Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Open Angle Glaucoma, Normal Tension Glaucoma
Ocular Blood Flow in Glaucoma Patients - the Leuven Eye Study
Glaucoma is a leading cause of blindness worldwide, whose treatment - intraocular pressure lowering - is only partially effective in preventing disease progression.
- Trial name
- NCT01840202
- Where
- Belgium
- Volunteers
- 770 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pseudarthrosis
rhBMP-2 vs Autologous Bone Grafting for the Treatment of Non-union of the Docking Site in Tibial Bone Transport
When there is a bone defect, bone transport is used to bridge the defect. Frequently, the bone in the docking site (where the transported bone comes together) doesn't heal.
- Trial name
- NCT01756144
- Testing
- rhBMP-2
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Denture Hygiene
Microbial Evaluation of Denture Cleaning and Overnight Storage
Clinical guidelines for denture care are available, but evidence for optimal nocturnal storage is missing. The investigators (Duyck J., Vandamme K., Teughels W.) therefore performed a study (submitted for publication) to evaluate…
- Trial name
- NCT02454413
- Testing
- denture brushing with water and soap, ultrasonic denture cleaning, cleansing tablet
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coronary Artery Disease, Anesthesia
Xenon as an Adjuvant to Propofol Anaesthesia in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery.
The investigators hypothesize that the application of 30% xenon as an adjuvant to general anesthesia with a target-controlled infusion of propofol is superior to general anesthesia with propofol alone with respect to hemodynamic…
- Trial name
- NCT01948765
- Testing
- Xenon and propofol, propofol
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastrointestinal Stromal Tumors
WB-DWI for Early Prediction of Therapy Response in Patients With Advanced Metastatic GIST Treated With Regorafenib
The purpose of this study is to evaluate WB DWI as early predictor of response to treatment with regorafenib or placebo in patients with advanced metastatic GIST.
- Trial name
- NCT01265979
- Testing
- Whole body diffusion MRI
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastro-intestinal Tumor, Accurate Staging
Whole Body Diffusion MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Gastro-intestinal Tumors
The aim of the study is to assess the value of whole body diffusion weighted MR imaging (WB-DWI) as a non-invasive method. On one hand for pretreatment lesion detection and post-therapeutic tumor recurrence but also for early…
- Conditions
- Gastro-intestinal Tumor, Accurate Staging, Whole-body Diffusion Weighted MRI, Non-invasive
- Trial name
- s51240 (NCT01224990)
- Testing
- Whole body diffusion MRI
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ovarian Cancer, Peritoneal Metastasis
Whole Body Diffusion MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Ovarian Cancer and Peritoneal Metastasis
Ovarian cancer is a gynecological cancer with a high risk of mortality. This is because the diagnosis is often been made in an advanced cancer stage with metastases throughout the peritoneum. An international study led by Prof.
- Trial name
- NCT01242436
- Testing
- intravenous contrast administration
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Focus of the Study:Protein Binding Characteristics of Voriconazole.
Plasma Protein Binding Characteristics of Voriconazole
The purpose of this study is to investigate the influence of hypoalbuminemia on the protein binding characteristics of the antifungal drug voriconazole in ICU patients.
- Trial name
- NCT01812473
- Testing
- Blood sampling
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bronchiolitis Obliterans, Lung Transplantation
Montelukast in Bronchiolitis Obliterans Syndrome
Chronic rejection (or Bronchiolitis Obliterans syndrome-BOS) is a major cause of mortality and morbidity after lung transplantation.
- Conditions
- Bronchiolitis Obliterans, Lung Transplantation, Graft Rejection
- Trial name
- MLK002 (NCT01211509)
- Testing
- Montelukast
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hematological Malignancy
A New Dosing Regimen for Posaconazole Prophylaxis in Children Based on Body Surface Area
A new prophylactic posaconazole dosing regimen of 120mg/m² tid is evaluated pharmacologically in children 13 years and younger, suffering from a hematologic malignancy.
