Clinical trials: open to volunteers, sponsored by University Health Network, Toronto
Postoperative, Pain
Effect of Erector Spinae (ESP) Block on Opioid Reduction and Enhanced Recovery After Posterior Cervical Spine Surgery
Patients undergoing spine surgery frequently experience significant pain after surgery. This can limit patient activity and hinder rehabilitation.
- Trial name
- NCT04646707
- Testing
- Erector Spinae (ESP) Block with Lidocaine/Bupivacaine
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University Health Network, Toronto
Obstructive Sleep Apnea (OSA)
Point of Care Ultrasound in Pregnant Women (PoCUS-OB)
Pregnant women with gestational age more than 20 weeks are at risk of developing Obstructive Sleep Apnea (OSA). OSA is a common underdiagnosed comorbid condition in pregnant women associated with adverse maternal and fetal…
- Trial name
- NCT06776237
- Testing
- PoCUS
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Stroke, Visual Impairment
Effectiveness of AV-stimulation in Immersive VR to Improve Visual Perception and Driving Performance
The goal of this clinical trial is to evaluate the effectiveness of an immersive virtual-reality (IVR) based stimulation program, in improving visual perception for people who have lost their driver's license due to perceptual or…
- Conditions
- Stroke, Visual Impairment, Low Vision, Virtual Reality
- Trial name
- Re:DriVR (NCT05703360)
- Testing
- Audiovisual Stimulation
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Hepatocellular Carcinoma (HCC), Macrovascular Invasion
Using Radiotherapy and Immunotherapy to Treat Advanced Liver Cancer Before Transplant
The goal of this clinical trial is to learn if locoregional therapy and immunotherapy can be used together to help patients with hepatocellular carcinoma (HCC) and macrovascular invasion achieve liver transplantation.
- Conditions
- Hepatocellular Carcinoma (HCC), Macrovascular Invasion, Liver Transplant Surgery, Downstaging
- Trial name
- MacroTrans (NCT06725121)
- Testing
- Atezolizumab & Bevacizumab, Yttrium-90 (Y-90), Stereotactic body radiotherapy (SBRT)
- Where
- 2 sites in Canada
- Volunteers
- 48 people
- Sponsor
- University Health Network, Toronto
Chronic Kidney Diseases
ODYSSEE Kidney Health Trial
INTRODUCTION Severe CKD is defined as a risk of greater than 10% for progressing to RRT [home hemodialysis (HHD), home peritoneal dialysis (HPD), and transplantation] within 2 years.
- Trial name
- ODYSSEE-KH (NCT06274710)
- Testing
- ODYSSEE-KH
- Where
- Canada
- Volunteers
- 344 people
- Sponsor
- University Health Network, Toronto
Diaphragm Injury, Respiratory Failure
Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
- Conditions
- Diaphragm Injury, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- DIASPORA (NCT03667027)
- Testing
- Respiratory support
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries, Sleep Apnea
Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI
This clinical trial will examine the efficacy of continuous positive airway pressure (CPAP) therapy in improving psychosocial, neurocognitive and behavioral consequences of moderate-to-severe sleep-related breathing disorders…
- Trial name
- NCT04007380
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries, Spine Disease
Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)
This randomized clinical trial will compare three groups of individuals with cervical/thoracic, complete or incomplete spinal cord injury (SCI) that will undergo: (i) early CPAP therapy in the management of moderate-to-severe…
- Trial name
- NCT05473689
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University Health Network, Toronto
Respiratory Insufficiency, Diaphragm Injury
Feasibility of Reducing Respiratory Drive Using the Through-flow System
Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury.
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Lung Injury
- Trial name
- Throughflow (NCT05642832)
- Testing
- Throughflow titration phase
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Liver Transplant Rejection, Immune System Suppression
Conversion of Maintenance Prograf to Envarsus in Liver Transplant Recipients
Prograf and Envarsus are two different formulations of Tacrolimus which is used as an immunosuppressant in liver transplant (LT) patients.
- Trial name
- NCT05655273
- Testing
- Prograf, Envarsus
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Stroke, CVA
COgnitive-somatoSensory-MOtor Training to Improve Arm and Hand Function After Stroke (iCOSMO)
The iCOSMO study investigates the feasibility and beneficial effects of an intervention combining sensation, motor and cognition to improve arm and hand function after chronic stroke.
