Clinical trials: sponsored by University Hospital, Brest
Pruritus, Chronic Pruritus
Establishment of a Patient Library in Patients With Pruritus Sine Materia
Very little is currently known about the pathophysiology of pruritus sine materia according to the etiology. The creation of this cohort should make it possible to improve our clinical and biological knowledge according to the…
- Conditions
- Pruritus, Chronic Pruritus, Itch
- Trial name
- PRURITHEQUE (NCT05678309)
- Testing
- Blood samples, skin swab sample, skin biopsy sample
- Where
- France
- Volunteers
- 175 people
- Sponsor
- University Hospital, Brest
Sensitive Scalp
Pathophysiological Study of the Sensitive Scalp
Sensitive skin is defined as a syndrome manifested by the occurrence of unpleasant sensations (tingling, burning, pain, pins and needles) in response to stimuli that should not normally cause them.
- Trial name
- SENSISCALP (NCT07156422)
- Testing
- A scalp biopsy using a 4 mm punch in the retroauricular hair zone, a general health questionnaire, Questionnaires concerning their sensitive scalp
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Brain Tumor Adult
The Impact of Paramedic Training in Simulation on the Experience of Patients Treated for Malignant Brain Tumors in Neurosurgery (IPSIMANON)
The goal of this clinical trial is to demonstrate that simulation training for paramedical staff in neurosurgery departments, in announcing and accompanying patients with a brain tumor, improves patient satisfaction when a…
- Trial name
- IPSIMANON (NCT06962215)
- Testing
- Paramedic training
- Where
- 11 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Cancer
Impact of Respiratory Rehabilitation on Quality of Life in Patients With Metastatic Non-small Cell Lung Cancer Treated With Immunotherapy and Chemotherapy in the Maintenance Phase
Lung cancer is highly prevalent, with approximately 46,363 new cases in 2018, accounting for 20.6% of cancer deaths in France. At diagnosis, 70% of patients have advanced or metastatic cancer, treatable only by palliative care.
- Trial name
- REHABIM (NCT06441773)
- Testing
- Respiratory Rehabilitation
- Where
- 3 sites in France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Brest
Physiopathology
Early Pulmonary Effects of Excursion Deep Diving With Closed-circuit Gas Recycling: SPIDD Study
Scuba diving with closed circuit gas rebreathers is currently booming. Initially developed for professional and military diving, this type of diving has become very successful in recreational activities.
- Trial name
- SPIDD (NCT05775562)
- Testing
- Pre and post dive examinations
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Patients Undergoing Esophagectomy, Patients With Severe Polytrauma
Evolution of the Lymphocyte Phenotype in Patients With Infection in Intensive Care Unit
Patients admitted for polytrauma, severe neurological injury, post-operative monitoring or sepsis/septic shock present with significant inflammation, leading to immunoparalysis, which is responsible for infection, particularly…
- Conditions
- Patients Undergoing Esophagectomy, Patients With Severe Polytrauma, Patients With Severe Neurological Lesion, Patients With Abdominal Infection
- Trial name
- REAPHEN (NCT06415474)
- Testing
- Lymphocyte Phenotyping Procedure
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Brest
Venous Thromboembolic Disease
Risk Factors of Venous Thromboembolism in Women During Hormonal Exposure
Young women have an increased risk of venous thromboembolism (VTE) during hormonale exposure (estrogen-containing pill or pregnancy).
- Trial name
- FIT-H (NCT03206372)
- Testing
- Case group, Control group
- Where
- 8 sites in France
- Volunteers
- 2,640 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Pulmonary Embolism, Quality of Life and Dyspnea
Impact on Quality of Life With Pulmonary RehAbilitation After Pulmonary eMBOlism: RAMBO Study
Pulmonary Embolism (PE) is a common and serious disease. Indeed, the annual incidence is 1/1000 patients per year and the 3-month mortality is 10%, which is twice that of myocardial infarction.
- Trial name
- RAMBO (NCT05015153)
- Testing
- Pulmonary rehabilitation (PR)
- Where
- 6 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Brest
Embolism and Thrombosis
Screening for Occult Malignancy in Patients With Unprovoked Venous Thromboembolism
Venous thromboembolism (VTE) can be the earliest sign of cancer. Identifying occult cancers at the time of VTE diagnosis may lead to significant improvement of patients' care.
- Trial name
- MVTEP2/SOME2 (NCT04304651)
- Testing
- Limited cancer screening, Limited cancer screening + FDG PET/CT
- Where
- 16 sites in Canada, France
- Volunteers
- 1,276 people
- Sponsor
- University Hospital, Brest
Pulmonary Arterial Hypertension (PAH)
Impact of Sotatercept on Pulmonary Artery and Right Ventricle Remodeling Imaging Assessed With 68Ga-FAPI PET/CT in Patients With PAH
Pulmonary arterial hypertension (PAH) is a rare, progressive disease characterized by structural changes in the pulmonary arteries, leading to increased pulmonary vascular resistance and elevated pulmonary arterial pressure and…
- Trial name
- SOFAPI (NCT07357974)
- Testing
- [68Ga]Ga-FAPI PET/CT, [68Ga]Ga-MAA PET/CT
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Brest
Prevention of Delirium
Comparison of an Inhaled Sedation Strategy to an Intravenous Sedation Strategy in Intensive Care Unit Patients Treated With Invasive Mechanical Ventilation
The objective of the study is to determine the impact on the frequency of occurrence of delirium of an early inhaled sedation strategy (from induction in rapid sequence if intubation in intensive care, or from admission if…
- Trial name
- INASED (NCT04341350)
- Testing
- Propofol + analgesic drug, Isoflurane + analgesic drug
- Where
- 12 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Brest
Brain Injuries
The NIPA Study Naloxegol Administration to Prevent Opioids Induced Gastrointestinal Motility Disturbance in Brain Injured PAtients
Impaired gastrointestinal transit (IGT) especially constipation, is common among patients under mechanical ventilation, occurring in up to 80 % of the patients during the first week, and has been associated with worse outcome in…
- Trial name
- NIPA (NCT05008926)
- Testing
- Naloxegol
- Where
- 10 sites in France
- Volunteers
- 370 people
- Sponsor
- University Hospital, Brest
Inflammatory Disease
68Gallium-FAPI46 PET/CT Imaging in Chronic Inflammatory and Fibrotic Diseases
This single-center pilot study is designed to explore the preliminary utility of the [68Ga] Ga-FAPI imaging agent in positron emission tomography (PET) combined with computed tomography (CT) for a range of chronic inflammatory…
- Trial name
- PARADISE (NCT06275477)
- Testing
- 68Ga-FAPI46
- Where
- France
- Volunteers
- 390 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism, Dyspnea
Ventilation/Perfusion PET/CT With Galligas and 68Ga-MAA for Regional Lung Function Assessment After Pulmonary Embolism
In patients with pulmonary embolism (PE), after three or six months of anticoagulation, persistent dyspnea and impairment of quality of life are observed in at least 30% of cases.
- Trial name
- EOLE (NCT05103670)
- Testing
- Ventilation/Perfusion PET/CT with Galligas and 68Ga-MAA
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Brest
Cystic Fibrosis
Microbial Biomarkers of EArly Pseudomonas Aeruginosa Colonization in CHildren With Cystic Fibrosis
The objective of this study is to evaluate the predictive nature of the biomarker Porphyromonas catoniae measured at the age of 12 months in the occurrence of colonization with Pseudomonas aeruginosa at 36 months of age in…
- Trial name
- BEACH (NCT03947957)
- Testing
- collection of expectoration, stools and blood
- Where
- 11 sites in France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Brest
Chronic Pain
Emotional Intelligence and Chronic Orofacial Pain
Chronic pain, lasting more than three months, is a widespread health issue that negatively impacts daily life, leading to significant emotional distress and functional impairment.
- Trial name
- IEDOF (NCT07280338)
- Testing
- Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Thrombosis Embolism, Thromboses, Venous
Cancer-related Venous Thromboembolic Disease - Cohort Study
Venous thromboembolic disease (VTE) is a common (1/1000), potentially serious disease (10% mortality when the clinical presentation is that of pulmonary embolism (PE)).
- Conditions
- Thrombosis Embolism, Thromboses, Venous, Cancer
- Trial name
- CAPE (NCT06393764)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Neuropathic Pain, Chronic Pain
Analgesic Effectiveness of Capsaicin 8% Cutaneous Patch in Children
This study concerns children aged to 12 to 17-years with local chronic neuropathic pain after trauma or surgery. It is a multicentric randomized controlled superiority trial in parallel arms : experimental arm: Capsaicin 8%…
- Trial name
- CAPSAPED (NCT05997979)
- Testing
- Capsaicin 8% patch, Hydrocolloid dressing
- Where
- 10 sites in France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism, Venous Thromboembolism
Residual Pulmonary Vascular Obstruction Index Computed With Ventilation/Perfusion SPECT/CT Imaging to Predict the Risk of Venous Thromboembolism Recurrence in Patients With Pulmonary Embolism (PRONOSPECT)
Major risk after pulmonary embolism (PE) is recurrence, fatal in 10% of patients. Patients with PE can be stratified in 3 groups according to the risk of recurrence : very low risk, high risk or Intermediate risk.
- Trial name
- PRONOSPECT (NCT06372730)
- Testing
- Ventilation/Perfusion Single Photon Emission Computed Tomography (V/Q SPECT/CT)
- Where
- 13 sites in France
- Volunteers
- 665 people
- Sponsor
- University Hospital, Brest
Thromboembolic Venous Disease
Prospective Cohort Study on the Determinants of Venous THromboembolic Recurrence
The main objective of the BREIZH-Cohorte study is to determine the incidence of recurrent short, medium and long-term thromboembolic venous disease as well as risk factors for recurrence in two specific populations: patients…
- Trial name
- BREIZH-Cohorte (NCT04297085)
- Testing
- Biologic sample
- Where
- 4 sites in France
- Volunteers
- 3,400 people
- Sponsor
- University Hospital, Brest