Clinical trials: sponsored by University Hospital, Antwerp
Obstructive Sleep Apnea
Correlation Between Upper Airway Endoscopy and Physiological Traits of Obstructive Sleep Apnea
OBJECTIVES To train and test a mathematical model to predict complete concentric collapse at the level of the palate (CCCp, primary) and other sites of upper airway collapse (secondary) during drug-induced sleep endoscopy (DISE)…
- Trial name
- NCT04753684
- Where
- Belgium
- Volunteers
- 181 people
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus, Type 1
cArdiopulmonary exerCise Test Assessing Multiple bIOmarkers iN Type 1 Diabetes
Collection of venous blood samples in male T1D patients to evaluate the behavior of different biomarkers (beta-hydroxybutyrate, lactate, glucose) during and after morning Aerobic (60% of VO2 max) and Symptom Limited Maximal…
- Trial name
- NCT05097339
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- University Hospital, Antwerp
Plastic Surgery Training
Plastic Surgery Training in Europe
Survey study to evaluate plastic surgery training in European countries.
- Trial name
- NCT05070806
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Anesthesia, Conduction, Pain, Postoperative
Combined PENG and LFCN Block for Total Hip Arthroplasty
A clinical trial investigating the effect of a combined locoregional anesthesia technique on the postoperative analgesia outcomes after a total hip arthroplasty. A PENG block will be used in combination with a LFCN block.
- Conditions
- Anesthesia, Conduction, Pain, Postoperative, Arthroplasty, Replacement, Hip
- Trial name
- NCT04996290
- Testing
- PENG + LFCN block, Ropivacaine injection
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Measurement of Critical Closing Pressure (Pcrit) During Drug-Induced Sleep Endoscopy (DISE)
This study intends to test the feasibility of measurement of the critical closing pressure (Pcrit) during drug-induced sleep endoscopy (DISE) for use in future studies, which are aimed at finding an alternative method for patient…
- Trial name
- Pcrit-DISE (NCT04232410)
- Testing
- Drug induced sleep endoscopy, Measurement of critical closing pressure of the uppper airway
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University Hospital, Antwerp
Amyloidosis Cardiac, Amyloid Polyneuropathy
Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM) in Patients With Idiopathic Peripheral Neuropathy
The goal of the present study is to determine the occurrence of wild-type and hereditary transthyretin amyloidosis cardiomyopathy among patients with the diagnosis of idiopathic peripheral neuropathy in the setting of a…
- Conditions
- Amyloidosis Cardiac, Amyloid Polyneuropathy, Amyloidosis, Heart Failure
- Trial name
- NCT04985734
- Testing
- Specific diagnostic work-up for ATTR-CM patients
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Titration of Oral Appliance Therapy: a Prospective, Randomized Cross-over Trial.
In this prospective randomized cross-over trial, 3 different titration procedures will be compared: 1. titration of the mandibular advancement device (MAD) in the home setting based on both the physical limits of the patient's…
- Trial name
- NCT03716648
- Testing
- DISE-assisted titration, PSG-guided titration, subjective titration
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea
Nasal Airway Stent (Nastent®) Study in OSA
This study intends to assess the effect of nasal airway stent (Nasten®) as a treatment modality in patients with sleep-disordered breathing (SDB) including snoring and/or obstructive sleep apnea (OSA).
- Trial name
- Nastent (NCT04305964)
- Testing
- Nastent® (a distally perforated soft silicon nasal tube), Polygraphy with WatchPAT™ 300
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- University Hospital, Antwerp
SARS-CoV Infection, Corona Virus Infection
Microbiome Therapy in Covid-19 Primary Care Support
This double-blind, randomized, placebo-controlled study aims to investigate whether a throat spray containing probiotic bacteria (i.e.
- Trial name
- MiCel (NCT04793997)
- Testing
- Microbiome spray
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Healthy
Microbiome Analysis of Skin and Airway Samples and Effect of Face Masks
The goal of this study is to optimize two methods for microbiome analysis of skin and upper airway samples (16S amplicon sequencing and Shotgun sequencing).
