Clinical trials: sponsored by University Hospital, Angers
Home-based Programs, EzyGain
EMMVIES : Walking Training at Home in VIrtual Reality for Children With Chronic Illnesses Impacting Physical Health
Over the past 30 years, the prevalence of congenital or acquired chronic diseases in children has risen, affecting between 10 and 30% of them, or at least 100,000 children in France.
- Conditions
- Home-based Programs, EzyGain, AMY Treadmill, Cerebral Palsy
- Trial name
- EMMVIES (NCT07021638)
- Testing
- EMMVIES program
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Angers
Aplasia
Tolerance of Teeth Brushing During Prolonged Aplasia
It is currently not allowed for patients with prolonged aplasia, following intensive chemotherapy, to brush teeth due to the risk of damaging the oral mucosa with risk of haemorrhage and infectious entrance door.
- Trial name
- UP-TIP (NCT03879252)
- Testing
- Toothbrush, Mouthwashes
- Where
- France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Angers
Postoperative Recovery
Impact of Postoperative Transitional Pain on Recovery After Thoracic Surgery
Postoperative transitional pain corresponds to the pain occuring between acute postoperative pain and chronic postsurgical pain (defined as pain persisting for at least 3 months after surgery).
- Trial name
- TRANSAT (NCT05450172)
- Testing
- QoR-15 questionnaire
- Where
- France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Angers
Dysautonomia, ACCUVEIN
Screening for Alterations in the Autonomic Nervous System
Dysautonomia is an alteration of the autonomic nervous system that manifests itself in different forms, some of which are very disabling. Dysautonomia accompanies many pathologies.
- Conditions
- Dysautonomia, ACCUVEIN, Superficial Veins, Sympathetic Nervous System
- Trial name
- SYMPA-VEIN (NCT07029191)
- Testing
- Progressive standing test
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Leber Hereditary Optic Neuropathy (LHON), Leber's Hereditary Optic Neuropathy (LHON)
Pilot Study of the Efficacy of Nicotinamide (Vitamin B3) in Leber's Hereditary Optic Neuropathy
Leber Hereditary Optic Neuropathy (LHON) is a rare genetic disease that causes sudden and severe vision loss, usually in young adults.
- Conditions
- Leber Hereditary Optic Neuropathy (LHON), Leber's Hereditary Optic Neuropathy (LHON), Mitochondrial Disease, Optic Nerve Disease
- Trial name
- NICOLHON (NCT07258667)
- Testing
- Nicotinamide treatment
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Angers
Pseudoxanthoma Elasticum, Tomography, Optical Coherence
CHOPXE - Analysis of Choriocapillaris Flow Deficits in Patients With Pseudoxanthoma Elasticum
This observational study sets out to compare choriocapillaris flow deficits between healthy control subjects and patients with pseudoxanthoma elasticum.
- Conditions
- Pseudoxanthoma Elasticum, Tomography, Optical Coherence, Retinal Disease
- Trial name
- CHOPXE (NCT07006649)
- Testing
- Opthtalmologic diagnosis tests
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
ARDS
V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)
This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation/perfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by…
- Trial name
- MISMATCHED FR (NCT05578742)
- Testing
- PEEP increase, PEEP decrease
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Dysraphism, Open Dysraphism
Study of Urinary Impact of Spinal Dysraphism in the Pediatric Population
Spinal dysraphisms are defined as a congenital malformation characterized by a defect in the closure of the neural tube in the caudal region.
- Conditions
- Dysraphism, Open Dysraphism, Closed Dysraphism
- Trial name
- SPINA (NCT07258654)
- Testing
- description of the impact
- Volunteers
- 210 people
- Sponsor
- University Hospital, Angers
Obstetric Trauma, Anal Sphincter Injury
Anal Incontinence After Obstetrical Anal Sphincter Injury
Obstetrical Anal Sphincter Injury is an identified risk factor for anal incontinence. The mechanisms and the risk factors for anal incontinence in Obstetrical Anal Sphincter Injury women are not well known.
- Conditions
- Obstetric Trauma, Anal Sphincter Injury, Anal Incontinence
- Trial name
- INCONT-LOSA (NCT04940494)
- Testing
- collection of data
- Where
- France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Angers
Shock Circulatory
Interest of Urinary Oxygen Partial Pressure (PO2u) in Predicting the Onset or Recovery of Acute Renal Failure During Shock States - OXYpi Study
Shock state is defined as an acute, life-threatening, circulatory failure with impaired tissue oxygenation (or tissue hypoxia). The cause of the shock state can be septic, anaphylactic, hypovolemic or cardiogenic.
- Trial name
- OXYpi (NCT06320509)
- Testing
- Continuous measurement of uPO2 (both groups)
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Angers
Unexpected Infant Death, Prevention & Control
Impact of Prevention of Safe Sleeping and Unexpected Infant Death
The sudden unexpected infant death (SUID) is defined as "the sudden death of a child aged from 1 month to 1 year who had been healthy until then, whereas nothing in his known history or in the history of events could have allowed…
- Conditions
- Unexpected Infant Death, Prevention & Control, Safe Sleeping
- Trial name
- MinUTE (NCT07237360)
- Testing
- Sleeping mode
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
NAFLD
Comparison of Two sTRAtegies For the Non-Invasive Diagnosis of advanCed Liver Fibrosis in NAFLD
NAFLD, closely linked to overweight and insulin resistance, has reached 25% prevalence worldwide. Advanced liver fibrosis(ALF) must be accurately diagnosed in NAFLD because it defines a subgroup of patients with impaired…
- Trial name
- TRAFIC (NCT04681573)
- Testing
- blood tests
- Where
- 20 sites in France
- Volunteers
- 1,045 people
- Sponsor
- University Hospital, Angers
Anticoagulants; Circulating, Hemorrhagic Disorder
Activates Charcoal for Patients Undergoing Invasive Procedure Delayed Due to Direct Oral Anticoagulants
This is a prospective, multicentric, randomized, open labeled superiority trial This study aims to evaluate the efficacy of oral activated charcoal for improving elimination of direct oral anticoagulants ( Rivaroxaban, Apixaban)…
- Trial name
- CACAOD (NCT02969746)
- Testing
- Activated Charcoal
- Where
- 6 sites in France
- Sponsor
- University Hospital, Angers
NAFLD
French Cohort for the Study of Non-invasive Tests of Liver Lesions in NAFLD/NASH (FreSH Cohort)
Currently, the management of non-alcoholic fatty liver disease (NAFLD) patients has two main limitations. First, there is no approved treatment in NAFLD.
- Trial name
- FreSH (NCT03695796)
- Testing
- biopsy-proven NAFLD patients with non-invasive tests of liver fibrosis (blood tests, elastography devices) and biobank
- Where
- 16 sites in France, Guadeloupe
- Volunteers
- 1,005 people
- Sponsor
- University Hospital, Angers
Leukemia, Lymphoma
Impact of an Early Warning System on the Prognosis of Patients With Hematological Malignancies Receiving Intensive Chemotherapy With or Without Hematopoietic Cell Transplantation.
Patients with hematologic malignancies requiring intensive chemotherapy are at risk for life-threatening complications. Organ failure may appear rapidly and delay in initiating life-sustaining interventions may result in…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma
- Trial name
- ALHERT (NCT06409767)
- Testing
- Real-time calculation of the NEWS with ICU admission if NEWS ≥ 7.
- Where
- 10 sites in France
- Volunteers
- 2,224 people
- Sponsor
- University Hospital, Angers
Epilepsy in Children
Prognostic Value of High-resolution Electrical Source Imaging on the Success of Pediatric Focal Epilepsy Surgery
This study investigates the usefulness of high resolution electrical source imaging (HR-ESI) in the setting of presurgical evaluation of drug-resistant focal epilepsy in children.
- Trial name
- ISEPEE (NCT06271785)
- Testing
- HR-EEG recording
- Where
- 9 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Angers
ADHD
Study of ADHD Children's Sensitivity to Memory Error Production
The purpose of the study is to test whether children with Attention Deficit/Hyperactivity Disorder (ADHD) are more susceptible to false memory production using a DRM paradigm.
- Trial name
- TDAH-DRM (NCT05365295)
- Testing
- DRM (Deese, Roediger et McDermott task)
- Where
- 2 sites in France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Angers
Medical Student
Impact of Regular Karate Practice on the Quality of Life and Health Outcomes of Students
A recent study reported that 52% of medical students had an anxiety disorder and 18% had a depressive syndrome. Following this publication, the Inspectorate General of Social Affairs commissioned a report on the quality of life…
- Trial name
- KARACADEMIC (NCT07116291)
- Testing
- Karate
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
D012893, Sleep Disorder
Prevalence of Sleep Disturbances in Elderly People Hospitalized in Medicine, Psychiatry and Rehabilitation Departments: TOPASE Prospective Study, RIPH 3
Objectives and evaluation criteria: The main objective of this study is to evaluate changes in sleep quality in patients aged 60 and over since their admission to a medical, psychiatric or medical and rehabilitation ward in one…
- Trial name
- TOPASE (NCT06659575)
- Where
- 10 sites in France
- Volunteers
- 104 people
- Sponsor
- University Hospital, Angers
D000096704, Cannabinoid Hyperemesis Syndrome
Cannabinoid Hyperemesis Syndrome. Prospective Multicenter Study of Patients Admitted to Adult Emergency Departments in Maine-et-Loire.
Cannabinoid hyperemesis syndrome (CHS) is characterized by incoercible abdominal pain and vomiting in patients with chronic cannabis use. Patients are relieved by hot showers, an easily performed diagnostic test.
- Trial name
- CANN-AIE (NCT06660901)
- Where
- 3 sites in France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Angers