- Trial name
- NCT02372357
- Testing
- Posaconazole prophylaxis 120 mg/m² tid, Blood sampling
- Where
- 2 sites in Belgium, Romania
- Volunteers
- 14 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sepsis
Pharmacokinetic/Pharmacodynamic Evaluation Amikacin in Critically Ill Patients Admitted at the Emergency Department
The aim of the study is the evaluation of PK/PD target attainment of amikacin in ED patients with severe sepsis and septic shock.
- Trial name
- NCT02365272
- Testing
- Amikacin
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Patients Treated With Voriconazole
Preliminary Experience of Routine Voriconazole Therapeutic Drug Monitoring (TDM) in a Tertiary Care Centre
The first goal of this study is to map all the subtherapeutic, therapeutic and supratherapeutic voriconazole plasma levels in the University Hospitals Leuven.
- Trial name
- NCT01418833
- Where
- Belgium
- Volunteers
- 160 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pneumology, Hematology
Determination of Voriconazole Levels in Saliva - Validation in Specific Subsets of Patients
The purpose of this study is to investigate the intra-saliva penetration of voriconazole in different subpopulations. The goal is to develop, optimize and validate an easy, non-invasive and painless procedure for Therapeutic Drud…
- Conditions
- Pneumology, Hematology, Internal Medicine, Pediatrics
- Trial name
- NCT01418846
- Where
- 3 sites in Belgium
- Volunteers
- 11 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Nephrotic Syndrome
Role of PACAP in Nehprotic Syndrome
This study will identify the role of PACAP (pituitary adenylate cyclase-activating polypeptide) deficiency in patients with nephrotic syndrome.
- Trial name
- NCT01411982
- Where
- Belgium
- Volunteers
- 29 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer, Elderly
Gene Polymorphisms and Gene Products as Biological Markers of Aging and Correlation With Clinical Geriatric Assessment, Tolerance of Chemotherapy and Outcome in Elderly Breast Cancer Patients
The goal is to study the biology of aging in breast cancer patients, and to study the impact of chemotherapy on aging related blood biomarkers.
- Trial name
- EBS (NCT00849758)
- Where
- 2 sites in Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer
Trial Exploring Feasibility of Densification and Optimal Sequencing of Postoperative Adjuvant Fluorouracil, Epirubicin Plus Cyclophosphamide (FEC) and Docetaxel Chemotherapy in Patients With High Risk Primary Operable Breast Cancer
The rationale of this randomized phase II study is to investigate the feasibility of sequenced densified FEC and docetaxel based regimens in patients with primary operable high-risk breast cancer.
- Trial name
- NCT00256360
- Testing
- dose dense with neulasta
- Where
- Belgium
- Volunteers
- 117 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Myelofibrosis, Myeloid Metaplasia
A Trial of Zoledronic Acid in Patients With Myelofibrosis With Myeloid Metaplasia (MMM)
In this trial, the question is addressed if zoledronic acid (Zometa, Novartis Pharma)could be of clinical benefit for patients with myelofibrosis and myeloid metaplasia (MMM).
- Trial name
- NCT00287261
- Testing
- zoledronic acid
- Where
- 6 sites in Australia, Belgium and 4 more
- Volunteers
- 17 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer, Elderly
Caelyx Adjuvant in Elderly Breast Cancer
This is an open label Phase II study in elderly patients (65y or older) with early breast cancer who are candidate for adjuvant chemotherapy.
- Trial name
- NCT00284336
- Testing
- Caelyx, endoxan
- Where
- 2 sites in Belgium
- Volunteers
- 16 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rhinitis
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls
Capsaicin nasal spray is used in daily practice against IR without knowledge about the exact mechanisms involved in this treatment.
- Trial name
- NCT01862523
- Testing
- Capsaicin, diluent
- Where
- Belgium
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cystic Fibrosis
Sputum Purulence as a Predictor of Cystic Fibrosis Exacerbations: a Prospective Cohort Trial.
To use the sputum colour chart as a predictor for cystic fibrosis exaerbations
- Trial name
- MucoSpuCo (NCT02309229)
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven