Clinical trials: sponsored by University College, London
Coronary Heart Disease
Alcohol Consumption and Coronary Heart Disease Onset
The primary aim of this study is to examine if long-term patterns of alcohol consumption are associated with time-to-onset for incident coronary heart disease (fatal and non-fatal), using data from multiple cohorts.
- Trial name
- NCT03133689
- Where
- United Kingdom
- Volunteers
- 35,132 people
- Sponsor
- University College, London
Tuberculosis
Improving the Management of Drug Resistant Tuberculosis in the UK
The 'rising tide' of antimicrobial resistance is a source of concern across most infectious diseases. In the UK, for example, 6.8% of the ~8,500 tuberculosis patients seen in 2012 were resistant to the cheap and effective…
- Trial name
- UK_DR-TB (NCT02875574)
- Testing
- Any treatment regimen, Bacterial mutation
- Where
- United Kingdom
- Volunteers
- 630 people
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease
GECo: Implementation and Effectiveness of COPD Self Management Action Plans in Low and Middle Income Countries
This study will randomise people with clinically significant COPD (GOLD Grade B-D) to usual care or provision of a self-management action plan supported by monthly follow-up visits from a community health worker trained in the…
- Trial name
- GECo2 (NCT03359915)
- Testing
- COPD Self-Management Plan
- Where
- 3 sites in Nepal, Peru and 1 more
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University College, London
Acute Myocardial Infarction
MI Mortality Risk and Between-hospital Risk Variation in the United Kingdom and Sweden
The study aims to investigate the differences in survival trajectories and hospital variability in myocardial infarction (MI) mortality rates in the UK and Sweden.
- Trial name
- NCT01359033
- Where
- 2 sites in Sweden, United Kingdom
- Volunteers
- 510,863 people
- Sponsor
- University College, London
Lymphoma
Low-Dose Radiation Therapy in Treating Patients With Follicular or Marginal Zone Non-Hodgkin's Lymphoma
RATIONALE: Radiation therapy uses high-energy x-rays to kill cancer cells. It is not yet known which regimen of low-dose radiation therapy is more effective in treating follicular non-Hodgkin's lymphoma.
- Trial name
- FoRT (NCT00310167)
- Testing
- radiation therapy
- Where
- United Kingdom
- Volunteers
- 614 people
- Sponsor
- University College, London
Stroke, Atrial Fibrillation (AF)
Clinical Relevance of Microbleeds In Stroke
Study I: CROMIS-2 (AF) Prospective cohort study of patients anticoagulated after cardioembolic stroke An observational inception cohort study (n=1425) of patients throughout the United Kingdom (UK) - (79 hospitals) started on…
- Conditions
- Stroke, Atrial Fibrillation (AF), Intracerebral Haemorrhage (ICH)
- Trial name
- CROMIS-2 (NCT02513316)
- Where
- United Kingdom
- Volunteers
- 2,490 people
- Sponsor
- University College, London
Bronchogenic Carcinoma
A New Pathway With BronchOscopic or Oesophageal Ultrasound for Lung Cancer Diagnosis and STaging (BOOST)
In the UK, staging of lung cancer is time consuming (taking on average more than 3 weeks), costly and inaccurate in up to 20% of cases.
- Trial name
- BOOST (NCT00652769)
- Testing
- Endobronchial or Endoscopic Ultrasound, Bronchoscopy, CT-guided biopsy, PET scan, Mediastinoscopy
- Where
- 4 sites in United Kingdom
- Volunteers
- 168 people
- Sponsor
- University College London Hospitals
Scleroderma, Scleroderma Renal Crisis
Zibotentan Better Renal Scleroderma Outcome Study
Many patients with scleroderma have damage to their kidneys caused by the disease. There is limited evidence for treatments to prevent this damage or stop it progressing.