- Trial name
- NCT04894422
- Testing
- Observational intervention
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Otitis Media With Effusion, Probiotics
Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With Effusion
The aim of this study is to investigate whether the microbiota in the upper respiratory tract (nasopharynx, adenoids and middle ear fluid) of otitis media with effusion (OME) patients is changed after 4 weeks of probiotic product…
- Conditions
- Otitis Media With Effusion, Probiotics, Adenoid Vegetations
- Trial name
- NCT03277820
- Testing
- Probactiol Mini
- Where
- Belgium
- Volunteers
- 37 people
- Sponsor
- University Hospital, Antwerp
Neuropathic Pain
Localized Neuropathic Pain: Topical Treatment Versus Systemic Treatment
Evaluation of topical treatment with lidocaine 5% patch (daily administration) or capsaicin 8% patch (periodic administration - upon reoccurrence of pain symptoms) in adult patients suffering from localized neuropathic pain (LNP)…
- Trial name
- PELICAN (NCT03348735)
- Testing
- Lidocaine patch 5%, Capsaicin 8% Patch, Pregabalin
- Where
- 13 sites in Belgium
- Volunteers
- 33 people
- Sponsor
- University Hospital, Antwerp
Hearing Loss
ICF in Cochlear Implant Users
The current project proposes a multi-center prospective follow-up cohort study aiming to realize an international framework to classify human functioning and disability in Cochlear Implant (CI) recipients using a standardized ICF…
- Trial name
- NCT04611555
- Where
- 5 sites in Australia, Belgium and 3 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Atopic Dermatitis
Study of the Skin Microbiome and the Potential of a Topical Probiotic Cream for Atopic Dermatitis
The skin microbiome of atopic dermatitis patients and healthy volunteers will be studies by collecting and analysing skin swabs on different timepoint.
- Trial name
- NCT04771910
- Testing
- Topical cream with live probiotic bacteria
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Cerebral Arterial Aneurysm, Ventricular Rate Response Pacing
Neuromonitoring During Rapid Ventricular Pacing in Patients Undergoing Cerebral Aneurysm Surgery
To evaluate the effect of rapid ventricular pacing on the oxygenation of the brain in patients scheduled for cerebral aneurysm clipping surgery or arteriovenous malformation surgery.
- Trial name
- NCT03185091
- Testing
- rapid ventricular pacing, Surgery
- Where
- Belgium
- Volunteers
- 7 people
- Sponsor
- University Hospital, Antwerp
Metastatic Colorectal Cancer
lead-in FOLICOLOR Trial: Following Therapy Response Through Liquid Biopsy in Metastatic Colorectal Cancer Patients
Detection of progressive disease by neuropeptide Y (NPY) methylation in liquid biopsies in patients with RAS and BRAF wild-type, unresectable, metastatic colorectal cancer receiving first-line treatment FOLFOX/FOLFIRI and…
- Trial name
- NCT04735900
- Testing
- Liquid biopsy sampling
- Where
- 6 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Antwerp
Gastroesophageal Reflux Disease and Position
Car Safety Seat and Gastroesophageal Reflux Disease
What's known? Prone position is no longer a treatment option for GERD because of the association with SIDS. Originally, positioning in an infant seat was recommended for infants with GERD.
- Trial name
- NCT01266551
- Testing
- car safety seat
- Where
- Belgium
- Sponsor
- University Hospital, Antwerp
Asthma
Monitoring Asthma Treatment Using Exhaled Nitric Oxide
Asthma is a chronic inflammatory condition in which the airways develop increased responsiveness to various stimuli such as exposure to an allergen, cold air or exercise.
- Trial name
- NOASTHMA (NCT00562991)
- Testing
- measurement of exhaled NO is used to guide treatment
- Where
- 7 sites in Belgium
- Volunteers
- 99 people
- Sponsor
- University Hospital, Antwerp
Vaginal Microbiome, Skin Microbiome
Integrated Genetic and Functional Analysis of the Female Microbiome in a Flemish Cohort
The aim of the project is to improve our knowledge on the stability and temporal dynamics of the Flemish female microbiome (vagina, skin and saliva) in relation to different lifestyle factors and environmental conditions and to…
- Conditions
- Vaginal Microbiome, Skin Microbiome, Saliva Microbiome
- Trial name
- Isala (NCT04319536)
- Testing
- no intervention
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Obstructive Sleep Apnea Syndrome
Efficacy of Additional Titration During Oral Appliance Treatment for Sleep-disordered Breathing.
In the protocol "Predicting therapeutic outcome of mandibular advancement device treatment in obstructive sleep apnea (PROMAD)", 100 patients with obstructive sleep apnea are included and started MAD treatment at 75% of maximal…
- Trial name
- NCT01666886
- Testing
- Mandibular Advancement Device (MAD)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Antwerp