Clinical trials: sponsored by University College, London
Primary Progressive Aphasia, Frontotemporal Dementia
Better Living With Non-memory-led Dementia
This is a feasibility study on the effects of an online-based training and education programme for carers of people with posterior cortical atrophy (PCA), primary progressive aphasia (PPA) and behavioural-variant frontotemporal…
- Conditions
- Primary Progressive Aphasia, Frontotemporal Dementia, Alzheimer Disease
- Trial name
- NCT05525377
- Testing
- Better living with non-memory led dementia course
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University College, London
Prostate Cancer
ReIMAGINE Prostate Cancer Risk
ReIMAGINE Prostate Cancer Risk is a multi-centre, prospective, observational, longitudinal cohort study of men referred to secondary care with a suspicion of prostate cancer.
- Trial name
- NCT04060589
- Testing
- Tissue donation, Blood Donation, Urine Donation
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University College, London
Informed Consent, Health Literacy, Risk, Spinal Puncture, Neurosurgery
Communicating Risks: Consent for Lumbar Puncture
The goal of this randomized control trial is to compare the effect of visual aids on the recall of probabilistic risks in healthy participants.
- Trial name
- NCT05717465
- Testing
- Anatomy diagrams, Standard informed consent
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University College London Hospitals
Plasmacytoma
Trial of Immunomodulatory Therapy in High Risk Solitary Bone Plasmacytoma
The purpose of the trial is to establish whether adjuvant therapy with lenalidomide + dexamethasone after radiotherapy can improve progression free survival in patients with high risk solitary bone plasmacytoma compared with RT…
- Trial name
- IDRIS (NCT02544308)
- Testing
- Lenalidomide, Dexamethasone, No further treatment
- Where
- 13 sites in United Kingdom
- Volunteers
- 36 people
- Sponsor
- University College, London
COVID-19
FLARE: Favipiravir +/- Lopinavir: A RCT of Early Antivirals
The current pandemic of SARS-CoV-2 causing COVID-19 disease is an unprecedented global emergency. COVID-19 appears to be a disease with an early phase where the virus replicates, coinciding with first presentation of symptoms…
- Trial name
- FLARE (NCT04499677)
- Testing
- Favipiravir, Lopinavir/ Ritonavir
- Where
- 2 sites in United Kingdom
- Volunteers
- 240 people
- Sponsor
- University College, London
COVID-19
Shaping Care Home COVID-19 Testing Policy
The goal of this interventional study is to investigate whether continued use of regular asymptomatic testing in staff is a feasible, effective and cost-effective strategy to reduce the impact of COVID-19 in care homes.
- Trial name
- VIVALDI-CT (NCT05639205)
- Testing
- Lateral Flow Device
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University College, London
Hemophilia B
A Factor IX Gene Therapy Study (FIX-GT)
Severe haemophilia B (HB) is a bleeding disorder where a protein made by the body to help make blood clot is either partly or completely missing.
- Trial name
- FIX-GT (NCT03369444)
- Testing
- FLT180a
- Where
- 11 sites in United States, Ireland and 2 more
- Volunteers
- 10 people
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Remote Assessment of Lung Disease and Impact on Physical and Mental Health
This cohort study aims to use the open-source RADAR-base mHealth platform to collect and analyze datasets associated with lung disease. This will include continuous data collected from wearable devices (e.g.
- Conditions
- Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease, Covid19
- Trial name
- RALPMH (NCT05630599)
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Osteoarthritis, Osteoporosis
Development of a Non-invasive Assessment of Human Bone Quality Using Spatially Offset Raman Spectroscopy
In this study spatially offset Raman spectroscopy (SORS), which allows the collection of Raman spectra through turbid media, is being applied to collect Raman spectra of bone.
- Conditions
- Osteoarthritis, Osteoporosis, Osteogenesis Imperfecta, Rickets / Osteomalacia
- Trial name
- NCT02814591
- Testing
- spatially offset Raman spectrometer (SORS)
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University College, London
Non-Dystrophic Myotonia
MExiletine Versus Lamotrigine in Non-Dystrophic Myotonias
This is a clinical trial to determine if Lamotrigine is non-inferior to Mexiletine for the treatment of myotonia in patients with Non-Dystrophic Myotonia. Non-dystrophic Myotonia is a genetic condition for which there is no cure.
- Trial name
- MEND (NCT05017155)
- Testing
- Mexiletine, Lamotrigine 25Mg Oral Tablet, Extended Release
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University College, London
Fluorescence Guided Surgery
Feasibility Trial for Real-time Identification of the Ureters With a Methylene-blue
This is a non-randomized prospective, open label, single site study to evaluate the feasibility of recruitment for the use of an Investigational Endoscopic Fluorescence Imaging System, PINPOINT, in intraoperative bilateral…
- Trial name
- TRIUMPh (NCT05111808)
- Testing
- Methylene blue fluorescence
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Atrial Fibrillation New Onset, Magnesium Deficiency
Point of Care RandOmisation Systems for Performing Embedded Comparative Effectiveness Trials Of Routine Treatments
Every day, doctors and nurses make hundreds of decisions about treatments - like when to start or stop them, or how frequently to give them.
- Trial name
- PROSPECTOR (NCT05149820)
- Testing
- Electronic Point of Care Randomisation tool, Magnesium
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Rectal Cancer, Lymph Node Metastasis
Radioisotope and Fluorescence Guidance in Rectal Cancer
A study to investigate if pelvic side wall lymph nodes that remain after neo-adjuvant chemoradiotherapy can be identified intraoperatively using dual radioisotope and fluorescence guidance.
- Trial name
- NCT05336643
- Testing
- Radiofluorescence
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Lung Cancer Squamous Cell
Electrocautery Ablation for the Prevention of Lung Cancer
This study evaluates whether EC treatment is effective in delaying the progression of high-grade lung lesion(s) to invasive lung cancer.
- Trial name
- EARL (NCT03870152)
- Testing
- Electrocautery Ablation (EC)
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University College, London
Prostate Cancer
Nivolumab and Ipilimumab Treatment in Prostate Cancer With an Immunogenic Signature
The primary objective is to test the following hypothesis: Patients with metastatic castrate resistant prostate cancer that have progressed following at least one line of therapy and have an immunogenic signature will respond to…
- Trial name
- NCT03061539
- Testing
- Nivolumab & Ipilimumab
- Where
- United Kingdom
- Volunteers
- 380 people
- Sponsor
- University College, London
Ovarian Cancer
Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients
ICON 9 will assess the efficacy, safety and tolerability of maintenance olaparib in combination with cediranib compared to maintenance olaparib alone following a response to platinum-based chemotherapy in women with relapsed…
- Trial name
- ICON9 (NCT03278717)
- Testing
- Olaparib, Cediranib
- Where
- 54 sites in Australia, Canada and 2 more
- Volunteers
- 330 people
- Sponsor
- University College, London
Renal Cell Carcinoma, Melanoma
REduced Frequency ImmuNE Checkpoint Inhibition in Cancers
The REFINE trial aims to asses whether giving an immunotherapy drug less-often to patients with advanced cancer, results in fewer side effects whilst continuing to be an effective treatment.
- Trial name
- REFINE (NCT04913025)
- Testing
- Nivolumab, Pembrolizumab
- Where
- 3 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- University College, London
Prostate Cancer
Novel MRI Assessment of Prostate Cancer VALIDATE-PRO
For 50 years the diagnosis of prostate cancer has been with Prostate Specific Antigen (PSA) blood testing and prostate biopsy. However, this approach resulted in over-diagnosis, over-treatment and missed clinical important…
- Trial name
- VALIDATE-PRO (NCT05017181)
- Where
- United Kingdom
- Volunteers
- 234 people
- Sponsor
- University College, London
Haematological Malignancies
Infusion of Depleted T Cells Following Unrelated Donor Stem Cell Transplant (ICAT)
The purpose of this study is to evaluate whether the administration of allodepleted donor T cells to patients with haematological malignancies after stem cell transplant can improve the recovery of the patients immune system.
- Trial name
- ICAT (NCT01827579)
- Testing
- CD25/71 allodepleted donor T-cells
- Where
- 2 sites in United Kingdom
- Volunteers
- 37 people
- Sponsor
- University College, London
Breastfeeding, Postnatal Depression
Mother and Late Preterm Lactation Study
Breastfeeding has various benefits for the mother and infant. It has the capability of reducing the risk of short term and long term problems for the infant, such as gastroenteritis, respiratory infections, type II diabetes and…
- Conditions
- Breastfeeding, Postnatal Depression, Stress, Psychological, Preterm Infant
- Trial name
- MAPLeS (NCT03791749)
- Testing
- Breastfeeding Support
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University College, London