Clinical trials: sponsored by University College, London
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Gemcitabine With or Without Cisplatin in Treating Patients With Unresectable Locally Advanced or Metastatic Cholangiocarcinoma or Other Biliary Tract Tumors
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- ABC-02 (NCT00262769)
- Testing
- cisplatin, gemcitabine hydrochloride
- Where
- 25 sites in United Kingdom
- Volunteers
- 324 people
- Sponsor
- University College, London
COPD
The MRC/ABPI COPD Cohort v1.7
The UK Medical Research Council (MRC) together with the Association of British Pharmaceutical Industries (ABPI) have recently funded a program designed to foster collaboration between academic COPD researchers and the…
- Trial name
- COPDMAP (NCT01620645)
- Testing
- CT scan and PA chest X-ray
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- University College, London
Chronic Obstructive Pulmonary Disease (COPD).
Development of an Optimal Antibiotic Regime for Long-term Therapy in Stable Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD) is the cause of considerable deaths, and exacerbations (flare up of symptoms) are a major cause of hospital admission in the UK.
- Trial name
- NCT01398072
- Testing
- Moxifloxacin, Azithromycin, Doxycycline
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University College, London
Stable Coronary Artery Disease
Prognostic Models for People With Stable Coronary Artery Disease
There is currently no published algorithm for secondary prevention prognosis of CHD that is representative of the England GP-registered population and that includes both symptomatic and asymptomatic patients (as identified…
- Trial name
- NCT01609465
- Where
- United Kingdom
- Volunteers
- 300,000 people
- Sponsor
- University College, London
Carcinoma, Squamous Cell
Phase I Study of Olaparib With Cisplatin Based Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck
The aim of this study is to find the safe dose and best dosing schedule of olaparib to give in combination with cisplatin based chemoradiotherapy (CRT) in patients with locally advanced head and neck cancer.
- Trial name
- ORCA (NCT01491139)
- Testing
- olaparib, cisplatin, Intensity Modulated Radiotherapy
- Sponsor
- University College, London
Diabetes (Insulin-requiring, Type 1 or Type 2)
Assessment of the Clinical Efficacy and Acceptability of Think Positive (T+) in Diabetes Management
New telemedicine systems have been designed to assist people suffering from diabetes in the management of their chronic disease. More recently the focus has been moving to portable systems equipped with Bluetooth.
- Trial name
- T+ (NCT00922376)
- Testing
- Mobile phone telehealth application: Think Positive (T+)
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- University College London Hospitals
Parkinson's Disease
Exendin-4 as a Treatment for Parkinson's Disease - Pilot Study
Exenatide is a licensed, safe and effective treatment for patients with Diabetes mellitus. Laboratory work has shown strong, reproducible evidence that this drug has beneficial "disease modifying" effects when given to animals…
- Trial name
- NCT01174810
- Testing
- Exenatide
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University College, London
Malignant Pleural Mesothelioma
A Phase I/II Study of First Line Vorinostat With Pemetrexed-cisplatin, in Patients With Malignant Pleural Mesothelioma
Mesothelioma is a relatively rare cancer which is becoming more common. It can affect one of two areas; the pleura (the lining of the lung) or the peritoneum (the lining of the abdomen).
- Trial name
- MESO-02 (NCT01353482)
- Testing
- Cisplatin, Pemetrexed, Vorinostat
- Sponsor
- University College, London
Lung Cancer
Carboplatin and Etoposide With or Without Thalidomide in Treating Patients With Limited-Stage or Extensive-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy such as carboplatin and etoposide use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00061919
- Testing
- Carboplatin, etoposide & thalidomide
- Where
- United Kingdom
- Volunteers
- 724 people
- Sponsor
- University College, London
Prostate Cancer
Imaging for Significant Prostate Cancer Risk Evaluation
The incidence of prostate cancer is rising however the number of deaths from prostate cancer is stable. Meaning the investigators are diagnosing many men with prostate cancer that will not impact on their life.
- Trial name
- PICTURE (NCT01492270)
- Testing
- Prostate HistoScanning, Multi-parametric MRI, Transperineal prostate mapping biopsy
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- University College London Hospitals
Respiratory Insufficiency
Physiological Response to Heliox21 and Air O2
This is a non-commercial study to explore the use of Heliox21 in a new patient cohort. The fundamental aim is to assess the therapeutic benefits of Heliox21 and practicalities of gas delivery in patients who require non-invasive…
- Trial name
- NCT01498432
- Testing
- Heliox21, Air O2
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University College, London
Lung Cancer, Precancerous Condition
Screening for Lung Cancer in Current or Past Smokers With Chronic Obstructive Pulmonary Disease
RATIONALE: Screening tests or exams may help doctors find lung cancer sooner, when it may be easier to treat. PURPOSE: This randomized clinical trial is studying screening tests or exams to see how well they work compared to…
- Trial name
- NCT00512746
- Testing
- cytology and cytometry specimen collection procedure, Chest x ray, Autofluorescence bronchoscopy
- Where
- 10 sites in United Kingdom
- Volunteers
- 1,569 people
- Sponsor
- University College, London
Head and Neck Cancer
Everolimus and Docetaxel in Treating Patients With Recurrent, Locally Advanced, or Metastatic Head and Neck Cancer
RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- DORA (NCT01313390)
- Testing
- docetaxel, everolimus, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University College, London
Lung Cancer, Metastatic Cancer
WBRT & Erlotinib in Advanced NSCLC and Brain Metastases
RATIONALE: Radiation therapy uses high energy x-rays to kill tumor cells. Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Trial name
- TACTIC (NCT00554775)
- Testing
- erlotinib hydrochloride
- Where
- 7 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
Isolated Mediastinal Lymphadenopathy, Sarcoidosis
A Clinical tRial of Endobronchial Ultrasound for the Diagnosis of MEDiastinal lymphadenopathY (REMEDY)
Enlarged glands in the chest (mediastinal lymphadenopathy) is a common problem and may have a variety of different causes. In the past an operation (mediastinoscopy) was required to diagnose the glands.
- Conditions
- Isolated Mediastinal Lymphadenopathy, Sarcoidosis, Tuberculosis, Lung Cancer
- Trial name
- REMEDY (NCT00932854)
- Testing
- EBUS
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University College London Hospitals
Radiation Enteritis, Radiation Proctitis
Study to Prevent Radiation Induced Damage to Bowel Using a Prebiotic Enhanced Diet.
The study will consist of pair of double-blind placebo-controlled trials of dietary supplementation with 15g/day FructoOligoSaccharide (FOS) for 7.5 weeks in patients with prostate carcinoma or 5 weeks in patients with cervical…
- Trial name
- NCT01414517
- Testing
- FructoOligoSaccharide, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- University College London Hospitals
Liver Cancer
Transarterial Chemoembolization Using Doxorubicin Beads With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01324076
- Testing
- doxorubicin-eluting beads, sorafenib tosylate, laboratory biomarker analysis
- Where
- 8 sites in United Kingdom
- Volunteers
- 412 people
- Sponsor
- University College, London
Right Hemisphere Stroke, Hemispatial Neglect
Dopamine Agonist for Hemispatial Neglect and Motor Deficit Post Stroke
The aim of this study is to assess the effect of the drug rotigotine on the syndrome of hemispatial neglect and motor deficits following strokes affecting the right hemisphere of the brain.
- Conditions
- Right Hemisphere Stroke, Hemispatial Neglect, Motor Deficit
- Trial name
- NCT00663338
- Testing
- Rotigotine
- Where
- 3 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Acute Coronary Syndromes
Coronary Mortality in South Asians: Aetiologic and Prognostic Effects
The purpose of this study is to determine the extent to which South Asian ethnicity is both an etiologic and prognostic factor for coronary disease, and investigate factors influencing outcomes.
- Trial name
- CALIBER (NCT01163513)
- Where
- United Kingdom
- Volunteers
- 100,000 people
- Sponsor
- University College, London
Depression, Anxiety
Depression and Anxiety in the Aetiology and Prognosis of Specific Cardiovascular Disease Syndromes: a CALIBER Study
People report feeling sad and low (depression) or worried (anxiety) appear more likely to subsequently suffer a heart attack, or angina. However it is not known whether depression or anxiety actually causes heart disease.
- Conditions
- Depression, Anxiety, Coronary Disease, Cardiovascular Disease
- Trial name
- NCT01240798
- Where
- United Kingdom
- Sponsor
- University College, London