- Conditions
- Scleroderma, Scleroderma Renal Crisis, Chronic Kidney Disease
- Trial name
- ZEBRA (NCT02047708)
- Testing
- Zibotentan
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University College, London
Viraemia
CMV Glycoprotein B (gB) Vaccine Long Term Antibody Response
The purpose of this study is to see how well the antibody levels found months to years after patients entered a previous randomised placebo-controlled trial of a glycoprotein B vaccine against cytomegalovirus have persisted and…
- Trial name
- NCT01883206
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London
Viraemia
Determining a Viral Load Threshold for Treating Cytomegalovirus (CMV)
This study aims to determine: a) whether those patients with 'low level' viral load results (between 200 and 3,000 copies/ml) could be monitored as opposed to starting preemptive therapy with valganciclovir, ganciclovir and/or…
- Trial name
- NCT00947141
- Testing
- ganciclovir (start when CMV PCR >200copies / ml x2), Monitor (Treatment starts when CMV PCR >3,000 copies / ml), Stop treatment when 2 levels CMV PCR <3,000 copies / ml
- Where
- United Kingdom
- Volunteers
- 165 people
- Sponsor
- University College, London
Post-menopausal Osteoporosis
Bone Healing in Healthy and Post-menopausal Osteoporotic Women
Both the pathogenesis and the treatment of osteoporosis may potentially interfere at different levels on the multi-stage complex cascade of events involved in bone healing/regeneration.
- Trial name
- NCT01826656
- Testing
- tooth extraction, CBCT scan, DXA scan
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University College, London
Periodontitis, Adult, Metabolic Syndrome
Genetic Variants and Oxidative Stress as Links Between Periodontitis and Metabolic Syndrome
The aim of this study is to investigate the systemic impact of periodontitis in patients with Metabolic Syndrome, by assessing measures of sub-clinical atherosclerosis and cardiovascular risk, microbial factors and host genetic…
- Trial name
- NCT03297749
- Testing
- Observational study (no intervention)
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 102 people
- Sponsor
- University College, London
Uveitis
Use of Simvastatin as a Steroid Sparing Agent for Uveitis Patients
The trial will compare the effect on disease control and immunosuppression treatment of adding simvastatin 80mg once daily, over a follow-up and treatment period of 2 years.
- Trial name
- NCT02252328
- Testing
- Simvastatin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College, London
Rectal Cancer
Capecitabine, Irinotecan Hydrochloride, Cetuximab, and Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EXCITE (NCT00972881)
- Testing
- cetuximab, capecitabine, irinotecan hydrochloride
- Where
- 5 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- University College, London
Glioblastoma
Gliadel Wafer and Fluorescence-Guided Surgery With 5-ALA Followed by Radiation Therapy And Temozolomide in Treating Patients With Primary Glioblastoma
RATIONALE: Drugs used in chemotherapy, such as Gliadel wafer and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01310868
- Testing
- 5-ALA, Gliadel wafers, Radiotherapy as normal based on standard clinical protocols determined by the neuro-oncologist
- Where
- 10 sites in United Kingdom
- Volunteers
- 59 people
- Sponsor
- University College, London
Periodontitis
Tooth Loss in Periodontitis Patients
Tooth loss in periodontitis patients is associated with patient and site factors as well as with treatment provided. Not much is known about long-term tooth loss in periodontitis patients in private practice in the UK.
- Trial name
- NCT02091258
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Cortical Dysplasia
Evaluating Dietary Intervention Before surgicaL Treatment for Epilepsy
The investigators are undertaking the first European Randomised Controlled Trial (RCT) for epilepsy surgery in children with FCD type II, to prospectively evaluate the role of the KD prior to surgery in improving seizure outcome.
- Trial name
- EDIBLE (NCT02261753)
- Testing
- Classical ketogenic diet
- Where
- 15 sites in United States, Austria and 6 more
- Volunteers
- 3 people
- Sponsor
- University College, London
Very Late Onset Schizophrenia
Social Isolation and Loneliness in Older People
Although psychotic disorders such as schizophrenia usually present in late adolescence or early adulthood, research suggests that a substantial subset of people are diagnosed for the first time after the age of 60.
- Trial name
- NCT03201731
- Volunteers
- 66 people
- Sponsor
- University College, London
Fabry Disease
Native T1 Mapping by Cardiovascular Magnetic Resonance Imaging in Rare Diseases
Fabry Disease (FD) is a rare, X-linked lysosomal storage disorder leading to left ventricular hypertrophy, myocardial fibrosis, arrhythmia and heart failure. Cardiac involvement is the leading cause of death in FD.
- Trial name
- FABRY400 (NCT03199001)
- Where
- 4 sites in Australia, United Kingdom
- Volunteers
- 400 people
- Sponsor
- University College, London
Hypothermia Following Anesthesia
Impact of Forced Air Warming on Perioperative Thermodynamics
The purpose of the study is to assess the temperature changes that take place throughout the body in a real world setting, when a patient is given general anaesthesia.
- Trial name
- NCT03191214
- Testing
- Intraoperative Forced Air Warming
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University College, London