee replacement. It is one of the most common orthopaedic (bone) surgeries performed and is usually very successful, but some people who have had a knee replacement feel pain that…
- Trial name
- NCT05286996
- Testing
- Iovera - Cryoneurolysis, Local anesthetic
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Endophthalmitis
Endophthalmitis Post Intravitreal Injections
Intravitreal injection (IVI) is an ophthalmological procedure used worldwide to treat ocular conditions. Its use has been steadily increasing for several years, because this method of drug delivery minimizes systemic exposure and…
- Trial name
- EPIIC (NCT04035369)
- Testing
- Tap and Inject (TAI), Pars Plana Vitrectomy (PPV)
- Where
- Canada
- Volunteers
- 310 people
- Sponsor
- Unity Health Toronto
COVID-19, COVID-19 Pneumonia
Self-proning and Repositioning in COVID-19 Outpatients at Risk of Complicated Illness
The rapid development of safe and effective COVID-19 treatment is a global health priority. Numerous studies evaluating therapies for this disease are currently underway, but the majority of these are in hospitalized patients…
- Conditions
- COVID-19, COVID-19 Pneumonia, Proning, Hospitalization
- Trial name
- NCT05518474
- Testing
- Self-proning
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
Hepatopulmonary Syndrome
Supine Exercise in Hepatopulmonary Syndrome Patients With Orthodeoxia
Hepatopulmonary syndrome (HPS) is a rare condition that presents in about a quarter of patients with liver cirrhosis. In addition, a small subset of these HPS patients also have orthodeoxia, defined as a drop in oxygen levels…
- Trial name
- NCT04004104
- Testing
- Upright Exercise, Supine Exercise
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Asthma
The Electronic Asthma Management System
This study is an extension of a pilot study in which investigators developed and tested a computerized tool to help physicians to determine if their patients' asthma is well controlled, advise them on medication changes required…
- Trial name
- eAMS (NCT03193242)
- Testing
- Electronic Asthma Management System: eAMS
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Respiratory Distress Syndrome, TTN
Use of Gentle Synchronized Negative Pressure in Helping Babies Breathe
The NeoVest delivery device is a wearable vest/shell that surrounds the infant's abdomen. It was developed using serial body measurements of infants previously admitted to the St. Michael's Hospital NICU (REB #15-183).
- Conditions
- Respiratory Distress Syndrome, TTN, RDS of Prematurity, Respiratory Distress, Newborn
- Trial name
- Neovest (NCT03510169)
- Testing
- NeoVest
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
COVID-19 Experience
Data Collection on the Model Schools Pediatric Health Initiative at 5 SBHC Sites: COVID-19 Questionnaire
The Model School Pediatric Health Initiative arose out of concern about health access inequities and disparities among some of Toronto's most vulnerable children living in our inner-city neighborhoods.
- Trial name
- SBHC (NCT04534595)
- Testing
- COVID-19
- Where
- Canada
- Volunteers
- 851 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Evaluation of Preterm NAVA Catheter Placement
Positioning of EDI Catheter In Premature Infants
Nasogastric (NG) and orogastric (OG) feeding tubes have a high incidence of malpositioning, occurring in up to 59% of preterm infants (Lopes 2019).
- Trial name
- PIPI (NCT05107713)
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Unity Health Toronto
Cardiovascular Diseases, Left Ventricular Hypertrophy
Empagliflozin and Cardiac Remodelling in People Without Diabetes
The purpose of this study is to evaluate the effects of empagliflozin on cardiac structure, function and circulating biomarkers in patients with cardiovascular risk factors, but without diabetes.
- Trial name
- EMPA-HEART 2 (NCT04461041)
- Testing
- Empagliflozin
- Where
- 4 sites in Canada, Taiwan
- Volunteers
- 169 people
- Sponsor
- Unity Health Toronto
Retinal Detachment, Metamorphopsia
Retinal Displacement After Pneumatic Versus Vitrectomy for Retinal Detachment (ALIGN)
This is a prospective cohort study, comparing the functional outcomes and the retinal displacement rates between two techniques for primary rhegmatogenous retinal detachment repair: Pars Plana Vitrectomy (PPV) and Pneumatic…
- Conditions
- Retinal Detachment, Metamorphopsia, Aniseikonia
- Trial name
- ALIGN (NCT04089033)
- Testing
- Pneumatic Retinopexy, Pars Plana Vitrectomy
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Unity Health Toronto
Colonic Polyp
Impact of Augmented Reality in Polypectomy Skills Acquisition in Simulation-based Endoscopy Training
Simulation-based training (SBT) is a safe and effective strategy for improving skills development in gastrointestinal endoscopy.
- Trial name
- NCT03826069
- Testing
- Augmented reality-based curriculum, Conventional Simulation Curriculum
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Gestational Diabetes Mellitus in Pregnancy
A Novel Care Pathway in Women With "Low-risk" Gestational Diabetes Mellitus
This study is a randomized controlled trial to study the effect of the use of a risk stratification screening tool for high- and low-risk gestational diabetes mellitus (GDM), and the implementation of a new low-impact care…
- Trial name
- NCT05596812
- Testing
- New Care Pathway
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto