Clinical trials: sponsored by Universitaire Ziekenhuizen KU Leuven
Heart Septal Defects, Atrial
Bosentan for Mild Pulmonary Vascular Disease in Asd Patients.
Volume overload due to left-to-right shunting in patients with atrial septal defect type secundum causes pulmonary vascular disease over a long period of time.
- Trial name
- BOMPA (NCT01218607)
- Testing
- Bosentan
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Congenital Heart Disease
Fontan Patients: Comprehensive Evaluation of Pulmonary Circulation and Ventricular Function
In patients with one anatomical or functional ventricular chamber, which encompasses a spectrum of rare and complex congenital cardiac malformations, a staged surgical approach in view of an ultimate Fontan operation has become…
- Trial name
- NCT01572363
- Testing
- Sildenafil
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Condition of Patient 3 Years After FESS-operation
Long-term Control in Rhinosinusitis After Functional Endoscopic Sinus Surgery (FESS)
State-of-the-art documents like ARIA and european position paper on rhinosinusitis (EPOS) provide clinicians with evidence-based treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS) respectively (1)(2)…
- Trial name
- NCT01777425
- Where
- 2 sites in Belgium
- Volunteers
- 389 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open Angle Glaucoma, Normal Tension Glaucoma
Study on Ocular Blood Flow and the Orbital Cerebrospinal Fluid Pressure in Glaucoma
Ocular blood flow has been consistently demonstrated to be altered in glaucoma patients when compared to otherwise healthy individuals.
- Trial name
- NCT01802463
- Where
- Belgium
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hepatocellular Carcinoma
Pretreatment MRI Predicting Outcome After Radio-frequency Ablation of HCC
HCC is classified as keratin (K) 19 positive or K19 negative. K19 is a biliary/hepatic progenitor cell (HPC) marker only expressed in a subset of HCC with poor prognosis and high risk of early recurrence after treatment…
- Trial name
- NCT02051283
- Testing
- RFA
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alzheimer's Disease
The Detection of Early Dementia With the Digital Game Memory
The investigators are going to test if it is possible to detect early dementia with the digital game "memory". The investigators are going to test 15 healthy people and 15 patients with early dementia.
- Trial name
- NCT02041728
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Alzheimer Disease, Late Onset
New Proteins in Body Fluids as Potential Biomarker for Alzheimer's Disease: a Pilot Study
Alzheimer's disease (AD) is the most common neurodegenerative disorder afflicting the elderly. Currently, some biochemical tests performed on Cerebrospinal Fluid (CSF) samples have demonstrated to discriminate to some extend…
- Trial name
- NCT01773915
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Allergic Rhinitis
Evaluating Symptom Control in in Allergic Rhinitis at Three Years After Starting Immunotherapy
Allergic rhinitis (AR) is defined as inflammation of the nasal mucosa after exposition to an allergen in sensitized patients. AR causes not only nasal symptoms such as sneezing, itchy nose, rhinorrhea and nasal obstruction, but…
- Trial name
- NCT01777438
- Where
- 2 sites in Belgium
- Volunteers
- 434 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obsessive-Compulsive Disorder
Refining the Target for Deep Brain Stimulation (DBS) in Severe, Treatment Refractory Obsessive Compulsive Disorder (OCD)
In select, therapy resistent patients with Obsessive Compulsive Disorder (OCD) Deep Brain Stimulation (DBS) has been used as a treatment.
- Trial name
- NCT01985815
- Testing
- VC/VS stimulation
- Where
- Belgium
- Volunteers
- 6 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Malignant Neoplasm of Lung
Endobronchial Valves in Persistent Air Leak
Because an endobronchial valve is a one-way inspiratory airway blocker, it is hypothesized that it could be also used for controlling persistent air leaks while maintaining the drainage of secretions. The U.S.
