Clinical trials: sponsored by Universitair Ziekenhuis Brussel
Emergency Delirium, Postoperative Delirium (POD)
Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational Study
Emergence delirium (ED) is a frequent complication in children undergoing general anesthesia, particularly following ENT procedures such as adenotonsillectomy.
- Conditions
- Emergency Delirium, Postoperative Delirium (POD), Adenotonsillectomy, Tonsillectomy
- Trial name
- CLONIDEX (NCT07913308)
- Testing
- Intravenous dexmedetomidine, Intravenous clonidine, Standard Anesthetic Care Without Alpha-2 Agonist
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitair Ziekenhuis Brussel
ICU Staff Attitudes Toward Family Presence, ICU Staff Experience of Family Presence
Attitudes, Experience and Adaptation to Family Presence in the ICU
The goal of the study is to verify how healthcare professionals in the Intensive Care Unit (ICU) experience the presence of family members before and after a more flexible visiting policy is introduced.
- Conditions
- ICU Staff Attitudes Toward Family Presence, ICU Staff Experience of Family Presence, Adaptation to Extended Family Presence in the ICU, Association Between Stress Sensitivity and Attitudes Toward Family Presence
- Trial name
- RUIMIZ (NCT07887009)
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Anal Fistula Surgery, Anal Fistula
The Use of Electronic Bidets Compared to Water Rinsing After Surgery for Anal Fistula or Haemorrhoidal Disease: a Pilot Study
There is still much to discover in the field of proctological postoperative care. There has already been some, albeit very little, research about its use post-haemorrhoidectomy as well as its possible effect on anal fissures, but…
- Conditions
- Anal Fistula Surgery, Anal Fistula, Hemorrhoidal Disease, Hemorrhoid Surgery
- Trial name
- bidet (NCT07874711)
- Testing
- Electronic bidet, standard water rinsing
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Effect of Recombinant Follicular Stimulating Hormone (FSH) Dosing Following Cori-follitropin Alfa
In the trial, women planned to be treated with 150μg corifollitropin alfa followed by rFSH in a fixed GnRH antagonist protocol will be asked to participate and sign the ICF.
- Trial name
- TBC (NCT03686852)
- Testing
- same medications but different dosages
- Where
- Belgium
- Volunteers
- 167 people
- Sponsor
- Universitair Ziekenhuis Brussel
SARS-CoV Infection
SARS-COV-2 Seroprevalence and Seroconversion Among Employees of the Universitair Ziekenhuis Brussel Following mRNA COVID-19 Vaccination
A novel zoonotic coronavirus was discovered in Wuhan (Hubei Province, China) mid-December 2019 and was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
- Trial name
- NCT04880174
- Testing
- serological testing
- Where
- Belgium
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Multiple Sclerosis
Validity and Reliability of the Language Memory Test (LMT) in Belgium
This study aims to evaluate the practical and research utility of a new test assessing language and memory in people with MS. To this end, we are administering the test to a group of 100 individuals with MS who are receiving…
- Trial name
- LMT-BE (NCT07868887)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Recurrent Glioblastoma
A Clinical Trial on Combined (Neo-)Adjuvant Intravenous Plus Intracranial Administration of Ipilimumab and Nivolumab in Recurrent Glioblastoma
The goal of this phase I interventional study is to determine the safety and feasibility of the proposed investigational (neo-)adjuvant treatment regimen in patients with resectable reccurent glioblastoma.
- Trial name
- NEO-GLITIPNI (NCT06097975)
- Testing
- Neo-adjuvant nivolumab and ipililumab IV + adjuvant nivolumab and ipililumab IV, Neurosurgery and intracavitary injection nivolumab and ipililumab, Adjuvant nivolumab IV + nivolumab and ipililumab intracavitary
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Universitair Ziekenhuis Brussel
Intrathecal Drug Delivery
Simulation-Based Intrathecal Pump Refill Training
Intrathecal drug delivery is an effective treatment option for patients with chronic (non-) cancer pain or spasticity who do not achieve sufficient benefit from conventional therapies.
- Trial name
- REFILL-IT (NCT07854834)
- Testing
- Simulation-based intrathecal pump refill training
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Melanoma Stage III, Melanoma Stage IV
A Clinical Trial of Regorafenib in Patients With Pretreated Advanced Melanoma
There are in total 3 cohorts. Cohort A: 16 patients will receive a daily dose of 80mg regorafenib up until progressive disease, unacceptable toxicity or withdrawal of consent.
- Trial name
- RegoMel (NCT05370807)
- Testing
- Regorafenib 40 MG Oral Tablet, Triplet therapy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Universitair Ziekenhuis Brussel
Solid Tumor, Metastases to Soft Tissue
Intratumoral Injection of Autologous CD1c (BDCA-1)+ myDC, AS01B, and Ipilimumab Plus Systemic Nivolumab
This phase II trial aims at investigating the role and effect of autologous CD1c (BDCA-1)+ myeloid dendritic cells in combination with intratumoral injection of the CTLA-4 blocking monoclonal antibody (mAb) ipilimumab and the…
- Trial name
- myDAvIpNi (NCT03707808)
- Testing
- intratumoral injection of autologous CD1c (BDCA-1)+ myDC, Intratumoral injection of ipilimumab and AS01b, IV nivolumab
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Universitair Ziekenhuis Brussel
CVID, SPAD
Microbiome, Dietary and Quality of Life Analysis of People Living With CVID Treated With or Without Immunoglobulins.
Our research group focusses on finding evidence-based diet strategies to overcome immune dysregulation either due to immune checkpoint inhibitors (ICI) or common variable immunodeficiency (CVID) (Figure 1).
- Conditions
- CVID, SPAD, Antibody Deficiency
- Trial name
- NCT07844668
- Testing
- Diet
- Where
- 2 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- Universitair Ziekenhuis Brussel
Intoxication by Drug
Hemadsorption to Enhance Drug Elimination in Intoxications
In this trial the investigators assess the effectiveness of applying a hemadsorber (cytosorb®) in removing benzodiazepines or tricyclic antidepressants in intoxicated patients admitted to ICU with prolonged impaired…
- Trial name
- MATRIX (NCT06922786)
- Testing
- Hemadsorption filter
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cataract, Fuchs Endothelial Corneal Dystrophy
Partial Range Of Field IOLs in DMEK-Enabled Procedures
Study Overview This study aims to evaluate the visual outcomes, quality of vision, and patient satisfaction after receiving an extended range PRoF intraocular lens (IOL) during triple Descemet Membrane Endothelial Keratoplasty…
- Trial name
- PROFIDE (NCT07441616)
- Testing
- combined cataract and lamellar endothelial keratoplasty
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Low Back Pain
Effectiveness of the SelfBack-App in Preventing and Treating Low Back Pain Versus no Intervention: a Non-randomized Clinical Trial
Low back pain (LBP) is the leading cause of disability worldwide and represents a major burden for both individuals and healthcare systems.
- Trial name
- NCT07785804
- Testing
- Selfback app, No Interventions
- Where
- Belgium
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Drug-induced Crystalline Nephropathy, Drug-induced Crystalluria
Drug-induced Crystalluria in Sulfamethoxazole, High Dose Ciprofloxacin and High Dose Amoxicillin
This study examines in hospitalized patients, treated with sulfamethoxazole, high dose ciprofloxacin or high dose iv amoxicillin, the incidence of drug-induced urinary crystal formation and its association with acute kidney…
- Conditions
- Drug-induced Crystalline Nephropathy, Drug-induced Crystalluria, Infections Treated With Sulfamethoxazole, High Dose Ciprofloxacin or High Dose iv Amoxicillin
- Trial name
- CRYSTALLINE (NCT07772752)
- Testing
- Crystalluria examination
- Where
- Belgium
- Volunteers
- 290 people
- Sponsor
- Universitair Ziekenhuis Brussel
Type1 Diabetes Mellitus
Continuous Monitoring of Glycemic Variability to Predict Dys- and Hyperglycemia in Asymptomatic Type 1 Diabetes
The goal of this longitudinal clinical trial is to measure variability of interstitial glucose levels with a user-friendly real-time continuous glucose monitoring (CGM) technology at regular intervals in normo- and dysglycemic…
- Trial name
- NCT05777330
- Testing
- Oral glucose tolerance test (OGTT), Hyperglycemic clamp test, Continuous glucose monitoring
- Where
- 6 sites in Belgium
- Volunteers
- 75 people
- Sponsor
- Universitair Ziekenhuis Brussel
Persistent Spinal Pain Syndrome Type 2, Failed Back Surgery Syndrome
Open and Closed Loop DTM SCS in Patients With PSPS Type 2: ENDLESS Study
Evaluation of the effectiveness of differential target multiplexed spinal cord stimulation for treatment of Persistent Spinal Pain Syndrome Type II (PSPS-T2).
- Conditions
- Persistent Spinal Pain Syndrome Type 2, Failed Back Surgery Syndrome, Failed Neck Surgery Syndrome
- Trial name
- ENDLESS (NCT07211308)
- Testing
- Spinal Cord Stimulation
- Where
- 5 sites in Belgium, Netherlands
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Secondary Hyperoxaluria, Nephrolithiasis
Lanthanum Carbonate (Fosrenol®) to Reduce Oxalate Excretion in Patients With Secondary Hyperoxaluria and Nephrolithiasis
This study investigates the efficacy and the safety of Lanthanum Carbonate for the reduction of urinary oxalate excretion in patients with secondary hyperoxaluria and nephrolithiasis.
- Trial name
- LaCa (NCT03346369)
- Testing
- Lanthanum Carbonate
- Where
- Belgium
- Volunteers
- 54 people
- Sponsor
- Universitair Ziekenhuis Brussel
Intrathecal Drug Delivery, Refractory Cancer Pain
Intrathecal Therapy Versus Standard Care for Severe Cancer Pain
Approximately 66% of patients with advanced cancer experience pain, which is often inadequately controlled and associated with a decline in health-related quality of life (HRQoL).
- Conditions
- Intrathecal Drug Delivery, Refractory Cancer Pain, Conventional Medical Management
- Trial name
- CAREGIVER (NCT07691840)
- Testing
- Intrathecal Drug Delivery, Comprehensive Medical Management
- Where
- Belgium
- Volunteers
- 72 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cochlear Implant, Sensorineural Hearing Loss
Anatomy-Based Fitting in Bimodal Cochlear Implant Users
The purpose of the study is to investigate the effect of an anatomy-based frequency distribution in comparison to a default frequency distribution in bimodal CI patients, i.e.
- Conditions
- Cochlear Implant, Sensorineural Hearing Loss, Hearing Aid
- Trial name
- NCT07691853
- Testing
- Anatomy-based fitting, Default fitting
- Where
- 2 sites in Belgium
- Volunteers
- 25 people
- Sponsor
- Universitair Ziekenhuis Brussel