- Conditions
- Stroke, CVA, Cerebrovascular Accident
- Trial name
- iCOSMO (NCT06498011)
- Testing
- Home Graded Repetitive Arm Supplementary Program (GRASP), integrated Somatosensory-MOtor training using a COgnitive approach(iCOSMO)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Cricoid Pressure
Validation of a Novel Handheld Device for Accurate Cricoid Pressure in Healthy Volunteers
Pulmonary aspiration of gastric contents is a leading cause of anesthesia-related morbidity and mortality, particularly in emergency surgeries and among patients who are not appropriately fasted prior to airway intervention.
- Trial name
- NCT06540625
- Testing
- the use of CP device application on human subjects.
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Respiratory Failure
Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane Oxygenation
The goal of this study is to design a pilot trial evaluating the safety, feasibility, pharmacokinetic modeling, and physiological effects of a volatile anesthetic, sevoflurane, directly administered in extracorporeal membrane…
- Trial name
- Vol-ECMO (NCT05680545)
- Testing
- Sevoflurane vaporized in ECMO machines
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Homeless Persons
Evaluation of a Supportive Housing Program for Adults Who Are Unhoused and Have Complex Health Needs
The study design is a cohort study with a propensity score-matched control group and difference-in-difference analysis to evaluate intervention effectiveness.
- Trial name
- NCT06723093
- Testing
- Social Medicine Housing Initiative
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Kidney Transplant, Kidney Failure
Preventing Delayed Graft Function in Kidney Transplant Patients
The health and quality of life benefits of kidney transplantation are reduced by delayed graft function (DGF). There are a number of modifiable risk factors associated with DGF, such as intraoperative hypotension, the type of…
- Conditions
- Kidney Transplant, Kidney Failure, Kidney Injury
- Trial name
- PDF (NCT06724211)
- Testing
- Treatment bundle of care, Control Group
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries
Time-effect of FEST+TST in the Upper-extremity Rehabilitation of Individuals with Traumatic SCI
The purpose of this study is to investigate whether the timing of delivery of functional electrical stimulation therapy in combination with task-specific training (FEST+TST) following spinal cord injury (SCI) influences…
- Trial name
- NCT04910204
- Testing
- FES Therapy combined with task-specific training (FEST+TST)
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University Health Network, Toronto
Prostate Cancer, Breast Cancer
Remote Monitoring of Patient Reported Outcomes to Improve the Efficacy of the Acute Phase Radiotherapy Review Process
Radiation therapy (RT) is a key component in the treatment of breast and prostate cancer. However, patients may experience significant side effects.
- Trial name
- PROMOTE (NCT06274892)
- Testing
- Remote monitoring PROs
- Where
- Canada
- Volunteers
- 124 people
- Sponsor
- University Health Network, Toronto
Hepatocellular Carcinoma
Durvalumab and Tremelimumab in Resectable HCC
Hepatocellular Carcinoma (HCC) is the third most common cause of death from cancer world wide and the incidence is rising globally. Despite surgical resection in appropriate patients, many patients recur.
- Trial name
- (NEOTOMA) (NCT05440864)
- Testing
- Tremelimumab
- Where
- 3 sites in Canada, Italy and 1 more
- Volunteers
- 28 people
- Sponsor
- University Health Network, Toronto
Primary Myelofibrosis, Polycythemia Vera
Myeloproliferative Neoplasms (MPNs) Patient Registry
The mandate of this MPN registry is to collect clinical information, including molecular results, from consenting patients with a variety of MPNs at different time points during the course of their disease.
- Conditions
- Primary Myelofibrosis, Polycythemia Vera, Essential Thrombocythemia, Mastocytosis
- Trial name
- NCT02760238
- Testing
- Observational
- Where
- Canada
- Volunteers
- 5,000 people
- Sponsor
- University Health Network, Toronto
Cholangiocarcinoma Resectable
Gemcitabine/Cisplatin/Nab-Paclitaxel and Rilvegostomig in Resectable iCCA
Biliary tract cancer is a highly aggressive and heterogeneous group of gastrointestinal cancers that arise from the intra- or extrahepatic bile ducts (CCA), or the gallbladder (GBC)(1-3).
- Trial name
- NEOLANGIO (NCT06569225)
- Testing
- Gemcitabine/Cisplatin/Nab-Paclitaxel and Rilvegostomig
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto