Clinical trials: sponsored by University College, London
Athletes, Healthy
The Influence of Chlorella Supplementation on Running Performance
Algae, such as chlorella, are gaining popularity as a nutritious additive to whole food or as a supplement. They contain a variety of beneficial nutrients like vitamins, minerals, healthy fats, and amino acids, which can have…
- Trial name
- NCT06479993
- Testing
- Chlorella supplementation
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University College, London
Long Covid19
Cognitive Rehabilitation for People With Cognitive Covid19
Cognitive impairment is increasingly recognised as a major component of long Covid, and is estimated to be present in 25-75% of affected individuals.
- Trial name
- NCT05731570
- Testing
- Cognitive rehabilitation
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- University College, London
COVID19
Study of Plasma Exchange in Severe COVID-19
The rationale in severe COVID19 infection is to undertake PEX to aid reduction of the hyperinflammation and reduce the morbidity and mortality to the lungs, but also systemically, such as the heart, kidneys and brain.
- Trial name
- COVIPLEX (NCT04623255)
- Testing
- OCTAPLAS
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University College, London
Cancer
Feasibility Trial Self-Acupuncture for Chemotherapy Cancer Patients
The proposed study will employ a pragmatic mixed methods randomised parallel-group exploratory design to determine the feasibility of delivering self-acupuncture within an NHS cancer care setting.
- Trial name
- SACC (NCT05929690)
- Testing
- Self-acupuncture
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College London Hospitals
Stroke, Acute, Atrial Fibrillation
OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial
OPTIMAS is a large, prospective, partially blinded randomised controlled trial of early (within ≤4 days [96hrs]) or standard (between day 7 and day 14 after stroke onset) initiation of anticoagulation after stroke in patients…
- Trial name
- OPTIMAS (NCT03759938)
- Testing
- Direct oral anticoagulant (DOAC)
- Where
- 44 sites in United Kingdom
- Volunteers
- 3,648 people
- Sponsor
- University College, London
Crohn's Disease
MRE Predictors of Disease Relapse After Stopping Biologics
This study aims to investigate if MR Enterography (MRE) improves the ability to predict which Crohn's disease patients will relapse quickly (disease comes back) after stopping biologic medication.
- Trial name
- METEOR (NCT06124287)
- Testing
- MR Enterography (MRE)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University College, London
Hodgkin Lymphoma
ANIMATE: Phase II Study of Nivolumab Monotherapy for Relapsed/Refractory Hodgkin Lymphoma
This is a single-arm, phase II, multi-centre study of the safety and efficacy of the PD-1 inhibitor, nivolumab, as second-line or third-line salvage therapy as a bridge to stem cell transplant (SCT) in relapsed/ refractory…
- Trial name
- ANIMATE (NCT03337919)
- Testing
- Nivolumab
- Where
- 10 sites in United Kingdom
- Volunteers
- 78 people
- Sponsor
- University College, London
Solid Tumor, Adult, Cancer
The PEACE (Posthumous Evaluation of Advanced Cancer Environment) Study
Historically, cancer research has been limited by sample acquisition in late stage disease, often restricted to single sites of disease with limited parallel clinical data collection in terms of prior therapy exposure.
- Trial name
- PEACE (NCT03004755)
- Testing
- Tissue Harvest
- Where
- 9 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College, London
Dentatorubral-Pallidoluysian Atrophy
Dentatorubral-pallidoluysian Atrophy Natural History and Biomarkers Study
DRPLA Natural History and Biomarkers Study (DRPLA NHBS) is a prospective observational study that will lay the foundation for clinical trials in DRPLA.
- Trial name
- DRPLA NHBS (NCT06273150)
- Testing
- Positive genetic test for pathological expansion in ATN1
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University College, London
Waldenstrom Macroglobulinemia
Rituximab and Ibrutinib (RI) Versus Dexamethasone, Rituximab and Cyclophosphamide (DRC) as Initial Therapy for Waldenström's Macroglobulinaemia
Waldenström's macroglobulinaemia (WM) is a rare type of slow growing lymphoma. It develops when white blood cells grow abnormally.
- Trial name
- RAINBOW (NCT04061512)
- Testing
- Dexamethasone, cyclophosphamide, rituximab, Rituximab, ibrutinib
- Where
- 25 sites in United Kingdom
- Volunteers
- 148 people
- Sponsor
- University College, London
Lymphoma
Rituximab in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Follicular Non-Hodgkin's Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00112931
- Testing
- rituximab, No treatment
- Where
- 72 sites in Australia, New Zealand and 1 more
- Volunteers
- 462 people
- Sponsor
- University College, London
Glaucoma, Open-Angle
Nicotinamide in Glaucoma (NAMinG): A Randomised, Placebo-controlled, Multi-centre, Phase III Trial
Glaucoma is the leading cause of sight impairment and blindness worldwide. It is a long-term eye disease which can cause permanent loss of sight and sometimes blindness and affects 1 in 50 people over 50 years of age.
- Trial name
- NAMinG (NCT05405868)
- Testing
- Nicotinomide
- Where
- 10 sites in United Kingdom
- Volunteers
- 496 people
- Sponsor
- University College, London
Lymphoma
Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin Lymphoma
RATIONALE: Imaging procedures, such as fludeoxyglucose F 18 (FDG)-PET/CT scan, done before, during, and after chemotherapy may help doctors assess a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00678327
- Testing
- bleomycin sulfate, filgrastim, pegfilgrastim
- Where
- United Kingdom
- Volunteers
- 1,202 people
- Sponsor
- University College, London
Health Behaviour, Tobacco Prevention
Intervention for Adolescent Tobacco Initiation Prevention
This school-based cluster randomized controlled trial aims to assess the feasibility of implementing the Adolescent Tobacco Initiation Prevention (IATIP) and evaluate the potential efficacy of IATIP in preventing tobacco…
- Conditions
- Health Behaviour, Tobacco Prevention, Well-being
- Trial name
- IATIP (NCT06399588)
- Testing
- Intervention for Adolescent Tobacco Initiation Prevention (IATIP)
- Where
- Bangladesh
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- University College, London
Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma
Trial of Haploidentical Stem Cell Transplantation for Haematological Cancers
This trial investigates stem cell transplants from partially mismatched donors in patients with blood and bone marrow cancers. The trial will test two kinds of transplants - a full intensity transplant using a high dose of…
- Conditions
- Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Acute Myeloid Leukaemia, Acute Lymphoblastic Leukaemia
- Trial name
- UK-Haplo (NCT01597219)
- Testing
- Reduced intensity haplodentical stem cell transplant, Myeloablative haploidentical stem cell transplant
- Where
- 12 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- University College, London
Glioblastoma
A Trial of Neoadjuvant Therapy in Patients With Newly Diagnosed Glioblastoma
The NeAT Glio trial will evaluate whether the addition of ipilimumab prior to the current standard treatment of surgery and chemoradiotherapy will improve survival in patients with newly diagnosed glioblastoma.
- Trial name
- NeAT Glio (NCT05074992)
- Testing
- Ipilimumab
- Where
- 4 sites in United Kingdom
- Volunteers
- 1 people
- Sponsor
- University College, London
Physical Inactivity
A Test of Different Incentives and How Effectively They Motivate Walking Behaviour
This study aims to test the effectiveness of different types of incentives to motivate walking among people who use a tracker app.
- Trial name
- NCT06395233
- Testing
- BetterPoints App
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University College, London
Huntington Disease
Huntington's Disease Young Adult Study 2.0
The goal of this observational study is to learn about the first signs of disease in young adult carriers of the gene for Huntington's disease.
- Trial name
- HD-YAS (NCT06391619)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 154 people
- Sponsor
- University College, London
Hiv, HIV Infections
Long-Acting Treatment in Adolescents (LATA)
The LATA trial will find out if taking a long-acting injectable form of HIV medicines, called cabotegravir and rilpivirine, every 2 month works as well as taking tablet HIV medicines every day in young people aged 12-19 years of…
- Conditions
- Hiv, HIV Infections, HIV-1-infection, Paediatric Human Immunodeficiency Virus Infection
- Trial name
- LATA (NCT05154747)
- Testing
- Cabotegravir, Rilpivirine Drug Combination, TLD
- Where
- 5 sites in Kenya, South Africa and 2 more
- Volunteers
- 476 people
- Sponsor
- University College, London
Spinal Cord Injuries
iCycle II: Recovery of Function Through FES Cycling With VR Biofeedback in People With SCI.
The annual incidence of traumatic spinal cord injury (SCI) is estimated at 2,500 (35 per week) in the UK and, due to advances in research and clinical management, the majority now have incomplete injuries, with significant…
- Trial name
- iCycle (NCT04902482)
- Testing
- iCycle Mark 3
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London