- Trial name
- NCT01451359
- Testing
- EndoBronchial Valve
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Endometriosis
Functional Outcome in Patients That Underwent Laparoscopic Sigmoid and/or Rectum Resection
Questionnaire To assess the functional outcome in patients that underwent laparoscopic sigmoid and/or rectum resection.
- Trial name
- NCT01953250
- Where
- Belgium
- Volunteers
- 143 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Atrial Fibrillation
Effectiveness of an Interdisciplinary, Nurse-coordinated Atrial Fibrillation Expert Program for Primary Care Patients
The purpose of this study is to assess the effectiveness of a newly developed interdisciplinary nurse-coordinated AF expert program for primary care patients.
- Trial name
- NCT01928121
- Testing
- Care provided by AF expert program
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Open Angle Glaucoma
Impact of a Tolerability Switch to Dorzolamide/Timolol Preservative-free Fixed Combination on Ocular Surface Symptoms
This study aims at validating in real-life clinical practice and using the self-reported Glaucoma Symptom Scale (GSS) questionnaire, the impact of a switch to preservative-free dorzolamide/timolol fixed combination (DTFC) in…
- Trial name
- NCT01923714
- Where
- Belgium
- Volunteers
- 103 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sedentary Lifestyle
A Structural Approach to Implement the Role of 'Physical Activity Counselors' in Sports and Exercise Promotion
The primary aim of this study is to investigate how a physical activity counselor can offer an added value in the sports and exercise promotion in Flanders.
- Trial name
- NCT01516099
- Testing
- General Practitioners, Social-cultural organizations
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Breast Cancer, Arthralgia
A Prospective Assessment of Loss of Grip Strength by Baseline BMI in Breast Cancer Patients Receiving Adjuvant Aromatase Inhibitors and Tamoxifen
The Logribmet study is a prospective study that evaluate grip strength changes in both hands of postmenopausal women with breast cancer receiving treatment with tamoxifen or an aromatase inhibitor.
- Trial name
- LOGRIBMET (NCT01223833)
- Where
- Belgium
- Volunteers
- 296 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bronchiectasis
Impact of Chronic Air Pollution on Non-cystic Fibrosis Bronchiectasis
We aim at investigation the impact of chronic air pollution exposure on non-cystic fibrosis bronchiectasis outcome.
- Trial name
- NCT01906047
- Where
- Belgium
- Volunteers
- 189 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Postoperative Dumping Syndrome
Study to Assess Safety and Efficacy of sc Pasireotide in Patients With Dumping Syndrome
Dumping Syndrome consists of (1) a too rapid gastric emptying, (2) an inappropriate release of GI hormones (as a reaction to the hyperosmolar contents in the duodenum) and (3) an hyperinsulinemic response to a too rapid…
- Trial name
- CSOM230BBE01T (NCT01895296)
- Testing
- Pasireotide
- Where
- Belgium
- Volunteers
- 9 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Failure
Resistive Index Measurements After Kidney Transplantation
The purpose of this study is to evaluate the prognostic performance of intrarenal resistive index in the first years after kidney transplantation on graft function and on patient and graft survival.
- Trial name
- NCT01879124
- Where
- Belgium
- Volunteers
- 346 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Malignant Biliary Obstruction
Percutaneous Transhepatic Cholangiography Versus Endoscopic Ultrasound Guided Biliary Drainage
Patients with obstructive jaundice due to locally advanced/metastatic malignancy with dilated intrahepatic bile ducts will be recruited from the department of Gastroenterology and Hepatology at the University Hospital of Leuven.
- Trial name
- PETRUS (NCT01686425)
- Testing
- Percutaneous transhepatic cholangiography vs. endoscopic biliary drainage
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Head and Neck Cancer
Dose De-escalation to the Elective Nodal Sites in Head and Neck Cancer
A randomized clinical trial was initiated to investigate whether a reduction of the dose to the elective nodal sites and the swallowing apparatus delivered by IMRT would result in a reduction of acute and late side effects…
- Trial name
- NCT01812486
- Testing
- dose de escalation, standard dose
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven